CA1324594C - Arrangement for and method of administering a pharmaceutical preparation - Google Patents
Arrangement for and method of administering a pharmaceutical preparationInfo
- Publication number
- CA1324594C CA1324594C CA000565898A CA565898A CA1324594C CA 1324594 C CA1324594 C CA 1324594C CA 000565898 A CA000565898 A CA 000565898A CA 565898 A CA565898 A CA 565898A CA 1324594 C CA1324594 C CA 1324594C
- Authority
- CA
- Canada
- Prior art keywords
- package
- pellets
- covering member
- backing sheet
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title description 6
- 239000008188 pellet Substances 0.000 claims abstract description 48
- 238000000576 coating method Methods 0.000 claims abstract description 17
- 239000011248 coating agent Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims description 18
- 239000000945 filler Substances 0.000 claims description 13
- 150000007514 bases Chemical class 0.000 claims description 9
- -1 antibacterials Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 239000004925 Acrylic resin Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 3
- 239000001095 magnesium carbonate Substances 0.000 claims description 3
- 125000005397 methacrylic acid ester group Chemical group 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000001088 anti-asthma Effects 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 239000000924 antiasthmatic agent Substances 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 229940125715 antihistaminic agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229940124579 cold medicine Drugs 0.000 claims description 2
- 239000002934 diuretic Substances 0.000 claims description 2
- 229940030606 diuretics Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 4
- 206010011224 Cough Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 229940125722 laxative agent Drugs 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 230000002936 tranquilizing effect Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 10
- 238000004090 dissolution Methods 0.000 abstract description 4
- 235000019640 taste Nutrition 0.000 abstract description 4
- 230000035807 sensation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 17
- 229940079593 drug Drugs 0.000 description 16
- 239000003826 tablet Substances 0.000 description 12
- 239000002775 capsule Substances 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000012669 liquid formulation Substances 0.000 description 4
- 238000002483 medication Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229960001708 magnesium carbonate Drugs 0.000 description 2
- 235000014380 magnesium carbonate Nutrition 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 1
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- MWQCHHACWWAQLJ-UHFFFAOYSA-N Prazepam Chemical compound O=C1CN=C(C=2C=CC=CC=2)C2=CC(Cl)=CC=C2N1CC1CC1 MWQCHHACWWAQLJ-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000307 algesic effect Effects 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960000503 bisacodyl Drugs 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
- 229960004166 diltiazem Drugs 0.000 description 1
- 229940018602 docusate Drugs 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 229960002146 guaifenesin Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229960000930 hydroxyzine Drugs 0.000 description 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229940063557 methacrylate Drugs 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- LYIHWEQBSAINHO-UHFFFAOYSA-N n,n-diethyl-2-(2-methoxy-6-prop-2-enylphenoxy)ethanamine;hydrochloride Chemical compound Cl.CCN(CC)CCOC1=C(CC=C)C=CC=C1OC LYIHWEQBSAINHO-UHFFFAOYSA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000002990 phenothiazines Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229940070721 polyacrylate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960004856 prazepam Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Abstract
ABSTRACT OF THE DISCLOSURE
A multitude of non-tacky coated pellets containing a pharmaceutical preparation is housed within a breakable packet which, when broken, enables ready removal of the pellets for the oral administra-tion of the preparation to a patient. The packet includes a bendable backing sheet and a fracturable covering member between which the pellets are held in a vacuum-sealed environment prior to use. The coating of the pellets also prevents dissolution of the preparation in the mouth to avoid the sensation of bitter medicinal taste.
A multitude of non-tacky coated pellets containing a pharmaceutical preparation is housed within a breakable packet which, when broken, enables ready removal of the pellets for the oral administra-tion of the preparation to a patient. The packet includes a bendable backing sheet and a fracturable covering member between which the pellets are held in a vacuum-sealed environment prior to use. The coating of the pellets also prevents dissolution of the preparation in the mouth to avoid the sensation of bitter medicinal taste.
Description
~ 1 324594 ARR~NGE~IENT FOR AND METHOD OF
ADMINISTERING A PH~RMA EUTICAL PREPARATION , ~ ~ , BACKGROUND'~F THE INVENTION
1. Field of the Invention This invention generally relates to an arrange-men~ for, and a method of, administering a pharrnaceutical preparation and, more particularly, to the adm~nistration of an orally active pharmaceutical preparation contained in non-tacky coated pellets by breaking open a frangible packet containing the pellets, and by pouring the pellets from the opened packet into a human or animal patientls mouth.
,i .
i 2. Description of Related Art ` Pharmaceutical preparations are traditionally 3~ orally administered to patients in many forms. Tablets 1~ are often used, but are not altogether desirable in certain cases. For example, depending on their size and coating, tablets can be diff1cult for certain pat-ients, particularly children or small animals, to swallow.
In some instances7 the tablets begin to dissolve imrned-, .
iately upon coming into contact with saliva i~ the ~-, mouth, causing the unpleasant taste of the medici~al ~i~ ; preparation to be sensed. In additio-n, relatively smaI1 tablets can be easily concealed or stolen. This ,~
..,`, " ~: ':;:;' : - :' ' ' : '' . - " : "": '' :" '. ., . ' ' :: '' ~ 2 ~ 1 324594 I
is a p~rticular importance in tne administration of ~ methadone~and like drugs to narcotic addicts, or other i medications to mental patients, because such patients may sometimes not swallow the tablets, but, instead, conceal them in their mouths or clothing in order to sell or dispose of the medicationO
Capsules are also commonly used, particularly in those cases where slow or sustained release of the pharmaceutical preparation is desired. Although gener-ally satisfactory for their intended purpose, capsules which enclose the pharmaceutical preparation within a gelatin container are generally larger in size than tablets and, hence, aggravate the swallowing problem.
1 To overcome this problem, some patien~s break open the 1 capsules to swallow the pharmaceutical preparation within ~^lj the gelatin container, but often the pharmaceutical prep-~1 aration has a bitter taste. In any event, the breaking open of a gelatin container can be messy and cause loss 1 of part of the dasage amount.
,,`! Liquid pharmaceutical formulations are also generally satisfactory, but often need to be refriger-ated or shaken prior to use. In some instances, such as certain pediatric antibiotic suspensions, prepara-' tion of the liquid formulations require addition of ~` water to a powder immediately prior to use. Unless ~j measuring spoons or the lik~ are used, the dosing o ,, .;, ~2 `. - 3 ~ 1 32 4 5~
;. i the liquid formulation may be inaccurate, and spillage is a fre~ent problem, particularly with children.
Also, liquid formu~ations of ten contain sweeteners, coloring and flavoring agents and other additives, ~any of which are not acceptable to nutrition-minded patients. Liquid formulations are also not stable for lengthy periods.
Another common problem with pharmaceutical preparations in tablet or capsule form is that there is very little room, if any, to print indicia on the ta~let or capsule itself. Such indicia could be very use~ul if they identified the preparation itself, the dosage amount, the expiration date, or provided warning notices or directions for use. To meet this need, some drug manufacturers will design a tablet with a characteristic shape or color, or imprint an identifying mark on the tablet. ~owe~er, no room exists on the tablet itself ,jj , for more pri~ed information and, generally, this in-.~
formation would be provided on a bottle or other rela-tively large-sized container housing the individual tablets or capsules.
. 1 .
;Z However, such large-sized bottles or contain-ers are generally too large to fit in one's pocket and, ' rather than being carried about, are generally stored in one's medicine cabinet and thus are out of sight of ,~,., ~j the patient when the tablet/capsule is being orally ~, ~,' - ~ - 1 32 4 5 94 taken. In the case where a patient takes multiple medicati~ns, the medications are often co-mingled in a pill box or similar unmarked container, whereby the medications can be identified, if at all, only by their size, shape and color and reference to a pharma-ceutical te~t. Elderly patients, especially, may be-come confused when unmarked medications are present in an unmarked holder, and may possibly take the wrong medication at the wrong time or exceed their recommended dosage of a given medication.
SUMr~ARY OF THE INVE~TION
, 1 Ob ects of the Invention It is a general object of this invention to provide a novel arrangement for administering pharma-ceutical preparations which avoids the aforementioned drawba~ks inherent in tablet, capsule or liquid formu-lations. ~~
It is another object of this invention to pro-- vide an easily-openable packet containing the pharma-;~ ceutical preparation ~or prompt dispensing of the prep-aration.
A further ob ject of this invention is to pro-' vide a mlniaturized, frangible packet small enough to be e~sily carried in one's pocket and large enough to bear indicia identifying, e.g., the pharmaceutical ., ,, ; 5 _ 1 3245~4 .~1 -preparation, th~ dos~ge, the expiration date, warning notices;~and use instructions.
Yet another object of this invention is to "
provide pharmaceutical preparations in the form of coated pellets which are easy to swallow or to combine with li~uids or foods for oral ingestion.
Still another object of this invention is to provide the coated pellets with non-tacky coatings to prevent -the pellets from adhering to one another or to their container during manufacturing, storage and/or use.
A still further object of this invention is '~6 ~;~ to orally administer the pellets while concealin~ ~he taste of the pharmaceutical preparation contained therein.
Another object of this invention is to sub-stantially prevent the pellets from dissolvin~ immedi-;:
~ ately upon entry into a patient's mouth, yet provide --;! for easy dis~olution in the stomach for quick absorp-~,ii tion into the bloodstream.
Yet another object of this invention is to , .~
administer the pharmaceutical preparation to persons of all ages, e.g., pediatric or geriatric patients, and to animals.
An additional object of this invention is to provide a novel form ~or pharmaceutical preparations administered to drug addic~s and psychiatric patients .... . .
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i vhich will substanti~lly prevent theft or concealment of the ~dications.
~`; Still another object of this invention is to provide a normally-sealed packet which, once its seal is broken, cannot be re-sealed, thereby preventing tampering with the medication.
.~ .
Another object of this invention is to pro-vide a readily disposable pellet-containing packet.
; A further object of this invention is to pro-vide a novel me~hod of administration of a pharmaceuti-cal preparation which is easy to swallow, inexpensive to manufacture, and convenient to use.
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1 2. Features of the Invention 1 In keeping with these objects, and others ! which will become apparent hereinafter, one feature of this invention resides, briefly stated, in an arrange-ment for, a~ a method of, administering one or more dosage units of a pharmaceutical preparation which com-prises a multitude of pellets containing the pharma-ceutical preparation contained in a breakable packet.
The breakable packet includes a backing sheet, prefer-ably constituted of a paper material, and a covering member,preferably constituted of ~ synthetic plastic i material and overlying the baic~ing sheet. The covering ! member and backing sheet together bound a compartment , ' , ~ .
:., q ` _ 7 _ 1324594 1 .
1i~ in which the pellets are contained. The pellets have ., .
non-tac~ coatings to prevent them from adhering to one ano~her and to the packet. The packet has a frangi-ble zone which, when broken, enables removal of the pel-J lets from the compartment.
;` In use, the backing sheet is bendable when '3' subjected to external forces, e.g~, moderate fingertip 3 pressures,at the frangible zone. When the backing sheet is bent, the covering member fractures at the frangible zone into fractured parts whereby an opening in the compartment is created~ permitting removal of the pel-3i lets. The fractured parts remain on the bent backing sheet for ease of disposal.
.'"J Preferably, the covering member includes a ; hollow main portion having a predetermined cross-sec-tion, a neck portion having a cross-section less than said predetermined cross-section, and a flange portion sealed and a~tached to one major surface of the backing sheet. In the preferxed embodiment, the frangible zone extends across the neck portion and, when the co~ering member fractures at the neck portion, walls are formed at the neck por~ion which bound a tapered pouring spout or funllel through which the pellets pass.
,:`i ,X,3 An opposite major surface of the backing sheet is advantageously applied with indicla to identify the pharmaceutical preparation itself, the dosage amount, ~1 . i 1 "' - 8 - 1 3~ 4 5 94 :i 1j the expiration date, and can provide warniny notices - or use i~structions, as desired.
! The covering member is preferably constituted of a light-transmissive material to permit viewing of the pellets through the covering member. In this way, a user can ~erify the extent to which the pellets have been removed from the packet.
Another feature o~ this invention resides in providing a non-tacky coating for each medication-con-taining pellet, said coating comprising a polymeric material, e.g., a cationic copolymeric acrylate resin based on me~hacrylate and neutral methacrylic acid esters. The coating further includes a basic compound filler that is soluble in acid. Any organic or inor-ganic compound having a high solubility rate in an acidic medium such as gastric juices may serve as the basic compound iller. As preferred embodiments, the filler may bR calcium carbonate., aluminum hydroxide or magnesium carbonate, or any mixture thereof.
In use, the pellet coating s mx~rding the pharm aceutical preparation prevents the latter from being dissolved upon contact with saliva in a patient's mouth and, lnstead, delays such dissolution ~ntil the pellets reach the gastric juices in the patient's i ' stomach. The basic compound dissolves in the acidic gastric ~uices and liberates the pharmaceutical preparation.
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, ; Thus, the basic compound filler may be us~ in an amount sufficient to f~cilitate the desired release charac-teristics of tlle prepaxation. TypicalLy, the filler ', ls present in the coating in an amount from about 10 to about 90~ by weight.
The polymeric material is advantageously ~` selected from the group consisting of cellulosic, poly-acrylate and polyvinyl alcoholic polymers.
A single packet may contain one or more com-,q " .
~, partments, each containing a ~raction of a recommended dose to be admiinistered to a patient. Likewise, multi-ple packets representing multiple doses can be provided on a common backing sheet or on a roll, and can be detached from the roll as required in order to allow precise dosages to be administered to the patient.
Th~average size of each pellet is generally ~ not greater than 1 mm in diameter.
u The novel features which are considered as .'~
characteristic of the invention are set forth in parti~
cular in the appended claims. The invention itself, i;l ' ~
~ however, both as to its construction and its method of ., ~ operation, together with additional objects and advan-.
tages thereof, best will be understood from the follow-ing description of specific embodiments when read in ~s connec~lon with the accompanying drawings.
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BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a front perspcctive view of an arrangement for admini~tering a pharmaceutical prep-aration in accordance with this invention;
FIG. 2 is an enlarged cross-sectional view taken on line 2--2 of FIG. 1;
I FIG. 3 is a greatly enlarged sectional view .~ of one of the multitude of pellets containing the ,, i pharmaceutical preparationi :1 FIG. 4 is a rear view of the arrangement of FIG. 1, bearing printed indicia; and FIG. 5 is a top plan ~iew of another arrange-ment for administering a pharmaceutical preparation in : accordance with this invention.
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~` DET~ILED DESCRIPTION OF TlJsE PREFERRED EMBODIMENTS
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Referring now to FIGs. 1 and 2, reference numeraL 10 generally identifies an arrangement for administering a pharmaceutical preparation. The ar~
rangement 10 comprises a multitude of pellets, a rep-, resentative one 12 of which is shown in enlarged sec-tional view in FIG. 3. The pellets 12 contain the pharmaceutical preparation to be administered to a ~i patient~
The arrangement 10 further comprises a break-able packet 14 for holding`the pellets 12. The packet includes a backing sheet 16, preferably constituted of ~; a paper material, although vinyl and other thin, flex-:
ible sheeting materials may be utilized. The backing sheet generally, although not necessarily, lies in a plane and has opposite major surfaces, namely, top surface 18 and bottom surface 20. The paper material `' of the backing sheet renders the same bendable, and provides a certain degree of frangibility.
The packet 14 further includes a covering :`~
member 22, preferably constituted of a synthetic plas-~ic material which is light-transmissive. The covering member 22 includes a hollow main portion 24 having a predetermined half-cylindrical cross-section, a neck portion 2~ having ~s half-frusto-conical cross-section less than said cross-sec~ion of main portion 24, a ,i >~3 s' ;
, head portion 28 having a half-spherical cross-section, ~nd a ge~er~lly pLanar flange portion 30 extending in a plane outwardly of the main, neck and head portions i and sealed to said top surface 18 of the backing sheet 16, preferably by means of a vacuum seal formed by heat and pressure. The main, neck and head portions extend ~; outwardly of top surface 18, and bound therewith a com-partment 32 in which the pellets 12 are contained-with ~j .
clearance.
The packet 34 is provided with a frangible zone 34 which, when broken, enables removal of the pel-i lets 12 from the compartment 12. In a preferred e~bodi-ment, the frangible zone 34 extends across the neck por-tion 26 at the juncture between the neck and head por-tions, i.e., where the covering member has its smallest cross-section.
1 :
As previously mentioned, the backing sheet hAs a certaL~ degree of frhngibility and is bendable when subjected to external orces at the neck portion.
The covering memher has a degree of rigidity andj hence, frangibility greater than that of the backing sheet so ^lj th~at the co~ering member fractures at the neck po~tion when external forces, e.g., fingertip pressure, bend ' the backing sheet.~ Indeed, in use, the synthetic plas-tic material of the covering member does not substan-tially exhibit plastic deformation, but, instead/
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cracks open, whereas, the paper backing sheet merely cr~ases~ The coverin~ member actually cracks into two fractured parts, ~oth of which remain attached to the bent backing sheet due to the presence of the flange portion 30. Once cracked open, the frusto-conically-shaped neck portion has tapered walls bound-ing a pouring spout thxough which the pellets may pass for administration of the pharmaceutical preparation.
The light-transmissive covering member permits the ,:
patient to view the pellets through the covering me~-ber to evaluate how many of the pellets have been re-moved from the compartment.
The junc~ure between the neck 26 and the head 28 portions of the covering member is sufficient, due to its reduced cross-section, to constitute the frangible zone at which the covering member is frac-~ ' tured. In some cases, it may be desirable to facili-tate the bre3king operation by further weakening the s frangible zone by providing a crease line across the rear of the backing sheet 16 immediately behind the aforementioned juncture. As shown in FIG. 4, the crease line can also be constituted by a series of ... ; , linear perforations 36, none of which goes entirely ' through the backing sheet in order to maintain the : ,.,1 ~ integrity and seal of the compartment 32.
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., Also shown in FIG. 4 is a set of exemplary ., .
indicia~applied, eOg., by printing, onto the bottom ~ sur~ace 20 of the backln~ sheet 16. The indicia may 0 include the identification of the drug, instructions as to how to break open the packet, the dosage amount of the pharmaceutical preparation within the packet, directions for use, the expiration date, a warning notice~ and any other information which the drug manu-, facturer wishes to impart to the patient. The indicia S need not be applied only to the bottom surface 20 of the backing sheet; they could equally as well be ap-plied to the front surface thereof, or to the covering me~er.
As shown in FIG. 5, more than one breakable ~i ~packet can be attached to the same backing shee~.
Thus, packets 14, 14A are both provided on a backing q, sheet 38 in an analogous ~.anner to that described earlier for packing sheet 16, except that the backing I sheet 38 is provided with a V-shaped notch 40 to permit `;i ready detachment of each packet from the backing sheet 38 by tearing along the notch 40. Alternativelyl each of the packets ~4, 14A may be separately opened for '! removal of the pellets by rupturing the juncture be-' tween the neck 26 and head 28 on each packet when de-slred, without separation of the backing sheets of the ! joined packets.
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l~ This invention also contemplates the provi-`~, sion o~ more than two p~c~ets on a single backing sheet 38 and, indeed, the packets can be mounted on a continuous strip wound in a roll, or on a large sheet, .
each packet being detachable from the strip by any con-venient tear-off means, or being separately rupturable for removal of the pelletized medication.
Turning, then, to FIG. 3, each pellet con-tains a core 42 of a pharmaceutical preparation com-prising one or more active ingredients, and pharma-ceutically acceptable excipients, binders and fillers, if any, as well as a non-tacky outer coating 44. Each , ' peller has an average total diameter of not greater than 1 mm. Each non-tacky coating includes a polymeric material, which advantageously comprises a polymer which is a cationic copolymeric acrylic resin based on metha-crylate and neutral methacrylic acid esters, and a basic compound filler. An example of such cationic *
copolymeric acrylic resin is EUDRAGIT E (Pharma ~3 International~.
,~y As a basic compound, any organic or inorganic ~, comp~und having a high degree of solubility in an acidic medium may be used and, as preferred embodi-ments, calcium carbonate, aluminum hydroxide or mag-nesium carbonate may be mentioned. The filler is pref-erably present in an amount from about 10% to about 90 i * Trade mark.
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~ ` - 16 - 1 324~94 ... .
` by weiqht of the coatin~, preferably in a range from `! .
about 3Q~ to abo~t 60~i by weight and, still more pref-erably, in amount about 504 by ~eight. The filler reduces the amount of polymer that is used, greatly :
reducing manufacturing costs. The filler reduces the tackiness of the polymer to not only reduce manufac-;~ turing difficulties in coating, but also promotes the ~, dissolution of the pellets in the gastric ~uices of a patient's stomach, as heretofore described.
ri A major purpose of the coating is also to mask the taste of the pharmaceutical preparation in i:~
~1 thè cores of the pellets and, accordingly, to delay `~
the dissolution of the pellets until they have reached ~t the patient's stomach.
Another embodiment of this invention involves utilizing as the polymeric material in the pellet coat-~ ing a water-soluble polymer such as gelatin or hydrogel '~ compounds. Examples of such water-soluble polymers are , acryl~mide, N vinyl pyrolidone and N,N'-methyl nebis-` acrylamide.
The pharmaceutical preparation itself can com-1 - prise any orally active, gut-absorbably active ingredi-Y~ ent including, by ~ay of example, :,~
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, . j , ., ~ . , ~ .,; .. ' ' ! ' .. .. ' ; - 16~ - 1 324 594 . . ~ .
~, ar,algesics, such as acetaminophen~ aspirin, ibuprofen, .. morphine; antiasthmatics,such as thcophy-lline, al~uterol, ' prednisone, prednlsolone; antimicrobials (antibacterials, :.:, antibiotics, antifungal agents), such as sulfa drugs, trimethoprim, nitro~urantoin, penicillins, cephalosporins, ~ tetracyclines, chloramphenicol, erythromycin, griscofulvin, :~i nystatin; antihistamines, such as phenylpropranolamine, pseudoephedrine,. clemastlne, terfenadine; anti-inflam-matory agents, such as phenylbutazones, salicylates, steroids, naproxen, piroxicam, indomethacin, ketoprofen, sulindac; antiepileptic agents, such as valproic acid, carbamazepine; couyh and cold medicines, such as dextro-methorphen, guaifenesin, chlorphenitamine, ammonium chloride; cardio~ascular agents, such as labetolol, :j propranolol, timolol, verapamil, diltiazem, ni~edipine, procainamide, guinidines; diuretics, such as furosemide, . ~ thiazides, spironolactone; laxativqs, such as docusate, bisacodyl; t~quilizers, such as lorazepam, prazepam, diazepam, chlordiazepoxide, hydroxyzine, meprobama~e~
phenothiazines; ~itamins.
''~`,! The backing sheet need not be constituted solely o~ paper, but may be coated with a plastic or . aluminum layer.
~3 ' ~.:
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:
`i In practice, the novel pharmaceutical dis-pensing ~rrangement is provided to a health profes-sional or to the patient who administers the pharma-ceutical preparation by rupturinq one or more of the individual dosage packets and pouring the contents ,.~
into the mouth of the patient ~or immediate swallowing, i with or without water or other accompanying liquid.
.' The pellets would normally be self-administered into ~3 . the mouth, except in the case of small children, `;1 elderly or incapacitated patients, or drug addicts, :~! psychiatric patients and otherswho may conceal or not ~ take their medication if self-administration is -.^ permitted.
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~ - 18 - 1324594 ", It will be understood that each of the ele-.~ .
ments described above, or two or more together, also may find a useful appllcation in other types of con-structions dif~ering from the types described above.
While the invention has been illustrated and ~1 described as embodied in an arrangement for, and method ? f, administering a pharrnaceutlcal preparation, it is not intended to be limited to the details shown, since various modifications and structural changes may be made wi~hout departing in any way from the splrit of the present invention.
Without further analysis, the foregoing will ~ ; so fully reveal the gist of the present invention that Z
others can, by applying current knowledge, readily adapt it or various applications without omitting features ;i~
that, from the standpoint of prior art, fairly consti-tute essential charaoteristics of the generic or speci-~ fic aspects g this invention and, therefore, such adap-,1; tations should and are intended to be comprehended within ~he meaning and range of equivalence of the fol-~ lowing claims.
.~ What is claimed as new and desired to be pro-;i . tected by Letters Patent is set forth in the appended ' claims.
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ADMINISTERING A PH~RMA EUTICAL PREPARATION , ~ ~ , BACKGROUND'~F THE INVENTION
1. Field of the Invention This invention generally relates to an arrange-men~ for, and a method of, administering a pharrnaceutical preparation and, more particularly, to the adm~nistration of an orally active pharmaceutical preparation contained in non-tacky coated pellets by breaking open a frangible packet containing the pellets, and by pouring the pellets from the opened packet into a human or animal patientls mouth.
,i .
i 2. Description of Related Art ` Pharmaceutical preparations are traditionally 3~ orally administered to patients in many forms. Tablets 1~ are often used, but are not altogether desirable in certain cases. For example, depending on their size and coating, tablets can be diff1cult for certain pat-ients, particularly children or small animals, to swallow.
In some instances7 the tablets begin to dissolve imrned-, .
iately upon coming into contact with saliva i~ the ~-, mouth, causing the unpleasant taste of the medici~al ~i~ ; preparation to be sensed. In additio-n, relatively smaI1 tablets can be easily concealed or stolen. This ,~
..,`, " ~: ':;:;' : - :' ' ' : '' . - " : "": '' :" '. ., . ' ' :: '' ~ 2 ~ 1 324594 I
is a p~rticular importance in tne administration of ~ methadone~and like drugs to narcotic addicts, or other i medications to mental patients, because such patients may sometimes not swallow the tablets, but, instead, conceal them in their mouths or clothing in order to sell or dispose of the medicationO
Capsules are also commonly used, particularly in those cases where slow or sustained release of the pharmaceutical preparation is desired. Although gener-ally satisfactory for their intended purpose, capsules which enclose the pharmaceutical preparation within a gelatin container are generally larger in size than tablets and, hence, aggravate the swallowing problem.
1 To overcome this problem, some patien~s break open the 1 capsules to swallow the pharmaceutical preparation within ~^lj the gelatin container, but often the pharmaceutical prep-~1 aration has a bitter taste. In any event, the breaking open of a gelatin container can be messy and cause loss 1 of part of the dasage amount.
,,`! Liquid pharmaceutical formulations are also generally satisfactory, but often need to be refriger-ated or shaken prior to use. In some instances, such as certain pediatric antibiotic suspensions, prepara-' tion of the liquid formulations require addition of ~` water to a powder immediately prior to use. Unless ~j measuring spoons or the lik~ are used, the dosing o ,, .;, ~2 `. - 3 ~ 1 32 4 5~
;. i the liquid formulation may be inaccurate, and spillage is a fre~ent problem, particularly with children.
Also, liquid formu~ations of ten contain sweeteners, coloring and flavoring agents and other additives, ~any of which are not acceptable to nutrition-minded patients. Liquid formulations are also not stable for lengthy periods.
Another common problem with pharmaceutical preparations in tablet or capsule form is that there is very little room, if any, to print indicia on the ta~let or capsule itself. Such indicia could be very use~ul if they identified the preparation itself, the dosage amount, the expiration date, or provided warning notices or directions for use. To meet this need, some drug manufacturers will design a tablet with a characteristic shape or color, or imprint an identifying mark on the tablet. ~owe~er, no room exists on the tablet itself ,jj , for more pri~ed information and, generally, this in-.~
formation would be provided on a bottle or other rela-tively large-sized container housing the individual tablets or capsules.
. 1 .
;Z However, such large-sized bottles or contain-ers are generally too large to fit in one's pocket and, ' rather than being carried about, are generally stored in one's medicine cabinet and thus are out of sight of ,~,., ~j the patient when the tablet/capsule is being orally ~, ~,' - ~ - 1 32 4 5 94 taken. In the case where a patient takes multiple medicati~ns, the medications are often co-mingled in a pill box or similar unmarked container, whereby the medications can be identified, if at all, only by their size, shape and color and reference to a pharma-ceutical te~t. Elderly patients, especially, may be-come confused when unmarked medications are present in an unmarked holder, and may possibly take the wrong medication at the wrong time or exceed their recommended dosage of a given medication.
SUMr~ARY OF THE INVE~TION
, 1 Ob ects of the Invention It is a general object of this invention to provide a novel arrangement for administering pharma-ceutical preparations which avoids the aforementioned drawba~ks inherent in tablet, capsule or liquid formu-lations. ~~
It is another object of this invention to pro-- vide an easily-openable packet containing the pharma-;~ ceutical preparation ~or prompt dispensing of the prep-aration.
A further ob ject of this invention is to pro-' vide a mlniaturized, frangible packet small enough to be e~sily carried in one's pocket and large enough to bear indicia identifying, e.g., the pharmaceutical ., ,, ; 5 _ 1 3245~4 .~1 -preparation, th~ dos~ge, the expiration date, warning notices;~and use instructions.
Yet another object of this invention is to "
provide pharmaceutical preparations in the form of coated pellets which are easy to swallow or to combine with li~uids or foods for oral ingestion.
Still another object of this invention is to provide the coated pellets with non-tacky coatings to prevent -the pellets from adhering to one another or to their container during manufacturing, storage and/or use.
A still further object of this invention is '~6 ~;~ to orally administer the pellets while concealin~ ~he taste of the pharmaceutical preparation contained therein.
Another object of this invention is to sub-stantially prevent the pellets from dissolvin~ immedi-;:
~ ately upon entry into a patient's mouth, yet provide --;! for easy dis~olution in the stomach for quick absorp-~,ii tion into the bloodstream.
Yet another object of this invention is to , .~
administer the pharmaceutical preparation to persons of all ages, e.g., pediatric or geriatric patients, and to animals.
An additional object of this invention is to provide a novel form ~or pharmaceutical preparations administered to drug addic~s and psychiatric patients .... . .
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; ` - 6 - 1 324 594 . ;
i vhich will substanti~lly prevent theft or concealment of the ~dications.
~`; Still another object of this invention is to provide a normally-sealed packet which, once its seal is broken, cannot be re-sealed, thereby preventing tampering with the medication.
.~ .
Another object of this invention is to pro-vide a readily disposable pellet-containing packet.
; A further object of this invention is to pro-vide a novel me~hod of administration of a pharmaceuti-cal preparation which is easy to swallow, inexpensive to manufacture, and convenient to use.
, ............................. .
1 2. Features of the Invention 1 In keeping with these objects, and others ! which will become apparent hereinafter, one feature of this invention resides, briefly stated, in an arrange-ment for, a~ a method of, administering one or more dosage units of a pharmaceutical preparation which com-prises a multitude of pellets containing the pharma-ceutical preparation contained in a breakable packet.
The breakable packet includes a backing sheet, prefer-ably constituted of a paper material, and a covering member,preferably constituted of ~ synthetic plastic i material and overlying the baic~ing sheet. The covering ! member and backing sheet together bound a compartment , ' , ~ .
:., q ` _ 7 _ 1324594 1 .
1i~ in which the pellets are contained. The pellets have ., .
non-tac~ coatings to prevent them from adhering to one ano~her and to the packet. The packet has a frangi-ble zone which, when broken, enables removal of the pel-J lets from the compartment.
;` In use, the backing sheet is bendable when '3' subjected to external forces, e.g~, moderate fingertip 3 pressures,at the frangible zone. When the backing sheet is bent, the covering member fractures at the frangible zone into fractured parts whereby an opening in the compartment is created~ permitting removal of the pel-3i lets. The fractured parts remain on the bent backing sheet for ease of disposal.
.'"J Preferably, the covering member includes a ; hollow main portion having a predetermined cross-sec-tion, a neck portion having a cross-section less than said predetermined cross-section, and a flange portion sealed and a~tached to one major surface of the backing sheet. In the preferxed embodiment, the frangible zone extends across the neck portion and, when the co~ering member fractures at the neck portion, walls are formed at the neck por~ion which bound a tapered pouring spout or funllel through which the pellets pass.
,:`i ,X,3 An opposite major surface of the backing sheet is advantageously applied with indicla to identify the pharmaceutical preparation itself, the dosage amount, ~1 . i 1 "' - 8 - 1 3~ 4 5 94 :i 1j the expiration date, and can provide warniny notices - or use i~structions, as desired.
! The covering member is preferably constituted of a light-transmissive material to permit viewing of the pellets through the covering member. In this way, a user can ~erify the extent to which the pellets have been removed from the packet.
Another feature o~ this invention resides in providing a non-tacky coating for each medication-con-taining pellet, said coating comprising a polymeric material, e.g., a cationic copolymeric acrylate resin based on me~hacrylate and neutral methacrylic acid esters. The coating further includes a basic compound filler that is soluble in acid. Any organic or inor-ganic compound having a high solubility rate in an acidic medium such as gastric juices may serve as the basic compound iller. As preferred embodiments, the filler may bR calcium carbonate., aluminum hydroxide or magnesium carbonate, or any mixture thereof.
In use, the pellet coating s mx~rding the pharm aceutical preparation prevents the latter from being dissolved upon contact with saliva in a patient's mouth and, lnstead, delays such dissolution ~ntil the pellets reach the gastric juices in the patient's i ' stomach. The basic compound dissolves in the acidic gastric ~uices and liberates the pharmaceutical preparation.
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, :.1. .
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, ; Thus, the basic compound filler may be us~ in an amount sufficient to f~cilitate the desired release charac-teristics of tlle prepaxation. TypicalLy, the filler ', ls present in the coating in an amount from about 10 to about 90~ by weight.
The polymeric material is advantageously ~` selected from the group consisting of cellulosic, poly-acrylate and polyvinyl alcoholic polymers.
A single packet may contain one or more com-,q " .
~, partments, each containing a ~raction of a recommended dose to be admiinistered to a patient. Likewise, multi-ple packets representing multiple doses can be provided on a common backing sheet or on a roll, and can be detached from the roll as required in order to allow precise dosages to be administered to the patient.
Th~average size of each pellet is generally ~ not greater than 1 mm in diameter.
u The novel features which are considered as .'~
characteristic of the invention are set forth in parti~
cular in the appended claims. The invention itself, i;l ' ~
~ however, both as to its construction and its method of ., ~ operation, together with additional objects and advan-.
tages thereof, best will be understood from the follow-ing description of specific embodiments when read in ~s connec~lon with the accompanying drawings.
:1 .
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.'~, `';' ` 1 3245q~ 10 -:
~" ,.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a front perspcctive view of an arrangement for admini~tering a pharmaceutical prep-aration in accordance with this invention;
FIG. 2 is an enlarged cross-sectional view taken on line 2--2 of FIG. 1;
I FIG. 3 is a greatly enlarged sectional view .~ of one of the multitude of pellets containing the ,, i pharmaceutical preparationi :1 FIG. 4 is a rear view of the arrangement of FIG. 1, bearing printed indicia; and FIG. 5 is a top plan ~iew of another arrange-ment for administering a pharmaceutical preparation in : accordance with this invention.
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~` DET~ILED DESCRIPTION OF TlJsE PREFERRED EMBODIMENTS
" ~
Referring now to FIGs. 1 and 2, reference numeraL 10 generally identifies an arrangement for administering a pharmaceutical preparation. The ar~
rangement 10 comprises a multitude of pellets, a rep-, resentative one 12 of which is shown in enlarged sec-tional view in FIG. 3. The pellets 12 contain the pharmaceutical preparation to be administered to a ~i patient~
The arrangement 10 further comprises a break-able packet 14 for holding`the pellets 12. The packet includes a backing sheet 16, preferably constituted of ~; a paper material, although vinyl and other thin, flex-:
ible sheeting materials may be utilized. The backing sheet generally, although not necessarily, lies in a plane and has opposite major surfaces, namely, top surface 18 and bottom surface 20. The paper material `' of the backing sheet renders the same bendable, and provides a certain degree of frangibility.
The packet 14 further includes a covering :`~
member 22, preferably constituted of a synthetic plas-~ic material which is light-transmissive. The covering member 22 includes a hollow main portion 24 having a predetermined half-cylindrical cross-section, a neck portion 2~ having ~s half-frusto-conical cross-section less than said cross-sec~ion of main portion 24, a ,i >~3 s' ;
, head portion 28 having a half-spherical cross-section, ~nd a ge~er~lly pLanar flange portion 30 extending in a plane outwardly of the main, neck and head portions i and sealed to said top surface 18 of the backing sheet 16, preferably by means of a vacuum seal formed by heat and pressure. The main, neck and head portions extend ~; outwardly of top surface 18, and bound therewith a com-partment 32 in which the pellets 12 are contained-with ~j .
clearance.
The packet 34 is provided with a frangible zone 34 which, when broken, enables removal of the pel-i lets 12 from the compartment 12. In a preferred e~bodi-ment, the frangible zone 34 extends across the neck por-tion 26 at the juncture between the neck and head por-tions, i.e., where the covering member has its smallest cross-section.
1 :
As previously mentioned, the backing sheet hAs a certaL~ degree of frhngibility and is bendable when subjected to external orces at the neck portion.
The covering memher has a degree of rigidity andj hence, frangibility greater than that of the backing sheet so ^lj th~at the co~ering member fractures at the neck po~tion when external forces, e.g., fingertip pressure, bend ' the backing sheet.~ Indeed, in use, the synthetic plas-tic material of the covering member does not substan-tially exhibit plastic deformation, but, instead/
. ..
. ~ !
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cracks open, whereas, the paper backing sheet merely cr~ases~ The coverin~ member actually cracks into two fractured parts, ~oth of which remain attached to the bent backing sheet due to the presence of the flange portion 30. Once cracked open, the frusto-conically-shaped neck portion has tapered walls bound-ing a pouring spout thxough which the pellets may pass for administration of the pharmaceutical preparation.
The light-transmissive covering member permits the ,:
patient to view the pellets through the covering me~-ber to evaluate how many of the pellets have been re-moved from the compartment.
The junc~ure between the neck 26 and the head 28 portions of the covering member is sufficient, due to its reduced cross-section, to constitute the frangible zone at which the covering member is frac-~ ' tured. In some cases, it may be desirable to facili-tate the bre3king operation by further weakening the s frangible zone by providing a crease line across the rear of the backing sheet 16 immediately behind the aforementioned juncture. As shown in FIG. 4, the crease line can also be constituted by a series of ... ; , linear perforations 36, none of which goes entirely ' through the backing sheet in order to maintain the : ,.,1 ~ integrity and seal of the compartment 32.
. ~ -.~ .
., Also shown in FIG. 4 is a set of exemplary ., .
indicia~applied, eOg., by printing, onto the bottom ~ sur~ace 20 of the backln~ sheet 16. The indicia may 0 include the identification of the drug, instructions as to how to break open the packet, the dosage amount of the pharmaceutical preparation within the packet, directions for use, the expiration date, a warning notice~ and any other information which the drug manu-, facturer wishes to impart to the patient. The indicia S need not be applied only to the bottom surface 20 of the backing sheet; they could equally as well be ap-plied to the front surface thereof, or to the covering me~er.
As shown in FIG. 5, more than one breakable ~i ~packet can be attached to the same backing shee~.
Thus, packets 14, 14A are both provided on a backing q, sheet 38 in an analogous ~.anner to that described earlier for packing sheet 16, except that the backing I sheet 38 is provided with a V-shaped notch 40 to permit `;i ready detachment of each packet from the backing sheet 38 by tearing along the notch 40. Alternativelyl each of the packets ~4, 14A may be separately opened for '! removal of the pellets by rupturing the juncture be-' tween the neck 26 and head 28 on each packet when de-slred, without separation of the backing sheets of the ! joined packets.
.
.
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., ~ - 15 `; I 324594 .
l~ This invention also contemplates the provi-`~, sion o~ more than two p~c~ets on a single backing sheet 38 and, indeed, the packets can be mounted on a continuous strip wound in a roll, or on a large sheet, .
each packet being detachable from the strip by any con-venient tear-off means, or being separately rupturable for removal of the pelletized medication.
Turning, then, to FIG. 3, each pellet con-tains a core 42 of a pharmaceutical preparation com-prising one or more active ingredients, and pharma-ceutically acceptable excipients, binders and fillers, if any, as well as a non-tacky outer coating 44. Each , ' peller has an average total diameter of not greater than 1 mm. Each non-tacky coating includes a polymeric material, which advantageously comprises a polymer which is a cationic copolymeric acrylic resin based on metha-crylate and neutral methacrylic acid esters, and a basic compound filler. An example of such cationic *
copolymeric acrylic resin is EUDRAGIT E (Pharma ~3 International~.
,~y As a basic compound, any organic or inorganic ~, comp~und having a high degree of solubility in an acidic medium may be used and, as preferred embodi-ments, calcium carbonate, aluminum hydroxide or mag-nesium carbonate may be mentioned. The filler is pref-erably present in an amount from about 10% to about 90 i * Trade mark.
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;~ _ .. . . . ... ....
~ ` - 16 - 1 324~94 ... .
` by weiqht of the coatin~, preferably in a range from `! .
about 3Q~ to abo~t 60~i by weight and, still more pref-erably, in amount about 504 by ~eight. The filler reduces the amount of polymer that is used, greatly :
reducing manufacturing costs. The filler reduces the tackiness of the polymer to not only reduce manufac-;~ turing difficulties in coating, but also promotes the ~, dissolution of the pellets in the gastric ~uices of a patient's stomach, as heretofore described.
ri A major purpose of the coating is also to mask the taste of the pharmaceutical preparation in i:~
~1 thè cores of the pellets and, accordingly, to delay `~
the dissolution of the pellets until they have reached ~t the patient's stomach.
Another embodiment of this invention involves utilizing as the polymeric material in the pellet coat-~ ing a water-soluble polymer such as gelatin or hydrogel '~ compounds. Examples of such water-soluble polymers are , acryl~mide, N vinyl pyrolidone and N,N'-methyl nebis-` acrylamide.
The pharmaceutical preparation itself can com-1 - prise any orally active, gut-absorbably active ingredi-Y~ ent including, by ~ay of example, :,~
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, . j , ., ~ . , ~ .,; .. ' ' ! ' .. .. ' ; - 16~ - 1 324 594 . . ~ .
~, ar,algesics, such as acetaminophen~ aspirin, ibuprofen, .. morphine; antiasthmatics,such as thcophy-lline, al~uterol, ' prednisone, prednlsolone; antimicrobials (antibacterials, :.:, antibiotics, antifungal agents), such as sulfa drugs, trimethoprim, nitro~urantoin, penicillins, cephalosporins, ~ tetracyclines, chloramphenicol, erythromycin, griscofulvin, :~i nystatin; antihistamines, such as phenylpropranolamine, pseudoephedrine,. clemastlne, terfenadine; anti-inflam-matory agents, such as phenylbutazones, salicylates, steroids, naproxen, piroxicam, indomethacin, ketoprofen, sulindac; antiepileptic agents, such as valproic acid, carbamazepine; couyh and cold medicines, such as dextro-methorphen, guaifenesin, chlorphenitamine, ammonium chloride; cardio~ascular agents, such as labetolol, :j propranolol, timolol, verapamil, diltiazem, ni~edipine, procainamide, guinidines; diuretics, such as furosemide, . ~ thiazides, spironolactone; laxativqs, such as docusate, bisacodyl; t~quilizers, such as lorazepam, prazepam, diazepam, chlordiazepoxide, hydroxyzine, meprobama~e~
phenothiazines; ~itamins.
''~`,! The backing sheet need not be constituted solely o~ paper, but may be coated with a plastic or . aluminum layer.
~3 ' ~.:
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:
`i In practice, the novel pharmaceutical dis-pensing ~rrangement is provided to a health profes-sional or to the patient who administers the pharma-ceutical preparation by rupturinq one or more of the individual dosage packets and pouring the contents ,.~
into the mouth of the patient ~or immediate swallowing, i with or without water or other accompanying liquid.
.' The pellets would normally be self-administered into ~3 . the mouth, except in the case of small children, `;1 elderly or incapacitated patients, or drug addicts, :~! psychiatric patients and otherswho may conceal or not ~ take their medication if self-administration is -.^ permitted.
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~ - 18 - 1324594 ", It will be understood that each of the ele-.~ .
ments described above, or two or more together, also may find a useful appllcation in other types of con-structions dif~ering from the types described above.
While the invention has been illustrated and ~1 described as embodied in an arrangement for, and method ? f, administering a pharrnaceutlcal preparation, it is not intended to be limited to the details shown, since various modifications and structural changes may be made wi~hout departing in any way from the splrit of the present invention.
Without further analysis, the foregoing will ~ ; so fully reveal the gist of the present invention that Z
others can, by applying current knowledge, readily adapt it or various applications without omitting features ;i~
that, from the standpoint of prior art, fairly consti-tute essential charaoteristics of the generic or speci-~ fic aspects g this invention and, therefore, such adap-,1; tations should and are intended to be comprehended within ~he meaning and range of equivalence of the fol-~ lowing claims.
.~ What is claimed as new and desired to be pro-;i . tected by Letters Patent is set forth in the appended ' claims.
:`
" ~
,, .
Claims (22)
1. A package for direct, oral administering a pharmaceutical preparation contained in a plurality of solid pellets having non-tacky coatings, comprising: a breakable packet including a backing sheet having opposite major planar surfaces; and a covering member overlying, and extending outwardly of, the backing sheet, said covering member having a flange portion sealed to one of said major surfaces and bounding therewith a sealed compartment in which only the solid pellets are sealingly contained, the covering member including a hollow main portion extending along a longitudinal direction, a neck portion adjacent the main portion, a head portion adjacent the neck portion, and a frangible zone which, when broken, opens the compartment for discharge of the solid pellets, the neck portion having tapered walls which converge toward each other along the longitudinal direction to a waist, the head portion having tapered walls which diverge away from each other along the longitudinal direction away from the waist, the covering member having its smallest dimension, as considered along a transverse direction generally perpendicular to the longitudinal direction, at the waist across which the frangible zone extends, and the neck portion forming a tapered pouring spout through which the solid pellets are poured from the opened compartment.
2. The package as defined in claim 1, wherein the covering member has a predetermined degree of frangibility, and wherein the backing sheet has a degree of frangibility less than said predetermined degree of frangibility.
3. The package as defined in claim 2, wherein backing sheet is constituted of a paper material coated with plastic or aluminum, and wherein the covering member is constituted of a synthetic plastic material.
4. The package as defined in claim 1, wherein the hollow main portion has a predetermined half-cylindrical cross-section, wherein the neck portion has a half-frusto-conical cross-section less than said predetermined cross-section, wherein the head portion has a half-spherical cross-section.
5. The package as defined in claim 4, wherein the backing sheet is bendable when subjected to external forces at the waist, and wherein the covering member fractures at the waist when said external forces bend the backing sheet.
6. The package as defined in claim 5, wherein the covering member fractures into fractured parts which remain attached to the bent backing sheet, one fractured part being the head portion, and another fractured part being the main and neck portions.
7. The package as defined in claim 1, wherein the covering member is constituted of a light-transmissive material to permit viewing of the pellets through the covering member.
8. The package as defined in claim 1, wherein the packet includes indicia applied onto the other of said major surfaces of the backing sheet.
9. The package as defined in claim 1, and further comprising another covering member overlying the backing sheet and bounding therewith another compartment in which additional pellets are contained.
10. The package as defined in claim 1, wherein each pellet has a diameter not greater than 1mm, said pellets being freely accommodated with clearance in the compartment.
11. The package as defined in claim 1, wherein each non-tacky coating includes a polymeric material.
12. The package as defined in claim 11, wherein each non-tacky coating further includes a basic compound filler that is soluble in acid.
13. The package as defined in claim 11, wherein the polymeric material includes a cationic copolymeric acrylate resin based on methacrylate and neutral methacrylic acid esters.
14. The package as defined in claim 12, wherein the basic compound filler is selected from the group consisting of calcium carbonate, aluminum hydroxide and magnesium carbonate.
15. The package as defined in claim 12, wherein the basic compound filler is present in the coating in an amount from about 10% to about 90% by weight.
16. The package as defined in claim 11, wherein the polymeric material is selected from the group consisting of cellulosic, polyacrylate and poly-vinyl alcoholic polymers.
17. The package as defined in claim 1, wherein the pharmaceutical preparation contained in the pellets is a fraction of a dose to be administered to a human patient.
18. The package as defined in claim 1, wherein the pharmaceutical preparation contained in the pellets is a multiple of a dose to to be administered to a human patient.
19. The package as defined in claim 1, wherein the pharmaceutical preparation comprises an active ingredient and pharmaceutically acceptable binders, fillers or excipients.
20. The package as defined in claim 19, wherein said active ingredient is orally active.
21. The package as defined in claim 20, wherein said orally active ingredient is selected from the group consisting of analgesics, antiasthmatics, antimicrobials, antibacterials, antibiotics, anti-fungal agents, antihistamines, anti-inflammatory agents, antiepeleptic agents, cough and cold medicines, cardiovascular agents, diuretics, laxatives, tranquilizers, and vitamins.
22
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1988/000868 WO1988006558A1 (en) | 1987-03-06 | 1988-03-07 | Arrangement for and method of administering a pharmaceutical preparation |
USPCT/US88/00868 | 1988-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1324594C true CA1324594C (en) | 1993-11-23 |
Family
ID=22208607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000565898A Expired - Fee Related CA1324594C (en) | 1988-03-07 | 1988-05-04 | Arrangement for and method of administering a pharmaceutical preparation |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA1324594C (en) |
IE (1) | IE62636B1 (en) |
-
1988
- 1988-05-04 CA CA000565898A patent/CA1324594C/en not_active Expired - Fee Related
- 1988-05-05 IE IE135188A patent/IE62636B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE62636B1 (en) | 1995-02-22 |
IE881351L (en) | 1989-09-07 |
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