BRPI0921669A2 - piperazina de arila e seu uso como antagonistas alfa 2c - Google Patents
piperazina de arila e seu uso como antagonistas alfa 2cInfo
- Publication number
- BRPI0921669A2 BRPI0921669A2 BRPI0921669A BRPI0921669A BRPI0921669A2 BR PI0921669 A2 BRPI0921669 A2 BR PI0921669A2 BR PI0921669 A BRPI0921669 A BR PI0921669A BR PI0921669 A BRPI0921669 A BR PI0921669A BR PI0921669 A2 BRPI0921669 A2 BR PI0921669A2
- Authority
- BR
- Brazil
- Prior art keywords
- antagonists
- alpha
- aryl piperazine
- piperazine
- aryl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- -1 aryl piperazine Chemical compound 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19335508P | 2008-11-20 | 2008-11-20 | |
| PCT/FI2009/000097 WO2010058060A1 (en) | 2008-11-20 | 2009-11-20 | Aryl piperazine and their use as alpha2c antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0921669A2 true BRPI0921669A2 (pt) | 2018-06-26 |
Family
ID=41490335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921669A BRPI0921669A2 (pt) | 2008-11-20 | 2009-11-20 | piperazina de arila e seu uso como antagonistas alfa 2c |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20110262352A1 (pt) |
| EP (1) | EP2364303A1 (pt) |
| JP (1) | JP5513515B2 (pt) |
| KR (1) | KR20110086747A (pt) |
| CN (1) | CN102216282A (pt) |
| AR (1) | AR074204A1 (pt) |
| AU (1) | AU2009317117A1 (pt) |
| BR (1) | BRPI0921669A2 (pt) |
| CA (1) | CA2741986A1 (pt) |
| CO (1) | CO6382156A2 (pt) |
| EA (1) | EA201170711A1 (pt) |
| GE (1) | GEP20135959B (pt) |
| IL (1) | IL212571A0 (pt) |
| MA (1) | MA32818B1 (pt) |
| MX (1) | MX2011005367A (pt) |
| NZ (1) | NZ592571A (pt) |
| TN (1) | TN2011000218A1 (pt) |
| TW (1) | TW201024282A (pt) |
| UA (1) | UA105647C2 (pt) |
| WO (1) | WO2010058060A1 (pt) |
| ZA (1) | ZA201103462B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201139406A (en) * | 2010-01-14 | 2011-11-16 | Glaxo Group Ltd | Voltage-gated sodium channel blockers |
| JOP20200052A1 (ar) * | 2013-12-19 | 2017-06-16 | Bayer Pharma AG | بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c |
| PE20160842A1 (es) * | 2013-12-19 | 2016-09-24 | Bayer Pharma AG | Piperidiniltetrahidroquinolinas sustituidas |
| CN106029657A (zh) * | 2013-12-19 | 2016-10-12 | 拜耳制药股份公司 | 作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物 |
| CN106029648A (zh) * | 2013-12-19 | 2016-10-12 | 拜耳制药股份公司 | 作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物 |
| TWI704145B (zh) * | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
| EA201990158A1 (ru) | 2016-06-29 | 2019-05-31 | Орион Корпорейшн | Производные бензодиоксана и их фармацевтическое применение |
| MA53711A (fr) | 2018-09-25 | 2021-12-29 | Bayer Ag | Antagonistes de récepteur alpha 2-adrénergiques de sous-type c (alpha-2c) pour le traitement de l'apnée du sommeil |
| WO2020225188A1 (en) | 2019-05-09 | 2020-11-12 | Bayer Aktiengesellschaft | COMBINATION OF AN α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA |
| EP3965766A1 (en) * | 2019-05-09 | 2022-03-16 | Bayer Aktiengesellschaft | Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| CN110615774B (zh) * | 2019-09-19 | 2022-11-11 | 安徽中医药大学 | 具有抗炎活性的苄基哌嗪类化合物、制法及医药用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2695295A (en) * | 1952-12-19 | 1954-11-23 | Mcneilab Inc | Unsymmetrical n, n'-substituted ethylenediamine and piperazine compounds |
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| JPS5515456A (en) * | 1978-07-19 | 1980-02-02 | Morishita Seiyaku Kk | 2-substituted-piperazinomethyl-1,4-benzodioxane |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| FI20000480A0 (fi) | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
| WO2003029239A1 (en) * | 2001-10-04 | 2003-04-10 | Wyeth | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands |
| PL372657A1 (en) | 2002-04-03 | 2005-07-25 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
| US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| WO2004067513A1 (en) | 2003-01-27 | 2004-08-12 | Oy Juvantia Pharma Ltd | Antagonists for alpha-2 adrenoceptors |
| TWI457122B (zh) * | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物 |
-
2009
- 2009-11-19 TW TW098139249A patent/TW201024282A/zh unknown
- 2009-11-20 WO PCT/FI2009/000097 patent/WO2010058060A1/en active Application Filing
- 2009-11-20 GE GEAP200912264A patent/GEP20135959B/en unknown
- 2009-11-20 AR ARP090104487A patent/AR074204A1/es not_active Application Discontinuation
- 2009-11-20 CN CN2009801455410A patent/CN102216282A/zh active Pending
- 2009-11-20 UA UAA201107596A patent/UA105647C2/uk unknown
- 2009-11-20 EA EA201170711A patent/EA201170711A1/ru unknown
- 2009-11-20 JP JP2011536911A patent/JP5513515B2/ja not_active Expired - Fee Related
- 2009-11-20 NZ NZ592571A patent/NZ592571A/xx not_active IP Right Cessation
- 2009-11-20 BR BRPI0921669A patent/BRPI0921669A2/pt not_active IP Right Cessation
- 2009-11-20 MX MX2011005367A patent/MX2011005367A/es not_active Application Discontinuation
- 2009-11-20 EP EP09763985A patent/EP2364303A1/en not_active Withdrawn
- 2009-11-20 KR KR1020117014010A patent/KR20110086747A/ko not_active Application Discontinuation
- 2009-11-20 CA CA2741986A patent/CA2741986A1/en not_active Abandoned
- 2009-11-20 US US13/130,102 patent/US20110262352A1/en not_active Abandoned
- 2009-11-20 AU AU2009317117A patent/AU2009317117A1/en not_active Abandoned
-
2011
- 2011-04-28 IL IL212571A patent/IL212571A0/en unknown
- 2011-05-05 TN TN2011000218A patent/TN2011000218A1/fr unknown
- 2011-05-11 ZA ZA2011/03462A patent/ZA201103462B/en unknown
- 2011-05-20 MA MA33873A patent/MA32818B1/fr unknown
- 2011-05-23 CO CO11063228A patent/CO6382156A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010058060A1 (en) | 2010-05-27 |
| AR074204A1 (es) | 2010-12-29 |
| NZ592571A (en) | 2013-03-28 |
| EP2364303A1 (en) | 2011-09-14 |
| MA32818B1 (fr) | 2011-11-01 |
| US20110262352A1 (en) | 2011-10-27 |
| AU2009317117A1 (en) | 2010-05-27 |
| UA105647C2 (uk) | 2014-06-10 |
| JP5513515B2 (ja) | 2014-06-04 |
| CO6382156A2 (es) | 2012-02-15 |
| CN102216282A (zh) | 2011-10-12 |
| EA201170711A1 (ru) | 2012-01-30 |
| MX2011005367A (es) | 2011-06-20 |
| TN2011000218A1 (en) | 2012-12-17 |
| IL212571A0 (en) | 2011-06-30 |
| GEP20135959B (en) | 2013-11-11 |
| JP2012509302A (ja) | 2012-04-19 |
| ZA201103462B (en) | 2012-01-25 |
| KR20110086747A (ko) | 2011-07-29 |
| CA2741986A1 (en) | 2010-05-27 |
| TW201024282A (en) | 2010-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2478 DE 03-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |