BRPI0715609A2 - COMPOUND, USE OF A COMPOUND, METHODS TO PRODUCE AN ANTIPROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, AND TO TREAT DISEASE IN A HOT BLOOD ANIMAL, AND PHARMACEUTICAL COMPOSITION - Google Patents
COMPOUND, USE OF A COMPOUND, METHODS TO PRODUCE AN ANTIPROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, AND TO TREAT DISEASE IN A HOT BLOOD ANIMAL, AND PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- BRPI0715609A2 BRPI0715609A2 BRPI0715609-0A2A BRPI0715609A BRPI0715609A2 BR PI0715609 A2 BRPI0715609 A2 BR PI0715609A2 BR PI0715609 A BRPI0715609 A BR PI0715609A BR PI0715609 A2 BRPI0715609 A2 BR PI0715609A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- blood animal
- hot blood
- produce
- pharmaceutical composition
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSTO, USO DE UM COMPOSTO,MÉTODO PARA PRODUZIR UM EFEITO ANTIPROLIFERATIVO EM UM ANIMAL DE SANGUE QUENTE, E PARA TRATAR UMA DOENÇA EM UM ANIMAL DE SANGUE QUENTE, E, COMPOSIÇÃO FARMACÊUTICA. É descrito um composto da fórmula (1) ou um sal farmaceuticamente aceitável deste, processos para sua preparação, composições farmacêuticas contendo-os e seu uso em terapia, por exemplo, particularmente no tratamento de doença proliferativa, tal como câncer, e particulamente em doença mediada por um mTOR quinase e/ou uma ou mais enzimas PI3K. COMPOUND, USE OF A COMPOUND, METHOD TO PRODUCE AN ANTIPROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, AND TO TREAT DISEASE IN A HOT BLOOD ANIMAL, AND PHARMACEUTICAL COMPOSITION. A compound of formula (1) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example, particularly in the treatment of proliferative disease, such as cancer, and particularly in disease, are described. mediated by an mTOR kinase and / or one or more PI3K enzymes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0616747A GB0616747D0 (en) | 2006-08-24 | 2006-08-24 | Novel compounds |
| US94854407P | 2007-07-09 | 2007-07-09 | |
| PCT/GB2007/003173 WO2008023159A1 (en) | 2006-08-24 | 2007-08-21 | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0715609A2 true BRPI0715609A2 (en) | 2013-10-08 |
Family
ID=37102735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0715609-0A2A BRPI0715609A2 (en) | 2006-08-24 | 2007-08-21 | COMPOUND, USE OF A COMPOUND, METHODS TO PRODUCE AN ANTIPROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, AND TO TREAT DISEASE IN A HOT BLOOD ANIMAL, AND PHARMACEUTICAL COMPOSITION |
Country Status (7)
| Country | Link |
|---|---|
| CN (2) | CN101541781B (en) |
| BR (1) | BRPI0715609A2 (en) |
| ES (1) | ES2393215T3 (en) |
| GB (1) | GB0616747D0 (en) |
| RU (1) | RU2440349C2 (en) |
| TW (1) | TW200817384A (en) |
| ZA (1) | ZA200901015B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY148688A (en) * | 2006-08-23 | 2013-05-31 | Kudos Pharm Ltd | 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors |
| SG181757A1 (en) * | 2009-12-28 | 2012-07-30 | Dev Center Biotechnology | Novel pyrimidine compounds as mtor and pi3k inhibitors |
| US8618111B2 (en) * | 2010-01-26 | 2013-12-31 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
| EP2678342B1 (en) * | 2011-02-25 | 2015-01-07 | Takeda Pharmaceutical Company Limited | N-substituted oxazinopteridines and oxazinopteridinones |
| CN103917530B (en) * | 2011-09-21 | 2016-08-24 | 塞尔佐姆有限公司 | The substituted urea of morpholino or carbamic acid derivative as MTOR inhibitor |
| KR102090792B1 (en) | 2012-05-15 | 2020-03-18 | 캔써 리서치 테크놀로지 리미티드 | 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof |
-
2006
- 2006-08-24 GB GB0616747A patent/GB0616747D0/en not_active Ceased
-
2007
- 2007-08-21 BR BRPI0715609-0A2A patent/BRPI0715609A2/en not_active IP Right Cessation
- 2007-08-21 CN CN200780039262.7A patent/CN101541781B/en not_active Expired - Fee Related
- 2007-08-21 TW TW96130916A patent/TW200817384A/en unknown
- 2007-08-21 RU RU2009110255/04A patent/RU2440349C2/en not_active IP Right Cessation
- 2007-08-21 ES ES07789273T patent/ES2393215T3/en active Active
- 2007-08-22 CN CNA2007800392665A patent/CN101558046A/en active Pending
-
2009
- 2009-02-12 ZA ZA200901015A patent/ZA200901015B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009110255A (en) | 2010-09-27 |
| ES2393215T3 (en) | 2012-12-19 |
| CN101558046A (en) | 2009-10-14 |
| CN101541781B (en) | 2014-01-08 |
| RU2440349C2 (en) | 2012-01-20 |
| TW200817384A (en) | 2008-04-16 |
| GB0616747D0 (en) | 2006-10-04 |
| CN101541781A (en) | 2009-09-23 |
| ZA200901015B (en) | 2010-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019010354A (en) | Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof. | |
| CO6390066A2 (en) | PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | |
| WO2009007749A3 (en) | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases | |
| DOP2010000012A (en) | PYRIMIDINE MORFOLINE DERIVATIVES USED IN DISEASES RELATED TO MTOR QUINASA AND / OR PI3K | |
| UY30559A1 (en) | DERIVATIVES OF MORFOLINO PIRIMIDINA, PREPARATION PROCESSES, COMPOSITIONS CONTAINING THEM AND APPLICATIONS | |
| BRPI0517634A (en) | thiazole derivative or a pharmaceutically acceptable derivative thereof, process for preparing a compound, pharmaceutical composition, use of a compound or pharmaceutically acceptable salt thereof, and method of treating a disease or condition | |
| ATE557015T1 (en) | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | |
| BR112015029491A2 (en) | imidazopyrrolidinone derivatives and their use in the treatment of disease | |
| BR112014029851A2 (en) | compound, inhibitors of ros1 kinase and ntrk kinase enzyme activity, pharmaceutical composition, antitumor agent, therapeutic agent for a tumor, method for treating a tumor, and, agent for treating a tumor | |
| HK1136292A1 (en) | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | |
| BR112015029512A8 (en) | pyrazolopyrrolidine derivatives, their uses, and pharmaceutical composition and combination | |
| EA200970595A1 (en) | DERIVATIVES OF SUBSTITUTED INDAZOLS ACTIVE AS KINAZ INHIBITORS | |
| EA201070167A1 (en) | SUBSTITUTED DERIVATIVES INDAZOLA, ACTIVE AS KINASE INHIBITORS | |
| BRPI0618552B8 (en) | pyrimidine derivative compounds linked to oxygen, pharmaceutical composition that includes said compounds, method of synthesis of the compounds and therapeutic uses thereof | |
| EA201000090A1 (en) | Triple substituted derivatives of pyrimidine for the treatment of proliferative diseases | |
| BRPI0513513A (en) | compound or a pharmaceutically acceptable salt thereof, process for preparing it, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, and methods for producing an eg5 inhibitory effect and an anticancer effect on a warm-blooded animal , and to treat carcinomas in a warm-blooded animal | |
| MX2008012422A (en) | Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors. | |
| BRPI0805826A2 (en) | spiro-substituted compounds as angiogenesis inhibitors, compound production method, pharmaceutical composition and treatment methods | |
| ATE514699T1 (en) | SUBSTITUTED PYRROLOPYRAZOLE DERIVATIVES AS KINASE INHIBITORS | |
| BRPI0912411B8 (en) | use of a human interleukin-2 mutein (hil-2 mutein) and pharmaceutical composition for the treatment and/or prophylaxis of an autoimmune disease | |
| BR112015029401A8 (en) | pyrazolo-pyrrolidin-4-one derivatives, their uses, and pharmaceutical composition and combination | |
| ATE485037T1 (en) | CANCER TREATMENT USING FTS AND 2-DEOXYGLUCOSE | |
| BRPI0715609A2 (en) | COMPOUND, USE OF A COMPOUND, METHODS TO PRODUCE AN ANTIPROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, AND TO TREAT DISEASE IN A HOT BLOOD ANIMAL, AND PHARMACEUTICAL COMPOSITION | |
| UA102219C2 (en) | Substotuted pyrazolo-quinazoline derivatives, process for the preparation and use thereof as kinase inhibitors | |
| FR2908131B1 (en) | AMINOBENZOCYCLOHEPTENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |