BRPI0821711A2 - Solid and crystalline dutasteride and processes for its preparation - Google Patents

Solid and crystalline dutasteride and processes for its preparation

Info

Publication number: BRPI0821711A2
Authority: BR; Brazil
Prior art keywords: dutasteride; crystalline; processes; preparation; solid
Prior art date: 2008-01-03

Application number

BRPI0821711-4A

Other languages

Portuguese (pt)

Inventor

Adriana Vecchioli

Dora Graciela Tombari

Constanza Pia Magnone

Maria Beatriz Garcia

Rafael Alberto Labriola

Original Assignee

Gador Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-01-03

Filing date

2008-12-30

Publication date

2015-06-16

2008-12-30 Application filed by Gador Sa filed Critical Gador Sa

2015-06-16 Publication of BRPI0821711A2 publication Critical patent/BRPI0821711A2/en

Links

JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 title 1
229960004199 dutasteride Drugs 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

BRPI0821711-4A 2008-01-03 2008-12-30 Solid and crystalline dutasteride and processes for its preparation BRPI0821711A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1880808P	2008-01-03	2008-01-03
PCT/EP2008/011137 WO2009083258A2 (en)	2008-01-03	2008-12-30	Solid and crystalline dutasteride and processes for preparation thereof

Publications (1)

Publication Number	Publication Date
BRPI0821711A2 true BRPI0821711A2 (en)	2015-06-16

Family

ID=40688488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821711-4A BRPI0821711A2 (en)	2008-01-03	2008-12-30	Solid and crystalline dutasteride and processes for its preparation

Country Status (8)

Country	Link
US (1)	US8153648B2 (en)
EP (1)	EP2238152B1 (en)
KR (1)	KR20110041431A (en)
AR (1)	AR070313A1 (en)
BR (1)	BRPI0821711A2 (en)
CA (2)	CA2709971A1 (en)
MX (1)	MX2010007294A (en)
WO (1)	WO2009083258A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011004242A2 (en) *	2009-07-09	2011-01-13	Aurobindo Pharma Limited	An improved process for the preparation of dutasteride
EP2468262A1 (en)	2010-12-06	2012-06-27	Krka Tovarna Zdravil, D.D., Novo Mesto	Pharmaceutical composition comprising dutasteride
HU230730B1 (en)	2011-06-30	2017-12-28	Richter Gedeon Nyrt	Process for the preparation of (5alpha,17beta)-n-[2,5-bis-(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androst-1-en-17-carboxylic amide
CN102417534B (en) *	2011-08-31	2013-04-10	重庆万利康制药有限公司	Synthesis technology of dutasteride
CN103570796A (en) *	2012-07-24	2014-02-12	重庆医药工业研究院有限责任公司	Preparation method of dutasteride type-I crystal
US9375433B2 (en)	2012-09-26	2016-06-28	Tangent Reprofiling Limited	Modulators of androgen synthesis
WO2014049071A1 (en) *	2012-09-26	2014-04-03	Tangent Reprofiling Limited	Modulators of androgen synthesis
KR101251625B1 (en) *	2012-09-28	2013-04-08	(주)비씨월드제약	Novel manufacturing method of dutasteride using novel intermediates
CN104292293B (en) *	2014-09-17	2016-04-06	广东众生药业股份有限公司	The preparation method of a kind of dutasteride's impurity I
CN106810594A (en) *	2016-12-30	2017-06-09	南京生命能科技开发有限公司	A kind of preparation method of high-purity dutasteride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
GB0026876D0 (en) *	2000-11-03	2000-12-20	Glaxo Group Ltd	Process
KR20050045988A (en)	2002-07-16	2005-05-17	지그프리드 리미티드	Method for introducing a 1,2-double bond into 3-oxo-4-azasteroid compounds
US7022854B2 (en)	2003-07-17	2006-04-04	Dr. Reddy's Laboratories, Limited	Forms of dutasteride and methods for preparation thereof
US20050059692A1 (en) *	2003-09-09	2005-03-17	Dr. Reddy's Laboratories Limited	Process for the preparation of 17beta-N-[2,5-bis(trifluoromethyl)phenyl] carbamoyl-4-aza-5-alpha-androst-1-en-3-one
EP1945615A2 (en) *	2005-11-10	2008-07-23	Dr. Reddy's Laboratories Ltd.	Preparation of dutasteride

2008
- 2008-12-22 AR ARP080105653A patent/AR070313A1/en unknown
- 2008-12-30 EP EP08868866.8A patent/EP2238152B1/en not_active Not-in-force
- 2008-12-30 CA CA2709971A patent/CA2709971A1/en not_active Abandoned
- 2008-12-30 MX MX2010007294A patent/MX2010007294A/en active IP Right Grant
- 2008-12-30 CA CA2891751A patent/CA2891751A1/en not_active Abandoned
- 2008-12-30 KR KR1020107014817A patent/KR20110041431A/en not_active Application Discontinuation
- 2008-12-30 BR BRPI0821711-4A patent/BRPI0821711A2/en not_active IP Right Cessation
- 2008-12-30 WO PCT/EP2008/011137 patent/WO2009083258A2/en active Application Filing
2009
- 2009-01-03 US US12/348,278 patent/US8153648B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US8153648B2 (en)	2012-04-10
WO2009083258A2 (en)	2009-07-09
CA2709971A1 (en)	2009-07-09
KR20110041431A (en)	2011-04-21
EP2238152A2 (en)	2010-10-13
AR070313A1 (en)	2010-03-31
MX2010007294A (en)	2010-10-25
US20090203724A1 (en)	2009-08-13
WO2009083258A3 (en)	2009-12-03
CA2891751A1 (en)	2009-07-09
EP2238152B1 (en)	2015-02-18

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Legal Events

Date	Code	Title	Description
2016-11-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 8A ANUIDADE.
2017-02-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]