BRPI0610322B8 - vegf receptor and hgf receptor signaling inhibitors and pharmaceutical composition - Google Patents
vegf receptor and hgf receptor signaling inhibitors and pharmaceutical compositionInfo
- Publication number
- BRPI0610322B8 BRPI0610322B8 BRPI0610322A BRPI0610322A BRPI0610322B8 BR PI0610322 B8 BRPI0610322 B8 BR PI0610322B8 BR PI0610322 A BRPI0610322 A BR PI0610322A BR PI0610322 A BRPI0610322 A BR PI0610322A BR PI0610322 B8 BRPI0610322 B8 BR PI0610322B8
- Authority
- BR
- Brazil
- Prior art keywords
- receptor signaling
- hgf
- pharmaceutical composition
- receptor
- signaling inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
inibidores de sinalização de receptor de vegf e receptor de hgf. a presente invenção refere-se à inibição de sinalização de receptor de vegf e sinalização de receptor de hgf. a invenção fornece compostos e métodos para inibição da sinalização de receptor de vegf e sinalização de receptor de hgf. a invenção também fornece composições e métodos para tratar doenças e condições proliferativas celulares.inhibitors of vegf receptor and hgf receptor signaling. The present invention relates to the inhibition of vegf receptor signaling and hgf receptor signaling. the invention provides compounds and methods for inhibiting vegf receptor signaling and hgf receptor signaling. the invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68303605P | 2005-05-20 | 2005-05-20 | |
US60/683,036 | 2005-05-20 | ||
US75490205P | 2005-12-29 | 2005-12-29 | |
US60/754,902 | 2005-12-29 | ||
US78505406P | 2006-03-22 | 2006-03-22 | |
US60/785,054 | 2006-03-22 | ||
PCT/IB2006/004306 WO2008041053A2 (en) | 2005-05-20 | 2006-05-19 | Inhibitors of vegf receptor and hgf receptor signaling |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0610322A2 BRPI0610322A2 (en) | 2010-06-15 |
BRPI0610322B1 BRPI0610322B1 (en) | 2020-12-01 |
BRPI0610322B8 true BRPI0610322B8 (en) | 2021-05-25 |
Family
ID=39190471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0610322A BRPI0610322B8 (en) | 2005-05-20 | 2006-05-19 | vegf receptor and hgf receptor signaling inhibitors and pharmaceutical composition |
Country Status (13)
Country | Link |
---|---|
US (2) | US8093264B2 (en) |
EP (1) | EP1957498B1 (en) |
JP (1) | JP5148499B2 (en) |
KR (1) | KR101378716B1 (en) |
CN (1) | CN101796055B (en) |
AU (1) | AU2006343808B2 (en) |
BR (1) | BRPI0610322B8 (en) |
CA (1) | CA2611370C (en) |
ES (1) | ES2623221T3 (en) |
IL (1) | IL187484A (en) |
MX (1) | MX2007014616A (en) |
NZ (1) | NZ564283A (en) |
WO (1) | WO2008041053A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
CN101031570B (en) * | 2004-07-30 | 2012-09-05 | 梅特希尔基因公司 | Inhibitors of VEGF receptor and HGF receptor signaling |
NZ563774A (en) | 2005-05-20 | 2010-04-30 | Methylgene Inc | Inhibitors of VEGF receptor and HGF receptor signaling |
PE20070619A1 (en) * | 2005-09-27 | 2007-07-02 | Wyeth Corp | I HAVE (2,3-b) PYRIDIN-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS |
TW200806675A (en) * | 2006-01-30 | 2008-02-01 | Array Biopharma Inc | Heterobicyclic thiophene compounds and methods of use |
CA2645137A1 (en) * | 2006-03-07 | 2007-09-13 | James F. Blake | Heterobicyclic pyrazole compounds and methods of use |
US20080064718A1 (en) * | 2006-03-22 | 2008-03-13 | Saavedra Oscar M | Inhibitors of protein tyrosine kinase activity |
CA2651898A1 (en) | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions |
US20110053931A1 (en) * | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
WO2009026717A1 (en) * | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
TW200916447A (en) * | 2007-08-29 | 2009-04-16 | Methylgene Inc | Sirtuin inhibitors |
EP2426108B1 (en) | 2007-08-29 | 2016-08-10 | MethylGene Inc. | Processes and intermediates for preparing fused heterocyclic kinase inhibitors |
US8906647B2 (en) | 2008-02-21 | 2014-12-09 | Sequoia Pharmaceuticals, Inc. | Diamide inhibitors of cytochrome P450 |
BRPI0923670A2 (en) * | 2008-03-05 | 2013-07-30 | Methylgene Inc | protein tyrosine kinase activity inhibitors and their use, as well as a composition comprising them |
JP5675614B2 (en) | 2008-08-26 | 2015-02-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Thienopyrimidine for pharmaceutical composition |
EP2340244A4 (en) | 2008-10-14 | 2012-07-25 | Ning Xi | Compounds and methods of use |
BRPI0920765A2 (en) * | 2008-10-29 | 2015-08-18 | Deciphera Pharmaceuticals Llc | Cilopropane amides and analogs that exhibit anticancer and antiproliferative activities |
RU2011142597A (en) * | 2009-03-21 | 2013-04-27 | Саншайн Лейк Фарма Ко., Лтд. | DERIVATIVES OF COMPOUND ETHERS OF AMINO ACIDS, THEIR SALTS AND METHODS OF APPLICATION |
AU2010339444A1 (en) * | 2009-12-30 | 2012-07-19 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
JP5575275B2 (en) | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Substituted alkyl group-containing thienopyrimidines for pharmaceutical compositions |
UY33246A (en) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | TIENOPIRIMIDINES CONTAINING CYCLLOQUAL FOR PHARMACEUTICAL COMPOSITIONS |
UY33241A (en) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ? Tienopyrimidines containing heterocycloalkyl for pharmaceutical compositions ?. |
CN101863911A (en) * | 2010-04-13 | 2010-10-20 | 艾琪康医药科技(上海)有限公司 | A process for preparing 1-R1-3, 4-dehydro-3 or 4-R6-piperidine |
EP2563794A4 (en) * | 2010-04-16 | 2013-12-04 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders |
KR20130091331A (en) | 2010-07-16 | 2013-08-16 | 교와 핫꼬 기린 가부시키가이샤 | Nitrogenated aromatic heterocyclic ring derivative |
US8664244B2 (en) | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
MY181439A (en) | 2011-02-28 | 2020-12-22 | Sunshine Lake Pharma Co Ltd | Substituted quinoline compounds and methods of use |
CN104936963B (en) | 2012-11-20 | 2017-11-28 | 普罗齐纳斯有限公司 | Sulfide derivative as kinases inhibitor |
AU2015249496A1 (en) | 2014-04-25 | 2016-09-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
CN105348213A (en) * | 2015-09-22 | 2016-02-24 | 武汉理工大学 | Preparation method for beta-fluoroalkyl-beta-amino acids compound |
FR3041640B1 (en) | 2015-09-30 | 2019-05-17 | Les Laboratoires Servier | NOVEL PYRROLO [2,3-d] PYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
RU2019108280A (en) | 2016-08-24 | 2020-09-25 | Аркьюл, Инк. | AMINOPYRROLOPYRIMIDINONE COMPOUNDS AND METHODS FOR THEIR APPLICATION |
CN108530464B (en) * | 2017-03-02 | 2020-10-27 | 深圳海王医药科技研究院有限公司 | Multi-target kinase inhibitor |
CN113874015A (en) | 2018-12-21 | 2021-12-31 | 细胞基因公司 | Thienopyridine inhibitors of RIPK2 |
CN110423218A (en) * | 2019-08-09 | 2019-11-08 | 新乡双鹭药业有限公司 | A kind of rich preparation method for impurity in Buddhist nun's synthesis of malic acid card |
CN113336768B (en) * | 2020-02-18 | 2022-08-19 | 深圳海王医药科技研究院有限公司 | Multi-target tyrosine kinase inhibitor |
CN114957136A (en) * | 2021-02-24 | 2022-08-30 | 南京科默生物医药有限公司 | Anti-tumor compound used as VEGFR inhibitor and application thereof |
CN115215803B (en) * | 2022-09-19 | 2022-12-30 | 苏州美诺医药科技有限公司 | Preparation method of 4-halogenated-1- (difluoromethyl) -1H-imidazole |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184211B1 (en) | 1993-11-30 | 2001-02-06 | Methylgene Inc. | Inhibition of DNA methyltransferase |
US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
US6268137B1 (en) | 1996-05-22 | 2001-07-31 | Methylgene, Inc. | Specific inhibitors of DNA methyl transferase |
US6020318A (en) | 1997-05-30 | 2000-02-01 | Methylgene, Inc. | DNA methyltransferase genomic sequences and antisense oligonucleotides |
CA2291595A1 (en) | 1997-05-30 | 1998-12-03 | Mcgill University | Dna methyltransferase genomic sequences and antisense oligonucleotides |
JP2001522853A (en) * | 1997-11-11 | 2001-11-20 | ファイザー・プロダクツ・インク | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
US6066625A (en) | 1998-02-03 | 2000-05-23 | Methylgene, Inc. | Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
IL139811A0 (en) | 1998-06-04 | 2002-02-10 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
US6953783B1 (en) | 1998-10-19 | 2005-10-11 | Methylgene, Inc. | Modulation of gene expression by combination therapy |
GB9906566D0 (en) * | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
KR20020007398A (en) | 1999-05-03 | 2002-01-26 | 추후제출 | Inhibition of histone deacetylase |
EP1181296A1 (en) | 1999-06-03 | 2002-02-27 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US6541661B1 (en) | 1999-11-23 | 2003-04-01 | Methylgene, Inc. | Inhibitors of histone deacetylase |
JP2004533850A (en) | 2000-03-24 | 2004-11-11 | メチルジーン・インコーポレーテッド | Inhibition of specific histone deacetylase isoforms |
EP1280764B1 (en) | 2000-03-24 | 2010-11-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
MXPA02012034A (en) | 2000-06-06 | 2003-04-25 | Pfizer Prod Inc | Thiophene derivatives useful as anticancer agents. |
US20020004511A1 (en) | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
ES2318649T3 (en) * | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | PROCEDURE FOR PREPARATION OF DERIVATIVES OF 4-FENOXI QUINOLINAS. |
AU2002345792A1 (en) | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
DE60233736D1 (en) * | 2001-06-22 | 2009-10-29 | Kirin Pharma K K | CHINOLIN DERIVATIVE AND CHINAZOLINE DERIVATIVES HARMING THE SELF-PHOSPHORYLATION OF THE HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICAL COMPOSITIONS CONTAINING THEREOF |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
CN1578663B (en) | 2001-09-14 | 2011-05-25 | 梅特希尔基因公司 | Inhibitors of histone deacetylase |
EP1483268A2 (en) | 2002-03-01 | 2004-12-08 | Pfizer Inc. | Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents |
CA2501265A1 (en) | 2002-10-17 | 2004-04-29 | Methylgene Inc. | Inhibitors of histone deacetylase |
CL2003002287A1 (en) | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPOUNDS DERIVED FROM TIENO [3,2-b] -PIRIDINA-6-CARBONITRILOS AND TIENEO [2,3-b] -PIRIDINA-5-CARBONITRILS, PHARMACEUTICAL COMPOSITION, PROCEDURE OF PREPARATION AND INTERMEDIARY COMPOUNDS, AND THEIR USE IN THE TREATMENT OF CANCER, APOPLEJIA, OSTEOPOROSIS |
MXPA06002296A (en) * | 2003-08-29 | 2006-05-22 | Pfizer | Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents. |
AU2004276337B2 (en) | 2003-09-24 | 2009-11-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2005030140A2 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
WO2005052872A1 (en) | 2003-11-21 | 2005-06-09 | Facil, Llc | Financial transaction system and method |
AU2005207946A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
AU2005225471B2 (en) | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
WO2005121125A1 (en) | 2004-06-09 | 2005-12-22 | Pfizer Inc. | Ether-linked heteroaryl compounds |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
CA2572331A1 (en) * | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
JP2008506714A (en) | 2004-07-16 | 2008-03-06 | サネシス ファーマシューティカルズ, インコーポレイテッド | Thienopyrimidines useful as aurora kinase inhibitors |
CN101031570B (en) * | 2004-07-30 | 2012-09-05 | 梅特希尔基因公司 | Inhibitors of VEGF receptor and HGF receptor signaling |
US7647492B2 (en) | 2004-09-15 | 2010-01-12 | Check Point Software Technologies Inc. | Architecture for routing and IPSec integration |
EP1844062A2 (en) | 2005-01-21 | 2007-10-17 | Methylgene, Inc. | Inhibitors of dna methyltransferase |
AU2006229343A1 (en) | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency |
JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Substituted Amid derivatives & methods of use |
TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
DE102005037499A1 (en) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | pyrazole |
JP2009521424A (en) * | 2005-12-19 | 2009-06-04 | メチルジーン インコーポレイテッド | Histone deacetylase inhibitors for enhancing antifungal activity |
TW200806675A (en) | 2006-01-30 | 2008-02-01 | Array Biopharma Inc | Heterobicyclic thiophene compounds and methods of use |
US20080064718A1 (en) | 2006-03-22 | 2008-03-13 | Saavedra Oscar M | Inhibitors of protein tyrosine kinase activity |
-
2006
- 2006-05-19 US US11/438,133 patent/US8093264B2/en active Active
- 2006-05-19 WO PCT/IB2006/004306 patent/WO2008041053A2/en active Application Filing
- 2006-05-19 CA CA2611370A patent/CA2611370C/en active Active
- 2006-05-19 ES ES06851548.5T patent/ES2623221T3/en active Active
- 2006-05-19 EP EP06851548.5A patent/EP1957498B1/en active Active
- 2006-05-19 CN CN2006800266085A patent/CN101796055B/en active Active
- 2006-05-19 MX MX2007014616A patent/MX2007014616A/en active IP Right Grant
- 2006-05-19 JP JP2008537239A patent/JP5148499B2/en active Active
- 2006-05-19 AU AU2006343808A patent/AU2006343808B2/en active Active
- 2006-05-19 KR KR1020077029798A patent/KR101378716B1/en active IP Right Grant
- 2006-05-19 BR BRPI0610322A patent/BRPI0610322B8/en active IP Right Grant
- 2006-05-19 NZ NZ564283A patent/NZ564283A/en unknown
-
2007
- 2007-11-19 IL IL187484A patent/IL187484A/en active IP Right Grant
-
2011
- 2011-12-08 US US13/314,362 patent/US8329726B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1957498B1 (en) | 2017-02-15 |
NZ564283A (en) | 2011-07-29 |
EP1957498A2 (en) | 2008-08-20 |
BRPI0610322B1 (en) | 2020-12-01 |
CN101796055B (en) | 2013-09-04 |
WO2008041053A2 (en) | 2008-04-10 |
US8329726B2 (en) | 2012-12-11 |
BRPI0610322A2 (en) | 2010-06-15 |
AU2006343808A1 (en) | 2008-04-10 |
US20070004675A1 (en) | 2007-01-04 |
WO2008041053A3 (en) | 2009-12-23 |
JP5148499B2 (en) | 2013-02-20 |
EP1957498A4 (en) | 2010-10-27 |
US8093264B2 (en) | 2012-01-10 |
AU2006343808B2 (en) | 2012-03-29 |
KR20080059112A (en) | 2008-06-26 |
IL187484A0 (en) | 2011-08-01 |
IL187484A (en) | 2014-04-30 |
CA2611370A1 (en) | 2006-11-20 |
JP2009504804A (en) | 2009-02-05 |
ES2623221T3 (en) | 2017-07-10 |
KR101378716B1 (en) | 2014-04-10 |
MX2007014616A (en) | 2009-08-12 |
US20120083482A1 (en) | 2012-04-05 |
CN101796055A (en) | 2010-08-04 |
CA2611370C (en) | 2014-11-25 |
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B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: APRESENTE O DEPOSITANTE COPIA DA FOLHA DE ROSTO DA PUBLICACAO INTERNACIONAL DO PEDIDO, CONFORME O DISPOSTO NO ITEM 9.3 DO AN NO 128/1997. |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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