CA1273633A - Insecticidal n-(optionally substituted)-n'- substituted-n,n'-disubstitutedhydrazines - Google Patents

Abstract

Patent Application of Adam Chi-Tung Hsu Donald W. Hamp for INSECTICIDAL N-(OPTIONALLY SUBSTITUTED)-N'-SUBSTITUTED-N,N'-DISUBSTITUTEDHYDRAZINES

DN86-37 DEW:pao Abstract This invention relates to insecticidal compositions containing N-(optionally substituted)-N'-substituted-N,N'-disubstitutedhydrazines, methods of using such composi-tions and novel N-(optionally substituted)-N'-substituted-N,N'-disubstitutedhydrazines.

Description

~73~

INSECTICIDAL N-~OPTIONALLY SUBSTITUTED)-N ' -SUBSTITUTED N ,N ' -DISUBSTITUTEDHYDRAZINES

Back~ound of the Invention This invention relates to N-(optionally substituted)-N'-substituted-N,N'-disubstitutedhydrazines, which are useful as insecticides, compositions containing those compounds and methods of their use. The disclosed hydrazines are new compounds.
The search for compounds which have a combination of excellent insecticidal activity and low undesirable toxicity is a continuing one because of factors such as the desire for compounds exhibiting greater activity, better selectivity, low undesirable environmental impact, low production cost and effectiveness against insects resistant to many known insecticides.
Compounds of the present invention are particularly suitable for controlling plant-destructive insects in crops of cultivated plants, ornamentals and forestry.
Certain hydrazine derivatives have been disclosed in the literature.
In 25 Aust. J._Chem., 523-529 (1972), several N,N'-dibenzoylhydrazine derivatives are disclosed includlng 7~ ;33 N'-1-propyl-; N'-n-propyl~ 2-methylpropyl)-;
N ' -( 3-methylbutyl)-i N ' -benzyl- and N'-phenyl-N,N'-dibenzoylhydrazine in which one or both nitrogen atoms are alkylated or phenylated. No biological activity is disclosed for those compounds.
In 61 Helv. Chim. Acta, 1477-1510 (1978), several N,N'-dibenzoylhydrazine and hydrazide derivatives including N'-t-butyl-N-benzoyl-N'-(4-nitrobenzoyl)-hydrazine are disclosed. No biological activity is disclosed for those compounds.
In 44 J.A.C.S., 2556-2567 (1922), isopropylhydrazine (CH3)2CH NH-NH2, symmetrical dlisopropylhydrazine, dibenzoylisopropylhydrazine and certain derivatives are disclosed. No biological activity is disclosed for ~hose compounds.
In 44 J~A~CoS~ ~ 1557-1564 ( 1972), isopropyl, menthyl and bornyl semicarbazides are disclosed. No biological activity is disclosed for those compounds.
In 48 J.A.C.S., 1030-1035 (1926), symmetrical di-methylphenylmethylhydrazine and certain related compounds including 1,2-bis-methylphenylmethyl-4-phenyl-semicarbazide are disclosed. No biological activity is disclosed for those compounds.
In 27 Bull. Chem. Soc. Japan, 624 627 (1954), certain hydrazine derivatives including alpha,beta-dibenzoyl-phenylhydrazine are disclosed. No biological activity is disclosed for those compounds.
In J. Chem_ Soc. (C), 1531-1536 (1966), N,N'-dibenzoylphenylhydrazine and N-acetyl-N'-benzoyl-p-nitro-phenylhydrazine are disclosed. No biological activity is disclosed for those compounds~
In 56B Chem. 8erichte, 954-962 (1923), symmetrical di-isopropylhydrazines, s~nmetrical diisobutyl- and certain derivatives including N,N'-diisobutyldibenzoyl 3~33 hydrazine are disclosed. No biological activity is disclosed for those compounds.
In 590 Annalen der Chemie, 1~36 (1954), certain N,N'-dibenzoylhydrazine derivatives are disclosed including N'-methyl- and N'-(2-phenyl)-isopropyl-N,N'-dibenzoyl-hydrazine. No biological activity is disclosed for those compounds~
In J. Chem. Soc., 4191-4198 (1952), N,N'-di-n-propyl~
hydrazine, N,N'-dibenzoylhydrazine and bis-3,5-dinitro-benzoyl hydrazine are disclosed No biological activity is disclosed for those compounds.
In 32 Zhur. Obs. Khim., 2806-2809 (1962), N'-2,4-methyl-2,4-pentadiene-N,N'-dibenzoylhydrazine is disclosed. No biological activity is disclosed.
In 17 Acta. Chim. Scand., 95-102 (1963~, 2-benzoyl-thiobenzhydrazide (C6H5-CS-NHNH-CO-C6~5) and certain hydrazone and hydrazine derivatives are disclosed including 1,2-dibenzoyl-benzylhydrazine. No biological activity is disclosd for tho e compounds~
In 25 Zhur. Obs. Khim, 1719-1723 (1955), N,N'-bis-_ cycloh xylhydrazine and N,N'-dibenzoylcyclohexylhydrazine are disclosed. No biological activity is disclosed for those compounds.
In _. Chem. Soc., 4793-4800 (1964), certain dibenzoylhydrazine derivatives are disclosed including tribenzoylhydrazine and NIN'-dibenzoylcyclohexyl-hydrazine. Wo biological activity is disclosed for those compounds.
In 36 J Prakt Chem., 197-201 (1967), certain dibenzoylhydrazine derivativPs including N'-ethyl-; N'-n-propyl~; N' isobutyl-; N'-neopentyl-; N'-n~heptyl-; and N'-cyclohexylmethyl-N,N'-dibenzoylhydrazines are disclosed. No biological activity i~ disclosed for those compounds~

In 26 J.O.C., 4336-4340 (1961) N'-t butyl-N,N'-di-(t-butoxycarbonyl)hydrazide is disclosed. No ~iological activity is di SG losed.
In 41 J~O.C., 3763-3765 (1976), N'-t-butyl-N-(phenylmethgxycarbonyl)~N'-(chlorocarbonyl)hydrazide is disclosed. No biological activity is disclosed, In 94 J.A.C.S., 7406-7416 (1972) N'-t-butyl-N,N'-dimethoxycarbonylhydra2ide is disclosed. ~o biological activity is disclosed.
In 43 J.O.C., 808-815 (1978), N'~t-butyl-N-ethoxy-carbonyl-N'-phenylaminocarbonylhydrazide and N'-t-butyl-N~
ethoxycarbonyl-N'-methylaminocarbonylhydrazide are disclosed. No biological activity is disclosed for those compounds.
In 39 J. Econ. Ent~, 416-417 (1946), certain .
N-phenyl-N'-ac~lhydrazines are disclosed and evaluated for their toxicity against codling moth larvae.
The N-(optionally substituted)-N'-substituted-N,N'-disubstitutedhydrazines of the present invention differ from known compounds primarily by their N and N' substituents.
Compounds of the present invention are also distinguished by their excellent insecticidal activity, particularly against insects of the orders Lepidoptera and Coleoptera, and most particularly a~ainst insects o~ the order Lepidoptera, without material adverse impact on benefioial in~ects.

SummarY of the Invention In accordance with the presen~ invention, there are provided novel insecticidal compounds having the formula:

i~ ' ~ ~3~i33 X Rl X' Il 1 11 . A-C-N-N - C-B

l3 S wherein X and X' are the same or different O, S or NR;
~1 is hydrogen; (Cl-C6)alkyl, (Cl C6)al y y having independently the stated number of carbon atoms in each alkyl group; (Cl-C6)alkylthioalkyl 10 . having independently the stated number of carbon atoms in each alkyl group; (C2-C6)alkenyl;
(C2-C6)alkynyl; or phen-(Cl-C4)alkyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (Cl-C4)-haloalkyl (cl-C4)alkoxY~ (Cl-C4)haloalko~Yi carboxy, (Cl-C~)alkoxycarbonyll (Cl-C4)-alkanoyloxy or NZZ';
R2 and R3 are the same or different hydrogen or (Cl-C~)alkyl;
; R4 is (Cl-C4)alkyl substituted with l to 4 fluoro;
straight chain (C2-C4)alkenyl; carboxyl;
(Cl-C3)alkoxycarbonyl; cyano; cyano substituted (Cl-C4)alkyl; ~Cl-C~)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or (Cl-C2)trialkylsilyl~
methyl having independently the stated number of carbon atoms in each alkyl group; provided that R2 and R3 are both alkyl when R4 is carboxyl or ~0 alkoxycarbonyl; and A and B are the same or different unsubstituted or substituted naphthyl where the substituents can ` ~7~36~.~3 be Erom one to three of the same or dif~erent halo; nitro; ~Cl-C4)alkoxy; (Cl-C4)alkyl or NZZ';

unsubstituted or substituted phenyl where the substituents can be from one to five of the same or different halo; nitroso; nitro; cyanoi hydroxy; (Cl-C6)alkyl; (Cl-C6)haloalkyl;
(Cl-C6)cyanoalkyl; (Cl-C6)hydroxyalkyl; (C1-C6)alkoxy; (Cl-C6)haloalkoxy; (Cl-C6)alkoxyalkyl having independ0ntly the stated number of carbon atoms in each alkyl group; (Cl-C6)alkoxyalkoxy having independently the stated number of carbon atoms in each alkyl group; (Cl-C6)alkylthio-alkoxy (-ORSR') having independently the stated number of carbon atoms in each alkyl group; (C
C6)alkoxycarbonyloxy (-OC02R); hydroxycarbonyl-oxy (-OC02H); (Cl-C6)alkanoyloxyalkyl having independently the stated number of carbon atoms in each alkyl group; (C2-C6)alkenyl optionally ~0 substituted with halo, cyano, (Cl-C~)alkyl, (Cl-C4)haloalkoxy, (Cl-C4)alkylthio or (Cl-C4)alkoxy; (Cl-C4)alkadienyl; (C2-C6)alkenyloxy;
(C2-C6)alkenylcarbonyl; (C2-C6)alkenyloxy-carbonyloxy; (C2-C6)alkynyl optionally substituted with halo, cyano, nitro, hydroxy, (Cl C4)alkoxy, (Cl-C4)haloalkyl, (Cl-C~)alkyl-thio or (Cl-C4)alkyl; carboxy; (Cl-C6)carboxy-alkyl having independently the stated number o~
carbon atoms in each alkyl group (-RC02~');
vO -COR; -COH; (Cl-C6)haloalkylcarbonyl; (Cl~C6)-alkoxycarbonyl (-C02R); (Cl-C6)haloalkoxy-carbonyl; (Cl-C6)alkanoyloxy (-OCOR); (Cl-C6)-alkoxycarbonylalkoxy ( ORC02R') having ~ ~7~36~3 independently the stated number of carbon atoms in each alkyl group; amino (-Nzæ~ ); amino substituted with hydroxy, ~Cl-C4)alkoxy or (Cl-C4)alkylthio; carboxamido (-CONZZ');
(C2-C6)alkenylcarbonylamino; (Cl-C6)-hydroxyalkylaminocarbonyl; aminocarbonyloxy (-OCONZZ'); amido (-NZCOZ'); alkoxycarbonylamino (-NZCO2Z'); thiocyanato; isothiocyanato;
(Cl-C6)thiocyanatoalkyl; (Cl-C6)alkylthio;
(Cl-C6)haloalkylthio; sulfoxide (-S(O)Z);
sulfonyl (-SO2Z); alkylsulfonyloxy (-OSO2R);
-OSO2H; sulfonamide (-SO2NZZ'); alkylthio-carbonyl (-CSR); -CSH; alkylcarbonylthio (-SCOR); -SCOH; thioamido (-NZCSZ');
unsubstituted or substituted phenyl having one to three of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (C1-C4)alkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (Cl-C4)alkanoyloxy, amino, (Cl-C4)alkylamino or (Cl-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; phenoxy where the phenyl ring is unsubstituted or substituted with one to three o~ the ~ame or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, carboxy, (Cl-C4)alkylcarbonyl, (Cl-C4)alkanoyloxy, amino, (Cl-C4)alkylamino or ( Cl-C4 ) dialkyl amino having independently the stated number of carbon atoms in each alkyl 3d group; benzoyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, y y, (Cl C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, carboxy, (Cl-C4)alkoxycarbonyl, 3 ~ ~
(Cl-C4)alkanoyloxy, amino, (Cl-C4)alkylamino or (Cl-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; benzoyloxy(Cl-C6)alkyl; phenylthio-S (Cl-C6)alkyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (Cl-C~)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (Cl-C4)alkanoyloxy, amino, (Cl-C4)alkylamino or (Cl-C4)dialkylamino having independen~ly the stated number of carbon atoms in each alkyl group; imino (-CR=N-R"') where R"' is hydroxy, (Cl-C4)alkyl, (Cl~C4)alkoxy, amino (-NZZ'), phenylamino, -COR, -COH or benzoyl; (C2-C6)-oxiranyl; acetylthiosemicarbazone; pyrrolyl;
oxazolyl, unsubstituted or substituted with one or two me~hyl groups; or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form together with the carbon atoms to which they are attached a 5 or 6 membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (Cl-C10)alkyl having one to four of the same or different halol cyano, nitro, hydroxy, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (Cl C4)alkanoyloxy, phenyl or ~NZZ';

unsubstituted or substituted (C3-C8)cycloalkyl or unsubstituted or substituted (C3-C8)cyclo-alkyl(Cl-C4)alkyl having one to four of the same or different halo, cyano, nitro, hydroxy, (Cl-- ~7~633 C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy, (cl~c4)alkanoyl~
(Cl-C4)al~oxycarbonyl, tC1-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C2-C8)alkenyl or unsubstituted or substituted (C2-C8)alkadienyl having a furyl, thienyl or pyridyl or having one to four of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (C3-C6)cycloalkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)halo-alkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (Cl-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C3-C~)cycloalkenyl or unsubstituted or substituted (C3-C8)cyclo-alkadienyl havin~ one to four of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)-alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy, (Cl-C4)alko carbonyl, (Cl-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C2-C8)alkynyl having one to four of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, ~Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)halo-alkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (Cl-C~
alkanoyloxy, phenyl or -NZZ';

phenalkyl having one to four carbon atoms in the alkyl group and the alkyl group is unsubstituted or substituted with one to three of the same or different halo, cyano~ hydroxy, (Cl-C4)alkoxy, (Cl-C4)alkoxycarbonyl or -NZZ', _9~

~ ~ ~73~
and the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)cyanoalkyl, (C1-C4)alkoxy, (Cl C4)haloalkoxy, carboxy, (Cl-C4)alkoxycarbonyl~ (Cl-C4)alkanoyloxy, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl or -NZZ';

phenalkenyl having two to six carbon atoms in the alkenyl group and the alkenyl group is unsubstituted or substituted with one to three of the same or different halo, cyano, hydroxy, (C1-C4)alkyl~ (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, (Cl-C4)alkoxycarbonyl or lS -NZZ', and the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy, (Cl-C4)alkoxycarbonyl, (cl-c4)alkanoyloxy or -NZZ';

unsubstituted or substituted five-membered heterocycle selected from furyl, thienyl, triazolyl, pyrrolyl, isopyrrolyl, pyrazolyl, isoimidazolyl, thiazolyl, isothiazolyl, oxazolyl and isooxazlyl where the substituents can be from one to three of the same or different halo;
nitro; hydroxy; (Cl-C6)alkyl; (Cl-C6)alkoxy;
carboxy; (Cl-C6)alkoxycarbonyl;
(Cl C~)carboxyalkyl (-RCO2H'); (Cl-C6)alkoxy-carbonylalkyl (-RCO2R') having independently the stated number of carbon atoms in each alkyl group; carboxamido (-CONZZ'); amino (-NZZ');

~73~
amido (-NZCOZ'); (Cl-C6)alkylthio; or unsubstituted or substituted phenyl having one to three of the same or different halo, nitro, (Cl-C6)alkyl, (Cl-C6)haloalkyl, (Cl-C6)alkoxy, (Cl-C6)haloalkoxy, carboxy, (Cl-C4)alkoxy-carbonyl or amino (-NZZ'); or unsubstituted or substituted six-membered heterocycle having one, two, three or four nitrogen atoms and two to five nuclear carbon atoms where the substituents can be from one to three of the same or different halo; nitro;
hydroxy; (Cl-C6)alkyl; (Cl-C6)alkoxy; carboxy;
(Cl-C6)alkoxycarbonyl; (Cl-C6)carboxyalkyl (-RCO2H); (Cl-C6)alkoxycarbonylalkyl (~RCO~R') having independently the stated number of carbon atoms in each alkyl group; carboxamido (-CONZZ'); amino (-NZZ'); amido ( NZCOZ');
(Cl-C6)alkylthio; or unsubstituted or substituted phenyl having one to three of the same or different halo, nitro, (Cl-C6)alkyl, (Cl-C6)haloalkyl, (Cl-C6)alkoxy, (Cl-C6)halo-alkoxy, carboxy, (Cl-C4)alkoxycarbonyl or amino (-NZZ');

where R, R' and R" are (Cl-C6)alkyl; Z and Z' are hydrogen or (Cl C4)alkyl; and agronomically acceptable salts thereof.
Also in accordance with the present invention, there are provided novel insecticidal compositions and methods of using such compositions wherein the compositions comprise an agronomically acceptable carrier and an insecticidally effective amount of, or from about 0O0001%
to about 99% by weight of the composition, a compound of Formula I above.

3~j33 Detailed Descri~tion of the Inventlon The term "halo" should be understood as including chloro, fluoro, bromo and iodo. The term "alkyl" by itself or as a part of another substituent, unless otherwise stated, includes straight or branched chain groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, isobutyl, neopentyl and the like and where indicated higher homologues and isomers such as _-octyl, isooctyl and the like. The term "haloalkyl" by itself or as part of another substituent is an alkyl group of the stated number of carbon atoms having one or more halo atoms bonded thereto such as chloromethyl, 1~ or 2-bromoethyl, trifluoromethyl and the like. Analogously, "cyanoalkyl" by itself or as part o~ another group is an alkyl group of the stated number of carbon atoms having one or more cyano groups ~onded thereto; "haloal~oxy" by itself or as part of another group is an alkoxy yroup of the stated number of carbon atoms having one or more halo atoms bonded thereto such as difluoromethoxy 9 trifluoromethoxy, 2-fluoroethoxy, 2,2,2-trifluoroethoxy and the like. "~lkenyl" and "alkynyl" by themsalves or as part of another substituent comprise straight and branched chain groups of the stated number of carbon atoms.
"Alkadienyl" is a straight or branched chain alkenyl group comprising two carbon-carbon double bonds that can be conjugated such as l,3-butadienyl, cumulated such as 1,2-propadienyl or isolated such as 1,4-pentadienyl.
Repre~entative examples of five-membered heterocycles includes 2-furyl; 3-furyl; 2-thisnyl; 3-thienyl; ~-(1,2,3-triazolyl); 3-(1,2,4-triazolyl); 5-(1,2,4-tria201yl); 2-pyrrolyl; 2-oxazolyl; and the like.
Because of their anticipated good insecticidal activity, compounds of the present invention for use in the insecticidal compositions and formulations include those where, independently i X and X' are O or 5;
R1 is hydrogen (C1-C~)alkyl; (C1-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; methylthiomethyl; (C2-C5)-alkenyl; ~C2-C5)alkynyl; or phen(C1-C2)~lkyl where the phenyl ring is unsubstituted or substituted with one or two halo, nltro, (C1-C4)alkyl or (C1-C4)alkoxy;
R2 and R3 are the sæme or diff~rent hydrogen or (Cl-C3)alkyl;
R4 is (Cl-C3)alkyl substituted with one to four fluoro; straight chain (C2-C4)alkenyl; carboxyl;
~Cl~C2)alkoxycarbonyl; cyano; cyano substituted (cl-c3)alkyl; (Cl-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or (Cl-C2)trialkylsilyl-; me~hyl having independently the stated number of carbon atoms in each alkyl group; provided that R2 and R3 are both alkyl when R4 is carboxyl or alkoxycarbonyl; and A and B are the sxme or different unsubstituted naphthyl;

unsubstituted or substituted phenyl where the substituents can he from one to three of the same or different halo; nitro; cyano;
~5 (Cl-C4)alkyl; (cl-c4)haloalkyl;
(Cl-C4)cyanoalkyl; (Cl~C4)alkoxy;
(Cl-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; -COZ; carboxy; (Cl-C4)alkoxycarhonyl;
(Cl-C4)alkanoyloxy; (C2-C6)alkenyl;
(C2-C6)alkynyl; amino (-NZ2'); thiocyanato;
(Cl-C4~alkylthio; alkylthiocarbonyl ( -CSR);
-CSH; unsubstituted or substituted phenyl having ~ ~3~33 i, .~
Y ., f one to two of the same or diferent halo, nitro, (Cl-C4)alkyl, (C1-C~)alkoxy, carboxy, -~ZZ';
ph~noxy where the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, nitro, (Cl-C4)alkyl, (Cl-C4)alkoxy, carboxy, -NZZ'; or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form a 5- or 6-membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (Cl~C8)alkyl having one to three of the same or different halo, cyano, (Cl-C4)alkoxy, phenyl, (Cl-C4)alkoxycarbonyl or (Cl-C4)haloalkoxy;

unsubstituted or substituted (C3-C6)cycloalkyl or unsubstituted or substituted (C3-C6)cycloalkyl(Cl-C4)alkyl having one or two of the same or different halo, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)alkanoyl or 2Q (Cl-C4)haloalkoxy;

unsubstituted or substituted (C2-C6)alkenyl having a furyl or one to three of the same or different (C1-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy or (Cl-C4)haloalkoxy;

unsubstituted or substi~.uted (C3-C6)cycloalkenyl having one or two o~ the same or differen~ halo, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy or (Cl-C4)haloalkoxy;
unsubstituted or phenyl substituted alkynyl;

-14~

- ' ' " ' : :

73~33 phenalkyl having one or two carbon atoms in the alkyl group and the alkyl group is unsubstituted or substituted with one or two of the same or different halo, (Cl-C4)alkyl, (Cl-C4)haloalkyl, S (Cl-C4)alkoxy or (Cl-C4)haloalkoxy and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, cyano, (Cl C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4~alkoxy or (Cl-C4)haloalkoxy;

phenalkenyl having two or three carbon atoms in the alkenyl group and the alkenyl group i5 unsubstituted or substituted with halo, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl C4)alkoxy or (Cl-C4)haloalkoxy and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, cyano, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy or (Cl-C4)haloalkoxy;

unsubstituted or substituted five-membered heterocycle selec~ed from furyl, thienyl, triazolyl, pyrrolyl, and oxazolyl where the substituents can be one or two of the same or different halo; nitro; (Cl-C~)alkyl; (Cl-C4)-alkoxy; -NZZ'; or unsubstituted or substituted phenyl having one or two of the same or different halo, nitro, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)halo-alkoxy~ carboxy or -NZZ'; or unsubstituted or substituted six-membered heterocycle having one or two nitrogen atoms and :: ~V~73~j3;~

4 to 5 nuclear carbon atoms whcre the substituents can be one or two of the same or different halo; nitro; (ClC4)alkyl; (Cl-C4)-alkoxy; (Cl-C4)thioalkoxy; -NZZ'; or unsubstituted or substituted phenyl.havIng one or two of the same or different halo, nitro, (Cl-C4)alkyl, (Cl-C4)haloalkyl, (Cl-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy or -NZZ';

where R and R' are (Cl-C4)alkyl; Z and Z' are hydrogen or (Cl-C4)alkyl; and ag-onomically acceptable salts.
Insecticidal compounds o~ the present invention believed to have very good activity for use in the insecticidal compositions and formulations of the present invention include those where, independently, x and X' are O or S;
Rl is hydrog~n; (Cl-C4)alkyl; ~Cl-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; (C2-C5)alkenyl;
(C2-C5)alkynyl; or benzyl where the phenyl ring is unsubstituted or substituted with one halo, nitro, : (Cl-C4)alkyl or (Cl-C4)alkoxy;
R2 and R3 are the same or different hydrogen or (Cl-C2)alkyl;
R4 is (Cl-C3)alkyl substituted with l to 4 fluoro;
straight chain (C2-C4)alkenyl; methoxycarbonyl;
cyano; cyano substituted (Cl~C2)alkyl; (Cl-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or (Cl-C2)trialkylsilylmethyl having independently the stated number of carbon atoms in each alkyl group; provided that R~ and R3 are both alkyl when R4 is methoxycarbonyl; and -16~

~i ~ ~"t~3633 A and B are the same or different unsubstituted naphthyl;

unsubstituted or substituted phenyl having one to three of the same or different halo; nitro;
cyano; (Cl-C4)alkyl; (Cl-C4)haloalkyl; (Cl-C4)-cyanoalkyl; (Cl-C4)alkoxy; (Cl-C4)alkoxyalkyl : having independently the stated number of carbon atoms in each alkyl group; -COZ; (Cl-C4)alkoxy-carbonyl; (C1-C4)alkanoyloxy; thiocyanato;
-NZZ'; (C1-C4)alkylthio; alkylthiocarbonyl (-CS2, -CS2Z); unsubstituted or substituted phenyl having one or two of the same or different halo, nitro, (C1-C4)alkyl, (Cl-C4)alkoxy, carboxy, -NZZ'; or phenoxy where the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, nitro, (Cl-C4)alkyl, (Cl-C4)alkoxy, carboxy, -NZZ' or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form a 5- or 6-membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (Cl-C6)alkyl having one to three of the same or different halo, cyano, nitro, carboxy, (Cl-C4)alkoxy, phenyl, (Cl-C4)alkoxycarbonyl or (Cl-C4)haloalkoxy;

unsubstituted or substituted (C3-C6)cycloalkyl or unsubstituted or substituted (C3-C6)cyclo-alkyl(Cl-C4)alkyl, where the substituent is halo, (Cl-C4)alkyl, (Cl-C4~alkanoyl, (Cl-C4)-alkoxy or (Cl-C4)haloalkoxy;

~,~7;~3 unsubstituted or substituted (C2-C6)alkenyl having one or two of the same or different halo, ~Cl-C4)alkyl, (Cl-C4)alkoxy or (Cl-C4)halo-alkoxy;

unsubstituted or substituted (C4-C6)cycloalkenyl where the substituent is halo (Cl-C4)alkyl, (C
C4)alkoxy or (Cl-C4)haloalkoxy;
unsubstituted or phenyl substituted alkynyl;

benzyl where the phenyl ring is unsubstituted or lo substituted with one or two of the same or difference halo, methyl or ethyl;

unsubstituted or substituted five-membered heterocycle selected from furyl, thienyl, pyrrolyl and oxazolyl where the substituents can be one or two of the same or different halo, nitro, (Cl-C4)alkyl or (Cl-C4)alkoxy; or unsubstitutad or substituted six-membered heterocycle having one or two nitrogen atoms and four to five nuclear carbon atoms where the substituents can be one or two of the same or different halo, nitro, (Cl-C~)alkyl, (Cl-C4)alkoxy or (Cl-C4)thioalkoxy;

where Z and Z' are hydrogen or (Cl C4)alkyl; and agronomically acceptable salts thereof.
Because of their anticipated excellent insecticidal activity, preferred compounds of the present invention for use in the insecticidal compositions and formulations of the~ presen~ invention include those where, independently, ~ 3~33 X and X' are O;
Rl is hydrogen; methyl; ethyl; (Cl-C2)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group (C2-C5)alkenyl;
s (C2-C5)alkynyl; or benzyl where the phenyl ring is unsubstituted or substituted with halo;
R2 and R3 are the same or different hydrogen or (Cl-C2)alkyl;
R4 is (Cl-C2)alkyl substituted with l to 4 fluoro;
13 straight chain (C2-C4)alkenyl; cyano; cyano substituted (Cl-C2)alkyl; (Cl-C2)trialkysilyl having independently the stated number of carbon atoms in each alkyl group; or (Cl-C2)trialkyl-silylmethyl having independently the stated number of carbon atoms in each alkyl group; and A and B are the same or different phenyl or substituted phenyl where the substituents can be from one to three of the same or different halo, nitro, (Cl-C4)alkyl, (Cl-C~)alkoxy or (Cl-C4)haloalkyl;

unsubstituted or ~ubstituted (Cl-C6)alkyl having one to two of the same or different halo, phenyl or cyano;
unsubst.ituted (C4-C6)cycloalkyl;

unsubstituted or substituted (C2-C6)alkenyl having one to three of the same or different halo or (Cl-C4)alkyl;
unsubstituted (C4-C6)cycloalkanyl;

phenalkyl having one or two carbon atoms in the alkyl group and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, (Cl-C4)alkyl or (Cl-C4)alkoxy;

and unsubstituted or substi~uted pyridyl or 2,5-pyrazinyl where the substituent can be halo, t o, (Cl C4)alkyl, (Cl-C4)alkoxy or (C1-C4)-thioalkoxy; or unsubstituted furyl or thienyl or an unsubstituted or substituted pyrrolyl where the substituent can be (Cl-C4)alkyl; and agronomically acceptable salts thereof.
Because of their anticipated outstanding insecticidal activity, more preferred compounds of the present invention for use in the insecticidal compositions and formulations of the present invention include those where, independently, X and X' are O;
~1 is hydrogen; methyl; methoxymethyl; (C2-C4)-alkenyl; ~C2-C5)alkynyl; benzyl; or 4-halobenzyl;
R2 and R3 are the same or different hydrogen, methyl or ethyl;
R4 is trifluoromethyl, 2,2,2-trifluoroethyl; straight chain (C2-C4)alkenyl; cyano; cyanomethyl;
(Cl-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or trimethylsilylmethyl; and A and B are the same or different phenyl or substituted phenyl where the substituents can be one, two or three of the same or different chloro, fluoro, bromo, iodo, nitro, methyl, ethyll methoxy or trifluoromethyl;

~ 73~i~33 (C2-C3) substituted alkenyl having one to three of the same or dif~'erent chloro, bromo, methyl or ethyl;
cyclohexenyl;
benzyl;

unsubstituted or substituted pyridyl or 2,5-pyrazinyl where the substituent can be halo, methyl, ethyl or methoxyi or unsubstituted furyl or thienyl or an unsubstituted or substituted pyrrolyl where the substituent can be ethyl or methyl; and agronomically acceptable sal's thereof.
Those N'-substituted-N,N'-diacylhydrazines of Formula I which possess a~idic or basic functional groups may be further reacted to form novel salts with appropriate bases or acids. These salts also exhibit pesticidal activityO
Typical salts are the agronomically acceptable metal salts, ammonium salts and acid addition saltsO Among the metal salts are those in which the metal cation is an alkali metal cation such as sodium, potassium, lithium or the like; alkaline earth metal cation such as calcium, magnesium, barium, strontium or the like; or heavy metal cation such as zinc, manganese, cupric, cuprous, ferric, ferrous, titanium, aluminum or the like. The ammonium salts include those in which the ammonium cation has the formula NR5R6R7R8 wherein each of RS, R6, R7 and R8 are independently hydrogen, hydroxy, (Cl-C4)alkoxy~ (Cl-C20~-- alkyl, (C3 C8)alkenyl, (C3-C8)alkynyl, (C2-C8)hydroxy-alkyl, (C2-C8)alkoxyalkyl, (C2-C6)aminoalkyl, (C2-C6)-~ ;~73~
haloalkyl, amino, (Cl-C4)alkyl- or ~Cl-C4)dialkylamino, substituted or unsubstituted phenyl, substituted or unsubstituted phenylalkyl, having up to four carbon atoms in the alkyl moiety, or any two o~ R5, R6, R7 or R8 can be taken together to form with the nitrogen atom a 5- or 6-membered heterocyclic ring, optionally having up to one additional hetero atom (e.g., oxygen, nitrogen, or sulfur) in the ring, and preferably saturated, such as piperidino, morpholino, pyrrolidino, piperazino or the like, or any three of R5, R6~ R7 or R8 can be taken together to form with the nitrogen atom a 5- or 6-memberad aromatic heterocyclic ring, such as piperazole or pyridine. When R5~ R6, R7 Or R8 Substituent in the ammonium group is a substituted phenyl or substituted phenylalkyl, the substituents on the phenyl and phenalkyl will generally be selected from halo, (C1-C8)alkyl, ~Cl-C4)alkoxy, hydroxy, nitro, trifluoromethyl, cyano, amino, (Cl-C4)alkylthio and the like. Such substituted phenyl groups pre~erably have up to two such substituents. Representative ammonium cations include ammonium, dimethylammonium, 2-ethylhexyl-ammonium, bis(2-hydroxyethyl)ammonium, tris(2-hydroxy-ethyl)ammonium, dicyclohexylammonlum, t-octylammonium,

2-hydroxyethylammonium, morpholinium, piperidinium, 2-phenethylammonium, 2-methylbenzylammonium, n-hexyl-ammonium, triethylammonium, trimethylammonium,tri(n-butyl)-ammonium, methoxyethylammonium, diisopropylammonium, pyridinium, dialkylammonium, pyrazolium, propargylammonium, dim~thylhydrazinium, octadecylammonium, 4-dichlorophenylammonium, 4-nitro-

3~ benzylammonium, benzyltrimethylammonium, 2-hydroxy-ethyldimethylo~tadecylammonium, 2-hydroxyethyldiethyl-octylammonium, decyltrimethylammonium/ hexyltriethyl-ammonium, 4-methylbenzyltrimethylammonium, and the like.
Among the acid addition salts are those in which the anion ~ ~7~3~3 is an agronomically acceptable anion such as hydro-chloride, hydrobromide, sulfate, nitrate, perchlorate, acetate, oxalate and the like.
The above-identified preferred embodiments are based on the 34 examples which were made, tested and disclosed infra and the disclosure in the following six related Canadian applications:
Canadian Patent Application No. 520,380, of Adam Chi-Tung Hsu et al, filed October 14, 1986;
Canadian Patent Application No. 529,977, of Raymond A. Murphy et al, filed February 18, 1987;
Canadian Patent Application No. 526,935, of Raymond A. Murphy et al, filed January 8, 1987;
Canadian Patent Application No. 530,163, of Adam Chi-Tung Hsu et al, filed February 20, 1987;
Canadian Patent Application No. 534,372, of Adam Chi--Tung Hsu et al~ filed April 10, 1987; and Canadian Patent Application No. 534,506, of Adam Chi-Tung Hsu et al, filed April 13, 1987.
These related applications disclose nearly 1,000 active compounds in which the presently disclosed R2, R3 and R4 are methyl and A and B are various unsubstituted and substituted moieties including alkyl, phenyl and 5- and 6-membered heterocyclic rings.
The present inventors have determined that a critical feature of the structure which leads to activity is not the t-butyl substituent of the above-mentioned related Canadian applications (R2~R3=R4=methyl) but that one of the nitrogens be substituted with a bulky substituent. This bulky substituent i5 preferably a trisubstituted alpha carbon or a trisubstituted beta carbon. ~owever, the bulky substituent may also be a trisubstituted gamma carbon or a disubstituted alpha carbon.
Compounds of the present invention which were made and used in insecticidal compositions and formulations include those where, independently, X and X' are O;
Rl is hydrogeni R2 and R3 are hydrogen, methyl and ethyl;

3~ 3 R4 is trifluoromethyl, cyano, allyl, methoxycarbony:L, and trimethylsilyl; and A and B are the same or different unsubstituted or substituted phenyl having one or two of the same or different chloro, fluoro, nitro, methyl and ethyl; or unsubstituted thienyl.
Since one of ordinary skill in the art would anticipate homologues to be active, the present invention also includes compounds for use in insecticidal compositions and formulations where, independently, X and X' are O;
Rl is hydrogen or methyl;
R2 and R3 are hydrogen or (Cl-C3)alkyl;
lS R4 is trifluoromethyl, 2,2,2-trifluoroethyl, cyano, cyanomethyl, straight chain (C2-C4)alkenyl, carboxyl, methoxycarbonyl, (Cl-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group or (Cl~C2)trialkyl-silylmethyl having independently the stated number of carbon atoms in each alkyl group; and A and B are the same or different thienyl or unsubstituted phenyl or substitu~ed phenyl where the substituents can be one to three of the same or different chloro, fluoro, nitro, methyl, ethyl or propyl; and agronomically acceptable salts thexeof.
The compounds of this invention or their precursors can be prepared according to the following processes.
Process A can be used when preparing compounds according to Formula I where X and X' are both oxygen and A and B
axe the same (for example, both A and B are phenyl or 4-chlorophenyl) or different (for example, A is 4-methyl-phenyl and B is 4-chlorophenyl).

-~4-3~i3~

Process A:

A-C-Cl + NHRlN~l - R3 Base ~ A C-NRl-NHC ~ R3 I Solvent II III IV

O R2 O O R2~ 1 ,R4 A-C-NR1-NHC--R3 + B-1~C1 BaSe ~ A-1-NR1--N 1-B
I Solvent IV V

where Rl, R~, R3, R4, A and B are as defined above for Formula I and X and X' are oxygen.

~hen R4 is cyano the intermediate IV may be made as ~ollows:

Step la O O
R2-1-R3 + M-CN + A-C-NRlNH2 _ HCl Solvent VIIa VI

A-C_NRl NHC~R3 CN
IVa where M = K, Na -25~

~ ~3~33 Process B can be used when preparing compounds according to Formula I where X and X' are oxygen, and Rl, R3, R4, ~ and B are as defined above for Formula I.

Process B:
Method 1 Step 1 Q O 0 ~3 ¦1 1 3 11 4 Catalyst A-C-NR NH2 + R -C-R (optional) ~ A-C-NR N=C
Solvent R4 VI VII VIII
Stap 2 Il / Reducina Aqent A-C-NRlN=C Solvent A-C-NR1NHCH
\ 4 Catalyst (optional) \ 4 R

VIII IX (IV) Ste~ 3 R \ H R4 Il / 11 11 1 11 A-C-NRlNHCH ~ B-C-Cl Base ~ A-C-N-N-C-B
\ R4 Solvent 11 IX (IV) V X (I) As can be seen above, the intermediate product of Step 2, the compounds of Formula IX, corresponds to the compounds of Formula IV. In addition, the compound of Formula X
corresponds to the compounds of Formula I where X and X' are oxygenO

~ ~3~3~3 Method 2 O Rl O
A-C-W +~N - N - C-B Solvent XI XII
O O
Il 11 A-C-N N - C-B
R f3 R
R
I

where Rl, R2, R3, X4, A and B are as def ined above for Formula I and W is a good leaving group such as halo, for example, chLoro; an alkoxy, for example, ethoxy~ methyl sulfonate (-OSo2cH3); or an ester~ for example, acetate (-OC(O)C~3).
Process C can be used when preparing compounds according to Formula I where A, B and Rl are as def ined for Formula I and one or both X and X' are sulfur.

Process C:
Step 1 X R2 X Rl Il l 11 1 A-C-Y + NHNHC-R3 Base . A-C - N- - NH
R1 R4 R4~C-R2 XIII III XIV

3 ~ 3 Ste 2:
X X' X X' ¦¦ R ' ll ll Rl ll A-C-N---NH + B-C-Y Base . A-C-N---N---C-B
¦ Solvent ~ l R R
XIV XV

where Rl, R2, R3, R4, A and B are as defined above for Formula I and one or both X and X' are sulfur, and Y is a good leaving group such as carboxyalkylthio (for example, carboxymethylthio, -SCH2C02H); alkylthio (for example, methylthio); or halo (for example, chloro).
Process D can be used when preparing compounds according to Formula I where X and X' are oxygen and Rl, A
and B are as defined above for Formula I.

Process D
Step l NHNHC--R3 + (Z-ot~c=o Base ~ Z-o-c-NRlNHl--R3 R1 R4 Solvent 14 III XVI XVII
Step 2 O R2 o oo Il 1 1 3 Z-O-C-NR NHC - R + B-C-Cl Base ~ Z-O-C-NR N - C -R4 Solvent ~4_1_R2 l3 XVII V XVIII

Step 3 ~

O O o ll 1 11 Rl ll Z-O-C-NR - N ~C-B Acid ~ NHN C-B
R4-C-R2 Solvent R4_¦_R2 XVIII XIX
Step 4 O o O o A~C-Cl + NHN C-B Base _ ~ A-C-~ - N - C-B
R4-C-R2 Solvent R4-C-R2 II XIX

wherein Rl, R2, R3, R4, A and B are as defined above for Formula I and Z is t-butyl; ethyl; phenyl; or benzyl.
The starting materials for each process are generally commercially available, or can be prepared by generally customary and known methods.
In process ~, a compound of Formula II is reacted with a monosubstituted hydrazine of Formula III or a corresponding acid addition salt such as the hydrochloride salt or the like in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford an intermediate product of Formula IV which can be isolated or further reacted with a compound of Formula V
in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford the desired product of Formula I.
When A and B are the same, for example, both A and B
are 4-chlorophenyl, two equivalents of a compound o ~73~33 Formula II or V are reacted with a monosubstituted hydrazine o~ Formula III in the presence of a base in an inert or substantially inert solvent or mixture of solvents to a~ford the desired product of Formula I~
Examples of the compounds of Formula II and/or Formula V which can be used in the above processes include benzoyl chloride, 4-chlorobenzoyl chloride, 4-methyl-benzoyl chloride, 3,5-dichlorobenzoyl chloride, 2-bromo-benzoyl chloride, 3-cyanobenzoyl chloride, 3-toluoyl chloride, 4-toluoyl chloride, 4-ethylbenzoyl chloride, 2-nitrobenzoyl chloride, 2,3~dimethylbenzoyl chloride, 2-nitro-5-toluoyl chloride and the like. The compounds of Formula II and/or Formula V are generally commercially available or can be prepared by known procedures.
Examples of the compounds of Formula III which can be used in the above processes include l,l-dimethyl-3-butenylhydrazine, (trimethylsilylmethyl)hydrazine, (1,1,1-tri~luoro-2-propyl)hydrazine, (2,2,2-trifluoroethyl)-hydrazine, (l-cyano-l-methyl)ethylhydrazine and the like. The compounds of Formula III are generally commercially available or can be prepared by known procedures. For example, the Grignard reagent addition product of acetone azine in diethyl ether is hydrolyzed by the adition of an acid (such as oxalic acid), in a suitable solvent or mixture of solvents (such as ethanol and diethyl ether, 1:1) to afford the monosubstituted hydrazine of Formula III.
Suitable solvents for use in the above processes include water; alcohols such as methanol, ethanol, isopropanol and the like; hydrocarbons such as toluene, xylene, hexane, heptane and the like; glyme; tetrahydro-~uran; acetonitrile; pyridine; or haloalkanes such as methylene chloride or mixtures of these solvents.

-3~-~ ~73~i3;3 Pre~erred solvents are water, toluene, methylene chloride or a mixture of these solvents.
Examples of bases for use in the above processes include tertiary amines such as triethylamine; pyridine;
potassium carbonate; sodium carbonate; sodium bicarbonate;
sodium hydroxide; or potassium hydroxide. Preferred bases are sodium hydroxide, potassium hydroxide or triethyl-amine.
In Process B, Method 1, a compound of Formula VI is reacted with a ketone or aldehyde of Formula VII in an inert or substantially inert solvent or mixture of solvents and optionally in the presence of a catalyst to a~ford an intermedia~e product of Formula VIII. The intermediate product of Formula VIII is then further reacted with a reducing agent in an inert or substantially inert solvent or mixture of solvents to afford a second intermediate product of Formula IX (IV) which can be isolated or further reacted with a compound of Formula V
in the presence of a base in an inert or substantially inert solvent or mixture o~ solvents to afford the desired product of Formula X (I).
Examples of the compounds of Formula VI which can be used in the above Process B, Method 1, include ~enzoylhydrazine, 4-chlorobenzoylhydrazine, 2-methylbenzoylhydrazine, 4-methylbenzoylhydrazine, 3,5-dichlorobenzoylhydrazine and the like. The compounds of ~ormula VI are generally commercially available or can be prepared by known procedures, Examples of the compounds of Formula VII which can be used in the above Process B, ~ethod 1, include trifluoro-acetone, methacrolein, ethyl pyruvate and the like. The compounds of Formula VII are generally commercially available or can be prepared by known procedures.

