BRPI0908474A2 - métodos de uso de cromatografia de troca de íon e de filtração de gel para purificação de vírus causador da catapora - Google Patents
métodos de uso de cromatografia de troca de íon e de filtração de gel para purificação de vírus causador da cataporaInfo
- Publication number
- BRPI0908474A2 BRPI0908474A2 BRPI0908474A BRPI0908474A BRPI0908474A2 BR PI0908474 A2 BRPI0908474 A2 BR PI0908474A2 BR PI0908474 A BRPI0908474 A BR PI0908474A BR PI0908474 A BRPI0908474 A BR PI0908474A BR PI0908474 A2 BRPI0908474 A2 BR PI0908474A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- ion exchange
- exchange chromatography
- gel filtration
- pox virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6548408P | 2008-02-12 | 2008-02-12 | |
PCT/CA2009/000141 WO2009100521A1 (en) | 2008-02-12 | 2009-02-12 | Methods using ion exchange and gel filtration chromatography for poxvirus purification |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0908474A2 true BRPI0908474A2 (pt) | 2016-07-26 |
Family
ID=40956580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0908474A BRPI0908474A2 (pt) | 2008-02-12 | 2009-02-12 | métodos de uso de cromatografia de troca de íon e de filtração de gel para purificação de vírus causador da catapora |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110165645A1 (pt) |
EP (1) | EP2240573A4 (pt) |
JP (2) | JP2011511640A (pt) |
KR (1) | KR20100113159A (pt) |
CN (1) | CN102257134B (pt) |
AU (1) | AU2009214768B2 (pt) |
BR (1) | BRPI0908474A2 (pt) |
CA (1) | CA2713891A1 (pt) |
IL (1) | IL207460A0 (pt) |
MX (1) | MX2010008970A (pt) |
WO (1) | WO2009100521A1 (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2760465A1 (en) | 2009-05-12 | 2010-11-18 | Transgene Sa | Method for orthopoxvirus production and purification |
BR112012026095A2 (pt) * | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
DK2596099T3 (da) | 2010-07-20 | 2020-02-24 | Bavarian Nordic As | Fremgangsmåde til høst af ekspressionsprodukter |
CN108404453B (zh) | 2010-07-30 | 2021-01-05 | Emd密理博公司 | 层析介质和方法 |
US9957485B2 (en) * | 2012-04-08 | 2018-05-01 | Inventprise, Llc | Systems and methods for virus propagation in cell cultures for vaccine manufacture |
CN105316296A (zh) * | 2014-06-13 | 2016-02-10 | 亚宝药业太原制药有限公司 | 一种纯化腺病毒颗粒的方法 |
EP3169341B1 (en) | 2014-07-16 | 2019-06-05 | Transgene SA | Oncolytic virus for expression of immune checkpoint modulators |
EP3188816B1 (en) | 2014-09-02 | 2021-06-09 | EMD Millipore Corporation | Chromatography media comprising discrete porous bundles of nanofibrils |
KR102582192B1 (ko) * | 2014-12-05 | 2023-09-25 | 후지필름 가부시키가이샤 | Tim 단백질 결합 담체, 당해 담체를 사용한 세포외막소포 및 바이러스의 취득 방법, 제거 방법, 검출 방법 그리고 당해 담체를 포함하는 키트 |
US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
US10954492B2 (en) * | 2015-06-10 | 2021-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Processes for production and purification of nucleic acid-containing compositions |
CN105219741A (zh) * | 2015-08-24 | 2016-01-06 | 深圳市百恩维生物科技有限公司 | 一种大规模获得高纯度、高活性慢病毒的工艺方法 |
EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
RU2768045C2 (ru) * | 2016-07-21 | 2022-03-23 | Спарк Терапьютикс, Инк. | СПОСОБ ПОЛУЧЕНИЯ ЧАСТИЦ РЕКОМБИНАНТНОГО АДЕНОАССОЦИИРОВАННОГО ВИРУСНОГО ВЕКТОРА (rAAV) |
MX2019002495A (es) * | 2016-09-01 | 2020-02-17 | Takeda Vaccines Inc | Metodos para producir virus para la produccion de vacunas. |
EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
CN106754346A (zh) * | 2016-12-12 | 2017-05-31 | 厦门华厦学院 | Dna微提取***及dna微提取方法 |
WO2018122088A1 (en) | 2016-12-28 | 2018-07-05 | Transgene Sa | Oncolytic viruses and therapeutic molecules |
EP3624851A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
EP3624845A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
SG11201912429RA (en) | 2017-06-21 | 2020-01-30 | Transgene Sa | Personalized vaccine |
CN107485891B (zh) * | 2017-07-20 | 2020-04-21 | 上海药明生物技术有限公司 | 改良的层析装置及其用于连续流层析的方法 |
WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
CN107603959A (zh) * | 2017-08-30 | 2018-01-19 | 四川大学 | 提高缓冲液盐离子浓度纯化病毒的方法 |
CN108159411A (zh) * | 2018-01-11 | 2018-06-15 | 江苏中慧元通生物科技有限公司 | 一种流感病毒亚单位疫苗纯化方法及其应用 |
WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
EP3617230A1 (en) | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
CA3111273C (en) | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
CN113453712A (zh) | 2018-12-28 | 2021-09-28 | 特兰斯吉恩股份有限公司 | M2缺陷型痘病毒 |
CN110241093A (zh) * | 2019-06-17 | 2019-09-17 | 深圳源兴基因技术有限公司 | 一种重组痘病毒的纯化方法 |
CN112143693A (zh) * | 2019-06-28 | 2020-12-29 | 杭州康万达医药科技有限公司 | 一种生产病毒的方法及收获液组合物 |
EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
MX2022011071A (es) | 2020-03-12 | 2022-09-23 | Bavarian Nordic As | Composiciones que mejoran la estabilidad del poxvirus. |
CN111876392A (zh) * | 2020-06-30 | 2020-11-03 | 恒瑞源正(上海)生物科技有限公司 | 一种大规模快速生产病毒载体的方法 |
CN116322740A (zh) | 2020-07-13 | 2023-06-23 | 特兰斯吉恩股份有限公司 | 免疫抑制的治疗 |
WO2022148736A1 (en) | 2021-01-05 | 2022-07-14 | Transgene | Vectorization of muc1 t cell engager |
WO2023025899A2 (en) | 2021-08-26 | 2023-03-02 | Transgene | Delivery system for targeting genes of the interferon pathway |
TW202321458A (zh) | 2021-09-22 | 2023-06-01 | 瑞典商生物創新國際公司 | 新穎抗體組合及其用途 |
CN114544815B (zh) * | 2022-03-01 | 2023-10-27 | 中牧实业股份有限公司 | 一种山羊痘病毒的定量检测方法 |
WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
WO2024003238A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | Epstein-barr-virus vaccine |
WO2024003239A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
WO2024003353A1 (en) | 2022-07-01 | 2024-01-04 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
WO2024038175A1 (en) | 2022-08-18 | 2024-02-22 | Transgene | Chimeric poxviruses |
CN115261341B (zh) * | 2022-09-05 | 2024-03-22 | 东曜药业有限公司 | 一种澄清溶瘤痘苗病毒收获液的方法 |
CN115873810B (zh) * | 2022-12-26 | 2024-02-09 | 苏州良辰生物医药科技有限公司 | 一种鼠白血病病毒的纯化方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
US5364773A (en) | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
JP3602530B2 (ja) | 1991-03-07 | 2004-12-15 | ヴァイロジェネティクス コーポレイション | 遺伝子操作したワクチン菌株 |
IT1248075B (it) * | 1991-06-18 | 1995-01-05 | Sclavo Spa | Processo per la purificazione del virus dell'epatite a (hav), virus cosi` purificato e composizioni vaccinali che lo contengono. |
UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
US5990091A (en) | 1997-03-12 | 1999-11-23 | Virogenetics Corporation | Vectors having enhanced expression, and methods of making and uses thereof |
US6410300B1 (en) * | 1998-01-12 | 2002-06-25 | The University Of North Carolina At Chapel Hill | Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV |
US6146874A (en) * | 1998-05-27 | 2000-11-14 | University Of Florida | Method of preparing recombinant adeno-associated virus compositions |
CN1289663C (zh) * | 2001-12-20 | 2006-12-13 | 巴法里安诺迪克有限公司 | 从感染细胞中回收和纯化痘病毒的方法 |
DE10232828A1 (de) * | 2002-07-19 | 2004-02-05 | Goldschmidt Ag | Verwendung von Antioxidantien in strahlenhärtbaren Beschichtungsmassen für die Herstellung von abhäsiven Beschichtungen |
AU2004249199B2 (en) * | 2003-06-18 | 2008-07-24 | Onyx Pharmaceuticals, Inc. | Method for purifying virus |
CA2555412C (en) * | 2004-02-23 | 2013-06-25 | Crucell Holland B.V. | Virus purification methods |
US20090042274A1 (en) * | 2004-07-27 | 2009-02-12 | Genomidea Inc. | Method of Purifying Virus Envelope |
US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
-
2009
- 2009-02-12 KR KR1020107020027A patent/KR20100113159A/ko active IP Right Grant
- 2009-02-12 WO PCT/CA2009/000141 patent/WO2009100521A1/en active Application Filing
- 2009-02-12 US US12/867,047 patent/US20110165645A1/en not_active Abandoned
- 2009-02-12 BR BRPI0908474A patent/BRPI0908474A2/pt active Search and Examination
- 2009-02-12 CA CA2713891A patent/CA2713891A1/en not_active Abandoned
- 2009-02-12 CN CN200980113708.5A patent/CN102257134B/zh not_active Expired - Fee Related
- 2009-02-12 EP EP09711236A patent/EP2240573A4/en not_active Withdrawn
- 2009-02-12 JP JP2010546187A patent/JP2011511640A/ja active Pending
- 2009-02-12 MX MX2010008970A patent/MX2010008970A/es unknown
- 2009-02-12 AU AU2009214768A patent/AU2009214768B2/en not_active Ceased
-
2010
- 2010-08-08 IL IL207460A patent/IL207460A0/en unknown
-
2014
- 2014-05-07 JP JP2014096127A patent/JP5898261B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2009214768A1 (en) | 2009-08-20 |
WO2009100521A1 (en) | 2009-08-20 |
JP2011511640A (ja) | 2011-04-14 |
US20110165645A1 (en) | 2011-07-07 |
AU2009214768B2 (en) | 2015-01-22 |
IL207460A0 (en) | 2010-12-30 |
KR20100113159A (ko) | 2010-10-20 |
JP5898261B2 (ja) | 2016-04-06 |
CN102257134A (zh) | 2011-11-23 |
EP2240573A1 (en) | 2010-10-20 |
JP2014138622A (ja) | 2014-07-31 |
CN102257134B (zh) | 2014-03-05 |
MX2010008970A (es) | 2011-05-30 |
EP2240573A4 (en) | 2011-08-31 |
CA2713891A1 (en) | 2009-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |