BRPI0815889A2 - Análise do perfil de glicosilação. - Google Patents

Análise do perfil de glicosilação.

Info

Publication number
BRPI0815889A2
BRPI0815889A2 BRPI0815889-4A2A BRPI0815889A BRPI0815889A2 BR PI0815889 A2 BRPI0815889 A2 BR PI0815889A2 BR PI0815889 A BRPI0815889 A BR PI0815889A BR PI0815889 A2 BRPI0815889 A2 BR PI0815889A2
Authority
BR
Brazil
Prior art keywords
profile analysis
glycosylation profile
glycosylation
analysis
profile
Prior art date
Application number
BRPI0815889-4A2A
Other languages
English (en)
Inventor
Markus Haberger
Dietmar Reusch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0815889A2 publication Critical patent/BRPI0815889A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
BRPI0815889-4A2A 2007-08-31 2008-08-20 Análise do perfil de glicosilação. BRPI0815889A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07017063 2007-08-31
PCT/EP2008/006835 WO2009027041A1 (en) 2007-08-31 2008-08-20 Glycosylation profile analysis

Publications (1)

Publication Number Publication Date
BRPI0815889A2 true BRPI0815889A2 (pt) 2014-10-14

Family

ID=38596692

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815889-4A2A BRPI0815889A2 (pt) 2007-08-31 2008-08-20 Análise do perfil de glicosilação.

Country Status (12)

Country Link
US (1) US20110117601A1 (pt)
EP (1) EP2188382A1 (pt)
JP (1) JP2010536355A (pt)
KR (1) KR20100038235A (pt)
CN (1) CN101784670A (pt)
AU (1) AU2008291358A1 (pt)
BR (1) BRPI0815889A2 (pt)
CA (1) CA2697091A1 (pt)
IL (1) IL202566A0 (pt)
RU (1) RU2010112236A (pt)
TW (1) TW200916585A (pt)
WO (1) WO2009027041A1 (pt)

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JP2012032203A (ja) * 2010-07-29 2012-02-16 Sumitomo Bakelite Co Ltd 抗体の糖鎖を調製する方法
EP2616809B1 (en) * 2010-09-17 2017-04-05 Prozyme, Inc. Isolation and deglycosylation of glycoproteins
JP5990000B2 (ja) * 2011-01-31 2016-09-07 公益財団法人野口研究所 Maldi質量分析法用測定試料調製方法
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
BR112014001120A2 (pt) * 2011-07-20 2017-02-21 Zepteon Incorporated métodos de separação de polipeptídeos
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
US9169331B2 (en) * 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
EP3754012A1 (en) * 2013-03-15 2020-12-23 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
GB201315705D0 (en) * 2013-09-04 2013-10-16 Univ Dublin Methods for predicting, diagmosing or monitoring infections
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
TWI642782B (zh) 2013-10-23 2018-12-01 健臻公司 重組醣蛋白及其用途
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
CN103983684B (zh) * 2014-04-14 2016-08-17 南昌大学 一种高效的maldi板上的糖基化抑制剂筛选方法
JP6750148B2 (ja) * 2014-04-25 2020-09-02 公益財団法人野口研究所 糖鎖切断抗体の製造方法及び均一糖鎖抗体
CN106459118B (zh) 2014-04-30 2019-09-24 贝克曼考尔特公司 聚糖样品制备
WO2015184325A2 (en) * 2014-05-30 2015-12-03 New England Biolabs, Inc. Deglycosylation reagents and methods
EP2975401B1 (en) * 2014-07-18 2019-12-25 Hexal AG Improved method of mapping glycans of glycoproteins in serum samples
JP6344117B2 (ja) * 2014-07-25 2018-06-20 株式会社島津製作所 磁性ビーズを用いた糖鎖又は糖ペプチドの精製濃縮方法
US9908932B2 (en) * 2014-10-15 2018-03-06 Alexion Pharmaceuticals, Inc. Methods of shifting an isoelectric profile of a protein product and uses thereof
WO2016187341A1 (en) * 2015-05-18 2016-11-24 The Regents Of The University Of California Systems and methods for predicting glycosylation on proteins
CN105277718B (zh) * 2015-09-29 2018-03-20 上海知先生物科技有限公司 用于恶性肿瘤相关筛查及评估的产品、应用及方法
US11680948B2 (en) 2016-08-12 2023-06-20 Abreos Biosciences, Inc. Detection and quantification of natalizumab
JP6850351B2 (ja) * 2016-12-21 2021-03-31 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 抗体のインビトロ糖鎖工学
EP3559249A1 (en) 2016-12-21 2019-10-30 H. Hoffnabb-La Roche Ag Method for in vitro glycoengineering of antibodies
EP3662287B1 (en) * 2017-08-01 2024-02-28 Amgen Inc. Systems and methods for real time preparation of a polypeptide sample for anaylsis with mass spectrometry
WO2019028191A1 (en) * 2017-08-01 2019-02-07 Amgen Inc. SYSTEMS AND METHODS FOR PERFORMING REAL-TIME GLYCAN ASSAY OF A SAMPLE
SG11202110968VA (en) 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
CN115078728A (zh) * 2021-03-11 2022-09-20 盛禾(中国)生物制药有限公司 一种融合蛋白的快速分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1587408A4 (en) * 2002-12-20 2007-09-05 Momenta Pharmaceuticals Inc GLYCAN MARKER FOR DIAGNOSIS AND MONITORING OF DISEASES
CA2608818A1 (en) * 2005-06-03 2006-12-14 Genentech, Inc. Method of producing antibodies with modified fucosylation level
JP2009509970A (ja) * 2005-09-22 2009-03-12 プロサイ インコーポレイテッド 酵母突然変異体において産生されるグリコシル化ポリペプチドおよびその使用方法

Also Published As

Publication number Publication date
RU2010112236A (ru) 2011-10-10
TW200916585A (en) 2009-04-16
WO2009027041A1 (en) 2009-03-05
EP2188382A1 (en) 2010-05-26
IL202566A0 (en) 2010-06-30
CA2697091A1 (en) 2009-03-05
KR20100038235A (ko) 2010-04-13
CN101784670A (zh) 2010-07-21
US20110117601A1 (en) 2011-05-19
JP2010536355A (ja) 2010-12-02
AU2008291358A1 (en) 2009-03-05

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]