~.~736~

Optionally, a catalyst may be used in Step 1, Method l of of Process ~. Suitable catalysts generally include organic acids such as acetic acid, trifluoroacetic acid, oxalic acid and the like; mineral acids such as hydrochloric acid, sulfuric acid, nitric acid and the like; arylsulfonic acids such as toluenesulfonic acid; or pyridinium ~oluenesulfonate~ Preferred catalysts are organic acids or arylsulfonic acids. Most preferred catalys~s are acetic acid or trifluoroacetic acid.
Suitable solvents for use in the above Process B, Method l, Step l, include alcohols such as methanol, ethanol, isopropanol and the like; hydrocarbons such as toluene, benzene; ethers such as tetrahydrofuran (THF), glyme and the like; or dimethylformamide. Preferred solvents are alcohols and hydrocarbons. Most preferred solvents are alcohols such as methanol or ethanol.
Examples of suitable reducing agents for use in the above Process ~, Method l, Step 2, include hydrides such as sodium borohydride and derivatives thereof such as sodium cyanoborohydride, lithium aluminum hydride and derivatives thereof and the like; or diborane~ Preferred reducing agents are sodium borohydride and derivatives thereof or lithium aluminum hydride and derivatives thereof. ~ost preferred as - reducing agents are borane and diborane.
~ptionally, in Process B, Method 1, Step 2, a catalyst may be included. Examples of suitable catalysts include organic acids such as acetic acid, trifluoroacetic acid; or mineral acids such as hydrochloric acid, sulfuric acid and the like. Preferred catalysts are organic acids or hydrochloric acid. Most preferred catalysts are acetic aci~, tri~luoroacetic acid or hydrochloric acid.
~uitable solvents for use in the above Process B, Method l, Step 2, include alcohols such as methanol, ..
~; ,.

7~3~i33 ethanol, isopropanol and the like; ethers such as tetrahydrofuran (THF), diethylether, glyme and the like;
or halohydrocarbons such as methylene chloride, chloroform and the like. Preferred solvents are alcohols and most S preferred are methanol or ethanol.
Step 3 of Process B, Method 1 corresponds to Step 2 o~ Process A. Consequently, those bases and solvents suitable for use in Step 2 of Process A are suitable for use in Step 3, Method 1 of Process B including the preferred bases and solvents described above.
In Process ~, Method 2, and N'-substituted-N'-benzoylhydrazine of Formula XII is reacted with a compound o$ Formula XI in the presence of a base in an inert or substantially inert solvent or mixture of solvents to af~ord the desired pro~uct of Formula I.
The compounds of Formula XI are generally commercially available or can be prepared from commercially available compounds by procedures well known to those skilled in the art as described below.
Examples of the compounds of Formula XII which can be used in the a~ove Process B, Method 2, include N'-(l,l-dimethyl-3-butenyl)-N'-benzoylhydrazine, N'-(trimethyl-silylmethyl)-N'-(4-meth~lbenzoyl)hydrazine, N'-(l,l,l-trifluoro-2-propyl)-N'-(2,4-dichlorobenzoyl~hydrazine, N'-(1-cyano-1-methyl)ethyl-N'-(2-methylbenzoyl)hydraæine and the like.
Suitable solvsnts for use in the above Process B, Method 2, include water; hydrocarbons such as toluene, xylene, hexane, heptane and the like; alcohols such as methanol, ethanol, isopropanol, and the like; ~lyme;
tetrahydrofuran; acetonitrile; pyridine; or haloalkanes such as methylene chloride; or mixtures of these solvents. Preferred solvents are water, toluene, methylene chloride or a mixture of these solvents.

~:7~ i33 Examples of bases suitable for use in the above Process C includes tertiary amines such as triethylamine;
pyridine; potassium carbonate; sodium carbonate; sodium bicarbonate; sodium hydroxide; or potassium hydroxide.
Pre~erred bases are sodium hydroxide, or triethylamine.
The compounds of Formula XI are commercially available, such as nicotinoyl chloride hydrochloride, lsonicotinOyl chloride hydrochloride and ethyl picolinate or can be prepared from commercially available materials by procedures known to those skilled in the art.
The compounds of Formula XII can be prepared by procedures known to those skilled in the art from commercially available reactants. By way of example, a suitably substituted hydrazine (such as (l,1,1-trifluoro-2-propyl)hydrazine) is reacted with an aldehyde or ketone (such as acetone) in the presence o~ a base (such as triethylamine) to afford a hydrazone which is then reacted with a benzoyl chloride in an inert or substantially inert solvent or mixture of solvents in the presence of a base (such as sodium hydroxide) to afford an N'-substituted-N'-~enzoylhydrazone which is then reacted with an acid (such as hydrochloric acid) to afford the compound of ~ormula XII. Alterna~ively, a suitable substituted hydrazine (such as (trimethylsilylmethyl)hydrazine) is reacted with di-tert-butyldicarbonate in an inert or substantially inert solvent or mixture of solvents (~uch as toluene/water) to afford an N'-(trimethylsilylmethyl)-N-t-butoxycarhonylhydrazine which is then reacted with a benzoylchloride in an inert or substantially inert solvent or mixt~re of solvents to afford an N'-(trimethylsilylmethyl)-N'-benzoyl N-t-butoxycarbonyl-hydrazine which is th~n reacted with an acid to afford the aesired compound of Formula XII.

`:' "

3 6 ~ 3 3 In Process C, a compound of Formula XIII is reacted with a monosubstituted hydrazine of Formula III or a corresponding acid addition salt such as the hydrochloride salt or the like in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford an intermediate compound of Formula XIV which can be isolated or further reacted with a compound of Formula XV in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford the desired product of Formula I.
In Process D, a monosubstituted hydrazine of Formula III or a corresponding acid addition salt, such as the hydrochloride salt or the like, is reacted with a compound of Formula XVI in the presence of a base in an inert or lS substantially inert solvent or mixture of solvents to afford an intermediate product of Formula XVII. The intermediate product of Formula XVII is then further reacted with a compound of Formula V in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford a second intermediate product of Formula XVIII. The second intermediate product of Formula XVIII is then further reacted with an acid in an inert or substantially inert solvent or mixture of solvents to afford a third intermediate product of Formula XIX. The third intermediate product of Formula XIX is then further reacted with a compound of Formula II in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford the desired product of Formula I.
Examples of the compounds of Formula XVI which can be used in the above Process D include di-t-butylcarbonate, diethylcarbonate, diphenylcarbonate, dibenzylcarbonate and the like. The compounds of Formula XVI are generally commercially available or can be prepared by known procedures.

3~3;3 Suitable solvents for use in the above Process D, Steps 1, 2 and 4 include water; tetrahydrofuran; dioxane;
toluene; alcohols such as methanol, ethanol and isopropanol; hexane; acetonitrile; pyridine; and haloalkanes such as methylene chloride; or mixtures of these solvents.
Preferred solvents are dioxane; toluene; tetrahydro-furan; pyridinei methylene chloride or water.
Most preferred solvents are dioxane; water or toluene.
Examples of the bases for use in the above Process D, Steps 1, 2 and 4 include tertiary amines such as triethyl-amine; pyridine; potassium carbonate~ sodium carbonate;
sodium bicarbonate; sodium hydroxide; and potassium hydroxide.
Preferred bases are sodium hydroxide; potassium hydroxide; pyridine or triethylamine.
Suitable solvents for use in the above Process D, Step 3 include alcohols such as methanol, ethanol and isopropanol; water; tetrahydrofuran; dioxane; and aceto-nitrile.
Preferred solvents are methanol or ethanol.
Examples of acids for use in the above Process D, Step 3 include concentrated hydrochloric acid or concentrated sulfuxic acid.
When A and B are the same, for example, both A and B
are unsubstituted phenyl, two equivalents of a compound Formula XIII or XV are reacted with a monosubstituted hydrazin~ of Formula III in the presence of a base in an inert or substantially inert solvent or mixture of solvents to afford the desired product of Formula I.
Examples of the compounds of Formula XIII and/or Formula XV which can be used in the above Process C
include 3-methyl-methylthio-thiobenzoate, 4-chloro~

~ ~73~j~33 methylthio-thiobenzoate, 4-methyl-methylthio-thiobenzoate, carboxymethylthio-thiobenzoate and the like. The compounds of Formula XIII and/or Formula XIV are generally commercially available or can be prepared by known procedures.
Suitable solvents for use in the above Process C are generally polar high-boiling solvents such as dimethyl-formamide (DMF); glyme; tetrahydrofuran (THF); and pyridine. The preferred solvent is pyridine.
Suitable bases for use in the above Process C include tertiary amines such as triethylamine; and pyridine. The preferred base is pyridine.
The above Processes A and B, Method 1, can be carried out at temperatures between about -20C and about 100C.
Preferably, these reactions are carried out between about -5C and about 50C.
The above Process B, Method 2, can be carried out at temperatures between about -50C and about 150C.
Preferably when W is a halo radical, the reaction is carried out between about 0C and about 30C. When W is alkoxy, the reaction is preferably carried out between about 100C and about 150C. When W is methyl sulfonate, the reaction is preferably carried out between about -20C
to about 20C. When W is an ester, the reaction is preferably carried out between about 0C and about 50C.
Process C can be carried out at temperatures between about 10C and 200C. Preferably, this reaction is carried out between about 70C and about lO~QC.
Pro~ess D can be carried out at temperatures between about 0C and 100C. Preferably, these reactions are carried out between about 0C and abou~ 50C.
Preparation of the compounds of the present invention by processes A, B, C and D are preferably carried out at about atmospheric pressure, although higher or lower pressures can be used if desired.

!

~ ~73~33 Substantially equirnolar amounts of reactants are preferably used in processes A, B and C, although higher or lower amounts can be used if desired.
Generally, about one equivalent of base is used per e~uivalent of starting material of Formula II, V, XI
and/or XIII. Where the acid addition salt of the mono-substituted hydrazine of Formula III is used, one additional equivalent o~ base is used. For example, in Process A, when substituents A and B are the same and a monosubstituted hydrazine is used, about two equivalents of base are used since about two equivalents of a suitably substituted benzoyl chloride of Formula II or V are employed. In Process A, when substituents A and B are different and an acid addition salt o~ the monosubstituted hydrazines o~ Formula III is used, about two equivalents of base are used in Step 1 and about one e~uivalent of base is used in Step 2.
Modifications to the above processes may be necessary to accommodate reactive functionalities of particular A
and/or B substituents. Such modifications would be apparent and kno~n to those skilled in the art.
It will be appreciated by those skilled in the art that electronic forces may give rise to more than one isomer o~ the compounds of Formula I such as enantiomers, Zs conformers and the like. There may be a dif~erence in properties such as physical characteristics and degree of biological activity between such isomers. Separation of a speci~ic isomer can be accomplished by standard techniques well known to those skilled in the art such as silica gel chromatography.
The agronomically acceptable salts embraced by Formula I of the invention can be prepared by reacting a metal hydroxide, a metal hydride or an amine or ammonium salt, such as a halide, hydroxide or alkoxide with a ~73~3;3 compound of Formula I having one or rnore hydroxy or carboxy groups or reacting a quaternary ammonium salt, such as chloride, bromide, nitrate or the like with a metal salt of a compound of Formula I in a suitable solvent. When metal hydroxides are used as reagents, useful solvents include water; ethers such as glyme and the like; dioxane; tetrahydrofuran; alcohols such as methanol, ethanol, isopropanol and the like. When metal hydrides are used as reagents, useful solvents include nonhydroxylic solvents, for example, ethers such as dioxane, glyme, diethylether and the like; tetrahydro-furan; hydrocarbons such as toluene, xylene, hexane, pentane, heptane, octane and the llke; dimethylformamide, and the like. When amines are used as reagents, useful solvents include alcohols, such as methanol or ethanol;
hydrocarbons, such as toluene, xylene, hexane and the like; tetrahydrofuran; ~lyme; dioxane; or water. When ammonium salts are used as reagents, useful solvents include water; alcohols, such as methanol or ethanol;
glyme; tetrahydrofuran; or the like. When the ammonium salt is other than a hydroxide or alkoxide, an additional base, such as potassium or sodium hydroxide, hydride, or alkoxide is generally used. The particular choice of solvent will depend on the rela-tive solubilities of the starting materials and the resultant salts, and slurries rather than solutions of certain reagents may be used to obtain the salts. Generally, equivalent amounts of the starting reagents are used and the salt-forming reaction i~ carried o~t at about 0C to about 100C, preferably at about room temperature.
The acid addition salts of the present invention can be preparad by reacting hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, acetic, propionic, ben~oic or other suitable acid with a compound of Formula I having 73~3 a basic functional group in a suitable solvent. Useful solvents include water, alcohols, ethers, esters, ketones, haloalkanes and the like. The particular choice of solvent will depend on the relative solubilities of the starting materials and the resulting salts and slurries rather than solutions of certain reagents may be used to obtain the salts. Generally, equivalent molar amounts of starting materials are used and the salt-forming reaction is carried out at from about -10C to about 100C, preferably at about room temperature.
Tha following examples will further illustrate this invention but are not intended to limit it in any way. In Table I, some N'-substituted-N,N'-diacyl hydrazines of the present invention that have been made are listed. The lS structure of these compounds was confirmed by NMR and in some cases by IR and/or elemental analysis. Specific illustrative preparation of the compounds of Examples 8, 15 and 28 are described after Table I.

3~;i;33 , .

TABLE I

O H O
Il l 11 A -C -N ~ N C ~ B
R4 ~1 ~ R2 Ex No. R2 R3 R4 A B
1 H Me CF3 C6H3Me2-2,3 C6H3C12-2,4 2 H Me CF3 C6H3Me2-2,3 C6H3Me2-3,5 3 H Me CF3 C6H3Me2-2,3 C6H3N02Me-2,5

4 H Me CF3 C6H5 C6H5 H H CF3 C6H3C12-3,4 C6H3C12-3,4 6 H H CF3 C6H4Cl-4 C6H4Cl-4 Me ~e CN C6H5 C6H5 Me Me CN C6H5 C6H4Cl-4 10 Me Me CN C6H44-Me C6H4Me-3 11 Me Me CN C6H5 C6H4Me-3 12 Me Me CN C6H4Cl-4 C6H4Cl-4 13 Me Me CN C6H4Me-4 C6H3Me23,5 14 Me Me CN C6H'LMe-4 C6H4F 4 lS Me Me CN C6H~Me-4 C6H4Me-4 16 Me Et CN C6H5 C6H5 17 Me Me CN S C6H4Me 3 18 Me Me CN C6H4Et-4 C6H3Me2-3,5 19 Me Me CN C6H4Me 2 C6H3Me~-3,5 2~ Me Me CN C6H4Cl-4 C6H4Me-3 21 Me Me CN C6~3F2-2,6 C6H4Cl-4 22 Me Me CN C6H4Me 2 C6H4~e-3 23 Me Me CN C6N4N02-2 C6H4Me-3 24 Me Me CN C6H4C1 2 C6H4Me-3 : "`'' ....;.~.: ~''"'''' " "' ,.:

3~7~ 3 . .

Me Me 02Me C6H5 C6H5 26 Me Me CH2CH=CH2 C6H4Me-4 C6H4Me-4 27 Me Me CH2CH=CH2 C6H4Me-3 C6H4Me-3 28 Me ~e C~2CH=CH2 C6H5 C6H5 29 H H SiMe3 C6H4Et-4 c6H3No2Me-2 ,5 H H SiMe3 C6H4Cl-4 C6H4Cl--4 31 ~ H SiMe3 C6Hg~Me-2 C6H4Me 2 32 H H SiMe3 C6H4N02-2 C6H4N02-2 3 3 H H SiMe3 C6H5 C6H5 34 H ~i SiMe3 C6H4Et-4 C6H3Me2-3 ~ 5 73~;3~
EXAMPLE NO. 8 - Preparation of N'~ cyano-l-methyl)e~hyl-N,N'-dibenzoylhydrazine To a suspension of benzoylhydrazine (13.6 g, 0.1 mole) in deionized water (50 ml) at 5C with stirring was dropwise added concentrated hydrogen chloride (9.8 9, 0.1 mole). To the resulting clear solution was added sodium cyanide (5.2 9, 0.1 mole) and acetone (6.5 g, 0.11 mole). A white and thick precipitate appeared. The cooling bath was removed and the reaction flask was stoppered tightly. The reaction mixture was stirred for 18 hours. The precipitate was collected by suction-filtration and was washed with a small amount of water to give 17.5 g (86.2% yielded) of desired intermediate, N'-(l-cyano-l-methyl)ethyl-N-benzoic acid hydrazide, as the lS starting material for the next stepO (m.p. 82-92C) To the solution of N'-(l-cyano-l-methyl)ethyl-N-benzoic acid hydrazide (2 g, 0.01 mole) in dry methylene chloride (25 ml) under nitrogen at room temperature with stirring was added benzoyl chloride (2.02 g, 0.014 mole). To the above mixture was dropwise added triethylamine (1.31 g, 0.013 mole). The reaction mixture was stirred at room temperature for 5 hours~ The reaction mixture was diluted with methylene chloride (50 ml), washed with water and brine. The organic layer was dried over MgS04 and the solvent was evaporated at reduced pressure to give a residue. The residue was treated with ethyl acetate/hexane mixture (1:1) a~fording a crude solid-formed product which was collected by suction-filtration (1 g, 33% yield). An analytical sample was obtained by crystallization from ethyl acetate/hexane (4:1), m.p. 202-204C. NMR and IR spectra showed the desired product.

73~33 Elemental Anal~sis C H N
Calc.(%)70.34 5.58 13.67 Found(%)70.20 5.67 13.40 S EXAMPLE NO. 15 - Preparation of N'~ cyano-l-meth l)eth l-N N'-di-4-toluovlhvdrazine Y _ Y
To the suspension of 4-toluic acid hydrazide (15.0 g, 0.1 mole) in water (150 ml) and ethanol (20 ml) at 5C
with stirring was dropwise added concentrated hydrogen chloride (10 g, 0.1 mole)O To the above still suspension was carefully added sodium cyanide (5.3 g, 0~1 mole) and acetone (6.6 g, 0.11 mole). The reaction flask was stoppered tightly and the cooling bath was removed. The resulting viscous reaction mixture was stirred at room temperature for more than 24 hours. The precipitate was collected by suction-filtration and was washed with a small amount of diluted hydrogen chloride and water affording 14.6 9. (64.8%) of N'-(l-cyano-l-methyl)ethyl 4-toluic acid hydrazide as the starting material for the next step. Analytical sample was obtained by crystallization from ethyl acetate/hexane (3:1), m.p. 146 148Co To the solution of N'-(l-cyano-l-methyl)ethyl 4-toluic acid hydrazide (2.17 9, 0.01 mole) in dry methylene ~5 chloride (65 ml) under nitrogen with magnetic stirring was added 4-dimethylaminopyridine catalyst (1.34 g, 0.U11 mole) followed by 4-methylbenzoyl chloride (2.52 g, 0.017 mole). To the above mixture was dropwise added triethylæmine (1.1 g, 0.011 mole). The reaction mixture ~0 was slightly exothermic. After stirring at room temperature or 40 minutes the reaction mixture was diluted with methylene chloride (50 ml), washed with diluted HCl solution (2X50 ml), dil NaOH (50 ml), H~O (50 ~ ~73~3~3 . .

ml) and brine. The organic layer was dried over MgSO~, and the solvent was evaporated under reduced pressure to give a residue. The residue was treated with ethyl acetate/hexane mixture (1:1) and the resulting solid was collected by suction-f.iltration and affording 2.75 9 (82%
yield) of almost pure product. (m.p. 192-198C) NMR and IR spectra showed the desired product.
By following substantially the procedures in Example 8 (without catalyst) or 15 (with catalyst) and using the reactants shown below in Table II, the products of Examples 8 to 24 were prepared.
TPELE II
Ex. Ccmpound of Ccmpound of Compound of No. Fonmula VI Fonmula VIIa Fonmula V
8 benzoylhydrazine acetone benzoyl chloride 9 ben2oyIhydrazine acetone 4-chlorobenzcyl chloride 10 4 toluoylhydrazine acetone 3-methylbenzoyl chloride 11 benzoylhydrazine acetone 3,methylbenzoyl chloride 12 4-chlorobenzoyl- acetone 4-chlorokenzoyl chloride hydrazine 13 4 toluoylhydrazine a oe tone 3,5-dimethylkenzoyl chloride 14 4-toluoylhydrazine acetone 4-fluorobenzoyl chloride 15 4 toluoylhydrazine acetone 4~methylbenzoyl chloride 16 benzoylhydrazine methylethylketone benzoyl chloride 17 thienoylhydrazine acetone 3-methylbenzoyl chloride 18 4-ethylbenzoyl- acetone 3,5-dimethylbenzoyl chloride hydr æine 19 2-toluoyLhydrazine acetone 3,5-dimethylbenzoyl chloride 20 4-chlorobenzoyl- acetone 3-methylbenzoyl chloride hydrazine '73~3 Ex. ~und of G~x~nd of Ccmpound of No. FormuLa VI Formula VIIaFormula V
~1 2,4-difluorobenzoyl- acetone4-chlorobenzoyl chloride hydrazine ~2 2-toluoylhydrazine acetone3-methylbenzoyl chloride 23 2-nitrobenzoyl- acetone3-methylbenzoyl chloride hydrazine 24 ~-chlorobe~oyl- acetone3-methylbe~oyl chloride hydrazine EXAMPLE NOO 2~ Pre~aration of N'-(1,1=dimethvl-3-butenvl)-N,N'-dibenzoylhydrazine To a gently refluxing solution of allyl magnesium bromide (3~0 ml of lM solution) was addad acetone azine (2~ 9) dissolved in diethyl ether (200 ml). The solution was re~luxed ~or three days. Upon cooling~ a saturated solution of ammonium chloride (50 ml) was added. The aqueous layer was separated and washed twice with diethyl ether (2~0 ml). The combined ether extracts were dried over anhydrous magnesium sulfate, filtered and the ether removed at reduced pressure. The product was distilled through a vigreux column at 3.1 torr and collected in a dry ice/acetone cooled receiving flask. The boiling point was 60-65C. lS g o~ product was collected.
oxalic acid (16.7 g) was dissolved in a solution of ethanol:diethyl eth~r (1:1) (150 ml) and water (3.3 9) was a~ded. To this acid solution was added the hydrazone (13 g) dissolved in diethyl ether (75 ml). The solution was stirred for 24 hours then filtered. The solid is washed once with diethyl ether. The filtrate was concentrated and combined with the solid to afford a 71% yield (17.2 9) of the hydrazine oxalate.
The l,l-dimethyl-3-butenylhydrazine oxalate (2 9) was dissolved in toluene and neutralized with 50~ aqueous sodium hydroxideO To this solution was added benzoyl ~3~ 3 chloride (2.8 9) and sodium hydroxide (50~ Aq. solution) (3.2 g) at 25C. The reaction mixture was warmed to room temperature and stirred. The mixture was diluted with hexane and filtered to afford an oily product which solidified upon standing. (m.p. 105-112C) Examples 26 and 27 were made generally in accordance with the procedures for Example 29 abova.
The (trimethylsilylmethyl)hydrazine, trifluoroalkyl hydrazine 2nd(2-carbomethoxy -2-propyl)hydrazine were made generally in accordance with the procedures from Noll, J.E~; Sprier, J.L.; Daubert, a.F.; JACS 73, 3867, 1951;
~ung, S.C.; Le; Breton, G.C.; JOC 46, 5413, 1981; and organic Synthesis Vol 5, pg. 43, respectively, From these starting materials Examples 1-7, 25 and 29-34 were made generally in accordance with the procedure for Example 28 above.
The react`ants shown below in Table III were used to prepare Examples 1-7 and 25 34.

TAELE III
Ex. Compound o~Co~x~nd of Cc0pound of No. FoDmula IIFonmula III Fornula V
1 2,3-dimathyl(1-methyl-2,2 t2- 2,4~dichloro benzoylchloride trifluoroethyl) benzoyl~oride hydrazine ~ 25 2 2,30d ~ ~ 1(1~me~1-2,2,2- 3,5-d~thyl ; . benzoylchloridatrifluoroethyl) benzoyl ~ oride h~dr~ine 3 2,3-d ~ thyl(1-methyl-2,2,2- 2-nitro-5-benzoylchloride trifluoroethyl) tolu~yl~loride hydrazine 4 benzoylchloride (1-me ~ 1-2,2,2- benzoylchloride tri~luoroethyl) hydrazine ~.~

~.2736~

E~c. Con~o~md o$ Cc~ound of Ca~und o~
No. Formula II Formula III ro:A.. l~ V
3,4-dichloro (2,2,2-trifluoroett~l) 3,4-dichloro benzoylchlori~e hydrazine benzoylchloride 6 4-chlorobenzoyl (2,2,2-trifluoroethyl) 4chlorobenzoyl chloride h~drazine chloride 7 benzoylchloride (2,2,2- trifluoroethyl) benzoylchloride hydrazine benzoylchloride (l~car~cmethc~y-l- benzoylchloride nethylethyl) - hydræir~
26~toluoylchloride (l,l-dim~thyl~3- 4-toluo5~1chloride bute~l)h~drazine 273-toluoylchloride (l,l~d~msthyl-3- 3-toluoylchloride butenyl)hydræine 28 benzoylchloride (1,1-d~methyl-3- benzoylchloride h~ter~l)hydrazine 29 4-ethylbenzoyl (trimethylsilyln~thyl) 2-nitro-5-toluoyl chloride hydrazine chloride 3(1 4-chlorobenzoyl (trimethylsilylmethyl) 4-chlorobenzoyl chloride hydrazine chloride 31 ;2-toluoyl (tri~thylsilylmethyl) 2-toluoyl shlori~:le hydræine chloride 32 ~-nitrobenzoyl (trimechylsilylsnethyl) 2-nitrobenzoyl chloride ~drazine chloride 33 ben~oyl ~tr~nethylsilylmethyl) benzoyl chloride hy~ræine c~loride 34 4ethylbenzoyl (tr~3thylsilylmethyl) 3,5-dimethyl chloride hydrazine benzoyl~loride It will b~ appreciated by those skilled in the art that compound~ of Fonnula I can be used as precursors ~or preparing other compounds of Formula I by procedures well known to those skil lad in the art. For example, a suitable comE~ound of Formula I can be reduced, alkylated, substituted, es'cerified, hydrolyzed or the like.

i~

736~33 As previously noted, the cornpounds of the present invention exhibit excellent insecticidal activity and are most active against insects of the orders Lepidoptera and Coleoptera.
In general, for the control of insects in agricul-ture, horticulture and forestry, the compounds of the present invention may be used at a dosage corresponding to from about 10 grams to about 10 kilograms of the active substanc~ per hectare and from about 100 grams to about 5 kilograms per hectare of the active substance ls preferred. The exact amount of dosage for a given situation can be routinely determined and depends on a variety of factors, for example, the substance used, the kind of insect, the formulation used, the state of the crop infested with the insect and the prevailing weather conditions. The term "insecticidal" as employed in the specification and claims of this application is to be construed as any means which adversely affects the existence or growth of the target insects at any stage in their life cycle. Such means can comprise a complete killing action, eradication, arresting in growth, inhibition, reducing in number, reproductive inhibition (such as ovicidal or chemisterilant) or any combination thereof. The term "control" as employed in the ~5 specification and claims of this application is to be construed as meaning "insecticldal" or protecting plants from insect damage. By "insecticidally effective amount"
is meant that dosage of active substance sufficient to exert insect "control."
The compounds of the present invention, for practical applications, can be utilized in the form of compositions or formulations. Examples of the preparation of compositions and formulations can be found in the American Chemical Society publication "Pesticidal ~7~
,, Formulation Research," (1969), Advances in Chemistry Series No. 86, written by Wade Van Valkenburg; and the Marcel Dekker, Inc. publication "Pesticide Formulations,"
(1973), edited by Wade Van Valkenburg. In these compositions and formulations, the active substance or substances are mi~ed with conventional inert agronomically acceptable (i.e., plant compatible and/or pesticidally inert) diluents or extenders such as solid carrier material or liquid carrier material, of the type usable in conventional compositions or formulations. By agronomically acceptable carrier is meant any substance which can be used to dissolve, disperse or diffuse the active ingredient in the composition without impairing the active ingredient's effectiveness and which by itself has no significant detrimental effect on the soil, equipment, desirable plants or agronomic environment. If desired, conventional adjuvants such as surfactants, stabilizers, antifoam agents and antidrift agents may also be added.
Examples of compositions and formulations according to the invention are aqueous solutions and dispersions, oily solutions and oil dispersions, pastes, dusting powders, wettable powders, emulsifiable concentrates, flowables, granules, baits, invert emulsions, aerosol compositions and fumigating candles.
Wettable powders, pastes, flowables and emulsifiable concentrates are concentrated preparations which are diluted with water before or during use.
Baits are preparations generally comprising a ~ood or other substance attractive to the target pest, that includes at least one lethal or non-lethal toxicant.
Lethal toxicants kill the pest upon ingesting the bait while non-lethal toxicants change the behavior, feeding habits and physiology of the pest for the purpose of control.

