BRPI9913360B8 - proteína de uricase recombinante quimérica, molécula de ácido nucléico isolada e purificada, vetor e célula hospedeira transformada. - Google Patents

proteína de uricase recombinante quimérica, molécula de ácido nucléico isolada e purificada, vetor e célula hospedeira transformada.

Info

Publication number
BRPI9913360B8
BRPI9913360B8 BRPI9913360A BR9913360A BRPI9913360B8 BR PI9913360 B8 BRPI9913360 B8 BR PI9913360B8 BR PI9913360 A BRPI9913360 A BR PI9913360A BR 9913360 A BR9913360 A BR 9913360A BR PI9913360 B8 BRPI9913360 B8 BR PI9913360B8
Authority
BR
Brazil
Prior art keywords
nucleic acid
vector
isolated
host cell
acid molecule
Prior art date
Application number
BRPI9913360A
Other languages
English (en)
Other versions
BR9913360A (pt
BR9913360B1 (pt
Inventor
Hershfield Michael
J Kelly Susan
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of BR9913360A publication Critical patent/BR9913360A/pt
Publication of BR9913360B1 publication Critical patent/BR9913360B1/pt
Publication of BRPI9913360B8 publication Critical patent/BRPI9913360B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C12N9/0048—Uricase (1.7.3.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
    • C12Y107/03—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C12Y107/03003—Factor-independent urate hydroxylase (1.7.3.3), i.e. uricase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

patente de invenção:<b>"oxidase de urato"<d>. a presente invenção refere-se, em geral, a proteínas de oxidase de urato (uricase) e moléculas de ácido nucléico codificando as mesmas. em particular, a invenção refere-se a proteínas de uricase as quais são particularmente úteis como, por exemplo, intermediários para produzir proteínas de uricase modificadas aperfeiçoadas com imunogenicidade reduzida e biodisponibilidade aumentada.
BRPI9913360A 1998-08-06 1999-08-05 proteína de uricase recombinante quimérica, molécula de ácido nucléico isolada e purificada, vetor e célula hospedeira transformada. BRPI9913360B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9548998P 1998-08-06 1998-08-06
PCT/US1999/017678 WO2000008196A2 (en) 1998-08-06 1999-08-05 Urate oxidase

Publications (3)

Publication Number Publication Date
BR9913360A BR9913360A (pt) 2001-07-03
BR9913360B1 BR9913360B1 (pt) 2013-09-24
BRPI9913360B8 true BRPI9913360B8 (pt) 2021-05-25

Family

ID=22252247

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9913360A BRPI9913360B8 (pt) 1998-08-06 1999-08-05 proteína de uricase recombinante quimérica, molécula de ácido nucléico isolada e purificada, vetor e célula hospedeira transformada.

Country Status (23)

Country Link
US (1) US7056713B1 (pt)
EP (2) EP2277998B1 (pt)
JP (3) JP2002524053A (pt)
KR (1) KR100841634B1 (pt)
CN (2) CN101280293B (pt)
AT (1) ATE483797T1 (pt)
AU (1) AU766421B2 (pt)
BR (1) BRPI9913360B8 (pt)
CA (1) CA2337967C (pt)
CY (1) CY1111001T1 (pt)
CZ (1) CZ304223B6 (pt)
DE (1) DE69942834D1 (pt)
DK (1) DK1100880T3 (pt)
ES (1) ES2352451T3 (pt)
HK (3) HK1037214A1 (pt)
HU (1) HU229774B1 (pt)
IL (3) IL141221A0 (pt)
NZ (1) NZ509633A (pt)
PL (1) PL207369B1 (pt)
PT (1) PT1100880E (pt)
RU (1) RU2290439C2 (pt)
WO (1) WO2000008196A2 (pt)
ZA (1) ZA200100974B (pt)

Families Citing this family (38)

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BRPI9912974B8 (pt) * 1998-08-06 2021-05-25 Univ Duke conjugados de peg-urato oxidase e seu uso
NZ509633A (en) * 1998-08-06 2003-04-29 Univ Duke A recombinant chimeric PEG-uricase with a long circulatory life and reduced immunogenicity
US20060188971A1 (en) * 1998-08-06 2006-08-24 Duke University Urate oxidase
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CN100371439C (zh) * 2003-04-07 2008-02-27 北京双鹭药业股份有限公司 一种重组假丝酵母尿酸氧化酶的制备方法
CN100334207C (zh) * 2004-04-27 2007-08-29 杭州北斗生物技术有限公司 一种黄曲霉尿酸氧化酶的制备方法
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CA2604399A1 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
AU2011257764B2 (en) * 2005-04-11 2012-04-05 Horizon Therapeutics Usa, Inc. A variant form of urate oxidase and use thereof
BRPI0612942A2 (pt) * 2005-04-11 2012-10-09 Savient Pharmaceuticals Inc forma variante de oxidase de urato e uso do mesmo
US9534013B2 (en) 2006-04-12 2017-01-03 Horizon Pharma Rheumatology Llc Purification of proteins with cationic surfactant
CN101402688B (zh) * 2008-11-18 2011-04-20 中国人民解放军军事医学科学院生物工程研究所 一种融合蛋白及其编码基因与应用
CA2756752C (en) 2009-03-24 2014-03-18 Meito Sangyo Co., Ltd. Improved type milk-clotting protease derived from a microorganism
EP3482768A1 (en) 2009-06-25 2019-05-15 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
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RU2460793C2 (ru) * 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
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CN102634492B (zh) 2011-02-14 2015-06-10 重庆富进生物医药有限公司 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用
CN102757945B (zh) * 2011-04-28 2015-03-18 杭州俊丰生物工程有限公司 人尿酸氧化酶蛋白及其制备方法和其聚乙二醇结合物
CN102260653B (zh) * 2011-06-30 2013-04-03 荣俊 一种peg化重组猪-人尿酸氧化酶融合蛋白的制备及应用方法
EP2986720B1 (en) * 2013-04-17 2017-09-06 Council of Scientific & Industrial Research Uricase mutants
CN103834623B (zh) * 2014-02-11 2017-11-07 中国药科大学 具有催化活性的人源尿酸氧化酶
CN104388467A (zh) * 2014-10-27 2015-03-04 李长贵 一种构建自发性高尿酸血症小鼠模型的方法及其用途
MY190411A (en) 2015-05-15 2022-04-21 Medimmune Llc Improved uricase sequences and methods of treatment
CN106554948B (zh) 2015-09-29 2019-06-25 上海生物制品研究所有限责任公司 突变型尿酸酶、peg修饰的突变型尿酸酶及其应用
CN108103079B (zh) * 2017-06-20 2021-07-13 北京锦篮基因科技有限公司 一种高尿酸血症的基因治疗药物
CN109554376B (zh) * 2018-11-13 2022-03-22 广西大学 一种碱性尿酸氧化酶及其在检测试剂盒和降低食品中尿酸的应用
CN111088268B (zh) * 2019-03-05 2022-08-02 北京锦篮基因科技有限公司 一种高尿酸血症的基因治疗药物
CA3139550A1 (en) 2019-05-10 2020-11-19 Peg-Bio Biopharm Co., Ltd. (Chongqing) Polyethylene glycol-modified urate oxidase
CN112646790A (zh) * 2019-10-11 2021-04-13 上海君实生物医药科技股份有限公司 改进的尿酸酶及其用于治疗高尿酸血症的方法
CN111920942A (zh) * 2020-08-24 2020-11-13 深圳前海鹰岗生物科技有限公司 一种用于快速溶解痛风石的聚合物微针及制备方法和应用
CN114438048A (zh) 2020-11-05 2022-05-06 重庆派金生物科技有限公司 尿酸氧化酶制剂及其应用
CN114438047A (zh) 2020-11-05 2022-05-06 重庆派金生物科技有限公司 制备聚乙二醇修饰的尿酸氧化酶的方法
CN112852772A (zh) * 2021-01-19 2021-05-28 中国科学院过程工程研究所 一种基于分子内交联和聚乙二醇修饰的尿酸氧化酶及其制备方法
CN112662640A (zh) * 2021-01-28 2021-04-16 中国药科大学 一种具有催化活性的尿酸氧化酶
CN113244412B (zh) * 2021-06-25 2021-10-26 深圳市瑞吉生物科技有限公司 一种基于mRNA剂型的治疗高尿酸血症或痛风的药物及其制备方法
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Also Published As

Publication number Publication date
WO2000008196A3 (en) 2000-03-30
WO2000008196A9 (en) 2000-07-13
JP5721954B2 (ja) 2015-05-20
JP2002524053A (ja) 2002-08-06
EP1100880A2 (en) 2001-05-23
DE69942834D1 (de) 2010-11-18
CA2337967A1 (en) 2000-02-17
EP2277998A1 (en) 2011-01-26
EP2277998B1 (en) 2016-04-20
AU5336599A (en) 2000-02-28
BR9913360A (pt) 2001-07-03
AU766421B2 (en) 2003-10-16
IL197339A0 (en) 2011-07-31
PL346222A1 (en) 2002-01-28
CZ304223B6 (cs) 2014-01-15
KR20010053633A (ko) 2001-06-25
DK1100880T3 (da) 2011-01-24
HU229774B1 (en) 2014-07-28
CA2337967C (en) 2011-11-01
HUP0103205A3 (en) 2006-01-30
CN1322243A (zh) 2001-11-14
ATE483797T1 (de) 2010-10-15
CN101280293B (zh) 2013-09-11
EP1100880A4 (en) 2002-04-17
PL207369B1 (pl) 2010-12-31
US7056713B1 (en) 2006-06-06
JP2010158244A (ja) 2010-07-22
WO2000008196A2 (en) 2000-02-17
IL141221A (en) 2010-06-16
IL197339A (en) 2015-02-26
BR9913360B1 (pt) 2013-09-24
RU2290439C2 (ru) 2006-12-27
HUP0103205A2 (hu) 2001-12-28
CZ2001466A3 (cs) 2001-07-11
HK1125402A1 (en) 2009-08-07
IL141221A0 (en) 2002-03-10
JP2013215199A (ja) 2013-10-24
CY1111001T1 (el) 2015-06-11
NZ509633A (en) 2003-04-29
HK1153508A1 (zh) 2012-03-30
CN101280293A (zh) 2008-10-08
ES2352451T3 (es) 2011-02-18
KR100841634B1 (ko) 2008-06-26
EP1100880B1 (en) 2010-10-06
HK1037214A1 (en) 2002-02-01
PT1100880E (pt) 2011-01-13
ZA200100974B (en) 2002-06-26

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