BRPI0912175A2 - métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado - Google Patents

métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado

Info

Publication number
BRPI0912175A2
BRPI0912175A2 BRPI0912175A BRPI0912175A BRPI0912175A2 BR PI0912175 A2 BRPI0912175 A2 BR PI0912175A2 BR PI0912175 A BRPI0912175 A BR PI0912175A BR PI0912175 A BRPI0912175 A BR PI0912175A BR PI0912175 A2 BRPI0912175 A2 BR PI0912175A2
Authority
BR
Brazil
Prior art keywords
liver enzyme
enzyme induction
identify
substance
individual
Prior art date
Application number
BRPI0912175A
Other languages
English (en)
Inventor
Alexandre Prokoudine
Bennard Van Ravenzwaay
Edgar Leibold
Eric Fabian
Georgia Coelho Palermo Cunha
Hennicke Kamp
Jan C Wiemer
Michael Manfred Herold
Ralf Looser
Timann B Walk
Volker Strauss
Werner Mellert
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of BRPI0912175A2 publication Critical patent/BRPI0912175A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
BRPI0912175A 2008-05-28 2009-05-25 métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado BRPI0912175A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08157077 2008-05-28
EP09151546 2009-01-28
PCT/EP2009/056312 WO2009153131A1 (en) 2008-05-28 2009-05-25 Means and methods for assessing liver enzyme induction

Publications (1)

Publication Number Publication Date
BRPI0912175A2 true BRPI0912175A2 (pt) 2015-10-06

Family

ID=41151807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912175A BRPI0912175A2 (pt) 2008-05-28 2009-05-25 métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado

Country Status (9)

Country Link
US (1) US8808979B2 (pt)
EP (1) EP2286235A1 (pt)
JP (2) JP2011522231A (pt)
CN (1) CN102105793A (pt)
AU (1) AU2009259535B2 (pt)
BR (1) BRPI0912175A2 (pt)
CA (1) CA2724512A1 (pt)
DE (1) DE112009001245T5 (pt)
WO (1) WO2009153131A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2529235B1 (en) 2010-01-29 2019-03-06 Metanomics GmbH Means and methods for diagnosing heart failure in a subject
JP5837581B2 (ja) * 2010-06-10 2015-12-24 メタノミクス ヘルス ゲーエムベーハー 肝疾患を診断する方法
WO2022187228A1 (en) * 2021-03-01 2022-09-09 Board Of Regents, The University Of Texas System Methods of detecting advanced liver fibrosis or hepatocellular carcinoma biomarkers in a sample

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
GB9519490D0 (en) * 1995-09-25 1995-11-29 Melvin William T Use of a cytochrome P450 enzyme in tumour cells as a marker and target
EP2462932A1 (en) * 2002-01-07 2012-06-13 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
AU2003219713A1 (en) * 2002-02-04 2003-09-02 Gene Logic, Inc. Primary rat hepatocyte toxicity modeling
JP2003304888A (ja) * 2002-03-14 2003-10-28 F Hoffmann La Roche Ag 化合物の毒性予測のための方法
CN1627955A (zh) * 2002-03-26 2005-06-15 科学与工业研究委员会 余甘子对与细胞色素p－450有关的肝毒性的治疗作用
WO2005034876A2 (en) * 2003-10-10 2005-04-21 Multicell Technologies, Inc. Use of cell lines to produce active therapeutic proteins
WO2005109006A1 (ja) * 2004-04-23 2005-11-17 Ajinomoto Co., Inc. 非アルコール性脂肪肝炎鑑別方法
US7645584B2 (en) * 2005-04-01 2010-01-12 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
DE602006013465D1 (de) 2005-07-25 2010-05-20 Basf Se Verfahren zur bereitstellung und analyse einer tierpopulation mit im wesentlichem identischem metabolom
EP1996718B1 (en) * 2006-03-06 2011-11-30 Ceetox Inc. Toxicity screening methods
CA2647122A1 (en) * 2006-03-24 2007-10-04 Metanomics Gmbh Means and method for diagnosing diabetes
EP1837657A1 (en) * 2006-03-24 2007-09-26 Metanomics GmbH Means and method for predicting or diagnosing diabetes
ATE536425T1 (de) * 2006-10-13 2011-12-15 Metabolon Inc Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon
WO2009036376A1 (en) * 2007-09-13 2009-03-19 University Of Hawaii Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease
WO2009059150A2 (en) * 2007-11-02 2009-05-07 Metabolon, Inc. Biomarkers for fatty liver disease and methods using the same
EP2286236B1 (en) * 2008-05-28 2016-04-20 Basf Se Methods for assessing liver toxicity
EP2157431A1 (en) * 2008-08-11 2010-02-24 One Way Liver Genomics, S.L. Method for the diagnosis of NASH using metabolic profiles
US8658353B2 (en) * 2008-11-25 2014-02-25 Corning Incorporated Liver cell toxicity assay

Also Published As

Publication number Publication date
JP2015042985A (ja) 2015-03-05
US8808979B2 (en) 2014-08-19
AU2009259535B2 (en) 2016-01-21
AU2009259535A8 (en) 2011-02-03
AU2009259535A1 (en) 2009-12-23
CA2724512A1 (en) 2009-12-23
WO2009153131A1 (en) 2009-12-23
JP2011522231A (ja) 2011-07-28
EP2286235A1 (en) 2011-02-23
US20110091929A1 (en) 2011-04-21
DE112009001245T5 (de) 2012-03-15
CN102105793A (zh) 2011-06-22

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2344 DE 08/12/2015

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]