BRPI1014123A2 - produção de isopreno melhorada usando o caminho dxp e mva. - Google Patents

produção de isopreno melhorada usando o caminho dxp e mva.

Info

Publication number
BRPI1014123A2
BRPI1014123A2 BRPI1014123A BRPI1014123A BRPI1014123A2 BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2 BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2
Authority
BR
Brazil
Prior art keywords
path
dxp
mva
isoprene production
improved isoprene
Prior art date
Application number
BRPI1014123A
Other languages
English (en)
Inventor
T Nielsen Alex
M Peres Caroline
H Wells Derek
V Vaviline Dmitrii
K Chotani Gopal
C Mcauliffe Joseph
Charles Miller Michael
Erin Muir Rachel
Weyler Walter
Quinn Beck Zachary
Original Assignee
Danisco Us Inc
Goodyear Tire & Rubber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Goodyear Tire & Rubber filed Critical Danisco Us Inc
Publication of BRPI1014123A2 publication Critical patent/BRPI1014123A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

produção de isopreno melhorada usando o caminho dxp e mva a presente invenção refere-se a métodos de produção de isopreno a partir de células cultivadas, com o uso de vários componentes do caminho dxp e caminho mva, ou componentes associados ao caminho dxp e ao caminho mva, polipeptídeos redox de interação por agrupamento ferro-enxofre e isopreno sintase. a invenção também fornece composições que incluem estas células cultivadas.
BRPI1014123A 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva. BRPI1014123A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18793009P 2009-06-17 2009-06-17
US18794109P 2009-06-17 2009-06-17
US31498510P 2010-03-17 2010-03-17
US31497910P 2010-03-17 2010-03-17
PCT/US2010/038904 WO2010148150A1 (en) 2009-06-17 2010-06-16 Improved isoprene production using the dxp and mva pathway

Publications (1)

Publication Number Publication Date
BRPI1014123A2 true BRPI1014123A2 (pt) 2019-07-02

Family

ID=43356749

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014123A BRPI1014123A2 (pt) 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva.

Country Status (10)

Country Link
US (2) US8507235B2 (pt)
EP (1) EP2443244A4 (pt)
CN (1) CN102753697A (pt)
AR (1) AR077115A1 (pt)
BR (1) BRPI1014123A2 (pt)
CA (1) CA2765805A1 (pt)
MY (1) MY158160A (pt)
SG (2) SG176936A1 (pt)
TW (2) TWI427149B (pt)
WO (1) WO2010148150A1 (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA201007564B (en) 2008-04-23 2012-01-25 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
US8470581B2 (en) * 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
US20100184178A1 (en) * 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
US20110039323A1 (en) * 2009-08-14 2011-02-17 Eric Lawrence Singsaas Isoprene Production
AU2010331946A1 (en) * 2009-12-18 2012-06-28 Danisco Us Inc. Purification of isoprene from renewable resources
JP5855576B2 (ja) * 2009-12-22 2016-02-09 ダニスコ・ユーエス・インク イソプレンガスの生成量を増大させるための膜バイオリアクター
WO2011160081A1 (en) 2010-06-17 2011-12-22 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
EP2601300A1 (en) 2010-08-06 2013-06-12 Danisco US Inc. Production of isoprene under neutral ph conditions
SG190043A1 (en) 2010-10-27 2013-06-28 Danisco Us Inc Isoprene synthase variants for improved production of isoprene
WO2012088462A1 (en) 2010-12-22 2012-06-28 Danisco Us Inc. Compositions and methods for improved isoprene production using two types of ispg enzymes
JP2014502844A (ja) 2010-12-22 2014-02-06 ダニスコ・ユーエス・インク 組み換え細胞による五炭糖の生物学的生産
WO2012135591A2 (en) * 2011-03-30 2012-10-04 Amyris, Inc. Microbial isoprenoid production using a heterologous dxp pathway
EP2702139A1 (en) 2011-04-29 2014-03-05 Danisco US Inc. Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
ES2699747T3 (es) 2011-04-29 2019-02-12 Danisco Us Inc Microorganismos recombinantes para la producción potenciada de mevalonato, isopreno e isoprenoides
EP2739658A1 (en) 2011-08-04 2014-06-11 Danisco US Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
US8951764B2 (en) 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
PL222067B1 (pl) * 2011-08-11 2016-06-30 Inst Biotechnologii I Antybiotyków Kaseta ekspresyjna, zastosowanie kasety ekspresyjnej, wektor ekspresyjny, komórka prokariotycznego gospodarza zawierająca wektor ekspresyjny, szczep bakteryjny oraz sposób wytwarzania polipeptydu
DK3339426T3 (da) 2011-10-07 2022-09-12 Danisco Us Inc Anvendelse af phosphoketolase i fremstillingen af mevalonat, isoprenoid-udgangsstoffer og isopren
BR112014010053A8 (pt) 2011-10-27 2017-06-20 Danisco Us Inc variantes de isopreno sintase com solubilidade aprimorada para produção de isopreno
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
JP2015510392A (ja) 2011-12-23 2015-04-09 ダニスコ・ユーエス・インク 低減したispa活性を有する宿主細胞を用いるイソプレン産生増強法
WO2013096863A1 (en) * 2011-12-23 2013-06-27 The Regents Of The University Of California Constructs and methods for improved isoprene biosynthesis
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
EP2898053B1 (en) 2012-09-20 2021-08-25 Danisco US Inc. Microtiter plates for controlled release of culture components to cell cultures
WO2014066892A1 (en) * 2012-10-26 2014-05-01 Coelho Pedro S De novo metabolic pathways for isoprene biosynthesis
EP2935364A2 (en) 2012-12-21 2015-10-28 Danisco US Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
CA2901588A1 (en) * 2013-03-07 2014-09-12 Calysta, Inc. Compositions and methods for biological production of isoprene
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
WO2014169144A2 (en) 2013-04-10 2014-10-16 Danisco Us Inc. Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids
CA2915980A1 (en) 2013-06-21 2014-12-24 Danisco Us Inc. Compositions and methods for clostridial transformation
CN103602626B (zh) * 2013-10-12 2016-02-10 中国科学院青岛生物能源与过程研究所 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌
CN103667153B (zh) * 2013-12-19 2015-05-13 中国石油大学(华东) 一株产聚3-羟基丁酸酯的嗜热菌
WO2015127305A2 (en) 2014-02-20 2015-08-27 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
WO2016015021A1 (en) 2014-07-24 2016-01-28 The Regents Of The University Of California Oxidative starch degradation by a new family of pmos
CA2939005C (en) 2014-09-17 2020-09-08 WCCO Belting, Inc. Environmentally friendly rubber composition
CN104372017B (zh) * 2014-11-05 2017-06-30 中国科学院青岛生物能源与过程研究所 一种提高基因工程菌异戊二烯及其衍生物产量的方法及应用
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CA3051472A1 (en) 2017-01-26 2018-08-02 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
US10662442B2 (en) * 2017-02-03 2020-05-26 Manus Bio Inc. Metabolic engineering for microbial production of terpenoid products
CN110468091B (zh) * 2018-05-09 2023-07-11 深圳艾格鑫科技有限公司 微生物及其用途
CN110468090B (zh) * 2018-05-09 2023-07-04 深圳艾格鑫科技有限公司 微生物及其用途
CN108715825B (zh) * 2018-06-01 2021-03-09 天津大学 基因过表达及获得的菌株、应用
CN109609424B (zh) * 2018-12-26 2020-07-31 浙江医药股份有限公司 用于生产法尼烯的大肠杆菌
US20220162188A1 (en) * 2019-01-15 2022-05-26 North Carolina State University Isoprenoids and methods of making thereof
EP3683227A1 (en) * 2019-01-16 2020-07-22 Biosyntia ApS Cell factories for improved production of compounds and proteins dependent on iron sulfur clusters

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8407828D0 (en) 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
NZ217373A (en) 1985-08-29 1990-10-26 Genencor Inc Production of heterologous peptide in filamentous fungi, vectors and dna
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
CA2097180C (en) 1990-12-10 2007-08-14 Timothy Fowler Saccharification of cellulose by cloning and amplification of the .beta.-glucosidase gene of trichoderma reesei
WO1995004134A1 (en) 1993-08-02 1995-02-09 Genencor International, Inc. Method of reducing complex carbohydrates in fermentation products
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US6176176B1 (en) 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
US6268328B1 (en) 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
US6316695B1 (en) * 1999-04-22 2001-11-13 Korea Kumho Petrochemical Co., Ltd. Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same
EP2281890A1 (en) * 2000-07-31 2011-02-09 Danisco US Inc. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU2002338340A1 (en) 2001-04-04 2002-10-21 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
US6998471B2 (en) 2001-07-25 2006-02-14 E.I. Du Pont De Nemours And Company Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods
EP1499709B1 (en) 2002-04-22 2012-01-04 E.I. Du Pont De Nemours And Company Promoter and plasmid system for genetic engineering
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
WO2005001036A2 (en) 2003-05-29 2005-01-06 Genencor International, Inc. Novel trichoderma genes
BRPI0416762A (pt) 2003-11-21 2007-02-27 Genencor Int expressão de enzimas hidrolisantes de amido granular em trinchoderma e processo para produzir glicose a partir de substratos de amido granular
US20050287625A1 (en) 2004-03-05 2005-12-29 Miller Edward S Jr Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
KR20120053088A (ko) * 2006-05-26 2012-05-24 아미리스 인코퍼레이티드 이소프레노이드의 생산 방법
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
WO2008128159A1 (en) 2007-04-16 2008-10-23 Amyris Biotechnologies, Inc. Production of isoprenoids
WO2009042070A2 (en) * 2007-09-20 2009-04-02 Amyris Biotechnologies, Inc. Production of isoprenoids
JP5262044B2 (ja) 2007-09-27 2013-08-14 凸版印刷株式会社 太陽電池裏面封止用シート及びこれを用いた太陽電池モジュール
SG191671A1 (en) 2007-12-13 2013-07-31 Danisco Us Inc Cultured cells that produce isoprene and methods for producing isoprene
US20090153993A1 (en) 2007-12-18 2009-06-18 Teradyne, Inc. Disk Drive Testing
WO2009100231A2 (en) 2008-02-06 2009-08-13 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
ZA201007564B (en) * 2008-04-23 2012-01-25 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
CA2729801A1 (en) 2008-07-02 2010-01-07 Danisco Us Inc. Compositions and methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
US8470581B2 (en) 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
CA2737195A1 (en) 2008-09-15 2010-03-18 The Goodyear Tire & Rubber Company Conversion of prenyl derivatives to isoprene
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
CA2737236A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Systems using cell culture for production of isoprene
US20100184178A1 (en) 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
JP5793424B2 (ja) 2008-12-30 2015-10-14 ダニスコ・ユーエス・インク イソプレンと副生成物の産出方法
US20100297749A1 (en) 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) 2009-06-17 2014-02-21 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
EP2477478B1 (en) 2009-09-15 2016-11-30 Sapphire Energy, Inc. A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
AU2010331946A1 (en) 2009-12-18 2012-06-28 Danisco Us Inc. Purification of isoprene from renewable resources
SG190043A1 (en) 2010-10-27 2013-06-28 Danisco Us Inc Isoprene synthase variants for improved production of isoprene
WO2012088462A1 (en) 2010-12-22 2012-06-28 Danisco Us Inc. Compositions and methods for improved isoprene production using two types of ispg enzymes
JP2014502844A (ja) 2010-12-22 2014-02-06 ダニスコ・ユーエス・インク 組み換え細胞による五炭糖の生物学的生産

