CA1049334A - Process for coating water soluble or water dispersible particles by means of the fluid bed technique - Google Patents

Process for coating water soluble or water dispersible particles by means of the fluid bed technique

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Publication number
CA1049334A
CA1049334A CA205,367A CA205367A CA1049334A CA 1049334 A CA1049334 A CA 1049334A CA 205367 A CA205367 A CA 205367A CA 1049334 A CA1049334 A CA 1049334A
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CA
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Prior art keywords
coating
particles
water soluble
water
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA205,367A
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French (fr)
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CA205367S (en
Inventor
Ole Worts
Poul Lindgreen
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Novo Terapeutisk Laboratorium AS
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Novo Terapeutisk Laboratorium AS
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Publication of CA1049334A publication Critical patent/CA1049334A/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38672—Granulated or coated enzymes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/18—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
    • B01J8/1872—Details of the fluidised bed reactor

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Detergent Compositions (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Paints Or Removers (AREA)

Abstract

ABSTRACT OF INVENTION

A process for coating water soluble or water dispersable particles by means of the fluid bed technique, comprising introduction of the particles to be coated in the fluid bed reactor and introduction of a coating fluid essentially consisting of an aqueous or substantially aqueous solution or dispersion of a macro-molecular film forming, water soluble or water dispersable coating agent by means of atomization, whereby the relative humidity of the outlet air is below 100%, and whereby the maximum size of the atomized droplets of the coating fluid does not exceed the minimum size of the particles to be coated, as well as the coated product prepared by the process.

Description

~049334 This invention relates to a process for coating water soluble or water dispersible particles by means of the fluid bed technique.
It is known to coat various particulate products having a particle size of less than about 10 mm, preferably less than 1 mm, in order to minimize dust formation, e.g. enzyme containing additives for detergent compositions in powder form. I-Iowever, considerable difficulties have been experienced in performing this coating. In practice it has hitherto been usual to utilize coating agents dissolved in organic solvents rather than in water when coating water soluble particles. The organic solvents have to be evaporated and recovered at a later stage of the process and may, furthermore, create a fire hazard and environmental problems. If, on the other hand, the organic solvent is not recovered, the coating process works in an uneconomical way~ ~ ~
Also, it is known to utilize the fluid bed technique to ~ -coat various water soluble or water dispersible particles by atomization of aqueous solutions of film forming, water soluble coating agents, this process being described in Wurster's USA
patent No. 3,196,827. However, in this known process it is difficult to avoid agglomeration of the particles to be coated, and it is mentioned that this known process is only suited for particles bigger than 30 mesh (ab. 0.6 mm). Also, by using Wurster's method it is difficult to obtain thin coatings.
~ We have now found that it is possible to utilize an ; aqueous or substantially aqueous liquid for coating particulate products having a particle size of less than about 1 mm in a fluid bed process whereby particles can be coated with an extremely thin coating and without substantial danger of agglomeration.
More specifically, the process of the invention for coating water soluble or water dispersible particles by means A~ .
~ ' of the fluid be~ technique comprises introdllcing the particles to be coated in a fluid bed reactor, the mean diameter of the particles to be coated being in the ran~e of from 0.1 to 0.6 mm, and introducing a coating fluid essentially consisting of an aqueous or substantially aqueous solution or dispersion of a macromolecular film forming, water soluble or water dispersible coating agent by means of atomization, wherein the relative humi-dity of the outlet air from the fluid bed reactor is below 100% and wherein the maxirnum size of the atomized droplets of the coating fluid does not exceed the minimum size of the particles ~ be coated.
The invention also relates to a coated product which has a core of active substance formed particles having a diameter of 0.1 - 0.6 mm, which core has a thin coating of a macromolecular film forming substance.
If the maximum size of the atomized droplets of the coating fluid exceeds the minimum size of the particles to be coated, agglomeration will occur.
m us, by means of the invention agglomeration can be avoided, and it is possible to perform the coating with a layer 20 as thin as about 0.1 - 10 ~, in a preferred embodiment 0.5 corresponding to about 1% of the dry particle weight. For a given thickness of the layer of coating agent a larger amount of coating agent, calculated on the particle weight, will be used with decreasing particle size. This will appear from the following Table I.
TABLE I
Amount of coating agent, calculated as percent by weight of the particles to be coated ALCALASE P * ALCALAS E M *
Thickness of Mean diameter of Mean diameter of coatinq particles 400 ~ partic _s 700 0.5 ~ 0.8 % 0.5 %

1.0 ~ 1.5 % 0.9 %

* trademark B` - -2-~ lthough the coating produced according to the invention in a preferred embodiment is very thin it is, according to the invention, also possible to produce coatings as thick as about 100 ~, if desired The minimum size of the particles to be coated can be determined by sieve analysis, and the maximum size of the atomized droplets of coating fluid can be read from charts available from the manufacturer of the nozzle, when the viscosity of the fluid and the pressure is known.
In a preferred embodiment of the process according to the invention the water soluble or water dispersible particles to be coated contain one or more enzymes as an active ingredient, e.g. proteases, amylases, lipases or celluloses.
In another preferred embodiment of the process according to the invention the enzyme or enzymes are bacterial proteinases.
In another preferred embodiment of the process according to the invention the bacterial proteinases are precoated in order to reduce dust formation.
In another preferred embodiment of the process according to the invention the bacterial proteinases are ALCALASE P or ALCALASE M.
ALCALASE, which is a trade mark belonging to NOVO
INDUSTRI A/S, is a microbial proteinase. ALCALASE P is a prilled ALCALASE. ALCALASE M is ALCALASE which is treated by means of a Marumerizer as described in our British Patent No. 1,362,365, issued on December 4, 1974, and in our published French Patent No. 2,099,349.
In another preferred embodiment of the process according to the invention the enzyme or enzymes are bacterial or fungal carbohydrases.

_3_ In another preferred embodiment of the process according to the invention the bacterial amylases are thermally stable amylases manufactured according to sritish Patent No. 1,296,839.
In another preferred embodiment of the process according to the invention the macromolecular film forming, water soluble or water dispersible coating agent is a cellulose derivative.
In another preferred embodiment of the process according to the invention the cellulose derivative is methyl cellulose, hydroxybutylmethyl cellulose, sodium carboxymethyl cellulose, hydroxyethylmethyl cellulose or hydroxypropylmethyl cellulose.
In another preferred embodiment of the process according to the invention the macromolecular film forming, water soluble or water dispersible coating agent is a polyvinylpyrrolidone.

104g334 ~ n another preferred embodiment of the process according to the in~ention t~le macromolecular film forming, water soluble or water dispersable coating agent is a polyethylene glycol~
preferably of a molecular weight of between about 400 and about 6000.
In another preferred embodiment of the process according to the invention the macromolecular film formingJ water soluble or water dispersable coating agent is a methacrylic resin.
In another preferred embodiment of the process according to the invention the macromolecular film forming, water soluble or water dispersable coating agent is gelatine.
In another preferred embodiment of the process according to the invention the coating fluid contains a-plasticizer.
In another preferred embodiment of the`process according to the invention the plasticizer is a glycerol.
In another preferred embodiment of the process according to the invention the glycerol is used in an amount of up to 60 % of the dry weight of the coating agent, preferably in an amount of between 10 and ~0 % of the dry weight of the coating agent.
In another preferred embodiment of the process according to the invention the concentration of the macromolecular film forming, water soluble or water dispersable coating agent in the coating fluid is between 2 and 50 weight-%.
In another preferre'd embodiment of the process according to the invention the concentration of the macromolecular film forming, water soluble or water dispersable coating agent in the coating fluid is between 4 and 10 weight-%.
In another preferred embodiment of the process according to the invention the mean diameter of the particles to be coated is between 0.1 and o.6 mm.
In another preferred embodiment of the process according to the invention the mean diameter of the particles to be coated is between 0.2 and o.6 mm.

1~4~334 1ll anot~le~ p~eferred em'~o~imerlt of tile p~ocess according to the invention the thlckness o~ the coating layer is be~ween 0.1 and 10 ~.
In another preferred embodiment o~ the process-according to the invention ~he thickness of the coating layer is between 0.5 and 1 ~. -The process according to the invention can be carried outin a continuous manner as well as batchwise. However, in a pre-ferred embodiment of the invention the process is carried out batchwise. In all the following examples the process is~ carried out batchwise.
The invention also encompasses a coated product comprising coated water soluble or water dispersable particles, whenever prepared by means of the process according to the invention.
The water soluble or water dispersable particles can be of any material which, for any reason, is to be coated. Examples of materials encompassed are enzyme additives, e.g. proteolytic enzyme additives for detergents, medicaments in pellet form, e.g.
oral penicillin preparations or hygroscopic substances, e.g.
fertilizers.
Coating of the particles is carried out for various reasons, e.g. in order to minimize dust formation, to protect against ultra-violet radiation, humidity or acidity, to minimize contamination, and the like.
The coating agent can be any macromolecular film forming, water soluble or water dispersable coating agent, e.g.
METHOCEL ~ MC 15: methyl cellulose of a methoxyl DS (Degree of Substitution) of 1.64 to 1.92 and o~ a DP (Degree of Poly-merization) corresponding to viscosities from 8 cP to 10,000 cP
in a 2 % aqueous solution at 20C.
TYLOSE ~ C 10: sodium carboxymethyl cellulose of a DS from 0.4 to 1.5 and a DP from 50 to 1000.

_ . ' , 10~9334 TYLoS~ 20: methylhydroxyeth~l cellulose (or hydroxyethylmethyl cellulose) of a methoxyl DS from 1.0 to
2.0, a hydroxyethyl DS from 0.1 to 0.5 and a DP from 50 to 1000.
l~ETHOCEL ~ XD 1181: hydroxypropylmethyl cellulose of a methoxyl DS from 1.0 to 2.0, a hydroxypropyl DS from 0.1 to 0.5, and a DP from 50 to 1000.
KOLLIDON ~ K 25 PVP: polyvinylpyrrolidone of an average molecular weight of 10,000, 40,000, 160,000 and 360,000 and mixtures thereof resulting in any intermediate average molecular weight.
CAR~30WAX ~ : polyethylene glycols of average mole-cular weights of 400, 600, 1000, 1540, 4000, 6000 and mixtures thereof of any intermediate average molecular weight.
EUDRAGIT ~ E 30 D: methacrylic resins, aqueous dispersions thereof. rrhis tablet lacquer is completely in-soluble in alkaline liquids.
SOLUGEL ~ : gelatine.
Polypropylene glycols.
Polyvinyl alcohols.
Alginates.
The concentration of the coating agent in the aqueous or substantially aqueous solution or dispersion corresponds to a viscosity which is suitable for atomization. Usually, as mentioned before, the concentration is between 2 and 50 weight-%, preferably between 4 and 10 weight-%. The limits, however, are highly dependent on the individual coating agent used. The average diameter of the particles to be coated is usually between 100 ~ and 600 to 1000 ~, preferably between 200 ~ and 600 ~. The relative humidity of the outlet air should usually not exceed 60%. The temperature of the air, which is used to fluidize the particles to be coated, should be adjusted in con-sideration of the nature of the particles to be coated.
7 ~
A~ ..

~04~334 I
Th~ (lualit~ o'~ t~ oatir,cr, is not; in~luenced by the shape of the particles. F3y use of tile process of the invention it is possible to produce a perf~ct coating on splleres and on irregularly shaped particles as ~ell. Several of the known coating procedures are not well adapted to the coating of irregularly shaped particles which li are imperfectly coated, only. Therefore, the present process offers special advantages in connection with the coating of irregularly shaped particles. An example of such irregularly shaped particles is a prilled enzyme product includin~ prilled ALCALASE or ALCALASE P. When prilled ALCALASE is coated in accordance with the invention a product consisting of irregularly shaped particles having a-perfect coating is formed. Due to the irregular shape these particles have a very raduced tendency to segregate from the other particles of detergent compositions in powder form.
An additive consisting of spheroidal particles having a density different from the density of the particles of the other components of a powdery detergent composition will have a tendency to segregate from said other particles and thereby create an inhomogeneous detergent composition. The above irregularly shaped particles therefore offer special advantages.
According to the invention the coating fluid may contain a plasticizer such as triacetin, which is illustrated in the following example 2.
By using glycerol as a plasticizer in the coating fluid coated particles having specially advantageous dust levels can be obtained according to the invention.
By using glycerol as a plasticizer in the coating fluid in an amount of up to 60 per cent of the dry weight of the coating agent or up to the point when the coated particles are beginning to adhere to each other, preferably in an amount between 10 and ~0 per cent of the dry weight of the coating agent, the dust level of the coated particles is reduced significantly which will appear from the following.

~049334 rn o~de~ l;o ~i~e a bet~er ur)t1erstarl~ing of how to correla~e the different parameters of the process in order to obtain a relative humidity o~ the outlet air of less than 100~ the following calculation with reference to example 21 is presented. The inlet air, which was the air in the plant, had the following charac-teristics:
Temperature: 20C
Relative humidity: 50 ~ corresponding to 7 g of H20/kg air.
The rate of the coating fluidlwas 1700 ml/min. or 102 litre/hour. The coating fluid had a specific gravity of 1.0 g/cm~
and contained 10 % by weight of coating agent, corresponding to a water inlet amount from the coating fluid of 91.8 kg/hour.
The rate of fluidizing air was 8000 N m~/hour or 9600 kg of air/hour. Thus, the fluidizing air introduced 0.007 x 9600 =
67.2 kg of water in the systém per hour.
Thus, per hour a total of 91.8 + 67.2 kg of water was introduced into the system. This corresponds to~159.0 kg of water, which was removed from the system together with'about 9~00 kg of air. As the outlet air had a temperature of between 2~and 27C
this amount of humidity in the outlet air corresponds to a relative humidity in the outlet air of between 95 and 75 %. It is noted that this relative humidity is within the limit given for the relative humidity in claim 1.
In order to illustrate the invention the following examples are presented.
- Examples l to 10 illustrate the preparation of the coating fluid.
Example 1 Methyl cellulose (METHOCEL ~ MC 15) 50 g Deionized water 1000 g The methyl cellulose is triturated with about 33~ g of boiling water, after which the rest of the water (optionally cold) is added with s-ir~ing. The solutio~ is allowed to stand in a cold place.

- .

Exanple 2 Metilyl cellulose (ME~[~-IOCEL ~ MC 15) 50 g Deioni~ed water 1000 g Triacetin 5 g A solution of methyl cellulose and deionized water is pre-pared as described in Example 1, whereupon the triacetin is added.

Example 3 Sodium carboxymethyl cellulose (TYLOSE ~ C 10) 50 g Deionlzed water 1000 g The sodium carboxymethyl cellulose is dissolved in the water with stirringJ using a high speed mixer.

Example 4 Sodium carboxymethyl cellulose (TYLOSE ~ C 10) 100 g Deionized water 1000 g The sodium carboxymethyl cellulose is dissolved in the water with stirring~ using a high speed mixer.

Example 5 Methylhydroxyethyl cellulose ~YLOSE ~ MH 20) 50 g Deionized water lOpO g The methylhydroxyethyl cellulose is dissolved in the water with stirring, using a high speed mixér.

Example 6 Hydroxypropylmethyl cellulose (METHOCEL ~ XD 1181) 50 g Deionized water 1000 g The hydroxypropylmethyl cellulose is dissolved in the water with stirring, uslng a high speed mlxer.

Example 7 Gelatine (SOLUGEL ~ ) 50 g Deionized water 1000 g The gelatine is dissolved in the water with stirring, using a high speed mixer.

Example 8 Polyvinylpyrrolidone (KOLLIDON ~ K 25) 50 g Deionized water 1000 g The polyvinylpyrrolidone is dissolved in the water with stirring, using a high speed mixer.
Example 9 Polyethylene glycol (CARBOWAX ~ 4000) 50 g Deionized water 1000 g The polyethylene glycol is dissolved in the water with stirring, using a high speed mixer.
Example 10 Polyethylene glycol (CARBOWAX ~ 6000) 50 g Deionized water 1000 g The polyethylene glycol is dissolved in the water with stirring, using a high speed mixer.
The solutions prepared according to Examples 1 to 10 are used for the coating of prilled ALCALASE (ALCALASE P) in conventional and common fluid bed systems as stated in Examples 11 to 14 and 21.
Example 11 -Apparatus: "STREBA-l" (Aeromatic AG,Basel) ALCALASE P: 1000 g Nozzle ~.
- Pressure 2 1/2 ato .
Internal diameter 0.8 mm ~ .
Inlet temperature of -:
fluidizing air: 41-43C
: Temperature of parti-culate material: 31~-33C
; 30 Feed rate of coating fluid: 6 1/2 ml/min.
Fluidizing air: 8-10 scale units -.~. ' . ~ .
. ,; .i, ;

~ a !rl D ~
.__ Apparatus: "WS(i-5" (W. Glatt, Haltingen, Germany) ALCALASE P: 6000 g Mozzle Position of jacket: 0.5 Pressure 1 1/2 ato.
Internal diameter: 1.2 mm Inlet temperature of fluidizing air: -~2-45C
Temperature of O
particulate material: 31 -33 C
Feed rate of coating fluid: 35 ml/min.
Air velocity: 2 1/2 m/sec.
Example 13 . Apparatus: "WSG-30" (W. Glatt, Haltingen~
Germany) ALCALASE P:. ~5,000 g Nozzle - Position of jacket: 0.3 Pressure: 6 ato.
Internal diameter: 1.8 mm Inlet temperature of fluidizing air: ~2-45C .
Temperature of O 0 particulate material: 31 -33 C
Feed rate of coating fluid: 187 ml/min.
Fluidizing air: 5 scale units Example 14 Apparatus: "STREBA-60" (Aeromatic AG, Basel) ALCALASE P: 135 kg Nozzle Position of jacket: 1.0 Pressure: 6 ato.
Internal diameter: 2~ mm :i nlet te~ t,ure oP
fluidizing air: 42-l~5C
Temperat,ure of particulate material: 31-3~C
Feed rate of coating flu'id: 325 ml/min.
Rate Or fluidiæing air: corresponding to position 3 of damper.

In all cases particulate products are produced having remark-ably good properties.
The amount of coating layer on the ~articles and the amount of dust present in some of the coated products prepared according to Examples 12 to 14 appear from the following table II.
Table II

Coating fluid Amount of Amount of dust Example p~epared according coating layer on in ~g/100 g of prod~cr No. to Example No.coated product Total Enzyme 1 1 % 20 2.1 1 1 % 20 1.6 6 1 % , 5 o.8 12 1 1/2 ~ 20 2.6 % 1 5 1 . 8 1 1 1/2 % 20 0. 8 6 2 % 10 1.1
3 % lo o.8 . -. .. _.
1 % 5 ~ 1.8 1 1/2 % 20 1.0 3 1 1 % 5 l.o 1 % lo 1.6 14 1 1/2 % 5o ~.4 1 1 % 15 1.6 Examples 15 to 20 illustrate the preparation of a coating fluid containing glycerol and corresponding coating fluids without glycerol.

.

' ' ' .
`'~' ' 1~49334 ~`xa.~t~
Methyl cell~llose (M~ HOCEL ~ MC 15) 50 g Deioni,zed water 950 g The methyl cellulose is triturated with about 33~ g Or boiling water, after which the rest Or the water (optionally cold) is added with stirring. The solution is allowed to stand in a cold place.

Example 16 Methyl cellulose (METHOCEL ~ MC 15) 42.5 g Glycerol 7,5 g Deionized water 950.0 g A solution of methyl cellulose and deionized water is prepared as described in Example 15, whereupon the glycerol is added.

Example 17 Sodium carboxymethyl cellulose (CELLOFAS ~ B 5) 100 g Deionized water 900 g The sodium carboxymethyl cellulose is triturated with about 3~3 g of boiling water, after which the rest of the water (optionally cold) is added with stirring. The solution is allowed to stand in a cold place.

Example 18 Sodium carboxymethyl cellulose (CELLOFAS ~ B 5) 85 g Glycerol ~ 15-g Deionized water 900 g A solution of sodium carboxymethyl cellulose and deionized water is prepared as described in Example 17, whereupon the glycerol is added.

Example 19 Sodium carboxymethyl cellulose (CEKOL ~ HS) 10,0 g Deionized water 900 g A solution af sodium carboxymethyl cellulose and deionized water is prepared as described in Example 17.

, -14-. .

.
.. .... . . .

~049334 E~ample 20 Sodium carbox~methyl cellulose (CEKOL ~ HS) 85 g Glycerol 15 g Deionized water goo g A solution of sodium carboxymethyl cellulose and deionized water is prepared as described in Example 17, whereupon the glycerol is added.

The solutions prepared according to Examples 15 to 20 are used for the co~ting o~ ALCALASE M in a fluid bed system as stated in Example 21 Example 21 Apparatus: "WSG-300" (W. Glatt, Haltingen, Gerrr~any) ALCALASE M: 600 kg Nozzle six-headed nozzle Internal diameter: 1.2 mm -~
Jacket diameter: 6.o mm Pressure: 6.o ato.

Inlet temperature of fluidizing air: 46-50C

Temperature of particulate material: 23-27C

Feed rate of coating fluid: 1700 ml/min.
Fluidizing air: 8000 N m3/hour In all cases particulate products are produced having rernark-ably good properties, especially in regard to the dust level.
The amount Or dust present in the coated products prepared according to Example 21 appears from the following table III.

. ' '. ' 109~334 'ilat~Le-:r~:r Coating ~ id Amount of Amount of dust Example prepared accordil~K coating layer on in ug/100 g of~Eroduct No. to E~'xarnple No. coated product Total Enzvme . _ _ _ _ _Y
. 1 % 20 1.2 16 1 % 10 0.5 21 17 1 ~ 15 1.6 1~ 1 % 10 0.7 19 1 ~ 30 1.~
1 ~ 10 0.8 . . _ It appears from the above table III ~hat by using glycerol as a plasticizer in the coating fluid a remarka'~ly advantageous effect on the dust level of the coated particles is obtained.

.

.

Claims (23)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:-
1. A process for coating water soluble or water dispersible particles by means of the fluid bed technique, which comprises introducing the particles to be coated in a fluid bed reactor, the mean diameter of the particles to be coated being in the range of from 0.1 to 0.6 mm, and introducing a coating fluid essentially consisting of an aqueous or substantially aqueous solution or dispersion of a macromolecular film forming, water soluble or water dispersible coating agent by means of atomi-zation, wherein the relative humidity of the outlet air from the fluid bed reactor is below 100% and wherein the maximum size of the atomized droplets of the coating fluid does not exceed the minimum size of the particles to be coated.
2. A process as claimed in claim 1, wherein the water soluble or water dispersible particles to be coated contain as an active ingredient one or more enzymes.
3. A process as claimed in claim 2, wherein the enzyme is bacterial proteinase.
4. A process as claimed in claim 3, wherein the bacterial proteinase is precoated in order to reduce dust formation.
5. A process as claimed in claim 4, wherein the bacterial proteinase is microbial proteinase.
6. A process as claimed in claim 3, wherein the bacterial proteinase is alkaline resistant proteinase.
7. A process as claimed in claim 2, wherein the enzyme or is bacterial or fungal carbohydrase.
8. A process as claimed in claim 7, wherein the bacterial amylase is thermally stable amylases.
9. A process as claimed in claim 1, wherein the macromolecular film forming, water soluble or water dispersible coating agent is a cellulose derivative.
10. A process as claimed in claim 9, wherein the cellulose derivative is methyl cellulose, hydroxybutylmethyl cellulose, sodium carboxymethyl cellulose, hydroxyethylmethyl cellulose or hydroxypropylmethyl cellulose.
11. A process as claimed in claims 1, 2 or 3, wherein the macromolecular film forming, water soluble or water dispersible coating agent is a polyvinylpyrrolidone.
12. A process as claimed in claims 1, 2 or 3, wherein the macromolecular film forming, water soluble or water dispersible coating agent is a polyethylene glycol, preferably of a molecular weight of between about 400 and about 6000.
13. A process as claimed in claims 1, 2 or 3, wherein the macromolecular film forming, water soluble or water dispersible coating agent is a methacrylic resin.
14. A process as claimed in claims 1, 2 or 3, wherein the macromolecular film forming, water soluble or water dispersible coating agent is a gelatine.
15. A process as claimed in claim 1, wherein the coating fluid contains a plasticizer.
16. A process as claimed in claim 15, wherein the plastici-zer is glycerol.
17. A process as claimed in claim 16, wherein the glycerol is used in an amount of up to 60% of the dry weight of the coat-ing agent, preferably in an amount between 10 and 30% of the dry weight of the coating agent.
18. A process as claimed in claim 9, wherein the concentration of the macromolecular film forming, water soluble or water dispersible coating agent in the coating fluid is between 2 and 50 weight-%.
19. A process as claimed in claim 18, wherein the concentration of the macromolecular film forming, water soluble or water dispersible coating agent in the coating fluid is between 4 and 10 weight-%.
20. A process as claimed in claim 1, in which the mean diameter of the particles to be coated is between 0.2 and 0.6 mm.
21. A process as claimed in claim 1, in which the thick-ness of the coating layer is between 0.1 and 10 µ.
22. A process as claimed in claim 21, in which the thick-ness of the coating layer is between 0.5 and 1 µ.
23. A process as claimed in claims 1, 2 or 3, in which the coating operation is performed batchwise.
CA205,367A 1973-07-23 1974-07-22 Process for coating water soluble or water dispersible particles by means of the fluid bed technique Expired CA1049334A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB34993/73A GB1483591A (en) 1973-07-23 1973-07-23 Process for coating water soluble or water dispersible particles by means of the fluid bed technique
GB1084274 1974-03-11

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CA1049334A true CA1049334A (en) 1979-02-27

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JP (1) JPS5071583A (en)
AT (1) AT357979B (en)
AU (1) AU498649B2 (en)
BE (1) BE817930A (en)
CA (1) CA1049334A (en)
CH (1) CH604923A5 (en)
DE (1) DE2435008A1 (en)
DK (1) DK384574A (en)
ES (1) ES428475A1 (en)
FI (1) FI219474A (en)
FR (1) FR2238530B1 (en)
GB (1) GB1483591A (en)
IE (1) IE41403B1 (en)
IT (1) IT1016947B (en)
NL (1) NL7409683A (en)
SE (1) SE7409471L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828882A (en) * 1987-03-16 1989-05-09 Canadian Patents & Developments Limited Particle encapsulation technique
US5211985A (en) * 1991-10-09 1993-05-18 Ici Canada, Inc. Multi-stage process for continuous coating of fertilizer particles

Families Citing this family (380)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS587497A (en) * 1981-07-06 1983-01-17 ダスキンフランチヤイズ株式会社 Bleaching agent composition
JPS60189548U (en) * 1984-05-24 1985-12-16 昭和電工株式会社 Detergent capsule with enzyme capsule
US4689297A (en) * 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
DE3764460D1 (en) * 1986-05-21 1990-09-27 Novo Industri As PRODUCTION OF AN ENZYME-CONTAINING GRANULATE AND ITS USE IN CLEANING AGENTS.
US4759956A (en) * 1987-05-22 1988-07-26 Lever Brothers Company Process for encapsulating particles using polymer latex
JP2815925B2 (en) * 1989-09-26 1998-10-27 花王株式会社 Method for coating particles for detergent formulation
US5254283A (en) * 1991-01-17 1993-10-19 Genencor International, Inc. Isophthalic polymer coated particles
DE69534513T2 (en) 1994-03-08 2006-07-27 Novozymes A/S NOVEL ALKALINE CELLULASES
BR9507229A (en) 1994-03-29 1997-09-16 Novo Nordisk As Amylase detergent additive detergent composition use of a detergent and an amylase construction of a recombinant cell expression vector dna and process to produce amylase
AR000862A1 (en) 1995-02-03 1997-08-06 Novozymes As VARIANTS OF A MOTHER-AMYLASE, A METHOD TO PRODUCE THE SAME, A DNA STRUCTURE AND A VECTOR OF EXPRESSION, A CELL TRANSFORMED BY SUCH A DNA STRUCTURE AND VECTOR, A DETERGENT ADDITIVE, DETERGENT COMPOSITION, A COMPOSITION FOR AND A COMPOSITION FOR THE ELIMINATION OF
ATE315083T1 (en) 1995-03-17 2006-02-15 Novozymes As NEW ENDOGLUCANASE
WO1998020115A1 (en) 1996-11-04 1998-05-14 Novo Nordisk A/S Subtilase variants and compositions
BR9712878A (en) 1996-11-04 2000-02-01 Novo Nordisk As Subtilase enzyme variant, processes for the identification of a protease variant showing autoproteolytic stability and for the production of a mutant subtilase enzyme and a subtilase variant, DNA sequence, vector, microbial host cell, composition and use of a variant of subtilase.
DE69941364D1 (en) 1998-11-27 2009-10-15 Novozymes As VARIANTS OF A LIPOLYTIC ENZYME
EP1803817B1 (en) 1998-12-18 2011-04-06 Novozymes A/S Subtilase enzymes of the I-S1 and I-S2 sub-groups having an additional amino acid residue in an active site loop region
WO2000047060A1 (en) 1999-02-10 2000-08-17 Dsm N.V. Granulates containing feed-enzymes
AU3419200A (en) 1999-03-31 2000-10-23 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
BR0009392B1 (en) 1999-03-31 2012-06-12 mutant of a polypeptide with alpha-amylase activity, and use of the polypeptide or variant.
DE60040282D1 (en) 1999-05-20 2008-10-30 Novozymes As SUBTILASE ENZYMES OF I-S1 AND I-S2 SUB-GROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID BETWEEN POSITIONS 132 AND 133
ATE408679T1 (en) 1999-05-20 2008-10-15 Novozymes As SUBTILASE ENZYMES OF THE I-S1 AND I-S2 SUBGROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID BETWEEN POSITIONS 127 AND 128
ATE408680T1 (en) 1999-05-20 2008-10-15 Novozymes As SUBTILASE ENZYMES OF THE I-S1 AND I-S2 SUBGROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID BETWEEN POSITIONS 128 AND 129
WO2000071691A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 125 and 126
WO2000071688A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 126 and 127
WO2000071687A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 129 and 130
DE19929257A1 (en) 1999-06-25 2000-12-28 Basf Ag Production of polymer-coated granulated animal feed additive, useful in production of pelletized animal feed, involves granulating mixture of carrier and enzyme and coating with suitable organic polymer
WO2001016285A2 (en) 1999-08-31 2001-03-08 Novozymes A/S Novel proteases and variants thereof
US6924133B1 (en) * 1999-10-01 2005-08-02 Novozymes A/S Spray dried enzyme product
JP3610431B2 (en) * 2000-07-17 2005-01-12 マークテック株式会社 Magnetic powder compound for wet magnetic particle testing
AU2001279614B2 (en) 2000-08-21 2006-08-17 Novozymes A/S Subtilase enzymes
DE60144430D1 (en) 2000-10-13 2011-05-26 Novozymes As SUBTILASE VARIANTS
EP1975229A3 (en) 2000-10-13 2009-03-18 Novozymes A/S Alpha-amylase variant with altered properties
DE60234523D1 (en) 2001-05-15 2010-01-07 Novozymes As ALPHA AMYLASE VERSION WITH CHANGED PROPERTIES
AU2002344842A1 (en) 2001-06-22 2003-01-08 Genencor International, Inc. Highly impact-resistant granules
ES2397267T3 (en) 2001-06-26 2013-03-05 Novozymes A/S Polypeptides with cellobiohydrolase I activity and polynucleotides encoding them
DK200101090A (en) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE60315412T3 (en) 2002-01-15 2012-09-20 Basf Se Granules containing feed enzymes
ES2359382T3 (en) 2002-10-01 2011-05-23 Novozymes A/S GH-61 FAMILY POLIPEPTIDES.
TWI319007B (en) 2002-11-06 2010-01-01 Novozymes As Subtilase variants
EP1572996B1 (en) 2002-12-11 2014-06-11 Novozymes A/S Detergent composition comprising endo-glucanase
US7348168B2 (en) 2002-12-20 2008-03-25 Novozymes A/S Polypeptides having cellobiohydrolase II activity and polynucleotides encoding same
DE60320679T2 (en) * 2002-12-24 2009-07-02 Genencor International, Inc., Palo Alto SOFTWARE, MECHANICALLY STABLE, ROBUST GRANULES
DE602004027723D1 (en) 2003-05-02 2010-07-29 Novozymes Inc VARIANTS OF BETA-GLUCOSIDASES
US7511005B2 (en) 2003-05-12 2009-03-31 Danisco Us Inc., Genencor Division Lipolytic enzyme elip
US20070213518A1 (en) 2003-05-12 2007-09-13 Jones Brian E Novel Lipolytic Enzyme Lip2
US20100129862A1 (en) 2003-05-12 2010-05-27 Jones Brian E Novel lipolytic Enzyme lip1
PL1639106T3 (en) 2003-06-19 2010-11-30 Novozymes As Proteases
AU2004252572B2 (en) 2003-06-25 2011-09-08 Novozymes A/S Polypeptides having alpha-amylase activity and polypeptides encoding same
EP1660637A4 (en) 2003-08-25 2009-10-21 Novozymes Inc Variants of glycoside hydrolases
ATE491788T1 (en) 2003-10-10 2011-01-15 Novozymes As PROTEASE VARIANTS
CN1871344A (en) 2003-10-23 2006-11-29 诺和酶股份有限公司 Protease with improved stability in detergents
DK1682656T3 (en) 2003-10-28 2013-11-18 Novozymes Inc Polypeptides with beta-glucosidase activity and polynucleotides encoding them
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
CN1980953B (en) 2004-01-30 2014-12-24 诺维信股份有限公司 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CN1942584B (en) 2004-02-13 2011-07-27 诺维信公司 Protease variants
US7148404B2 (en) 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
ATE541034T1 (en) 2004-06-21 2012-01-15 Novozymes As NOCARDIOPSIS PROTEASES
EP3620523A3 (en) 2004-07-05 2020-08-19 Novozymes A/S Alpha-amylase variants with altered properties
DK1794296T3 (en) 2004-09-21 2012-07-30 Novozymes As subtilases
ATE533843T1 (en) 2004-09-21 2011-12-15 Novozymes As SUBTILATE
DE602005026541D1 (en) 2004-09-21 2011-04-07 Novozymes As SUBTILASES
EP2295555A3 (en) 2004-09-30 2011-08-10 Novozymes, Inc. Polypeptides having lipase activity and polynucleotides encodig same
CA2606475C (en) 2005-04-27 2015-06-16 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
EP2385111B1 (en) 2005-07-08 2016-09-07 Novozymes A/S Subtilase variants
EP1920053B1 (en) 2005-08-16 2011-10-26 Novozymes A/S Subtilases
EP1920052A2 (en) 2005-08-16 2008-05-14 Novozymes A/S Polypeptides of strain bacillus sp. p203
NZ566984A (en) 2005-09-30 2011-12-22 Novozymes Inc Methods for enhancing the degradation or conversion of cellulosic material
EP1998793A1 (en) 2006-03-22 2008-12-10 Novozymes A/S Use of polypeptides having antimicrobial activity
ES2538360T3 (en) 2006-07-21 2015-06-19 Novozymes, Inc. Methods to increase the secretion of polypeptides that have biological activity
BRPI0722093A2 (en) 2006-12-21 2014-04-01 Danisco Us Inc Genencor Div COMPOSITIONS AND USES FOR A BACILLUS ALPHA AMILASE POLYPEPTIDE 195
KR20100014954A (en) 2007-03-09 2010-02-11 다니스코 유에스 인크. Alkaliphilic bacillus species a-amylase variants, compositions comprising a-amylase variants, and methods of use
DE102007016139A1 (en) 2007-03-30 2008-10-02 Jenabios Gmbh Method for regioselective oxygenation of N-heterocycles
AU2008325250B2 (en) 2007-11-05 2013-06-13 Danisco Us Inc. Variants of Bacillus sp. TS-23 alpha-amylase with altered properties
US8206966B2 (en) 2007-11-05 2012-06-26 Danisco Us Inc. Alpha-amylase variants with altered properties
DK2245130T3 (en) 2008-02-04 2021-01-18 Danisco Us Inc TS23 -ALPHA AMYLASE VARIANTS WITH CHANGED PROPERTIES
WO2009149271A2 (en) 2008-06-06 2009-12-10 Danisco Us Inc. Production of glucose from starch using alpha-amylases from bacillus subtilis
DK2297312T3 (en) 2008-06-06 2013-12-16 Danisco Us Inc Alpha-amylase variants of Bacillus subtilis and methods for their use
JP5492879B2 (en) 2008-06-06 2014-05-14 ダニスコ・ユーエス・インク Geobacillus stearothermophilus alpha amylase (AmyS) variant with improved properties
MX2010013122A (en) 2008-06-06 2011-01-21 Danisco Inc Saccharification enzyme composition and method of saccharification thereof.
CA2738447C (en) 2008-09-25 2019-01-08 Danisco Us Inc. Alpha-amylase blends and methods for using said blends
ES2526867T3 (en) 2008-11-20 2015-01-16 Novozymes Inc. Polypeptide having amylolytic enhancer activity and polynucleotides encoding it
WO2010065830A1 (en) 2008-12-04 2010-06-10 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EP2376527A1 (en) 2008-12-12 2011-10-19 Novozymes Inc. Polypeptides having lipase activity and polynucleotides encoding same
ES2362460T3 (en) 2008-12-23 2011-07-05 Basf Se MIXED CRYSTALS, PROCEDURE FOR OBTAINING AND USE IN THE MANUFACTURE OF BAKERY PRODUCTS.
CN102341495A (en) 2009-03-10 2012-02-01 丹尼斯科美国公司 ALPHA-AMYLASES ASSOCIATED with BACILLUS MEGATERIUM DSM90, and method for using same
CN103923895A (en) 2009-04-01 2014-07-16 丹尼斯科美国公司 Compositions and methods comprising alpha-amylase variants with altered properties
BRPI1012590A2 (en) 2009-04-08 2015-09-22 Danisco Us Inc Genencor Div halomonas strain wdg-195-related alpha-amylases and methods of using them
DK3269804T3 (en) 2009-09-17 2020-11-23 Novozymes Inc POLYPEPTIDES WITH CELLULOLYSIS IMPROVING ACTIVITY AND POLYNUCLEOTIDES ENCODING THEM
CA2775048A1 (en) 2009-09-25 2011-03-31 Novozymes A/S Use of subtilisin variants for cleaning proteinaceous stains on hard surfaces
US20120172280A1 (en) 2009-09-25 2012-07-05 Novozymes A/S Protease Variants
ES2560805T3 (en) 2009-09-29 2016-02-22 Novozymes Inc. Polypeptides with cellulolytic enhancing activity and polynucleotides that encode them
DK2483296T3 (en) 2009-09-30 2015-11-02 Novozymes Inc Polypeptides having cellulolytic enhancing activity and polynucleotides encoding them
BR112012007390A2 (en) 2009-09-30 2015-09-15 Novozymes As isolated polypeptide having cellulolytic enhancing activity, isolated polynucleotide, methods for making the polypeptide, for producing a precursor cell mutant, for inhibiting expression of a polypeptide, for producing a protein, for degrading or converting a cellulosic material, for producing a product fermentation, and to ferment a cellulosic material, transgenic plant, plant part or plant cell transformed with a polynucleotide, double stranded inhibitor molecule, and detergent composition
IN2012DN02731A (en) 2009-10-23 2015-09-11 Danisco Us Inc
WO2011076897A1 (en) 2009-12-22 2011-06-30 Novozymes A/S Use of amylase variants at low temperature
US8435577B2 (en) 2010-01-04 2013-05-07 Novozymes A/S Alpha-amylases
US9045514B2 (en) 2010-01-22 2015-06-02 Dupont Nutrition Biosciences Aps Methods for producing amino-substituted glycolipid compounds
CN113186178A (en) 2010-02-10 2021-07-30 诺维信公司 Variants and compositions comprising variants with high stability in the presence of chelating agents
EP2357220A1 (en) 2010-02-10 2011-08-17 The Procter & Gamble Company Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent
WO2011102933A1 (en) 2010-02-18 2011-08-25 Danisco Us Inc. Amylase from nesterenkonia and methods of use, thereof
EP2622070B1 (en) 2010-09-30 2016-08-03 Novozymes, Inc. Variants of polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CN103282489B (en) 2010-09-30 2016-12-14 诺维信股份有限公司 There is polypeptide variants and the coded polynucleotide thereof of cellulolytic enhancing activity
US9676830B2 (en) 2010-11-18 2017-06-13 Novozymes, Inc. Chimeric polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2012110562A2 (en) 2011-02-16 2012-08-23 Novozymes A/S Detergent compositions comprising metalloproteases
WO2012110564A1 (en) 2011-02-16 2012-08-23 Novozymes A/S Detergent compositions comprising m7 or m35 metalloproteases
EP2675884A1 (en) 2011-02-16 2013-12-25 Novozymes A/S Detergent compositions comprising metalloproteases
EP2678352B1 (en) 2011-02-23 2017-12-06 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US9410136B2 (en) 2011-03-31 2016-08-09 Novozymes, Inc. Methods for enhancing the degradation or conversion of cellulosic material
US20140031272A1 (en) 2011-04-08 2014-01-30 Danisco Us Inc. Compositions
WO2012149344A1 (en) 2011-04-29 2012-11-01 Novozymes, Inc. Methods for enhancing the degradation or conversion of cellulosic material
CN103620029B (en) 2011-06-24 2017-06-09 诺维信公司 Polypeptide and their polynucleotides of coding with proteinase activity
EP2540824A1 (en) 2011-06-30 2013-01-02 The Procter & Gamble Company Cleaning compositions comprising amylase variants reference to a sequence listing
IN2014CN00597A (en) 2011-06-30 2015-04-03 Novozymes As
EP2551335A1 (en) 2011-07-25 2013-01-30 The Procter & Gamble Company Enzyme stabilized liquid detergent composition
MX2014001594A (en) 2011-08-15 2014-04-25 Novozymes As Polypeptides having cellulase activity and polynucleotides encoding same.
US20140295027A1 (en) 2011-08-19 2014-10-02 Novozymes A/S Polypeptides Having Protease Activity
JP2014530598A (en) 2011-09-22 2014-11-20 ノボザイムスアクティーゼルスカブ Polypeptide having protease activity and polynucleotide encoding the same
EP2748316B1 (en) 2011-10-17 2018-12-19 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
MX355356B (en) 2011-10-17 2018-04-17 Novozymes As Alpha-amylase variants and polynucleotides encoding same.
EP4345161A2 (en) 2011-10-28 2024-04-03 Danisco Us Inc Variant maltohexaose-forming alpha-amylase variants
US10351834B2 (en) 2011-11-21 2019-07-16 Novozymes, Inc. GH61 polypeptide variants and polynucleotides encoding same
CN103958657A (en) 2011-11-25 2014-07-30 诺维信公司 Subtilase variants and polynucleotides encoding same
MX351916B (en) 2011-11-25 2017-11-03 Novozymes As Polypeptides having lysozyme activity and polynucleotides encoding same.
EP3272862A1 (en) 2011-12-16 2018-01-24 Novozymes, Inc. Polypeptides having laccase activity and polynucleotides encoding same
WO2013092635A1 (en) 2011-12-20 2013-06-27 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP2607468A1 (en) 2011-12-20 2013-06-26 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
US20150017700A1 (en) 2011-12-22 2015-01-15 Danisco Us Inc. Compositions and methods comprising a lipolytic enzyme variant
US20140342431A1 (en) 2011-12-22 2014-11-20 Danisco Us Inc. Variant Alpha-Amylases and Methods of Use, Thereof
EP2798062B1 (en) 2011-12-28 2018-02-21 Novozymes A/S Polypeptides having protease activity
CN110777016A (en) 2011-12-29 2020-02-11 诺维信公司 Detergent compositions with lipase variants
CN104350149A (en) 2012-01-26 2015-02-11 诺维信公司 Use of polypeptides having protease activity in animal feed and detergents
US10093911B2 (en) 2012-02-17 2018-10-09 Novozymes A/S Subtilisin variants and polynucleotides encoding same
EP2628785B1 (en) 2012-02-17 2016-05-18 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
EP2823026A1 (en) 2012-03-07 2015-01-14 Novozymes A/S Detergent composition and substitution of optical brighteners in detergent compositions
EP2841567B1 (en) 2012-04-27 2017-07-26 Novozymes, Inc. Gh61 polypeptide variants and polynucleotides encoding same
EP2847308B1 (en) 2012-05-07 2017-07-12 Novozymes A/S Polypeptides having xanthan degrading activity and polynucleotides encoding same
JP2015518707A (en) 2012-05-11 2015-07-06 ダニスコ・ユーエス・インク Use of ASPERGILLUSCLAVATUS-derived alpha amylase for saccharification
WO2013171241A1 (en) 2012-05-16 2013-11-21 Novozymes A/S Compositions comprising lipase and methods of use thereof
WO2014007921A1 (en) 2012-06-08 2014-01-09 Danisco Us Inc. Variant alpha amylases with enhanced activity on starch polymers
US20150184208A1 (en) 2012-06-19 2015-07-02 Novozymes A/S Enzymatic reduction of hydroperoxides
BR112014031882A2 (en) 2012-06-20 2017-08-01 Novozymes As use of an isolated polypeptide, polypeptide, composition, isolated polynucleotide, nucleic acid construct or expression vector, recombinant expression host cell, methods for producing a polypeptide, for enhancing the nutritional value of an animal feed, and for the treatment of protein, use of at least one polypeptide, animal feed additive, animal feed, and detergent composition
EP2859109A2 (en) 2012-08-16 2015-04-15 Danisco US Inc. Process for producing glucose from starch employing the aspergillus clavatus alpha-amylase and a pullulanase
BR112015003724A2 (en) 2012-08-22 2017-08-08 Novozymes As isolated polypeptide, composition, use of a composition, isolated polynucleotide, nucleic acid construct or expression vector, recombinant host cell, and methods of producing a polypeptide and producing a protein.
WO2014029821A1 (en) 2012-08-22 2014-02-27 Novozymes A/S Metalloproteases from alicyclobacillus sp.
US20160145540A1 (en) 2012-08-22 2016-05-26 Novozymes A/S Detergent Compositions Comprising Metalloproteases
US20180112203A1 (en) 2012-11-20 2018-04-26 Danisco Us Inc. Amylase with maltogenic properties
CN110628528B (en) 2012-12-07 2021-09-14 诺维信公司 Preventing adhesion of bacteria
JP6499081B2 (en) 2012-12-11 2019-04-10 ダニスコ・ユーエス・インク Trichoderma reesei host cell expressing glucoamylase from Aspergillus fumigatus and method of use thereof
WO2014090940A1 (en) 2012-12-14 2014-06-19 Novozymes A/S Removal of skin-derived body soils
EP2931911A1 (en) 2012-12-14 2015-10-21 Danisco US Inc. Method of using alpha-amylase from aspergillus fumigatus and isoamylase for saccharification
EP2904105A1 (en) 2012-12-20 2015-08-12 Danisco US Inc. Method of using alpha-amylase from aspergillus terreus and pullulanase for saccharification
DK2935575T3 (en) 2012-12-21 2018-07-23 Danisco Us Inc ALPHA-amylase variants
WO2014099525A1 (en) 2012-12-21 2014-06-26 Danisco Us Inc. Paenibacillus curdlanolyticus amylase, and methods of use, thereof
ES2655032T3 (en) 2012-12-21 2018-02-16 Novozymes A/S Polypeptides that possess protease activity and polynucleotides that encode them
EP3321360A3 (en) 2013-01-03 2018-06-06 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
EP3336183B1 (en) 2013-03-11 2021-05-12 Danisco US Inc. Alpha-amylase conbinatorial variants
CN105189724A (en) 2013-03-14 2015-12-23 诺维信公司 Enzyme and inhibitor containing water-soluble films
CN105051174B (en) 2013-03-21 2018-04-03 诺维信公司 Polypeptide and their polynucleotides of coding with lipase active
AR096270A1 (en) 2013-05-14 2015-12-16 Novozymes As DETERGENT COMPOSITIONS
US20160083703A1 (en) 2013-05-17 2016-03-24 Novozymes A/S Polypeptides having alpha amylase activity
EP3786269A1 (en) 2013-06-06 2021-03-03 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
WO2014200657A1 (en) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase from streptomyces xiamenensis
WO2014200656A1 (en) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase from streptomyces umbrinus
WO2014200658A1 (en) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase from promicromonospora vindobonensis
WO2014204596A1 (en) 2013-06-17 2014-12-24 Danisco Us Inc. Alpha-amylase from bacillaceae family member
US20160145596A1 (en) 2013-06-27 2016-05-26 Novozymes A/S Subtilase Variants and Polynucleotides Encoding Same
FI3013956T3 (en) 2013-06-27 2023-05-23 Novozymes As Subtilase variants and polynucleotides encoding same
US20160152925A1 (en) 2013-07-04 2016-06-02 Novozymes A/S Polypeptides Having Anti-Redeposition Effect and Polynucleotides Encoding Same
US20160160196A1 (en) 2013-07-09 2016-06-09 Novozymes A/S Polypeptides with Lipase Activity And Polynucleotides Encoding Same
MX2020001159A (en) 2013-07-19 2021-07-07 Danisco Us Inc Compositions and methods comprising a lipolytic enzyme variant.
EP3027747B1 (en) 2013-07-29 2018-02-07 Novozymes A/S Protease variants and polynucleotides encoding same
EP2832853A1 (en) 2013-07-29 2015-02-04 Henkel AG&Co. KGAA Detergent composition comprising protease variants
CN117904081A (en) 2013-07-29 2024-04-19 诺维信公司 Protease variants and polynucleotides encoding same
WO2015049370A1 (en) 2013-10-03 2015-04-09 Novozymes A/S Detergent composition and use of detergent composition
EP3060659B1 (en) 2013-10-03 2019-05-29 Danisco US Inc. Alpha-amylases from exiguobacterium, and methods of use, thereof
EP3052622B1 (en) 2013-10-03 2018-09-19 Danisco US Inc. Alpha-amylases from a subset of exiguobacterium, and methods of use, thereof
JP6560214B2 (en) 2013-11-20 2019-08-14 ダニスコ・ユーエス・インク Mutant α-amylase with reduced sensitivity to protease cleavage and method of use thereof
WO2015094809A1 (en) 2013-12-19 2015-06-25 Danisco Us Inc. Chimeric fungal alpha-amylases comprising carbohydrate binding module and the use thereof
EP3083954B1 (en) 2013-12-20 2018-09-26 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
CN105849121B (en) 2014-01-22 2020-12-29 诺维信公司 Polypeptides having lipase activity and polynucleotides encoding same
US20160348035A1 (en) 2014-03-05 2016-12-01 Novozymes A/S Compositions and Methods for Improving Properties of Non-Cellulosic Textile Materials with Xyloglucan Endotransglycosylase
CN106062271A (en) 2014-03-05 2016-10-26 诺维信公司 Compositions and methods for improving properties of cellulosic textile materials with xyloglucan endotransglycosylase
EP3117001B1 (en) 2014-03-12 2019-02-20 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
EP3126479A1 (en) 2014-04-01 2017-02-08 Novozymes A/S Polypeptides having alpha amylase activity
WO2015157656A1 (en) 2014-04-10 2015-10-15 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CA2943029C (en) 2014-04-11 2022-09-20 Novozymes A/S Detergent composition
CN106715465B (en) 2014-04-15 2021-10-08 诺维信公司 Polypeptides having lipase activity and polynucleotides encoding same
CN106459937A (en) 2014-05-27 2017-02-22 诺维信公司 Methods for producing lipases
US10023852B2 (en) 2014-05-27 2018-07-17 Novozymes A/S Lipase variants and polynucleotides encoding same
CN106414729A (en) 2014-06-12 2017-02-15 诺维信公司 Alpha-amylase variants and polynucleotides encoding same
WO2015195777A1 (en) 2014-06-19 2015-12-23 E. I. Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
US9714403B2 (en) 2014-06-19 2017-07-25 E I Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
CN106661566A (en) 2014-07-04 2017-05-10 诺维信公司 Subtilase variants and polynucleotides encoding same
EP3739029A1 (en) 2014-07-04 2020-11-18 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2016079110A2 (en) 2014-11-19 2016-05-26 Novozymes A/S Use of enzyme for cleaning
CN107075489A (en) 2014-11-20 2017-08-18 诺维信公司 Alicyclic acid bacillus variant and the polynucleotides for encoding them
CA2963331A1 (en) 2014-12-04 2016-06-09 Novozymes A/S Subtilase variants and polynucleotides encoding same
CA2965231A1 (en) 2014-12-05 2016-06-09 Novozymes A/S Lipase variants and polynucleotides encoding same
EP3399031B1 (en) 2014-12-15 2019-10-30 Henkel AG & Co. KGaA Detergent composition comprising subtilase variants
US20180000076A1 (en) 2014-12-16 2018-01-04 Novozymes A/S Polypeptides Having N-Acetyl Glucosamine Oxidase Activity
CN107002061A (en) 2014-12-19 2017-08-01 诺维信公司 Ease variants and the polynucleotides encoded to it
EP3234093B1 (en) 2014-12-19 2020-05-27 Novozymes A/S Protease variants and polynucleotides encoding same
WO2016162556A1 (en) 2015-04-10 2016-10-13 Novozymes A/S Laundry method, use of dnase and detergent composition
CN107636134A (en) 2015-04-10 2018-01-26 诺维信公司 Detergent composition
CN107835853B (en) 2015-05-19 2021-04-20 诺维信公司 Odor reduction
CN108012543B (en) 2015-06-16 2022-01-04 诺维信公司 Polypeptides having lipase activity and polynucleotides encoding same
EP3106508B1 (en) 2015-06-18 2019-11-20 Henkel AG & Co. KGaA Detergent composition comprising subtilase variants
CN108012544A (en) 2015-06-18 2018-05-08 诺维信公司 Subtilase variants and the polynucleotides for encoding them
CN107922896A (en) 2015-06-30 2018-04-17 诺维信公司 Laundry detergent composition, for washing method and composition purposes
US10920203B2 (en) 2015-07-01 2021-02-16 Novozymes A/S Methods of reducing odor
EP3950939A3 (en) 2015-07-06 2022-06-08 Novozymes A/S Lipase variants and polynucleotides encoding same
CA2991114A1 (en) 2015-09-17 2017-03-23 Novozymes A/S Polypeptides having xanthan degrading activity and polynucleotides encoding same
AU2016323412B2 (en) 2015-09-17 2021-04-01 Henkel Ag & Co. Kgaa Detergent compositions comprising polypeptides having xanthan degrading activity
JP2018535664A (en) 2015-10-07 2018-12-06 ノボザイムス アクティーゼルスカブ Polypeptide
EP3362558A1 (en) 2015-10-14 2018-08-22 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
CN108291212A (en) 2015-10-14 2018-07-17 诺维信公司 Polypeptide variants
US11028346B2 (en) 2015-10-28 2021-06-08 Novozymes A/S Detergent composition comprising protease and amylase variants
US11001821B2 (en) 2015-11-24 2021-05-11 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3384019B1 (en) 2015-12-01 2020-06-24 Novozymes A/S Methods for producing lipases
CN108779448B (en) 2015-12-09 2023-08-18 丹尼斯科美国公司 Alpha-amylase combination variants
MX2018007485A (en) 2015-12-30 2018-08-01 Novozymes As Enzyme variants and polynucleotides encoding the same.
JP2019504625A (en) 2016-01-29 2019-02-21 ノボザイムス アクティーゼルスカブ β-glucanase variant and polynucleotide encoding the same
EP3433347B1 (en) 2016-03-23 2020-05-06 Novozymes A/S Use of polypeptide having dnase activity for treating fabrics
WO2017173190A2 (en) 2016-04-01 2017-10-05 Danisco Us Inc. Alpha-amylases, compositions & methods
WO2017173324A2 (en) 2016-04-01 2017-10-05 Danisco Us Inc. Alpha-amylases, compositions & methods
CN109312270B (en) 2016-04-08 2022-01-28 诺维信公司 Detergent composition and use thereof
JP6959259B2 (en) 2016-04-29 2021-11-02 ノボザイムス アクティーゼルスカブ Detergent composition and its use
WO2017191160A1 (en) 2016-05-03 2017-11-09 Novozymes A/S Alpha-amylase variants and polynucleotides encoding the same
JP6985295B2 (en) 2016-05-09 2021-12-22 ノボザイムス アクティーゼルスカブ Mutant polypeptides with improved performance and their use
WO2017202979A1 (en) 2016-05-24 2017-11-30 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
CN109312321A (en) 2016-05-24 2019-02-05 诺维信公司 Composition comprising the polypeptide with galactanase activity and the polypeptide with betagalactosidase activity
MX2018014234A (en) 2016-05-24 2019-03-28 Novozymes As Polypeptides having alpha-galactosidase activity and polynucleotides encoding same.
CN109196098A (en) 2016-05-24 2019-01-11 诺维信公司 Composition comprising the polypeptide with galactanase activity and the polypeptide with betagalactosidase activity
CN109715792A (en) 2016-06-03 2019-05-03 诺维信公司 Subtilase variants and the polynucleotides that it is encoded
US11203732B2 (en) 2016-06-30 2021-12-21 Novozymes A/S Lipase variants and compositions comprising surfactant and lipase variant
WO2018002261A1 (en) 2016-07-01 2018-01-04 Novozymes A/S Detergent compositions
JP2019522988A (en) 2016-07-05 2019-08-22 ノボザイムス アクティーゼルスカブ Pectate lyase mutant and polynucleotide encoding the same
BR112019000089A2 (en) 2016-07-08 2019-07-09 Novozymes As xylanase variant, composition, granule, animal feed additive, liquid formulation, animal feed, methods for enhancing one or more performance parameters of an animal, for solubilizing xylan from plant-based material, for releasing starch from material to to improve the nutritional value of an animal feed, to prepare a pasta or baked product prepared from the dough, to produce a xylanase variant and to obtain a xylanase variant, use of a xylanase variant, process of producing a fermentation product, isolated polynucleotide, nucleic acid construct or expression vector, and recombinant host cell.
WO2018007153A1 (en) 2016-07-08 2018-01-11 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
WO2018007573A1 (en) 2016-07-08 2018-01-11 Novozymes A/S Detergent compositions with galactanase
EP3485010A1 (en) 2016-07-13 2019-05-22 The Procter and Gamble Company Bacillus cibi dnase variants and uses thereof
WO2018015295A1 (en) 2016-07-18 2018-01-25 Novozymes A/S Lipase variants, polynucleotides encoding same and the use thereof
US11512300B2 (en) 2016-08-24 2022-11-29 Novozymes A/S Xanthan lyase variants and polynucleotides encoding same
EP3504331A1 (en) 2016-08-24 2019-07-03 Henkel AG & Co. KGaA Detergent compositions comprising xanthan lyase variants i
WO2018037065A1 (en) 2016-08-24 2018-03-01 Henkel Ag & Co. Kgaa Detergent composition comprising gh9 endoglucanase variants i
CN109863244B (en) 2016-08-24 2023-06-06 诺维信公司 GH9 endoglucanase variants and polynucleotides encoding same
EP3532592A1 (en) 2016-10-25 2019-09-04 Novozymes A/S Detergent compositions
US20190292493A1 (en) 2016-12-12 2019-09-26 Novozymes A/S Use of polypeptides
CN110662836B (en) 2017-03-31 2024-04-12 丹尼斯科美国公司 Alpha-amylase combination variants
EP3607040A1 (en) 2017-04-04 2020-02-12 Novozymes A/S Polypeptide compositions and uses thereof
EP3607041A1 (en) 2017-04-04 2020-02-12 Novozymes A/S Glycosyl hydrolases
EP3385362A1 (en) 2017-04-05 2018-10-10 Henkel AG & Co. KGaA Detergent compositions comprising fungal mannanases
ES2728758T3 (en) 2017-04-05 2019-10-28 Henkel Ag & Co Kgaa Detergent compositions comprising bacterial mannanas
WO2018185280A1 (en) 2017-04-06 2018-10-11 Novozymes A/S Cleaning compositions and uses thereof
EP3607037A1 (en) 2017-04-06 2020-02-12 Novozymes A/S Cleaning compositions and uses thereof
EP3626809A1 (en) 2017-04-06 2020-03-25 Novozymes A/S Cleaning compositions and uses thereof
EP3607042A1 (en) 2017-04-06 2020-02-12 Novozymes A/S Cleaning compositions and uses thereof
EP3607044A1 (en) 2017-04-06 2020-02-12 Novozymes A/S Cleaning compositions and uses thereof
WO2018184817A1 (en) 2017-04-06 2018-10-11 Novozymes A/S Cleaning compositions and uses thereof
US11078445B2 (en) 2017-05-05 2021-08-03 Novozymes A/S Compositions comprising lipase and sulfite
WO2018206535A1 (en) 2017-05-08 2018-11-15 Novozymes A/S Carbohydrate-binding domain and polynucleotides encoding the same
EP3401385A1 (en) 2017-05-08 2018-11-14 Henkel AG & Co. KGaA Detergent composition comprising polypeptide comprising carbohydrate-binding domain
EP3622064A1 (en) 2017-05-08 2020-03-18 Novozymes A/S Mannanase variants and polynucleotides encoding same
US20210130743A1 (en) 2017-05-08 2021-05-06 Novozymes A/S Mannanase Variants and Polynucleotides Encoding Same
WO2018224544A1 (en) 2017-06-08 2018-12-13 Novozymes A/S Compositions comprising polypeptides having cellulase activity and amylase activity, and uses thereof in cleaning and detergent compositions
WO2018234465A1 (en) 2017-06-22 2018-12-27 Novozymes A/S Xylanase variants and polynucleotides encoding same
EP3673060A1 (en) 2017-08-24 2020-07-01 Henkel AG & Co. KGaA Detergent composition comprising xanthan lyase variants ii
CA3071078A1 (en) 2017-08-24 2019-02-28 Novozymes A/S Xanthan lyase variants and polynucleotides encoding same
US11624059B2 (en) 2017-08-24 2023-04-11 Henkel Ag & Co. Kgaa Detergent compositions comprising GH9 endoglucanase variants II
EP3673058A1 (en) 2017-08-24 2020-07-01 Novozymes A/S Gh9 endoglucanase variants and polynucleotides encoding same
CN111050565A (en) 2017-09-01 2020-04-21 诺维信公司 Animal feed additive comprising a polypeptide having protease activity and uses thereof
JP2020531037A (en) 2017-09-01 2020-11-05 ノボザイムス アクティーゼルスカブ Animal feed additives containing polypeptides with protease activity and their use
WO2019057902A1 (en) 2017-09-22 2019-03-28 Novozymes A/S Novel polypeptides
JP7114697B2 (en) 2017-09-27 2022-08-08 ザ プロクター アンド ギャンブル カンパニー Detergent composition containing lipase
EP3688150A1 (en) 2017-09-27 2020-08-05 Novozymes A/S Lipase variants and microcapsule compositions comprising such lipase variants
CN111417725A (en) 2017-10-02 2020-07-14 诺维信公司 Polypeptides having mannanase activity and polynucleotides encoding same
CN111373036A (en) 2017-10-02 2020-07-03 诺维信公司 Polypeptides having mannanase activity and polynucleotides encoding same
WO2019076800A1 (en) 2017-10-16 2019-04-25 Novozymes A/S Cleaning compositions and uses thereof
US11866748B2 (en) 2017-10-24 2024-01-09 Novozymes A/S Compositions comprising polypeptides having mannanase activity
ES2910120T3 (en) 2017-10-27 2022-05-11 Procter & Gamble Detergent compositions comprising polypeptide variants
MX2020004149A (en) 2017-10-27 2020-08-03 Novozymes As Dnase variants.
DE102017125558A1 (en) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa CLEANING COMPOSITIONS CONTAINING DISPERSINE I
WO2019086528A1 (en) 2017-11-01 2019-05-09 Novozymes A/S Polypeptides and compositions comprising such polypeptides
EP3704219B1 (en) 2017-11-01 2024-01-10 Novozymes A/S Polypeptides and compositions comprising such polypeptides
DE102017125560A1 (en) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa CLEANSING COMPOSITIONS CONTAINING DISPERSINE III
US11725197B2 (en) 2017-12-04 2023-08-15 Novozymes A/S Lipase variants and polynucleotides encoding same
MX2020006423A (en) 2017-12-20 2020-12-03 Dsm Ip Assets Bv Animal feed compositions and uses thereof.
MX2020006598A (en) 2017-12-20 2020-12-10 Dsm Ip Assets Bv Animal feed compositions comprising muramidase and uses thereof.
BR112020012438A2 (en) 2018-01-11 2020-11-24 Novozymes A/S composition, animal feed or animal feed additive, and, method of improving the release of xylan from animal feed.
CA3088793A1 (en) 2018-02-06 2019-08-15 Novozymes Bioag A/S Methods of protecting a plant from fungal pests
CN111757930A (en) 2018-02-08 2020-10-09 诺维信公司 Lipase variants and compositions thereof
US20210123033A1 (en) 2018-02-08 2021-04-29 Novozymes A/S Lipases, Lipase Variants and Compositions Thereof
KR20200124258A (en) 2018-02-23 2020-11-02 헨켈 아게 운트 코. 카게아아 Detergent composition comprising xanthan lyase and endoglucanase variant
EP3775190A1 (en) 2018-03-29 2021-02-17 Novozymes A/S Mannanase variants and polynucleotides encoding same
CN112262207B (en) 2018-04-17 2024-01-23 诺维信公司 Polypeptides comprising carbohydrate binding activity in detergent compositions and their use for reducing wrinkles in textiles or fabrics
EP3781680A1 (en) 2018-04-19 2021-02-24 Novozymes A/S Stabilized cellulase variants
US11661592B2 (en) 2018-04-19 2023-05-30 Novozymes A/S Stabilized endoglucanase variants
EP3784048A1 (en) 2018-04-25 2021-03-03 Novozymes A/S Animal feed compositions and uses thereof
BR112020024491A2 (en) 2018-06-05 2021-03-02 Novozymes Bioag A/S methods of foliar application of a composition, of controlling plant pests on a plant or part of a plant and / or inducing resistance to a plant pest on a plant or part of a plant, of controlling or preventing pest damage in a plant plant propagation material, a plant, part of a plant and / or plant organ, to control or prevent damage from a lepidopteran pest on a plant and to control or prevent damage from an insect pest on a plant.
WO2019236687A1 (en) 2018-06-05 2019-12-12 Novozymes Bioag A/S Methods of protecting a plant from fungal pests
WO2020007863A1 (en) 2018-07-02 2020-01-09 Novozymes A/S Cleaning compositions and uses thereof
WO2020007875A1 (en) 2018-07-03 2020-01-09 Novozymes A/S Cleaning compositions and uses thereof
EP3818140A1 (en) 2018-07-06 2021-05-12 Novozymes A/S Cleaning compositions and uses thereof
WO2020008024A1 (en) 2018-07-06 2020-01-09 Novozymes A/S Cleaning compositions and uses thereof
WO2020043836A1 (en) 2018-08-31 2020-03-05 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
MX2021003035A (en) 2018-09-17 2021-08-11 Dsm Ip Assets Bv Animal feed compositions and uses thereof.
WO2020058225A1 (en) 2018-09-17 2020-03-26 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
AU2019341519A1 (en) 2018-09-17 2021-03-18 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
US20220040271A1 (en) 2018-09-17 2022-02-10 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
WO2020070009A1 (en) 2018-10-02 2020-04-09 Novozymes A/S Endonuclease 1 ribonucleases for cleaning
WO2020070209A1 (en) 2018-10-02 2020-04-09 Novozymes A/S Cleaning composition
US20230287306A1 (en) 2018-10-02 2023-09-14 Novozymes A/S Cleaning Composition
EP3861008A1 (en) 2018-10-03 2021-08-11 Novozymes A/S Polypeptides having alpha-mannan degrading activity and polynucleotides encoding same
WO2020074499A1 (en) 2018-10-09 2020-04-16 Novozymes A/S Cleaning compositions and uses thereof
EP3864122A1 (en) 2018-10-09 2021-08-18 Novozymes A/S Cleaning compositions and uses thereof
WO2020074545A1 (en) 2018-10-11 2020-04-16 Novozymes A/S Cleaning compositions and uses thereof
EP3647398B1 (en) 2018-10-31 2024-05-15 Henkel AG & Co. KGaA Cleaning compositions containing dispersins v
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
US11959111B2 (en) 2018-12-21 2024-04-16 Novozymes A/S Polypeptides having peptidoglycan degrading activity and polynucleotides encoding same
DE102019200138A1 (en) 2019-01-08 2020-07-09 Beiersdorf Ag Preparation with cellulose particles coated with vinylamine / N-vinylformamide copolymer
DE102019200135A1 (en) 2019-01-08 2020-07-09 Beiersdorf Ag Preparation with silica particles coated with vinylamine / N-vinylformamide copolymer
EP3942032A1 (en) 2019-03-21 2022-01-26 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
EP3947619A1 (en) 2019-04-03 2022-02-09 Novozymes A/S Polypeptides having beta-glucanase activity, polynucleotides encoding same and uses thereof in cleaning and detergent compositions
US20220364138A1 (en) 2019-04-10 2022-11-17 Novozymes A/S Polypeptide variants
WO2020208056A1 (en) 2019-04-12 2020-10-15 Novozymes A/S Stabilized glycoside hydrolase variants
EP3994255A1 (en) 2019-07-02 2022-05-11 Novozymes A/S Lipase variants and compositions thereof
WO2021030400A1 (en) 2019-08-13 2021-02-18 Novozymes Bioag A/S Pesticidal combinations of yersinia and proteases
EP4022019A1 (en) 2019-08-27 2022-07-06 Novozymes A/S Detergent composition
EP4022020A1 (en) 2019-08-27 2022-07-06 Novozymes A/S Composition comprising a lipase
WO2021055395A1 (en) 2019-09-16 2021-03-25 Novozymes A/S Polypeptides having beta-glucanase activity and polynucleotides encoding same
CN114616312A (en) 2019-09-19 2022-06-10 诺维信公司 Detergent composition
WO2021064068A1 (en) 2019-10-03 2021-04-08 Novozymes A/S Polypeptides comprising at least two carbohydrate binding domains
WO2021078839A1 (en) 2019-10-22 2021-04-29 Novozymes A/S Animal feed composition
US20220411773A1 (en) 2019-12-20 2022-12-29 Novozymes A/S Polypeptides having proteolytic activity and use thereof
AU2020405786A1 (en) 2019-12-20 2022-08-11 Henkel Ag & Co. Kgaa Cleaning compositions comprising dispersins IX
WO2021122120A2 (en) 2019-12-20 2021-06-24 Henkel Ag & Co. Kgaa Cleaning compositions comprising dispersins viii
EP4077620A1 (en) 2019-12-20 2022-10-26 Henkel AG & Co. KGaA Cleaning compositions comprising dispersins vi
WO2021122117A1 (en) 2019-12-20 2021-06-24 Henkel Ag & Co. Kgaa Cleaning composition coprising a dispersin and a carbohydrase
WO2021130167A1 (en) 2019-12-23 2021-07-01 Novozymes A/S Enzyme compositions and uses thereof
US20230159861A1 (en) 2020-01-23 2023-05-25 Novozymes A/S Enzyme compositions and uses thereof
WO2021152120A1 (en) 2020-01-31 2021-08-05 Novozymes A/S Mannanase variants and polynucleotides encoding same
JP2023511739A (en) 2020-01-31 2023-03-22 ノボザイムス アクティーゼルスカブ Mannanase variants and polynucleotides encoding them
WO2021163030A2 (en) 2020-02-10 2021-08-19 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
EP3892708A1 (en) 2020-04-06 2021-10-13 Henkel AG & Co. KGaA Cleaning compositions comprising dispersin variants
US20230143128A1 (en) 2020-04-08 2023-05-11 Novozymes A/S Carbohydrate binding module variants
CN115516071A (en) 2020-04-21 2022-12-23 诺维信公司 Cleaning compositions comprising polypeptides having fructan-degrading activity
EP4152945A1 (en) 2020-05-18 2023-03-29 DSM IP Assets B.V. Animal feed compositions
WO2021233937A1 (en) 2020-05-18 2021-11-25 Dsm Ip Assets B.V. Animal feed compositions
EP3936593A1 (en) 2020-07-08 2022-01-12 Henkel AG & Co. KGaA Cleaning compositions and uses thereof
EP4204551A2 (en) 2020-08-25 2023-07-05 Novozymes A/S Variants of a family 44 xyloglucanase
MX2023003821A (en) 2020-10-07 2023-04-13 Novozymes As Enzymatic feed preservation.
EP4225905A2 (en) 2020-10-07 2023-08-16 Novozymes A/S Alpha-amylase variants
CN116390651A (en) 2020-10-15 2023-07-04 帝斯曼知识产权资产管理有限公司 Methods of modulating gastrointestinal metabolites
WO2022084303A2 (en) 2020-10-20 2022-04-28 Novozymes A/S Use of polypeptides having dnase activity
US20230399588A1 (en) 2020-10-28 2023-12-14 Novozymes A/S Use of lipoxygenase
BR112023008326A2 (en) 2020-10-29 2023-12-12 Novozymes As LIPASE VARIANTS AND COMPOSITIONS COMPRISING SUCH LIPASE VARIANTS
US20230399632A1 (en) 2020-11-02 2023-12-14 Novozymes A/S Glucoamylase Variants and Polynucleotides Encoding Same
EP4244325A1 (en) 2020-11-13 2023-09-20 Novozymes A/S Detergent composition comprising a lipase
WO2022106404A1 (en) 2020-11-18 2022-05-27 Novozymes A/S Combination of proteases
WO2022106400A1 (en) 2020-11-18 2022-05-27 Novozymes A/S Combination of immunochemically different proteases
EP4039806A1 (en) 2021-02-04 2022-08-10 Henkel AG & Co. KGaA Detergent composition comprising xanthan lyase and endoglucanase variants with im-proved stability
EP4291646A2 (en) 2021-02-12 2023-12-20 Novozymes A/S Alpha-amylase variants
US20240060061A1 (en) 2021-03-15 2024-02-22 Novozymes A/S Dnase variants
EP4060036A1 (en) 2021-03-15 2022-09-21 Novozymes A/S Polypeptide variants
EP4359518A1 (en) 2021-06-23 2024-05-01 Novozymes A/S Alpha-amylase polypeptides
WO2023288294A1 (en) 2021-07-16 2023-01-19 Novozymes A/S Compositions and methods for improving the rainfastness of proteins on plant surfaces
WO2023061928A1 (en) 2021-10-12 2023-04-20 Novozymes A/S Endoglucanase with improved stability
WO2023116569A1 (en) 2021-12-21 2023-06-29 Novozymes A/S Composition comprising a lipase and a booster
EP4234664A1 (en) 2022-02-24 2023-08-30 Evonik Operations GmbH Composition comprising glucolipids and enzymes
WO2023165507A1 (en) 2022-03-02 2023-09-07 Novozymes A/S Use of xyloglucanase for improvement of sustainability of detergents
WO2023165950A1 (en) 2022-03-04 2023-09-07 Novozymes A/S Dnase variants and compositions
WO2023170177A1 (en) 2022-03-08 2023-09-14 Novozymes A/S Fusion polypeptides with deamidase inhibitor and deamidase domains
EP4242303A1 (en) 2022-03-08 2023-09-13 Novozymes A/S Fusion polypeptides with deamidase inhibitor and deamidase domains
WO2023194388A1 (en) 2022-04-07 2023-10-12 Novozymes A/S Fusion proteins and their use against eimeria
WO2023194204A1 (en) 2022-04-08 2023-10-12 Novozymes A/S Hexosaminidase variants and compositions
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
WO2023247348A1 (en) 2022-06-21 2023-12-28 Novozymes A/S Mannanase variants and polynucleotides encoding same
WO2023247664A2 (en) 2022-06-24 2023-12-28 Novozymes A/S Lipase variants and compositions comprising such lipase variants
WO2024003143A1 (en) 2022-06-30 2024-01-04 Novozymes A/S Mutanases and oral care compositions comprising same
WO2024012912A1 (en) 2022-07-15 2024-01-18 Novozymes A/S Polypeptides having deamidase inhibitor activity
WO2024083819A1 (en) 2022-10-20 2024-04-25 Novozymes A/S Lipid removal in detergents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828882A (en) * 1987-03-16 1989-05-09 Canadian Patents & Developments Limited Particle encapsulation technique
US5211985A (en) * 1991-10-09 1993-05-18 Ici Canada, Inc. Multi-stage process for continuous coating of fertilizer particles
US5399186A (en) * 1991-10-09 1995-03-21 Ici Canada, Inc. Apparatus and process for coating particles

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