3~

The invert emulsions are mainly used for air application, where large areas are treated with a comparatively small amount of preparation. The invert emulsion may be prepared in the spraying apparatus shortly before, or even during, the spraying operation by emulsifying water in an oil solution or an oil dispersion of the active substance.
Compositions and formulations are prepared in a known manner, for instance by extending the active compounds with conventional dispersible liquid diluent carriers and/or dispersible solid carriers optionally with the use of carrier vehicle assistants, e.g., conventional sur~ace-active agents, including emulsifying agents and/or dispersing agents, whereby, for example, in the case where water is used as diluent, organic solvents may be added as auxiliary solvents. The following may be chiefly considered for use as conventional carrier vehicles for this purpose: aerosol propellants which are gaseous at normal temperatures and pressures, such as halogenated hydrocarbons, e.g., dichlorodifluoromethane and trifluoro-chloromethane, as well as butane, propane, nitrogen and carbon dioxide; inert dispersible liquid diluent carriers, including inert organic solvents, such as aromatic hydrocarbons (e.g., benzene, toluene, xylene, alkyl naphthalenes, etc.), halogenated, especially chlorinated, aromatic hydrocarbons (e.g., chlorobenzenes, etc.), cycloalkanes (e.g., cyclohexane, etc.), parafEins (e.g., petroleum or mineral oil fractions), chlorinated aliphatic hydrocarbons (e.g., methylene chloride, chloroe-thylenes, etc.), vegetable oils (e.g., soybean oil, cottonseed oil, corn oil, etc.), alcohol~ (e.g., methanol, ethanol, propanol, butanol, glycol, etc.) as well as ethers and esters thereof (e.g., glycol monomethyl 0ther, etc.), amines (e.g., ethanolamine, etc.), amides (e.g., dimethyl ~,~d~73~i~33 formamide, etc.), sulfoxides (e~gO, dimethyl sulfoxide, etc.), acetonitrile, ketones (e.g., acetone, methyl thyl ketone, methyl isobutyl ketone, cyclohexanone, isophorone, etc.), and/or water; solid carriers including ground natural minérals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as highly-dispersed silicic acid, alumina and silicatesi solid carriers for granules include crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, as well as synthetic granules of inorganic and organic meals, and granules of organic material such as sawdust, coconut shells, corn cobs and tobacco stalks. The following may be chiefly considered for use as conventional carrier vehicle assistants: emulsifying agents, such as cationic and/or nonionic and/or anionic emulsifying agents (e.g., polyethylene oxide esters of fatty acids, polyethyIene oxide ethers of fatty alcohols, alkyl sulfates, alkyl sulfonates, aryl sulfonates, alburnin hydrolysates, etc~, and especially alkyl arylpolyglycol ethers, magnesium stearate, sodium oleate, etc.); and/or dispersing agents, such as lignin, sulfite waste liquors, methyl cellulose, etc.
Adhesives such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, can be used in the for~ulations.
If desired/ it is possible to use coloran~s in compositions and formulations containing compounds of the present invention such as inorganic pigments, for example, iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestufs and metal phthalocyanine dyestufs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

~ ~'7~;33 The active compounds of the present invention may be employed alone or in the form of mixtures with one another and/or with such solid and/or liquid dispersible carrier vehicles and/or with other known compatible active agents, esp0cially plant protection agents, such as other insecticides, arthropodicides, nematicides, fungicides, bactericides, rodenticides, herbicides, fertilizers, growth-regulating agents, synergists, etc., if desired, or in the form of particular dosage preparations for specific application made therefrom, such as solutions, emulsions, suspensions, powders, pastes, and granules which are thus ready for use.
As concerns commercially marketed preparations, these generally contemplate carrier composition mixtures in which the active compound is present in an amount substantially between about 0.1% and 99% by weight, and preferably between about 1% and 75% by weight, of the mixture. Carrier composition mixtures suitable for direct application or field application generally contemplate those in which the active compound is used in an amount substantially between about 0.0001% and 5%, preerably between about 0.001% and 3%, by weight of the mixture.
Thus the present invention contemplates overall formula-tions and compositions which comprise mixtures of a conventional dispersible carrier such as (1) a dispersible inert finely divided carrier solid, and/or (2) a dispersible carrier liquid such as an inert organic solvent and/or water, preferably including a surface active effective amount of a carrier vehicle assistant (e.g., a surface-active agent, such as an emulsifying agent and/or a dispersing agent), and an amount of the active compound generally, between about 0.0001~ and about 99~ by weight of the composition, preferably between about 0.001% and about 90% by weight of the composition, and 3~i~ 3 more pref-erably between about 0001% and about 75% b~
weight of the composition, which is effective for the purpose in question.
The active compounds can be applied as sprays by methods commonly employed, such as conventional high-gallonage hydraulic sprays, low gallonage sprays, ultra-low-volume sprays, airblast spray, aerial sprays, and dusts. If low volume applications are desired, a solution of the compound is usually used. In ultra-low-volume applications, a liquid composition containing the active compound is usually applied as a spray (e.g., mist) by means of atomizing equipment in finely divided form (average particle size of from about 50 to about 100 microns or less) using airplane crop spraying tech-niques. Typically only a few liters per hectare are needed and often amounts up to about 15 to 1000 g/hectare,preferably about 40 to 600 g/hectare are sufficient. With ultra-low-volume, it is possible to use highly concen-trated liquid compositions with said liquid carrier vehicles containing from about 20 to about 95% by weight of the active compound.
Furthermore, the present invention contemplates methods of killing, combatting or controlling insects, which comprises contacting insects with a correspondingly combative or toxic amount (i.e., an insecticidally effective amount) of at least one active compound of the invention alone or together with a carrier vehicle (composition or formulation) as noted above. The term "contacting" as employed in the specification and claims of this application is to be construed as applying to at least one of (a) such insects and (b) the corresponding habitat thereof (i.e., the locus to be protected, for example, to a growing crop or to an area where a crop is to be grown) the active compound of this invention alone ~ ~.,73~i~3 or as a constituent of a composition or formulation. The instant formulations or compositions are applied in the usual manner, for instance by spraying, atomizing, vaporizing, scattering, dusting, watering, squirting, S sprinkling, pouring, fumigating, dry dressing, moist dressing, wet dressing, slurry dressing, encrusting and the like.
It will be realized, of course, that the concen-tration of the particular active compound utilized in 1~ admixture with the carrier vehicle will depend upon such factors as the type of equipment employed, method of application, area to be treated, types of pests to be controlled and degree of infestation. Therefore, in special cases it is possible to go above or below the aforementioned concentration ranges.
Granular preparations are produced for example, by taking up the active substance in a solvent and by using the resulting solution, as the case may be in the presence of a binder, to impregnate a granular carrier material, such as porous granules (for example, pumice and attaclay~, or chopped tobacco ~tems or the like.
A granular preparation (frequently termed a "pellet") may alternatively be produced by compressing the active substance together with powderéd minerals in the presence of lubricants and binders and by disintegrating and straining the composite to the desired grain size.
Dusts are obtainable by intimately mixing the active substance with an inert solid carrier material in a concentration of from about 1 to about 5~% by weight.
Examples of suitable solid carrier materials are talc, kaolin, pipe clay, diatomaceous earth, dolomite, gypsum~
chalk, bentonite, attapulgite and colloidal SiO2 or mixtures of these and similar substances. Alternatively organic carrier materials such as, for example, ground walnut shells may be used.
~55-73~3 Wettable powders and flowables are produced by mixing from about 10 to about 99 parts by weight of a solid inert carrier such, for example, as the aforementioned carrier materials with from about 1 to about 80 parts by weight of the active substance optionally dissolved in a volatile solvent such as acetone, from about 1 to about 5 parts by weight of a dispersing agent such, for example, as the lignosulfonates or alkylnaphthalene sulfonates known for this purpose and preferably also from about 0.5 to about 5 parts by weight of a wetting agent, such as fatty alcohol sulfates, or alkylarylsulfonates of fatty acid condensation products.
In the case of flowables, a liquid inert carrier such as water is also included.
To produce emulsifiable concentrates the active compound is dissolved or finely divided in a suitable solvent which preferably is poorly miscible with water, an emulsifier being added to the resulting solution.
Examples o suitable solvents are xylene, toluene, high-boiling aromatic petroleum distillates, for example solvent naph~ha, distilled tar oil and mixtures of these liquids. Examples of suitable emulsifiers are alkyl-phenoxypolyglycol ethers, polyoxyethylene sorbitan esters of fatty acids or polyoxyethylene sorbitol esters of fatty acids. The concentration of the active compound in these emulsi~iable concentrates is not restricted within narrow limits and may vary between about 2% and about 50% by weight depending upon toxicant solubility. A suitable liquid highly concentrated primary composition other than an emulsifiable concentrate is a solution of the active substance in a liquid which is readily miscible with water, for example, acetone, to which solution a dispersant and, as the case may be, a wetting agent are added. When such a primary composition is diluted with d ~3~;~3 water shortly before or during the spraying operation an aqueous dispersion of the active substance is obtained.
An aerosol preparation according to the invention is obtained in the usual manner by incorporating the active

5 substance or a solution thereof in a suitable solvent in a volatile liquid suitable for use as a propellant such, for example, as a mixture of chlorine and fluorine derivatives of methane and ethane~
Fumigating candles or fumigating powders, i.e., preparations which when burning are capable of emitting a pesticidal smoke, are obtained by taking up the active substance in a combustible mixture which may, ~or example, comprise a sugar or a wood, preferably in the ground form, as a fuel, a substance to sustain combustion such, for example, as ammonium nitrate or potassium chlorate, and furthermore a substance for retarding combustion, for example kaolin, bentonite and/or colloidal silicic acid.
A bait preparation comprises a food or other substance attractive to pests, a carrier, the toxicant and may optionally include other substances commonly used in preparations of this kind, such as, a preservative to inhibit bacterial and fungal growth, a waterproofing agent to prevent disintegration under wet conditions and dyes or colorants as described above.
In addition to the aforementioned ingredients, the preparations according to the invention may also contain other substances commonly used in preparations of this kind.
For example, a lubricant, such as calcium stearate or magnesium stearate, may be added to a wettable powder or to a mixture to be granulated. Fur~hermore, there may, for example, be added "adhesives" such as polyvinyl-alcohol cellulose derivatives or other colloidal ~3~ 3 materials, such as casein, to improve the adherence of this pesticide to the surface to be protected.
Representative preparation of compositions and formulations including the compounds of the present S invention are set forth below as Examples A through I by way of illustration but not limitation.

Example A
Granular Ingredient %/wt.
Toxicant and toxicant impurities ~.25 Triton~ X-305 (binder) 0.25 (Octylphenyl-30-ethylene oxide ethanol) Agsorb~ 24/48 (diluent)99.50 (Montmorillonite clay) Preparation: The toxicant and Triton~ X-305 are dissolved into methylene chloride and the mixture is added to the Agsorb~ with continuous mixing. The methylene chloride is then allowed to evaporate.

Example B
Dust Ingredie,nt %/wt.
Toxicant and toxicant impurities 1.0 Talc gg.o Preparation: Toxicant is dissolved in excess acetone and the mixture is impregnated onto the talc. The acetone is then permitted to evaporate.

~ ~ ~ 3 Exarnple C
Wettable Powder Ingredient ~/wt.
Toxicant and toxicant impurities 31.3 Duponal3 WA ~ry (wetter) 2.0 (Sodium lauryl sulfate) Reax~ 45A (dispersant) 5.0 (Sodium lignin sulfonate) Barden clay (diluent) 31.7 HiSil~ 233 (diluent) 30.0 (Sodium silica~

Preparation: The toxicant, optionally dissolved in a volatile solvent, is absorbed onto the Barden clay and HiSil~ carriers. The Duponal~ and Reax~ are then added and the entire dry mixture blended until homogeneous. Th0 composition is then micronized to a fine particle size.

Example D
Emulsifiable Concentrate Ingredient %/wt.
Toxicant and toxicant impurities 15.0 Sponto~ 232T (emulsifier) 6.0 (Anionic and nonionic blend of the following surfactants: calcium dodecyl benzene sulfonate; and ethoxylated alkylphenol) Sponto~ 234T (emulsifier) 4.0 (Anionic and nonionic blend of the following surfactants: calcium dodecyl benzene sulfonate; and aO ethoxylated alkylphenol) Cyclohexanone (solvent) 22.5 ~L~73~3 Tenneco~ 500-100 (solvent) 5Z.5 (Aromatic solvent mixture principally comprising xylene, cumene and ethyl benzene having a boiling point range of 290-345F) Preparation: All ingredients are mixed together with continuous agitation until a homogeneous clear solution is obtained.

Example E
Aerosol Ingredient ~/wt.
Toxicant and toxicant impurities 0.5 "Freon 12"* (dichlorodifluoromethane) 99.5 Preparation: The components are mixed and packaged under pressure in a suitable container equipped with a release spray valv~.

Example F
Fumiqatinq Candle or Fumigating Powder In~redient %/wt.
Toxicant and toxicant impurities 1.0 Wood dust 96.0 Starch 3.0 Preparation: Toxicant, wood dust, and starch are blended together and then molded into a candle using a small amount of water to activate the starch.

* Trademark ~.'i 3~i;33 Example G
Balt Method A
Ingredient %/wt.
Toxicant and toxicant impurities 1.00 Wheat Bran (carrier and attractant) 89.95 Corn Syrup (attractant) 7.00 Corn Oil (attractant) 2.00 Kathon~ 4200 (preservative) 0O05 (2~n-octyl-4-isothiazolin-3-one) Preparation: The corn oil and corn syrup are added to the wheat bran with adequate mixing. The toxicant and Kathon~ are premixed with excess acetone and this solution is added to the wheat bran base with continued mixing.
The acetone is then permitted to evaporate.

Method B
In~redient Toxicant and toxicant impurities 0.06 Granulated Sugar (carrier and attractant) 99.94 Exam~e H
Pellet Same as Example G, Method A, with this addition: the bait composition is formed into l/4" diameter by 3/8" long pellets using a suitable die and press apparatus.

Flowable In~redient %/wt.
Toxicant and toxicant impurities 31.3 Duponal~ WA Dry (wetter) 2.0 (Sodium lauryl sulfate) ~3~3 ... I

Reax~ ~5A (dispersant) 5~0 ~Sodium lignin sulfonate) HiSil~ 233 (diluent) 30~0 (Sodium silica) Kelzan~ (thickener) 0.5 (Xanthan gum) Water 31.2 Preparztion The toxicant is a~sorbed onto the HiSil~
carrier The Duponal~ and Reax~ are then added and the entire dry mixture blended until homogeneous~ The composition is then micronized to a fine particle sizeO
The resulting powder i5 suspended in water and the Kelzan~
addedl.

Compositions and fonmulations according to the present invention may also include known pesticidal compounds. This expands ~he spectrum of activity of the preparations and may ~ive rise to synergism.
The following known insecticidal, fungicidal and acarlcidal compounds are suitable for use in such a combined preparation.
Insecticides such as:
Chlorinated hydrocarbons, for example, 2,2-bis~-chlorophenyl~ trichloroethane and hexachloroepoxyoctahydrodimethanonaphthalene;
Carbamates, for example, N methyl-l-n~phthylcarbamates;
Dinitrophenol~, for example, 2-methyl-4,6-dinitrophenol and 2-(2-butyl)-4,6-dinitrophenyl-3,3-dimethyl--acrylate;
Organic phosphorus compounds, such as dimethyl-2-methoxy-3-carbonyl-1-methylvinyl phosphate, O,O-diethyl-O~e-nitrophenylphosphorothioa~e: N-monomethylamide of O,O-dimethyldithiophosphorylacetic acid;

"` ~;c:73~

Diphenylsulfide~, for example, ~-chlorobenzyl or p-chloro-phenyl sulfide and 2,4,4',5-tetrachlorodiphenyl-sulfide;
Diphenylsulfonates, for example, ~-chlorophenylbenzene-sulfonate;
Methylcarbinols, for example, 4,4-dichloro-1-trichloro-methylbenzhydrol;
Quinoxaline compounds, such as methylquinoxaLine dithio-carbonate;
Amidines such as N'-(4-chloro-2~methylphenyl) N,N-dimethylformamidine;
Pyrethroids such as Allethrin;
Biologicals ~uch as Bacillus thuringiensis preparations;
Organic tin compounds such as tricyclohexyltin hydroxide;
Synergists such as piperonyl butoxide;
Insect growth regulators such as N-benzoyl-phenyl ureas, for example, diflubenzuron.

Fungicides such as:
Organic mercury compounds, for example, phenylmercury-acetate and methylmercurycyanoguanide;
Organic tin compounds, for example, triphenyltin hydroxide and triphenyltin acetate;
Alkylenebisdithiocarbamates, for example, zinc ethylene-bisthiocarbamate and manganese ethylenebisdithio-carbamate; and 2,~-dinitro 6-(2-octyl-phenylcrotonate), l-bis(dimethyl-amino)phosphoryl-3-phenyl-5-amino~1,2,4-triaæole, 6-methylquinoxaline 2,3-dithiocar~onate, 1,4-dithio-anthraquinone-2,3-dicarbonitrile, N-triclloromethyl-~ thiophthalimide, N-trichloromethylthiotetrahydro-phthalimide, N-(1,1,2,2-tetrachloroethylthio)-tetra-hydrophthalimide, N-dichlorofluoromethylthio-N-phenyl N' dimethylsulfonyldiamide and tetrachloroiso-phthalonitrile.

~ 7~36~3 Biological Activi~
It has been found by biological evaluation that compounds according to the present invention have pesticidal activity and are capable of controlling larvae and adult forms o~ pests, especially insects ~rom the orders Lepidoptera and Coleoptera and most especlally insects from the order Lepidopter~. One skilled in the art will know how to determine the activity of a given compound against a given insect and the dosage required to obtain general or selective insecticidal effects. The compounds of the present invention in part affect the normal development of insects, particularly insects from the order Lepidoptera, by directly and/or indirectly influencing the moulting process.
As previously noted, the compounds of the Qresent invention are particularly suitable for controlling plant destructive insects in crops of cultivated plants, such as, but not limited to, cotton, vegetables, corn and other cereals and the like; forestry, such as, but not limited .o, bir_h, spruce, pine, fir and the like; and ornamental plants, Llowers and trees. Compounds o~ the present invention ara also particularly suitable for controlling insects destructive to stored commodities such as seeds and the like; ~ruit crops, such as, but not limited to fruit and/or citrus trees, raspberry bushes and the like;
and turf, such as, but not limited to, lawns, sod and the like.
In evaluating the pesticidal activity o~ the compounds of this invention, the ollowing test procedures were employed.
A test solution containing 600 parts per million (ppm) was made by dissolving the tast compound in a solvent (acetone:methanol, l:l), adding water to give an ~L,q~36~;3 acetone:methanol:water system of 5:5:90 and then a surfactant. A 1:1 mixture of an alkylarylpolyetheralcohol (sold under the trademark Triton~ X-155) and a modified phthalic glycerol alkyl resin (sold under the trademark Triton~ B-1956) was utilized at the equivalent of 1 ounce per 100 gal. of test solution as a surfactant.
Initial evaluations were made on one or more of the following pests:
Code Symbol Common Name Latin Name SAW Southern Armyworm Spodoptera eridania MBB Mexican Bean Beetle Epilachna varivestis For the foliar bean beetle and armyworm tests, individual bean (Phaseolus limensis var. Woods' Prolific) leaves are placed on moistened pieces of filter paper in Petri dishes. The leaves are then sprayed with the test solution using a rotating turntable and allowed to dry.
The dishes are infested with 10 third instar larvae of Southern armyworm or Mexican bean beetle. The dishes are then covered.
The percent mortality for the bean beetle and armyworm evaluations are determined 96 hours a~ter treatment. Evaluations are based on a scale of 0-100 percent in which 0 equals no activity and 100 equals total kill.
The rotating turntable consists of a fixed, continuously operating spray no~zle under which targets are rotated at a fixed speed and distance. If the target is a Petri dish (such as for the armyworm), the distance from the nozzle is 15 inches. If the target is a Mason jar, the distance between the screened lid and the nozzle is 6 inches (10 inches from the base of the jar to the noz.zle). The nozzle is located 8 inches from the rotating shaft. The targets on individual platforms revolve around the shat at l revolution per 2U seconds but only a brief portion of this time occurs in the spray path. Targets pass only once under the nozzle and then are removed to drying hoods.
The nozzle used is a 1/4 JCO Spraying Systems (Wheaton, Illinois) air atomizing nozzle equipped with a No. 2850 fluid cap and No. 70 air cap. At the lO psig air pressure used and with liquid siphon feed 0.5 GPH (gallons per hour) are delivered in a round spray pattern with a 21 spray angle. Targets are misted with spray droplets to the point that the droplets coalesce to form a uniform thin film insufficient to drown test organisms.
All treatments are maintained at 75-80F under continuous fluorescent light in a well-ventilated room.
The results of the initial insecticidal evaluations are given in Table IV.

TABL E IV
- Initlal Biologica-l Evaluations Fo 1 i ar Ap pl i ca t i on Test Species ExamPle No. SAW MBB

O

Fo ~ on _ Test Species _ Example No. _SAW BB

27 lO0 28 lO0 39 lO0 31 lO0 _ 32 lO0 It should be understood that the instant specification and examples are set forth by way of illustration and not limitation, and that various modifications and changes may be made without departing from the spirit and scope of the present invention as defined by the appended claims.

' :,., " .. :,

Claims (19)

WHAT IS CLAIMED IS:

1. An insecticidally active compound having the formula I

wherein X and X' are the same or different O, S or NR;
R1 is hydrogen; (C1-C6)alkyl; (C1-C6)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; (C1-C6)alkylthioalkyl having independently the stated number of carbon atoms in each alkyl group; (C2-C6)alkenyl;
(C2-C6)alkynyl; or phen-(C1-C4)alkyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)-haloalkyl (C1-C4)alkoxy, (C1-C4)haloalkoxy , carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)-alkanoyloxy or NZZ';
R2 and R3 are the same or different hydrogen or (C1-C4)alkyl;
R4 is (C1-C4)alkyl substituted with 1 to 4 fluoro;
straight chain (C2-C4)alkenyl; carboxyl;
(C1-C3)alkoxycarbonyl; cyano; cyano substituted (C1-C4)alkyl; (C1-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group, or (C1-C2)trialkylsilyl-methyl having independently the stated number of carbon atoms in each alkyl group; provided that R2 and R3 are both alkyl when R4 is carboxyl or alkoxycarbonyl; and A and B are the same or different unsubstituted or substituted naphthyl where the substituents can be from one to three of the same or different halo; nitro; (C1-C4)alkoxy; (C1-C4)alkyl or NZZ';

unsubstituted or substituted phenyl where the substituents can be from one to five of the same or different halo; nitroso; nitro; cyano;
hydroxy; (C1-C6)alkyl; (C1-C6)haloalkyl;
(C1-C6)cyanoalkyl; (C1-C6)hydroxyalkyl; (C1-C6)alkoxy; (C1-C6)haloalkoxy; (C1-C6)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; (C1-C6)alkoxyalkoxy having independently the stated number of carbon atoms in each alkyl group; (C1-C6)alkylthio-alkoxy (-ORSR') having independently the stated number of carbon atoms in each alkyl group; (C1-C6)alkoxycarbonyloxy (-OCO2R); hydroxycarbonyl-oxy (-OCO2H); (C1-C6)alkanoyloxyalkyl having independently the stated number of carbon atoms in each alkyl group; (C2-C6)alkenyl optionally substituted with halo, cyano, (C1-C4)alkyl, (C1-C4)haloalkoxy, (C1-C4)alkylthio or (C1-C4)alkoxy; (C1-C4)alkadienyl; (C2-C6)alkenyloxy;
(C2-C6)alkenylcarbonyl; (C2-C6)alkenyloxy-carbonyloxy; (C2-C6)alkynyl optionally substituted with halo, cyano, nitro, hydroxy, (C1-C4)alkoxy, (C1-C4)haloalkyl, (C1-C4)alkyl-thio or (C1-C4 ) alkyl; carboxy; (C1-C6)carboxy-alkyl having independently the stated number of carbon atoms in each alkyl group (-RCO2R');

-COR; -COH; (C1-C6)haloalkylcarbonyl; (C1-C6)-alkoxycarbonyl (-CO2R); (C1-C6)haloalkoxy-carbonyl; (C1-C6)alkanoyloxy (-OCOR); (C1-C6)-alkoxycarbonylalkoxy (-ORCO2R') having independently the stated number of carbon atoms in each alkyl group; amino (-NZZ'); amino substituted with hydroxy, (C1-C4)alkoxy or (C1-C4)alkylthio; carboxamido (-CONZZ');
(C2-C6)alkenylcarbonylamino; (C1-C6)-hydroxyalkylaminocarbonyl; aminocarbonyloxy (-OCONZZ'); amido (-NZCOZ'); alkoxycarbonylamino (-NZCO2Z'); thiocyanato; isothiocyanato;
(C1-C6)thiocyanatoalkyl; (C1-C6)alkylthio;
(C1-C6)haloalkylthio; sulfoxide (-S(O)Z);
sulfonyl (-SO2Z); alkylsulfonyloxy (-OSO2R);
-OSO2H; sulfonamide (-SO2NZZ'); alkylthio-carbonyl (-CSR); -CSH; alkylcarbonylthio (-SCOR); -SCOH; thioamido (-NZCSZ');
unsubstituted or substituted phenyl having one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, amino, (C1-C4)alkylamino or (C1-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; phenoxy where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, carboxy, (C1-C4)alkylcarbonyl, (C1-C4)alkanoyloxy, amino, (C1-C4)alkylamino or (C1-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; benzoyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, amino, (C1-C4)alkylamino or (C1-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; benzoyloxy(C1-C6)alkyl; phenylthio-(C1-C6)alkyl where the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, amino, (C1-C4)alkylamino or (C1-C4)dialkylamino having independently the stated number of carbon atoms in each alkyl group; imino (-CR=N-R'") where R'" is hydroxy, (C1-C4)alkyl, (C1-C4)alkoxy, amino (-NZZ'), phenylamino, -COR, -COH or benzoyl; (C2-C6)-oxiranyl; acetylthiosemicarbazone; pyrrolyl;
oxazolyl, unsubstituted or substituted with one or two methyl groups; or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form together with the carbon atoms to which they are attached a 5 or 6 membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (C1-C10)alkyl having one to four of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkoxy, (C1-C4)haloalkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, phenyl or -NZZ';

unsubstituted or substituted (C3-C8)cycloalkyl or unsubstituted or substituted (C3-C8)cyclo-alkyl(C1-C4)alkyl having one to four of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, carboxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C2-C8)alkenyl or unsubstituted or substituted (C2-C8)alkadienyl having a furyl, thienyl or pyridyl or having one to four of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C3-C6)cycloalkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)halo-alkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C3-C8)cycloalkenyl or unsubstituted or substituted (C3-C8)cyclo-alkadienyl having one to four of the same or different halo, cyano, nitro, hydroxy, (C1-C4)-alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, carboxy, (C1-C4)alkoxy-carbonyl, (C1-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted (C2-C8)alkynyl having one to four of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)halo-alkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)-alkanoyloxy, phenyl or -NZZ';

phenalkyl having one to four carbon atoms in the alkyl group and the alkyl group is unsubstituted or substituted with one to three of the same or different halo, cyano, hydroxy, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl or -NZZ', and the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)cyanoalkyl, (C1-C4)alkoxy, (Cl-C4)haloalkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl or -NZZ', phenalkenyl having two to six carbon atoms in the alkenyl group and the alkenyl group is unsubstituted or substituted with one to three of the same or different halo, cyano, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, (C1-C4)alkoxycarbonyl or -NZZ', and the phenyl ring is unsubstituted or substituted with one to three of the same or different halo, cyano, nitro, hydroxy, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, carboxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy or -NZZ';

unsubstituted or substituted five-membered heterocycle selected from furyl, thienyl, triazolyl, pyrrolyl, isopyrrolyl, pyrazolyl, isoimidazolyl, thiazolyl, isothiazolyl, oxazolyl and isooxazlyl where the substituents can be from one to three of the same or different halo;
nitro; hydroxy; (C1-C6)alkyl; (C1-C6)alkoxy;

carboxy; (C1-C6)alkoxycarbonyl; (C1-C6)carboxy alkyl (-RCO2H'); (C1-C6)alkoxycarbonylalkyl (-RCO2R') having independently the stated number of carbon atoms in each alkyl group; carboxamido (-CONZZ'); amino (-NZZ'); amido (-NZCOZ');
(C1-C6)alkylthio; or unsubstituted or substituted phenyl having one to three of the same or different halo, nitro, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl (C1-C6)halo-alkoxy, carboxy, (C1-C4)alkoxycarbonyl or amino (-NZZ'); or unsubstituted or substituted six-membered heterocycle having one, two, three or four nitrogen atoms and two to five nuclear carbon atoms where the substituents can be from one to three of the same or different halo; nitro;
hydroxy; (C1-C6)alkyl; (C1-C6)alkoxy; carboxy;
(C1-C6)alkoxycarbonyl; (C1-C6)carboxyalkyl (-RCO2H); (C1-C6)alkoxycarbonylalkyl (-RCO2R') having independently the stated number of carbon atoms in each alkyl group; carboxamido (-CONZZ'); amino (-NZZ' ); amido (-NZCOZ');
(C1-C6)alkylthio; or unsubstituted or substituted phenyl having one to three of the same or different halo, nitro, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)halo-alkoxy, carboxy, (C1-C4)alkoxycarbonyl or amino (-NZZ');

where R, R' and R" are (C1-C6)alkyl; Z and Z' are hydrogen or (C1-C4)alkyl; and agronomically acceptable salts thereof.

2. A compound according to claim 1 wherein X and X' are O or S;
R1 is hydrogen (C1-C4)alkyl; (C1-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group;
methylthiomethyl; (C2-C5)alkenyl;
(C2-C5)alkynyl; or phen(C1-C2)alkyl where the phenyl ring is unsubstituted or substituted with one or two halo, nitro, (C1-C4)alkyl or (C1-C4)alkoxy;
R2 and R3 are the same or different hydrogen or (C1-C3)alkyl;
R4 is (C1-C3)alkyl substituted with one to four fluoro; straight chain (C2-C4)alkenyl; carboxyl;
(C1-C2)alkoxycarboxyl; cyano; cyano substituted (C1-C3)alkyl; (C1-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or (C1-C2)trialkylsilyl-methyl having independently the stated number of carbon atoms in each alkyl group; provided that R2 and R3 are both alkyl when R4 is carboxyl or alkoxycarbonyl; and A and B are the same or different unsubstituted naphthyl;

unsubstituted or substituted phenyl where the substituents can be from one to three of the same or different halo; nitro; cyano;
(C1-C4)alkyl; (C1-C4)haloalkyl;
(C1-C4)cyanoalkyl; (Cl-C4)alkoxy;
(C1-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; -COZ; carboxy; (C1-C4)alkoxycarbonyl;
(C1-C4)alkanoyloxy; (C2-C6)alkenyl;
(C2-C6)alkynyl; amino (-NZZ'); thiocyanato;

(C1-C4)alkylthio; alkylthiocarbonyl (-CSR);
-CSH; unsubstituted or substituted phenyl having one to two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, carboxy, -NZZ';
phenoxy where the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, carboxy, -NZZ'; or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form a 5- or 6-membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (C1-C8)alkyl having one to three of the same or different halo, cyano, (C1-C4)alkoxy, phenyl, (C1-C4)alkoxycarbonyl or (C1-C4)haloalkoxy;

unsubstituted or substituted (C3-C6)cycloalkyl or unsubstituted or substituted (C3-C5)cycloalkyl(C1-C4)alkyl having one or two of the same or different halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)alkanoyl or (C1-C4)haloalkoxy;

unsubstituted or substituted (C2-C6)alkenyl having a furyl or one to three of the same or different (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy;

unsubstituted or substituted (C3-C6)cycloalkenyl having one or two of the same or different halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy;

unsubstituted or phenyl substituted alkynyl;

phenalkyl having one or two carbon atoms in the alkyl group and the alkyl group is unsubstituted or substituted with one or two of the same or different halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy;

phenalkenyl having two or three carbon atoms in the alkenyl group and the alkenyl group is unsubstituted or substituted with halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy;

unsubstituted or substituted five-membered heterocycle selected from furyl, thienyl, triazolyl, pyrrolyl, and oxazolyl where the substituents can be one or two of the same or different halo; nitro; (C1-C4)alkyl; (C1-C4)-alkoxy; -NZZ'; or unsubstituted or substituted phenyl having one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)halo-alkoxy, carboxy or -NZZ'; or unsubstituted or substituted six-membered heterocycle having one or two nitrogen atoms and 4 to 5 nuclear carbon atoms where the substituents can be one or two of the same or different halo; nitro; (C1-C4)alkyl, (C1-C4)-alkoxy; (C1-C4)thioalkoxy; -NZZ'; or unsubstituted or substituted phenyl having one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, carboxy or -NZZ';

where R and R' are (C1-C4)alkyl; Z and Z' are hydrogen or (C1-C4)alkyl; and agronomically acceptable salts.

3. A compound according to claim 2 wherein X and X' are O or S;
R1 is hydrogen; (C1-C4)alkyl; (C1-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group;
(C2-C5)alkenyl; (C2-C5)alkynyl; or benzyl where the phenyl ring is unsubstituted or substituted with one halo, nitro, (C1-C4) alkyl or (C1-C4)alkoxy ;
R2 and R3 are the same or different hydrogen or (C1-C2)alkyl;
R4 is (C1-C3)alkyl substituted with 1 to 4 fluoro; straight chain (C2-C4)alkenyl;
methoxycarbonyl; cyano; cyano substituted (C1-C2)alkyl; (C1-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or (C1-C2)trialkylsilylmethyl having independently the stated number of carbon atoms in each alkyl group; provided that R2 and R3 are both alkyl when R4 is methoxycarbonyl; and A and B are the same or different unsubstituted naphthyl;

unsubstituted or substituted phenyl having one to three of the same or different halo; nitro;
cyano; (C1-C4)alkyl; (C1-C4)haloalkyl; (C1-C4)-cyanoalkyl; (C1-C4)alkoxy; (C1-C4)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group; -COZ; (C1-C4)alkoxy-carbonyl; (C1-C4)alkanoyloxy; thiocyanato;
-NZZ'; (C1-C4)alkylthio; alkylthiocarbonyl (-CSZ, -CS2Z); unsubstituted or substituted phenyl having one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, carboxy, -NZZ'; or phenoxy where the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, carboxy, -NZZ' or when two adjacent positions on the phenyl ring are substituted with alkoxy groups, these groups may be joined to form a 5- or 6-membered dioxolano or dioxano heterocyclic ring;

unsubstituted or substituted (C1-C6)alkyl having one to three of the same or different halo, cyano, nitro, carboxy, (C1-C4)alkoxy, phenyl, (C1-C4)alkoxycarbonyl or (C1-C4)haloalkoxy;

unsubstituted or substituted (C3-C6)cycloalkyl or unsubstituted or substituted (C3-C6)cyclo-alkyl(C1-C4)alkyl, where the substituent is halo, (C1-C4)alkyl, (C1-C4)alkanoyl, (C1-C4)-alkoxy or (C1-C4)haloalkoxy;

unsubstituted or substituted (C2-C6)alkenyl having one or two of the same or different halo, (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)halo-alkoxy;

unsubstituted or substituted (C4-C6)cycloalkenyl where the substituent is halo (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)haloalkoxy;

unsubstituted or phenyl substituted alkynyl;

benzyl where the phenyl ring is unsubstituted or substituted with one or two of the same or difference halo, methyl or ethyl;

unsubstituted or substituted five-membered heterocycle selected from furyl, thienyl, pyrrolyl and oxazolyl where the substituents can be one or two of the same or different halo, nitro, (C1-C4)alkyl or (C1-C4)alkoxy; or unsubstituted or substituted six-membered heterocycle having one or two nitrogen atoms and four to five nuclear carbon atoms where the substituents can be one or two of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)thioalkoxy;

where Z and Z' are hydrogen or (C1-C4)alkyl; and agronomically acceptable salts thereof.

4. A compound according to claim 3 wherein X and X' are O;
R1 is hydrogen; methyl; ethyl; (C1-C2)alkoxyalkyl having independently the stated number of carbon atoms in each alkyl group (C2-C5)alkenyl; (C2-C5)alkynyl; or benzyl where the phenyl ring is unsubstituted or substituted with halo;
R2 and R3 are the same or different hydrogen or (C1-C2)alkyl;
R4 is (C1-C2)alkyl substituted with 1 to 4 fluoro;
straight chain (C2-C4)alkenyl; cyano; cyano substituted (C1-C2)alkyl; (C1-C2)trialkysilyl having independently the stated number of carbon atoms in each alkyl group; or (C1-C2)trialkyl-silylmethyl having independently the stated number of carbon atoms in each alkyl group; and A and B are the same or different phenyl or substituted phenyl where the substituents can be from one to three of the same or different halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)haloalkyl;

unsubstituted or substituted (C1-C6)alkyl having one to two of the same or different halo, phenyl or cyano;
unsubstituted (C4-C6)cycloalkyl;

unsubstituted or substituted (C2-C6)alkenyl having one to three of the same or different halo or (C1-C4)alkyl;

unsubstituted (C4-C6)cycloalkenyl;

phenalkyl having one or two carbon atoms in the alkyl group and the phenyl ring is unsubstituted or substituted with one or two of the same or different halo, (C1-C4)alkyl or (C1-C4)alkoxy;

and unsubstituted or substituted pyridyl or 2,5-pyrazinyl where the substituent can be halo, nitro, (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)-thioalkoxy; or unsubstituted furyl or thienyl or an unsubstituted or substituted pyrrolyl where the substituent can be (C1-C4)alkyl; and agronomically acceptable salts thereof.

5. A compound according to claim 4 wherein X and X' are O;
R1 is hydrogen; methyl; methoxymethyl; (C2-C4)-alkenyl; (C2-C5)alkynyl; benzyl; or 4-halobenzyl;
R2 and R3 are the same or different hydrogen, methyl or ethyl;
R4 is trifluoromethyl; 2,2,2-trifluoroethyl;
straight chain (C2-C4)alkenyl; cyano;
cyanomethyl; (C1-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group; or trimethylsilylmethyl; and A and B are the same or different phenyl or substituted phenyl where the substituents can be one, two or three of the same or different chloro, fluoro, bromo, iodo, nitro, methyl, ethyl, methoxy or trifluoromethyl;

(C2-C3) substituted alkenyl having one to three of the same or different chloro, bromo, methyl or ethyl:
cyclohexenyl;
benzyl;

unsubstituted or substituted pyridyl or 2,5-pyrazinyl where the substituent can be halo, methyl, ethyl or methoxy; or unsubstituted furyl or thienyl or an unsubstituted or substituted pyrrolyl where the substituent can be ethyl or methyl; and agronomically acceptable salts thereof.

6. A compound according to claim 2 wherein X and X' are O;
R1 is hydrogen or methyl;
R2 and R3 are hydrogen or (C1-C3)alkyl;
R4 is trifluoromethyl, 2,2,2-trifluoroethyl, cyano, cyanomethyl, straight chain (C2-C4)-alkenyl, carboxyl, methoxycarbonyl, (C1-C2)trialkylsilyl having independently the stated number of carbon atoms in each alkyl group or (C1-C2)trialkylsilylmethyl having independently the stated number of carbon atoms in each alkyl group; and A and B are the same or different thienyl or unsubstituted phenyl or substituted phenyl where the substituents can be one to three of the same or different chloro, fluoro, nitro, methyl, ethyl or propyl; and agronomically acceptable salts thereof.

7. A compound according to claim 6 wherein X and X' are O;
R1 is hydrogen;
R2 and R3 are hydrogen, methyl and ethyl;
R4 is trifluoromethyl, cyano, allyl, methoxycarbonyl, and trimethylsilyl; and A and B are the same or different unsubstituted or substituted phenyl having one or two of the same or different chloro, fluoro, nitro, methyl and ethyl; or unsubstituted thienyl; and agronomically acceptable salts thereof.

8. A compound according to claim 7 wherein X and X' are O;
R1 is hydrogen; and R2 is hydrogen, R3 is methyl, R4 is trifluoromethyl, and A and B are the same or different unsubstituted or substituted phenyl where the substituents can be one or two of the same or different chloro, methyl or nitro;
R2 and R3 are the same or different methyl or ethyl, R4 is cyano, and A and B are the same or different unsubstituted or substituted phenyl where the substituents can be one or two of the same or different chloro, fluoro, methyl, ethyl or nitro;

R2 and R3 are methyl, R4 is allyl, and A and B are the same or different unsubstituted or methyl substituted phenyl; or R2 and R3 are hydrogen, R4 is trimethylsilyl, and A
and B are the same or different substituted phenyl where the substituents can be one or two of the same or different methyl, ethyl or nitro;
and agronomically acceptable salts thereof.

9. A compound according to claim 8 wherein X and X' are O;
R1 is hydrogen; and R2 is hydrogen, R3 is methyl, R4 is trifluoromethyl, and A and B are unsubstituted phenyl, or A is 2,3-dimethylphenyl and B is 2,4-dichlorophenyl, 3,5-dimethylphenyl or 2-nitro-5-methylphenyl;
R2 and R3 are methyl, R4 allyl, and A and B are both unsubstituted phenyl or 3-methylphenyl; or R2 and R3 are hydrogen, R4 is trimethylsilyl, and A
is 4-ethylphenyl and B is 2-nitro-5-methyl-phenyl, or A and B are both 2-methylphenyl or 2-nitrophenyl; and agronomically acceptable salts thereof.

10. A compound according to claim 8 wherein X and X' are O;
R1 is hydrogen;
R2 and R3 are methyl;
R4 is cyano; and A and B are the same or different unsubstituted or substituted phenyl where the substituents can be one or two of the same or different chloro, fluoro, methyl, ethyl or nitro; and agronomically acceptable salts thereof.

11. An insecticidal composition comprising an agronomically acceptable carrier and an insecticidally effective amount of the compound of any of claims 1, 8, 9 or 10.

12. An insecticidal composition comprising an agronomically acceptable carrier and an insecticidally effective amount of the compound of any of claims 5, 6 or 7.

13. The composition according to claim 11 wherein said compound is present at from about 0.0001 to about 99%
by weight of the composition.

14. The composition according to claim 11 wherein said compound is present at from about 0.01 to about 99%
by weight of the composition.

15. A method of controlling insects which comprises contacting said insects with the insecticidal composition according to claim 11.

16. The method of claim 15 wherein said composition is applied at from about 10 grams to about 10 kilograms per hectare of the compound.

17. The method of claim 16 wherein said composition is applied at from about 100 grams to about 5 kilograms per hectare of the compound.

18. The method of claim 15 wherein said insects are from the order of Lepidoptera or Coleoptera.

19. The method of claim 18 wherein said insects are from the order of Lepidoptera.