Also Published As

Publication number Publication date
MY158160A (en) 2016-09-15
WO2010148150A1 (en) 2010-12-23
AR077115A1 (es) 2011-08-03
EP2443244A1 (en) 2012-04-25
TWI427149B (zh) 2014-02-21
TW201412988A (zh) 2014-04-01
CA2765805A1 (en) 2010-12-23
US8507235B2 (en) 2013-08-13
SG10201403297UA (en) 2014-10-30
CN102753697A (zh) 2012-10-24
US20110014672A1 (en) 2011-01-20
EP2443244A4 (en) 2014-11-26
US20140162337A1 (en) 2014-06-12
TW201111512A (en) 2011-04-01
SG176936A1 (en) 2012-02-28

Similar Documents

Publication Publication Date Title
BRPI1014123A2 (pt) produção de isopreno melhorada usando o caminho dxp e mva.
BR112012030197A2 (pt) diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase.
BRPI0823506A8 (pt) composições e métodos para a produção de isoprene
MY161071A (en) Methods of producing isoprene and a co-product
WO2010031076A3 (en) Conversion of prenyl derivatives to isoprene
MY156256A (en) Compositions and methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
BR112013010551A8 (pt) variantes de isopreno sintase para produção aprimorada de isopreno
MX2011013700A (es) Cepa talaromyces y composiciones de enzimas.
MX2012004310A (es) Metodo para caracterizar almenos un microorganismo por medio de espectrometria de masa.
BR112015018783A2 (pt) mistura íntima seca, composição, método de preparação de uma mistura íntima seca e método de aumento da germinação, crescimento, metabolismo e/ou atividade enzimática de esporos bacterianos
BR112013031414A2 (pt) métodos para converter material lignocelulósico em produtos úteis
BR112014015910A2 (pt) composição
BR112013031307A2 (pt) métodos para tratamento de material lignocelulósico
BR112013007441A2 (pt) produção de alfa-olefinas usando sintases de policetídeo
BR112014027303A2 (pt) identificação de variantes de isopreno sintase com propriedades optimizadas para a produção de isopreno
BR112012033493A2 (pt) 1-hidróxi-octa-hidroazulenos como fragrâncias
BR112013009083A8 (pt) anticorpos humanos de oncostatin m e métodos de uso
MX337203B (es) Novedosas moleculas inhbidoras de jnk.
BR112012012192A2 (pt) b-glicosidades variantes recombinantes thermoascus aurantiacus para produção de açúcares fermentáveis a partir da biomassa celulósica
BR112012015583A2 (pt) métodos para purificação de cucurbiturila
WO2010030091A3 (ko) 생물학적 헴철 생산 방법 및 그에 의해 생산된 헴철 추출물을 포함하는 철분보충 조성물
MY182946A (en) Production of organic acids by fermentation at low ph
FI20115328A0 (fi) Uusia kutinaaseja, niiden tuottaminen ja käytöt
LT2013016A (lt) Aktyvuotos-potencijuotos formos antikūno poveikio padidinimo būdas
EA201490275A1 (ru) Композиции и способы получения изопрена

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2531 DE 09-07-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]