BRPI0621841B8 - formulação líquida - Google Patents
formulação líquidaInfo
- Publication number
- BRPI0621841B8 BRPI0621841B8 BRPI0621841A BRPI0621841A BRPI0621841B8 BR PI0621841 B8 BRPI0621841 B8 BR PI0621841B8 BR PI0621841 A BRPI0621841 A BR PI0621841A BR PI0621841 A BRPI0621841 A BR PI0621841A BR PI0621841 B8 BRPI0621841 B8 BR PI0621841B8
- Authority
- BR
- Brazil
- Prior art keywords
- liquid formulation
- polyethylene glycol
- poly
- polyoxystearate
- deamidation
- Prior art date
Links
- 239000012669 liquid formulation Substances 0.000 title abstract 3
- -1 poly(oxyethylene) Polymers 0.000 abstract 3
- 239000004475 Arginine Substances 0.000 abstract 1
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 1
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 1
- 239000000854 Human Growth Hormone Substances 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 229920002564 Polyethylene Glycol 3500 Polymers 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
formulações líquidas. desamidação(25°c) é aqui revelada uma formulação líquida estável que compreende o hormônio do crescimento humano; l-lisina, l-arginina ou polieti- leno glicol 300; e copolímero de poli(oxietileno) poli(oxipropileno), polietileno glicol- 15 polioxiestearato ou polietileno glicol-35 óleo de rícino.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/KR2006/002640 WO2008004717A1 (en) | 2006-07-06 | 2006-07-06 | A stable liquid formulation of human growth hormone |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0621841A2 BRPI0621841A2 (pt) | 2011-12-20 |
BRPI0621841B1 BRPI0621841B1 (pt) | 2020-12-29 |
BRPI0621841B8 true BRPI0621841B8 (pt) | 2021-05-25 |
Family
ID=38894670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0621841A BRPI0621841B8 (pt) | 2006-07-06 | 2006-07-06 | formulação líquida |
Country Status (11)
Country | Link |
---|---|
US (1) | US8409586B2 (pt) |
EP (1) | EP2049148B1 (pt) |
JP (1) | JP5180202B2 (pt) |
CN (1) | CN101505789A (pt) |
BR (1) | BRPI0621841B8 (pt) |
ES (1) | ES2605022T3 (pt) |
HK (1) | HK1216992A1 (pt) |
HU (1) | HUE031329T2 (pt) |
LT (1) | LT2049148T (pt) |
PT (1) | PT2049148T (pt) |
WO (1) | WO2008004717A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011001273A (ja) * | 2009-06-16 | 2011-01-06 | Eci Inc | eMIPを有効成分とする水溶性製剤 |
CA2780554C (en) * | 2009-11-17 | 2017-08-15 | Ipsen Pharma S.A.S. | Formulation for hgh and rhigf-1 combination |
WO2013096835A1 (en) * | 2011-12-23 | 2013-06-27 | Abbvie Inc. | Stable protein formulations |
CN105658201A (zh) * | 2013-11-12 | 2016-06-08 | 卡迪拉保健有限公司 | ***的制剂 |
US9908976B2 (en) | 2015-03-18 | 2018-03-06 | Psmg, Llc | Stable polyethylene glycol particle dispersions and methods for forming the stable dispersions |
CN110151988A (zh) * | 2018-02-11 | 2019-08-23 | 百奥泰生物制药股份有限公司 | 一种靶向治疗TNF-α相关疾病的人抗体制剂 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61296598A (ja) | 1985-06-21 | 1986-12-27 | Mitsubishi Electric Corp | Mosダイナミツクramのダミ−ワ−ド線駆動回路 |
EP0303746B2 (en) * | 1987-08-21 | 1998-12-02 | Mallinckrodt Group Inc. | Stabilization of growth promoting hormones |
US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
WO1994003198A1 (en) | 1992-07-31 | 1994-02-17 | Genentech, Inc. | Human growth hormone aqueous formulation |
ZA965368B (en) * | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
KR970006498A (ko) | 1995-07-31 | 1997-02-21 | 유충식 | 활성형 인성장호르몬의 정제 방법 |
AUPN801296A0 (en) * | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
KR100210840B1 (ko) | 1996-12-24 | 1999-07-15 | 구본준 | 기계 화학적 연마 방법 및 그 장치 |
KR19990001217A (ko) | 1997-06-13 | 1999-01-15 | 윤종용 | 스탠바이 모드에서의 시스템 구동방법 및 장치 |
JP3723857B2 (ja) | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
KR100316347B1 (ko) | 1998-09-15 | 2002-08-27 | 한미약품(주) | 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법 |
KR100573704B1 (ko) | 1998-12-02 | 2006-07-21 | 동아제약주식회사 | 인성장 호르몬의 안정화된 액상제제_ |
IL149008A0 (en) * | 1999-10-04 | 2002-11-10 | Chiron Corp | Stabilized liquid polypeptide-containing pharmaceutical compositions |
PT1455839E (pt) | 1999-10-08 | 2013-04-24 | Nektar Therapeutics | Derivados de poli(etilenoglicol) heterobifuncionais e seus métodos de preparação |
AU2001271491A1 (en) * | 2000-06-26 | 2002-01-08 | Monsanto Technology Llc | Non-aqueous surfactant-containing formulations for extended release of somatotropin |
CA2491478A1 (en) * | 2002-07-09 | 2004-01-15 | Sandoz Ag | Liquid formulations with high concentration of human growth hormone (hgh) comprising phenol |
US20060252682A1 (en) * | 2003-03-18 | 2006-11-09 | Ares Trading S.A. | Liquid growth hormone formulation and process of preparation thereof |
KR100537260B1 (ko) | 2003-09-03 | 2005-12-19 | 한미약품 주식회사 | 인간 성장 호르몬의 안정화된 액상 제제용 조성물 |
WO2005028516A2 (en) | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
EP1663296A4 (en) * | 2003-09-25 | 2009-11-25 | Cangene Corp | LIQUID FORMULATION OF HUMAN GROWTH HORMONE CONTAINING POLYETHYLENE GLYCOL |
DE10355189B4 (de) | 2003-11-26 | 2015-04-30 | Johnson & Johnson Medical Gmbh | Verfahren zum Herstellen eines chirurgischen Implantats sowie chirurgisches Implantat |
CA2551510C (en) | 2003-12-23 | 2013-07-30 | Pharmacia Corporation | Stable growth hormone liquid formulation |
-
2006
- 2006-07-06 PT PT67691865T patent/PT2049148T/pt unknown
- 2006-07-06 LT LTEP06769186.5T patent/LT2049148T/lt unknown
- 2006-07-06 EP EP06769186.5A patent/EP2049148B1/en active Active
- 2006-07-06 JP JP2009517937A patent/JP5180202B2/ja active Active
- 2006-07-06 ES ES06769186.5T patent/ES2605022T3/es active Active
- 2006-07-06 BR BRPI0621841A patent/BRPI0621841B8/pt active IP Right Grant
- 2006-07-06 CN CNA2006800556995A patent/CN101505789A/zh active Pending
- 2006-07-06 WO PCT/KR2006/002640 patent/WO2008004717A1/en active Application Filing
- 2006-07-06 HU HUE06769186A patent/HUE031329T2/hu unknown
- 2006-07-06 US US12/307,661 patent/US8409586B2/en active Active
-
2016
- 2016-04-29 HK HK16104967.3A patent/HK1216992A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN101505789A (zh) | 2009-08-12 |
HUE031329T2 (hu) | 2017-07-28 |
HK1216992A1 (zh) | 2016-12-16 |
ES2605022T3 (es) | 2017-03-10 |
JP5180202B2 (ja) | 2013-04-10 |
BRPI0621841A2 (pt) | 2011-12-20 |
WO2008004717A9 (en) | 2013-08-29 |
EP2049148A4 (en) | 2013-12-11 |
EP2049148B1 (en) | 2016-09-28 |
PT2049148T (pt) | 2016-12-30 |
EP2049148A1 (en) | 2009-04-22 |
WO2008004717A1 (en) | 2008-01-10 |
LT2049148T (lt) | 2016-11-25 |
JP2009542629A (ja) | 2009-12-03 |
BRPI0621841B1 (pt) | 2020-12-29 |
US8409586B2 (en) | 2013-04-02 |
US20090298768A1 (en) | 2009-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0621841B8 (pt) | formulação líquida | |
ATE471144T1 (de) | Intranasale verabreichung von schnell wirkendem insulin | |
MX2011011772A (es) | Formulaicones estables de anticuerpos humanos anti-tnf-alfa con alta concentracion de proteina. | |
EP2422794A3 (en) | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation | |
ITMI20020399A0 (it) | Composizioni dietetiche e/o farmaceutiche per uso umano e/o animale abase di preparati microbici probiotici | |
ECSP088165A (es) | Formulaciones liquidas | |
WO2014100777A3 (en) | Antimicrobial compositions | |
ITBO20050388A1 (it) | Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche | |
WO2008154368A3 (en) | Topical poloxamer formulations for enhancing microvascular flow: compositions and uses thereof | |
MX2008011085A (es) | Composiciones antimicrobianas y metodos para sellar cateteres. | |
BRPI0510269A (pt) | composições de dalbavancina para o tratamento de infecções bacterianas | |
TW200605870A (en) | Topical methadone compositions and methods for using the same | |
MY146654A (en) | Nicotine-carrier vaccine formulation | |
WO2010118926A3 (de) | Verwendung organomodifizierter, im siliconteil verzweigter siloxane zur herstellung kosmetischer oder pharmazeutischer zusammensetzungen | |
MX2009005308A (es) | Composiciones que comprenden peroxido de benzoilo, al menos un derivado del acido naftoico y al menos un compuesto del tipo polimeros de poliuretano o derivados de estos y sus usos. | |
ATE332136T1 (de) | Mittel, wie nikotinamide oder cadpr zur behandlung von hautkrankheiten | |
WO2012051116A8 (en) | Clevidipine emulsion formulations containing antimicrobial agents | |
NO20072931L (no) | Forbedret doseringsregime av temozolomid for behandling av kreft basert pa pasientens MGMT-niva | |
WO2011106493A3 (en) | Oral care compositions comprising magnolia bark extract or a synthetic analog thereof | |
WO2007139760A3 (en) | Resorbable polymer compositions for use in medicine, dentistry, and surgery | |
NZ594618A (en) | Transdermal pharmaceutical preparations | |
NZ718163A (en) | Extended-release formulation for reducing the frequency of urination and method of use thereof | |
NO20082098L (no) | Formuleringer av AICA-ribosid | |
DK1684719T3 (da) | Alfa-1-antitrypsin-sammensætninger og behandlingsfremgangsmåder, der anvender sådanne sammensætninger | |
TNSN07203A1 (en) | Pharmaceutical compositions for the treatment of cellulite |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/07/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |