CA1282787C - Synthese de derives d'amino(arloxy)propanols et d'amino(aryl)ethanols - Google Patents

Synthese de derives d'amino(arloxy)propanols et d'amino(aryl)ethanols

Info

Publication number
CA1282787C
CA1282787C CA000522978A CA522978A CA1282787C CA 1282787 C CA1282787 C CA 1282787C CA 000522978 A CA000522978 A CA 000522978A CA 522978 A CA522978 A CA 522978A CA 1282787 C CA1282787 C CA 1282787C
Authority
CA
Canada
Prior art keywords
aryl
alkyl
phenyl
metal
propoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000522978A
Other languages
English (en)
Inventor
Ghanshyam Patil
Khuong H.X. Mai
William L. Matier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of CA1282787C publication Critical patent/CA1282787C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA000522978A 1985-12-04 1986-11-14 Synthese de derives d'amino(arloxy)propanols et d'amino(aryl)ethanols Expired - Lifetime CA1282787C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80440685A 1985-12-04 1985-12-04
US804,406 1985-12-04

Publications (1)

Publication Number Publication Date
CA1282787C true CA1282787C (fr) 1991-04-09

Family

ID=25188898

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000522978A Expired - Lifetime CA1282787C (fr) 1985-12-04 1986-11-14 Synthese de derives d'amino(arloxy)propanols et d'amino(aryl)ethanols

Country Status (6)

Country Link
EP (1) EP0248879A4 (fr)
JP (1) JPS63502585A (fr)
AU (2) AU604005B2 (fr)
CA (1) CA1282787C (fr)
WO (1) WO1987003583A1 (fr)
ZA (1) ZA868713B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990668A (en) * 1985-12-04 1991-02-05 E. I. Du Pont De Nemours And Company Optically active aryloxypropanolamines and arylethanolamines
SE8801518D0 (sv) * 1988-04-22 1988-04-22 Astra Pharma Prod A novel process
US5032584A (en) * 1988-10-26 1991-07-16 G. D. Searle & Co. S-diastereomer of an n6 -((2-hydroxypropyl)aryl)adenosine and its medicinal uses
US5030624A (en) * 1988-10-26 1991-07-09 G. D. Searle & Co. R-diastereomer of an N6 -[(2-hydroxypropyl)aryl]adenosine and its medicinal uses
US4992535A (en) * 1988-10-26 1991-02-12 G. D. Searle & Co. Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines
DE3844410A1 (de) * 1988-12-30 1990-07-19 Lindner Wolfgang Inversion der alkohol-konfiguration in alpha-aminoalkoholen ueber intramolekulare substitution der sulfonsaeureester
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
TW482756B (en) 1997-02-07 2002-04-11 Shell Int Research Process for the manufacture of intermediates for epoxy compounds, process for the manufacture of epoxy compounds and epoxy compounds obtained therewith
EP2667866B1 (fr) * 2011-01-27 2015-05-20 Baxter International Inc Utilisation de (s)-esmolol pour contrôler l'irritation veineuse associée aux traitements des maladies cardiaques
EP2667867B1 (fr) * 2011-01-27 2015-05-27 Baxter International Inc Méthodes permettant de traiter la tachycardie et/ou de réguler la fréquence cardiaque tout en minimisant et/ou régulant l'hypotension
CN102408285B (zh) * 2011-09-15 2013-11-20 东北师范大学 一种甲苯衍生物的苄基碳氢直接胺化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
US4990668A (en) * 1985-12-04 1991-02-05 E. I. Du Pont De Nemours And Company Optically active aryloxypropanolamines and arylethanolamines

Also Published As

Publication number Publication date
AU5756290A (en) 1990-10-11
WO1987003583A1 (fr) 1987-06-18
EP0248879A4 (fr) 1990-02-26
AU631433B2 (en) 1992-11-26
JPS63502585A (ja) 1988-09-29
ZA868713B (en) 1987-06-24
AU6774987A (en) 1987-06-30
AU604005B2 (en) 1990-12-06
EP0248879A1 (fr) 1987-12-16

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