BRPI0923589A2 - uso de uma composição espumável essencialmente livre de ingredientes farmaceuticamente ativos para o tratamento da pele humana. - Google Patents

uso de uma composição espumável essencialmente livre de ingredientes farmaceuticamente ativos para o tratamento da pele humana.

Info

Publication number
BRPI0923589A2
BRPI0923589A2 BRPI0923589A BRPI0923589A BRPI0923589A2 BR PI0923589 A2 BRPI0923589 A2 BR PI0923589A2 BR PI0923589 A BRPI0923589 A BR PI0923589A BR PI0923589 A BRPI0923589 A BR PI0923589A BR PI0923589 A2 BRPI0923589 A2 BR PI0923589A2
Authority
BR
Brazil
Prior art keywords
treatment
active ingredients
pharmaceutically active
human skin
essentially free
Prior art date
Application number
BRPI0923589A
Other languages
English (en)
Inventor
Gerald Städtler
Klaus Graupe
Original Assignee
Intendis Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40796237&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923589(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intendis Gmbh filed Critical Intendis Gmbh
Publication of BRPI0923589A2 publication Critical patent/BRPI0923589A2/pt
Publication of BRPI0923589B1 publication Critical patent/BRPI0923589B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/046Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/122Foams; Dry foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
BRPI0923589-2A 2008-12-23 2009-12-22 Uso de uma composição espumável essencialmente livre de ingredientes farmaceuticamente ativos para tratamento da pele humana, e recipiente com uma válvula de saída BRPI0923589B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14015208P 2008-12-23 2008-12-23
US61/140,152 2008-12-23
EP08022333A EP2210588B1 (en) 2008-12-23 2008-12-23 Foamable composition essentially free of pharmaceutically active ingredients for the treatment of human skin
EP08022333.2 2008-12-23
PCT/EP2009/009350 WO2010072422A1 (en) 2008-12-23 2009-12-22 Use of a foamable composition essentially free of pharmaceutically active ingredients for the treatment of human skin

Publications (2)

Publication Number Publication Date
BRPI0923589A2 true BRPI0923589A2 (pt) 2016-07-26
BRPI0923589B1 BRPI0923589B1 (pt) 2019-04-24

Family

ID=40796237

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923589-2A BRPI0923589B1 (pt) 2008-12-23 2009-12-22 Uso de uma composição espumável essencialmente livre de ingredientes farmaceuticamente ativos para tratamento da pele humana, e recipiente com uma válvula de saída

Country Status (34)

Country Link
US (2) US8658138B2 (pt)
EP (2) EP2210588B1 (pt)
JP (2) JP5795261B2 (pt)
KR (1) KR20110103972A (pt)
CN (1) CN102325522B (pt)
AR (1) AR074839A1 (pt)
AT (1) ATE500817T1 (pt)
AU (1) AU2009331845B2 (pt)
BR (1) BRPI0923589B1 (pt)
CA (1) CA2748346C (pt)
CL (1) CL2011001468A1 (pt)
CO (1) CO6390034A2 (pt)
CR (1) CR20110337A (pt)
CU (1) CU20110132A7 (pt)
DE (1) DE602008005497D1 (pt)
DK (2) DK2210588T3 (pt)
EA (1) EA021762B1 (pt)
EC (1) ECSP11011137A (pt)
ES (2) ES2364692T3 (pt)
HK (1) HK1166263A1 (pt)
HR (2) HRP20110429T1 (pt)
HU (1) HUE034651T2 (pt)
IL (1) IL213359A (pt)
MX (1) MX2011006381A (pt)
NZ (1) NZ593575A (pt)
PE (1) PE20120109A1 (pt)
PL (2) PL2210588T3 (pt)
PT (2) PT2210588E (pt)
SG (1) SG171948A1 (pt)
SV (1) SV2011003948A (pt)
TW (1) TW201034695A (pt)
UA (1) UA106062C2 (pt)
WO (1) WO2010072422A1 (pt)
ZA (1) ZA201104600B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
MXPA05004278A (es) 2002-10-25 2005-10-05 Foamix Ltd Espuma cosmetica y farmaceutica.
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
PL2210588T3 (pl) * 2008-12-23 2011-09-30 Intendis Gmbh Kompozycje pianotwórcze do leczenia skóry ludzkiej zasadniczo niezawierające aktywnych składników farmaceutycznych
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
BRPI0925099A2 (pt) * 2009-06-24 2018-10-16 Strategic Science & Tech Llc composição tópica contendo ibuprofeno
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
WO2011039638A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Topical tetracycline compositions
CN103429247A (zh) 2010-12-29 2013-12-04 战略科学与技术有限责任公司 ***功能障碍和其它适应症的治疗
FR2994386B1 (fr) * 2012-08-07 2016-06-24 Thorel Jean-Noel Inhibition de l'adhesion de micro-organismes pathogenes par un ester de saccharose et/ou de sorbitan dans le traitement cosmetique de l'atopie cutanee
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
CN108938674A (zh) * 2017-05-27 2018-12-07 福建省山河药业有限公司 红色诺卡氏菌细胞壁骨架在制备治疗皮肤病变药物中的用途
FR3069775B1 (fr) * 2017-08-02 2020-02-14 Roquette Freres 1,4 :3,6 dianhydrohexitols pour hydrater la peau
MX2021009602A (es) * 2019-03-06 2021-09-08 Isdin Sa Uso de trigliceridos caprilicos y capricos para el tratamiento de una enfermedad o afeccion mediada por deficiencia de filagrina o colageno.
JP2020048566A (ja) 2019-11-20 2020-04-02 ハスクバーナ・アーベー インテリジェント散水システム

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423323B2 (en) * 1997-08-18 2002-07-23 Stephanie Neubourg Foam skin cream, uses of the foam skin protection cream and a process for its preparation
DE29825037U1 (de) * 1997-08-18 2004-04-29 Neubourg, Stephanie Schaum-Hautcreme mit Harnstoff
GB9903639D0 (en) * 1999-02-17 1999-04-07 Unilever Plc Liquid cleansing composition
JP4190303B2 (ja) * 2002-02-18 2008-12-03 日本精化株式会社 カチオン性共重合体
IL152486A0 (en) * 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9265725B2 (en) * 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7704518B2 (en) * 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
MXPA05004278A (es) 2002-10-25 2005-10-05 Foamix Ltd Espuma cosmetica y farmaceutica.
US10117812B2 (en) * 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
AU2004261063A1 (en) 2003-08-04 2005-02-10 Foamix Ltd. Foam carrier containing amphiphilic copolymeric gelling agent
EP2977043A3 (en) * 2003-08-25 2016-04-06 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
JP4722434B2 (ja) * 2004-08-31 2011-07-13 株式会社ダイゾー 発泡性エアゾール組成物
CA2610662A1 (en) * 2005-05-09 2007-05-18 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
EP2029106A2 (en) * 2006-06-07 2009-03-04 Foamix Ltd. Foamable vehicle comprising polypropylene glycol alkyl ether and pharmaceutical compositions thereof
MX2009002536A (es) * 2006-09-08 2009-04-14 Foamix Ltd Composicion espumable coloreada o coloreable y espuma.
JP4851907B2 (ja) * 2006-10-05 2012-01-11 Necディスプレイソリューションズ株式会社 ポンプユニットおよびそれを用いたプロジェクタ
PL2210588T3 (pl) * 2008-12-23 2011-09-30 Intendis Gmbh Kompozycje pianotwórcze do leczenia skóry ludzkiej zasadniczo niezawierające aktywnych składników farmaceutycznych

Also Published As

Publication number Publication date
US20100247449A1 (en) 2010-09-30
UA106062C2 (uk) 2014-07-25
CN102325522B (zh) 2013-12-25
CU20110132A7 (es) 2012-01-31
CA2748346C (en) 2017-08-22
DK2381925T3 (da) 2017-06-26
EP2381925A1 (en) 2011-11-02
AR074839A1 (es) 2011-02-16
MX2011006381A (es) 2011-09-27
ZA201104600B (en) 2022-03-30
IL213359A (en) 2014-09-30
BRPI0923589B1 (pt) 2019-04-24
DK2210588T3 (da) 2011-06-27
HRP20110429T1 (hr) 2011-08-31
ES2628218T3 (es) 2017-08-02
KR20110103972A (ko) 2011-09-21
SV2011003948A (es) 2011-12-06
US20140190854A1 (en) 2014-07-10
CN102325522A (zh) 2012-01-18
ES2364692T3 (es) 2011-09-12
US8986658B2 (en) 2015-03-24
EA201170876A1 (ru) 2012-02-28
PT2381925T (pt) 2017-06-23
EP2210588B1 (en) 2011-03-09
NZ593575A (en) 2013-08-30
JP2015157860A (ja) 2015-09-03
PE20120109A1 (es) 2012-02-08
TW201034695A (en) 2010-10-01
IL213359A0 (en) 2011-07-31
CL2011001468A1 (es) 2012-02-17
JP5795261B2 (ja) 2015-10-14
HK1166263A1 (en) 2012-10-26
CR20110337A (es) 2011-12-28
EA021762B1 (ru) 2015-08-31
AU2009331845B2 (en) 2015-11-12
DE602008005497D1 (de) 2011-04-21
SG171948A1 (en) 2011-07-28
CO6390034A2 (es) 2012-02-29
AU2009331845A1 (en) 2011-06-30
PL2381925T3 (pl) 2017-09-29
HRP20170865T1 (hr) 2017-09-08
HUE034651T2 (en) 2018-02-28
EP2381925B1 (en) 2017-03-15
EP2210588A1 (en) 2010-07-28
ECSP11011137A (es) 2011-08-31
CA2748346A1 (en) 2010-07-01
JP2012513430A (ja) 2012-06-14
PL2210588T3 (pl) 2011-09-30
ATE500817T1 (de) 2011-03-15
WO2010072422A1 (en) 2010-07-01
US8658138B2 (en) 2014-02-25
PT2210588E (pt) 2011-06-07

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