BRPI0919937A2 - composto, e, método para melhorar a atividade de adjuvante de uma imidazoquinolina - Google Patents
composto, e, método para melhorar a atividade de adjuvante de uma imidazoquinolinaInfo
- Publication number
- BRPI0919937A2 BRPI0919937A2 BRPI0919937A BRPI0919937A BRPI0919937A2 BR PI0919937 A2 BRPI0919937 A2 BR PI0919937A2 BR PI0919937 A BRPI0919937 A BR PI0919937A BR PI0919937 A BRPI0919937 A BR PI0919937A BR PI0919937 A2 BRPI0919937 A2 BR PI0919937A2
- Authority
- BR
- Brazil
- Prior art keywords
- imidazoquinoline
- enhancing
- compound
- adjuvant activity
- adjuvant
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title 1
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 229940124669 imidazoquinoline Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10821008P | 2008-10-24 | 2008-10-24 | |
| US22422609P | 2009-07-09 | 2009-07-09 | |
| US22993309P | 2009-07-30 | 2009-07-30 | |
| PCT/US2009/061867 WO2010048520A1 (en) | 2008-10-24 | 2009-10-23 | Lipidated imidazoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0919937A2 true BRPI0919937A2 (pt) | 2016-02-16 |
Family
ID=42119702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919937A BRPI0919937A2 (pt) | 2008-10-24 | 2009-10-23 | composto, e, método para melhorar a atividade de adjuvante de uma imidazoquinolina |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8624029B2 (pt) |
| EP (1) | EP2341933B1 (pt) |
| JP (1) | JP5695569B2 (pt) |
| KR (1) | KR20110077004A (pt) |
| CN (1) | CN102264394B (pt) |
| AU (1) | AU2009308278B2 (pt) |
| BR (1) | BRPI0919937A2 (pt) |
| CA (1) | CA2741291A1 (pt) |
| CY (1) | CY1119981T1 (pt) |
| DK (1) | DK2341933T3 (pt) |
| ES (1) | ES2656813T3 (pt) |
| HR (1) | HRP20180063T1 (pt) |
| HU (1) | HUE036531T2 (pt) |
| IL (1) | IL212417A (pt) |
| LT (1) | LT2341933T (pt) |
| MX (1) | MX2011004249A (pt) |
| NO (1) | NO2341933T3 (pt) |
| PL (1) | PL2341933T3 (pt) |
| PT (1) | PT2341933T (pt) |
| SI (1) | SI2341933T1 (pt) |
| TR (1) | TR201802083T4 (pt) |
| WO (1) | WO2010048520A1 (pt) |
| ZA (1) | ZA201103590B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20120106A1 (es) | 2008-12-09 | 2012-02-20 | Gilead Sciences Inc | Moduladores de receptores tipo toll |
| PL2491035T3 (pl) | 2009-10-22 | 2018-01-31 | Gilead Sciences Inc | Pochodne puryny lub deazapuryny przydatne do leczenia (między innymi) infekcji wirusowych |
| GB201009273D0 (en) | 2010-06-03 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel vaccine |
| CA2810011A1 (en) * | 2010-09-01 | 2012-03-08 | Novartis Ag | Adsorption of immunopotentiators to insoluble metal salts |
| US8728486B2 (en) | 2011-05-18 | 2014-05-20 | University Of Kansas | Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| EP2638896A1 (en) * | 2012-03-14 | 2013-09-18 | Bioneer A/S | Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood |
| EP2674170B1 (en) | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
| EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
| US20140242112A1 (en) * | 2012-11-30 | 2014-08-28 | Glaxosmithkline Biologicals S.A. | Novel vaccine |
| EP2769738B1 (en) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
| US9295732B2 (en) | 2013-02-22 | 2016-03-29 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
| WO2015023958A1 (en) * | 2013-08-15 | 2015-02-19 | The University Of Kansas | Toll-like receptor agonists |
| GB201321242D0 (en) | 2013-12-02 | 2014-01-15 | Immune Targeting Systems Its Ltd | Immunogenic compound |
| US10821175B2 (en) | 2014-02-25 | 2020-11-03 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| BR112017000528A2 (pt) | 2014-07-11 | 2017-11-14 | Gilead Sciences Inc | moduladores dos receptores toll-like para o tratamento do hiv |
| KR20190125537A (ko) | 2014-09-16 | 2019-11-06 | 길리애드 사이언시즈, 인코포레이티드 | 톨-유사 수용체 조정제의 고체 형태 |
| BE1023340B1 (fr) | 2014-11-13 | 2017-02-08 | Glaxosmithkline Biologicals S.A. | Composes |
| WO2017021912A1 (en) | 2015-08-06 | 2017-02-09 | Glaxosmithkline Intellectual Property Development Limited | Combined tlrs modulators with anti ox40 antibodies |
| EP3355933B1 (en) | 2015-09-29 | 2020-05-06 | Sumitomo Dainippon Pharma Co., Ltd. | Adenine conjugate compounds and their use as vaccine adjuvants |
| PL3868741T3 (pl) | 2015-10-07 | 2024-01-29 | Sumitomo Pharma Co., Ltd. | Kompozycja zawierająca związek pirymidynowy i antygen pochodzący od patogenu |
| CA3008054A1 (en) | 2015-12-14 | 2017-06-22 | Glaxosmithkline Biologicals S.A. | Phospholipidation of imidazoquinolines and oxoadenines |
| WO2017102652A1 (en) * | 2015-12-14 | 2017-06-22 | Glaxosmithkline Biologicals S.A. | Pegylated imidazoquinolines as tlr7 and tlr8 agonists |
| US9966457B2 (en) * | 2016-03-18 | 2018-05-08 | Globalfoundries Inc. | Transistor structure with varied gate cross-sectional area |
| BE1024865B1 (fr) * | 2016-09-07 | 2018-07-31 | Glaxosmithkline Biologicals Sa | Derives d'imidazoquinoleine |
| US11253476B2 (en) | 2017-03-29 | 2022-02-22 | Sumitomo Dainippon Pharma Co., Ltd. | Vaccine adjuvant formulation |
| CN111757755A (zh) | 2017-12-21 | 2020-10-09 | 大日本住友制药株式会社 | 包含tlr7激动剂的组合药物 |
| CN112839673A (zh) | 2018-07-23 | 2021-05-25 | 日本国立感染症研究所所长代表之日本国 | 包含流感疫苗的组合物 |
| KR20220018503A (ko) | 2019-05-23 | 2022-02-15 | 더 유니버시티 오브 몬타나 | Tlr 수용체 리간드에 기반한 백신 애주번트 |
| CN112778372A (zh) * | 2019-11-11 | 2021-05-11 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
| US20230373997A1 (en) * | 2020-10-08 | 2023-11-23 | Icahn School Of Medicine At Mount Sinai | Imdq-peg-chol adjuvant and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ285420B6 (cs) * | 1990-04-24 | 1999-08-11 | Ústav Organické Chemie A Biochemie Avčr | N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití |
| US5466467A (en) * | 1994-03-30 | 1995-11-14 | The United States Of America As Represented By The Secretary Of The Navy | Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes |
| JP2005519990A (ja) * | 2001-10-12 | 2005-07-07 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | イミダゾキノリン化合物を用いて免疫応答を増強するための方法および産物 |
| CA2495570C (en) * | 2002-08-15 | 2012-12-04 | 3M Innovative Properties Company | Immunostimulatory compositions and methods of stimulating an immune response |
| US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| JP2007514644A (ja) | 2003-04-10 | 2007-06-07 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫反応を向上させる方法および組成物 |
| ES2544477T3 (es) * | 2003-10-03 | 2015-08-31 | 3M Innovative Properties Company | Imidazoquinolinas sustituidas con alcoxi |
| EP1550458A1 (en) * | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| US20060051374A1 (en) * | 2004-04-28 | 2006-03-09 | 3M Innovative Properties Company | Compositions and methods for mucosal vaccination |
| US8907153B2 (en) * | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| BRPI0515316A (pt) * | 2004-09-14 | 2008-07-15 | Chiron Corp | compostos de imidazoquinolina |
| CA2634349A1 (en) * | 2005-12-23 | 2007-06-28 | Jado Technologies Gmbh | Means and methods for the treatment and prevention of allergic diseases |
-
2009
- 2009-10-23 KR KR1020117011672A patent/KR20110077004A/ko active IP Right Grant
- 2009-10-23 EP EP09822779.6A patent/EP2341933B1/en active Active
- 2009-10-23 TR TR2018/02083T patent/TR201802083T4/tr unknown
- 2009-10-23 PT PT98227796T patent/PT2341933T/pt unknown
- 2009-10-23 CA CA2741291A patent/CA2741291A1/en not_active Abandoned
- 2009-10-23 US US13/125,342 patent/US8624029B2/en active Active
- 2009-10-23 LT LTEP09822779.6T patent/LT2341933T/lt unknown
- 2009-10-23 CN CN200980153132.5A patent/CN102264394B/zh not_active Expired - Fee Related
- 2009-10-23 WO PCT/US2009/061867 patent/WO2010048520A1/en active Application Filing
- 2009-10-23 DK DK09822779.6T patent/DK2341933T3/da active
- 2009-10-23 ES ES09822779.6T patent/ES2656813T3/es active Active
- 2009-10-23 SI SI200931796T patent/SI2341933T1/en unknown
- 2009-10-23 MX MX2011004249A patent/MX2011004249A/es active IP Right Grant
- 2009-10-23 PL PL09822779T patent/PL2341933T3/pl unknown
- 2009-10-23 HU HUE09822779A patent/HUE036531T2/hu unknown
- 2009-10-23 AU AU2009308278A patent/AU2009308278B2/en not_active Ceased
- 2009-10-23 JP JP2011533375A patent/JP5695569B2/ja not_active Expired - Fee Related
- 2009-10-23 NO NO09822779A patent/NO2341933T3/no unknown
- 2009-10-23 BR BRPI0919937A patent/BRPI0919937A2/pt not_active IP Right Cessation
-
2011
- 2011-04-17 IL IL212417A patent/IL212417A/en active IP Right Grant
- 2011-05-16 ZA ZA2011/03590A patent/ZA201103590B/en unknown
-
2013
- 2013-12-20 US US14/135,900 patent/US8946421B2/en active Active
-
2018
- 2018-01-15 HR HRP20180063TT patent/HRP20180063T1/hr unknown
- 2018-01-23 CY CY20181100086T patent/CY1119981T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2656813T3 (es) | 2018-02-28 |
| WO2010048520A1 (en) | 2010-04-29 |
| PT2341933T (pt) | 2018-02-13 |
| EP2341933A4 (en) | 2012-03-14 |
| CY1119981T1 (el) | 2018-12-12 |
| IL212417A (en) | 2017-01-31 |
| CN102264394A (zh) | 2011-11-30 |
| EP2341933A1 (en) | 2011-07-13 |
| JP5695569B2 (ja) | 2015-04-08 |
| PL2341933T3 (pl) | 2018-04-30 |
| SI2341933T1 (en) | 2018-03-30 |
| KR20110077004A (ko) | 2011-07-06 |
| US8624029B2 (en) | 2014-01-07 |
| ZA201103590B (en) | 2012-10-31 |
| DK2341933T3 (da) | 2018-01-29 |
| AU2009308278B2 (en) | 2014-11-27 |
| AU2009308278A1 (en) | 2010-04-29 |
| US20110282061A1 (en) | 2011-11-17 |
| NO2341933T3 (pt) | 2018-04-21 |
| MX2011004249A (es) | 2011-07-20 |
| IL212417A0 (en) | 2011-06-30 |
| HUE036531T2 (hu) | 2018-07-30 |
| CN102264394B (zh) | 2014-01-01 |
| HRP20180063T1 (hr) | 2018-02-23 |
| CA2741291A1 (en) | 2010-04-29 |
| JP2012506865A (ja) | 2012-03-22 |
| TR201802083T4 (tr) | 2018-03-21 |
| LT2341933T (lt) | 2018-04-10 |
| US20140323731A1 (en) | 2014-10-30 |
| EP2341933B1 (en) | 2017-11-22 |
| US8946421B2 (en) | 2015-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2538 DE 27-08-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |