BRPI0709965C1 - farmacocinética da administração iontoforética de sumatriptano - Google Patents

farmacocinética da administração iontoforética de sumatriptano

Info

Publication number
BRPI0709965C1
BRPI0709965C1 BRC10709965-7A BRPI0709965A BRPI0709965C1 BR PI0709965 C1 BRPI0709965 C1 BR PI0709965C1 BR PI0709965 A BRPI0709965 A BR PI0709965A BR PI0709965 C1 BRPI0709965 C1 BR PI0709965C1
Authority
BR
Brazil
Prior art keywords
sumatriptan
pharmacokinetics
iontophoretic administration
iontophoretic
administration
Prior art date
Application number
BRC10709965-7A
Other languages
English (en)
Inventor
Carter R Anderson
Russell L Morris
Terri B Sebree
Original Assignee
Nupathe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nupathe Inc filed Critical Nupathe Inc
Publication of BRPI0709965A2 publication Critical patent/BRPI0709965A2/pt
Publication of BRPI0709965C2 publication Critical patent/BRPI0709965C2/pt
Publication of BRPI0709965C1 publication Critical patent/BRPI0709965C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

FORMULAçõES MELHORADAS DE POLIAMINA PARA A IONTOFORESE DO COMPOSTO TRIPTANO. São descritos uma ataduara a distribuição lontoforética de sumatriptano siptano.
BRC10709965-7A 2006-04-13 2007-04-12 farmacocinética da administração iontoforética de sumatriptano BRPI0709965C1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79181906P 2006-04-13 2006-04-13
US60/791.819 2006-04-13
US81413106P 2006-06-16 2006-06-16
US60/814.131 2006-06-16
PCT/US2007/009000 WO2007120747A2 (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Publications (3)

Publication Number Publication Date
BRPI0709965A2 BRPI0709965A2 (pt) 2011-08-02
BRPI0709965C2 BRPI0709965C2 (pt) 2011-12-20
BRPI0709965C1 true BRPI0709965C1 (pt) 2011-12-20

Family

ID=38610170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC10709965-7A BRPI0709965C1 (pt) 2006-04-13 2007-04-12 farmacocinética da administração iontoforética de sumatriptano

Country Status (13)

Country Link
US (4) US7973058B2 (pt)
EP (1) EP2012871A4 (pt)
JP (3) JP5580042B2 (pt)
CN (2) CN101472644B (pt)
AU (1) AU2007238685B2 (pt)
BR (1) BRPI0709965C1 (pt)
CA (2) CA2935569A1 (pt)
EA (1) EA023147B1 (pt)
HK (1) HK1203867A1 (pt)
IL (1) IL194553A (pt)
MX (1) MX2008012922A (pt)
NZ (2) NZ610790A (pt)
WO (1) WO2007120747A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007238685B2 (en) * 2006-04-13 2012-09-13 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
EP2756756B1 (en) * 2008-04-28 2016-01-06 Zogenix, Inc. Novel formulations for treatment of migraine
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
AU2009259601B2 (en) 2008-06-19 2014-09-18 Lts Lohmann Therapie-Systeme Ag Composition for transdermal delivery of cationic active agents
US8155737B2 (en) * 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
AU2009262967C1 (en) * 2008-06-25 2015-12-24 Fe3 Medical, Inc Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
CN104043194A (zh) 2008-12-30 2014-09-17 纽帕特公司 离子透入给药***
US8190252B2 (en) 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
WO2010093472A2 (en) * 2009-02-12 2010-08-19 Incube Labs, Llc Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8821945B2 (en) 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
US8417330B2 (en) * 2009-06-26 2013-04-09 Incube Labs, Llc Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use
US8903485B2 (en) * 2009-08-06 2014-12-02 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
US8845612B2 (en) * 2009-08-10 2014-09-30 Nupathe Inc. Methods for iontophoretically treating nausea and migraine
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
WO2011100376A2 (en) * 2010-02-10 2011-08-18 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
PE20140214A1 (es) 2010-08-27 2014-02-19 Gruenenthal Chemie 2-oxo- y 2-tioxo-dihidroquinolina-3-carboxamidas sustituidos como moduladores kcnq2/3
PT2609083E (pt) 2010-08-27 2015-07-01 Gruenenthal Gmbh 2-oxi-quinolina-3-carboxamidas substituídas como moduladores de kcnq2/3
CN106955415B (zh) 2011-03-24 2019-06-18 因卡伯实验室有限责任公司 用于治疗剂的两阶段经皮离子电渗递送的***及方法
WO2012154704A2 (en) 2011-05-06 2012-11-15 Incube Labs, Llc System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
US9744353B2 (en) 2012-11-14 2017-08-29 Teva Pharmaceuticals International Gmbh Detection of presence and alignment of a therapeutic agent in an iontophoretic drug delivery device
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
GB2554455A (en) 2016-09-29 2018-04-04 Feeligreen Sa Skin treatment device and method for delivery of an active ingredient into the human skin by means of iontophoresis, using an array of electrodes
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
JP7285259B2 (ja) * 2017-09-12 2023-06-01 エルテーエス ローマン テラピー－ジステーメ アーゲー イオントフォレーシス用マイクロニードルデバイス
US11318292B2 (en) * 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CN114340620A (zh) * 2019-06-28 2022-04-12 帕斯帕特技术有限公司 曲坦微穿孔递送***
US11364225B2 (en) 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4856188A (en) 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US5605536A (en) 1983-08-18 1997-02-25 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5651768A (en) 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US4883457A (en) * 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4822802A (en) 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
US4927408A (en) 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
DE4014913C2 (de) 1990-05-10 1996-05-15 Lohmann Therapie Syst Lts Miniaturisiertes transdermales therapeutisches System für die Iontophorese
CA2183875C (en) 1992-06-02 2003-10-14 Robert M. Myers Electrotransport drug delivery device
DE4314976C1 (de) 1993-05-06 1994-10-06 Lohmann Therapie Syst Lts Transdermale therapeutische Systeme zur Verabreichung von Wirkstoffen, Verfahren zu ihrer Herstellung und ihre Verwendung
US5807571A (en) * 1993-05-06 1998-09-15 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic systems for administering indole serotonin agonists
US5458569A (en) 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
US5533971A (en) 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5700481A (en) * 1995-03-17 1997-12-23 Takeda Chemical Industries, Ltd. Transdermal drug delivery process
JPH08317997A (ja) * 1995-03-17 1996-12-03 Takeda Chem Ind Ltd 経皮透過方法
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
AU699774B2 (en) 1995-06-05 1998-12-17 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US5983130A (en) 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US5688232A (en) 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US5941843A (en) * 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US5882677A (en) * 1997-09-30 1999-03-16 Becton Dickinson And Company Iontophoretic patch with hydrogel reservoir
JP4290271B2 (ja) 1998-04-14 2009-07-01 久光製薬株式会社 経皮透過方法
SE9802864D0 (sv) * 1998-08-27 1998-08-27 Pharmacia & Upjohn Ab Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder
CA2367485A1 (en) 1999-04-12 2000-10-19 Hisamitsu Pharmaceuticals Co., Inc. Device for iontophoresis
US6312716B1 (en) * 1999-05-10 2001-11-06 Peierce Management Llc Patch and method for transdermal delivery of bupropion base
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
US6421561B1 (en) * 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
CN100346788C (zh) * 2000-07-31 2007-11-07 尼科梅德丹麦有限公司 用于鼻内给药的芬太尼组合物
US6653014B2 (en) 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
DE60230796D1 (de) * 2001-10-24 2009-02-26 Power Paper Ltd Vorrichtung für die kontrollierte abgabe eines wirkstoffes in die haut
US20030225002A1 (en) * 2002-02-26 2003-12-04 Livingstone Ian R. Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
JP4191951B2 (ja) 2002-04-25 2008-12-03 ソントル ファルマペプティド 抗微生物剤投与装置および組立品
CA2512854C (en) 2002-06-28 2010-02-09 Alza Corporation A reservoir for use in electrotransport drug delivery
US6745071B1 (en) 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system
RU2326893C2 (ru) 2003-04-16 2008-06-20 Кориум Интернэшнл Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними
US8734421B2 (en) * 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US20050228336A1 (en) * 2004-04-07 2005-10-13 Preston Keusch Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
UY28935A1 (es) 2004-06-03 2005-07-29 Alza Corp Sistema y metodo para la administracion transdermica de un anticoagulante
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US7856263B2 (en) 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
JP2009509674A (ja) 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 活性物質の全身送達のためのイオントフォレーシス方法及び装置
AU2007238685B2 (en) * 2006-04-13 2012-09-13 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds

Also Published As

Publication number Publication date
CN104138634B (zh) 2016-09-07
US20080287497A1 (en) 2008-11-20
CA2650412A1 (en) 2007-10-25
CN104138634A (zh) 2014-11-12
JP2016163723A (ja) 2016-09-08
EA023147B1 (ru) 2016-04-29
AU2007238685B2 (en) 2012-09-13
US7973058B2 (en) 2011-07-05
NZ596498A (en) 2013-05-31
JP5925844B2 (ja) 2016-05-25
NZ610790A (en) 2015-05-29
EA200802146A1 (ru) 2009-06-30
US20110213294A1 (en) 2011-09-01
CN101472644B (zh) 2014-04-23
JP5580042B2 (ja) 2014-08-27
WO2007120747A3 (en) 2008-04-24
IL194553A (en) 2016-03-31
BRPI0709965C2 (pt) 2011-12-20
CA2650412C (en) 2016-09-27
US8470853B2 (en) 2013-06-25
HK1203867A1 (en) 2015-11-06
JP2009533451A (ja) 2009-09-17
JP2014221798A (ja) 2014-11-27
WO2007120747A2 (en) 2007-10-25
EP2012871A4 (en) 2015-07-22
BRPI0709965A2 (pt) 2011-08-02
US9272137B2 (en) 2016-03-01
US20110213330A1 (en) 2011-09-01
CA2935569A1 (en) 2007-10-25
MX2008012922A (es) 2008-12-17
AU2007238685A1 (en) 2007-10-25
EP2012871A2 (en) 2009-01-14
US20160317464A1 (en) 2016-11-03
CN101472644A (zh) 2009-07-01

Similar Documents

Publication Publication Date Title
BRPI0709965C1 (pt) farmacocinética da administração iontoforética de sumatriptano
CY1120741T1 (el) Θεραπεια οζωδους σκληρυνσης
CY1121125T1 (el) Συνθεσεις για τη θεραπευτικη αντιμετωπιση του πονου και/ή της φλεγμονης
GT200900283A (es) "terapia de combinación con un compuesto actuando como un inhibidor del receptor adp plaquetario".
PA8720801A1 (es) Nuevas combinaciones terapeuticas para el tratamiento de la depresion
CY1115971T1 (el) Νεο παραγωγο φαινυλ ιμιδαζολιου ως αναστολεας ενζυμου pde10a
EA201000784A1 (ru) Антагонисты пути hedgehog и их терапевтические применения
CY1124331T1 (el) Αυξημενη βιοδιαθεσιμοτητα δραστικης ουσιας σε θεραπεια ναλτρεξονης
CL2009000316A1 (es) Compuestos derivados de urea de benzomorfanos y sus sales, inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de trastornos metabolicos.
MX2009001327A (es) Compuestos de indol.
CR11229A (es) Pirimidil ciclopentanos como inhibidores de proteina cinasa akt
CY1113314T1 (el) (3-αρυλ-πιπεραζιν-1-υλ) παραγωγα της 6,7-διαλκοξυκιναζολινης, 6,7-διαλκοξυφθαλαζινης και 6,7-διαλκοξυϊσοκινολινης
TNSN08178A1 (en) Triazolopyridine derivatives as inhibitors of lipases and phospholipases
EA201491607A1 (ru) Модуляторы толлподобных рецепторов
MX2009002666A (es) Compuestos de n-metilaminometil isoindol, composiciones que los comprenden y metodos que utilizan los mismos.
EA201170832A1 (ru) Пуриновые соединения
CY1110824T1 (el) Διασπεipoμενη στο στομα φαρμακευτικη συνθεση για απο του στοματος, μεσω του στοματικου βλεννογονου ή υπογλωσσια χορηγηση αγομελατινης
EA201201263A1 (ru) Фармацевтическая композиция, содержащая этексилат дабигатрана
DE602005024012D1 (de) Lösungsmittelfreies amorphes rapamycin
MY146506A (en) Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
MX2010002736A (es) Derivados de 1-amino-alquilciclohexano para el tratamiento de tinnitus coclear.
DK1641803T3 (da) Thienopyrimidinderivater som kaliumkanalinhibitorer
CY1117893T1 (el) Θεραπευτικα σχηματα
HK1201763A1 (en) Polyamine enhanced formulations for triptan compound iontophoresis
NO20080035L (no) Benzooksazol-2-on derivater som lipase og fosfolipaseinhibitorer

Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE:

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE:

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE: REFERENTE A RPI 2243 DE 31/12/2013, POR TER SIDO INDEVIDO.

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE: REFERENTE A RPI 2243 DE 31/12/2013, POR TER SIDO INDEVIDO.

B25A Requested transfer of rights approved

Owner name: TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH)

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE:

Owner name: TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH)

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE:

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

Free format text: IMPROVED ADDITIONAL INVENTOR'S CERTIFICATE: