BRPI0819759A2 - Compositions and methods for inhibiting ds-rna-dependent protein kinase activation and tumor growth inhibition - Google Patents

Compositions and methods for inhibiting ds-rna-dependent protein kinase activation and tumor growth inhibition

Info

Publication number
BRPI0819759A2
BRPI0819759A2 BRPI0819759-8A BRPI0819759A BRPI0819759A2 BR PI0819759 A2 BRPI0819759 A2 BR PI0819759A2 BR PI0819759 A BRPI0819759 A BR PI0819759A BR PI0819759 A2 BRPI0819759 A2 BR PI0819759A2
Authority
BR
Brazil
Prior art keywords
rna
inhibiting
compositions
methods
tumor growth
Prior art date
Application number
BRPI0819759-8A
Other languages
Portuguese (pt)
Inventor
Michael John Tisdale
Helen Laura Eley
Steve Thomas Russel
Kevin Burke Miller
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40099551&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819759(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nestec Sa filed Critical Nestec Sa
Publication of BRPI0819759A2 publication Critical patent/BRPI0819759A2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
BRPI0819759-8A 2007-11-26 2008-10-03 Compositions and methods for inhibiting ds-rna-dependent protein kinase activation and tumor growth inhibition BRPI0819759A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99013407P 2007-11-26 2007-11-26
US3737108P 2008-03-18 2008-03-18
PCT/US2008/078667 WO2009070378A1 (en) 2007-11-26 2008-10-03 Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition

Publications (1)

Publication Number Publication Date
BRPI0819759A2 true BRPI0819759A2 (en) 2015-05-05

Family

ID=40099551

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819759-8A BRPI0819759A2 (en) 2007-11-26 2008-10-03 Compositions and methods for inhibiting ds-rna-dependent protein kinase activation and tumor growth inhibition

Country Status (14)

Country Link
US (1) US20110077198A1 (en)
EP (1) EP2222297A1 (en)
JP (1) JP2011504879A (en)
CN (1) CN101868235A (en)
AR (1) AR069479A1 (en)
AU (1) AU2008329988A1 (en)
BR (1) BRPI0819759A2 (en)
CA (1) CA2706656A1 (en)
CL (1) CL2008003524A1 (en)
MX (1) MX2010005768A (en)
RU (1) RU2010126171A (en)
TW (1) TW200924744A (en)
WO (1) WO2009070378A1 (en)
ZA (1) ZA201004528B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2381934A2 (en) * 2008-12-23 2011-11-02 Carmel - Haifa University Economic Corp Ltd. Improving cognitive function
CN102481009A (en) * 2009-08-13 2012-05-30 雀巢产品技术援助有限公司 Nutritional compositions including exogenous nucleotides
CN102595936A (en) * 2009-09-25 2012-07-18 雀巢产品技术援助有限公司 Nutritional compositions including theanine and exogenous nucleotides
AU2010310515B2 (en) * 2009-10-22 2016-01-07 University Of Southern California Methods and nutritional formulations to increase the efficacy and reduce the side effects of cancer treatment
FR2970414B1 (en) * 2011-01-14 2013-03-22 Univ Paris Descartes PREVENTIVE ACTION OF CITRULLINE ON THE SPONTANEOUS DEVELOPMENT OF TUMORS
CN104053438A (en) * 2011-10-18 2014-09-17 味之素株式会社 Therapeutic agent for pancreatic cancer and/or biliary tract cancer
JP2015500805A (en) * 2011-11-29 2015-01-08 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ Cognitive enhancement method
KR101909433B1 (en) * 2011-12-02 2018-10-18 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 Agent for reducing adverse side effects of kinase inhibitor
WO2014066426A1 (en) * 2012-10-22 2014-05-01 University Of Southern California Methods and formulations promoting tissue/organ regeneration, longevity and healthspan
KR101668074B1 (en) 2015-02-12 2016-10-21 전북대학교산학협력단 Composition comprising PKR inhibitor for preventing or treating severe bronchial asthma
JOP20190146A1 (en) 2016-12-19 2019-06-18 Axcella Health Inc Amino acid compositions and methods for the treatment of liver diseases
CN107158388B (en) * 2017-07-11 2021-03-23 上海市第一人民医院 Application of MIIP pS303 blocking agent in preparation of antitumor drugs
CN111295187A (en) 2017-08-14 2020-06-16 胺细拉健康公司 Amino acid composition for treating liver diseases
EP3810123A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
WO2023208028A1 (en) * 2022-04-29 2023-11-02 中国科学院分子细胞科学卓越创新中心 Circular rna with 16 bp-26 bp double-stranded stem-loop structure for treating psoriasis or alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577769A4 (en) * 1991-03-29 1994-06-01 Us Commerce Pharmaceutical compositions and methods for preventing skin tumor formation and causing regression of existing tumors
US6326466B1 (en) * 1996-07-30 2001-12-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Double-stranded RNA dependent protein kinase derived peptides to promote proliferation of cells and tissues in a controlled manner
US6326465B1 (en) * 1997-02-24 2001-12-04 The Johns Hopkins University Immunomodulatory polypeptides derived from the invariant chain of MHC class II
US6864061B2 (en) * 2000-09-14 2005-03-08 Genetrol Biotherapeutics, Inc. Method for screening compounds for anti-inflammatory activity
WO2007013696A1 (en) * 2005-07-29 2007-02-01 Torii Pharmaceutical Co., Ltd. Anti-tumor agent comprising 6'-amidino-2'-naphthyl4- guanidinobenzoate or salt thereof
BRPI0619179A2 (en) * 2005-11-30 2011-09-13 Nestec Sa Methods For Treating Muscle Loss
US20100247538A1 (en) * 2007-05-29 2010-09-30 Yale University IL-18 and Protein Kinase R Inhibition for the Treatment of COPD

Also Published As

Publication number Publication date
AU2008329988A1 (en) 2009-06-04
EP2222297A1 (en) 2010-09-01
US20110077198A1 (en) 2011-03-31
ZA201004528B (en) 2011-11-30
WO2009070378A1 (en) 2009-06-04
JP2011504879A (en) 2011-02-17
RU2010126171A (en) 2012-01-10
AR069479A1 (en) 2010-01-27
CA2706656A1 (en) 2009-06-04
CL2008003524A1 (en) 2010-01-22
MX2010005768A (en) 2010-06-11
TW200924744A (en) 2009-06-16
CN101868235A (en) 2010-10-20

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Ipc: A61K 31/553 (2006.01), A23L 33/13 (2016.01), A61K