BRPI0600285C1 - compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas - Google Patents

compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas

Info

Publication number
BRPI0600285C1
BRPI0600285C1 BRC10600285-4A BRPI0600285A BRPI0600285C1 BR PI0600285 C1 BRPI0600285 C1 BR PI0600285C1 BR PI0600285 A BRPI0600285 A BR PI0600285A BR PI0600285 C1 BRPI0600285 C1 BR PI0600285C1
Authority
BR
Brazil
Prior art keywords
lipid
analogs
pharmaceutical compounds
nanostructures
paclitaxel
Prior art date
Application number
BRC10600285-4A
Other languages
English (en)
Inventor
Alcides Jose Zago
Original Assignee
Brz Biotecnologia Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brz Biotecnologia Ltda filed Critical Brz Biotecnologia Ltda
Priority to BRC10600285-4A priority Critical patent/BRPI0600285C1/pt
Priority to CNA2007800017443A priority patent/CN101365447A/zh
Priority to AU2007204550A priority patent/AU2007204550A1/en
Priority to EP07701600A priority patent/EP1978957A4/en
Priority to JP2008549721A priority patent/JP2009523133A/ja
Priority to CA002636336A priority patent/CA2636336A1/en
Priority to PCT/BR2007/000015 priority patent/WO2007079560A2/en
Publication of BRPI0600285A publication Critical patent/BRPI0600285A/pt
Priority to US12/217,028 priority patent/US20090011005A1/en
Publication of BRPI0600285C1 publication Critical patent/BRPI0600285C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

COMPOSTOS FARMACêUTICOS CONTENDO NANOPARTìCULAS úTEIS PARA TRATAMENTO DE LESõES REESTENóTICAS. São descritas compostos farmacêuticos contendo nanoestruturas lipídicas carreadoras de rapamicina ou análogos, paclitaxel ou análogos, ou a combinação de rapamicina ou análogos e paclitaxel ou análogos úteis para a estabilização (não progressão) ou redução da placa ateromatosa e para a prevenção e tratamento da reestenose intra-stent, assim como de outras doenças e processos biológicos caracterizados pela proliferação celular aumentada e/ou desordenada, sendo as nanoestrutu ras lipídicas selecionadas dentre lipoproteinas LDL e/ou VLDL associadas ou não a componentes lipídicos compatíveis com a administração intravenosa como fosfatidilcolina, fosfolipideos, lecitinas, colesterol e seus ésteres, e triacilgliceróis, em que as lipoproteinas plasmáticas são livres, acetiladas ou oxidadas. Essas nanoestruturas lipídicas compreendem nanoemu Isões, lipossomas de dimensões nanométricas, carreadores lipídicos nanoestruturados, nanopartículas lipídicas sólidas, e/ou similares.
BRC10600285-4A 2006-01-13 2006-01-13 compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas BRPI0600285C1 (pt)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRC10600285-4A BRPI0600285C1 (pt) 2006-01-13 2006-01-13 compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas
CNA2007800017443A CN101365447A (zh) 2006-01-13 2007-01-12 用于治疗再狭窄病变的含有纳米粒子的药物组合物
AU2007204550A AU2007204550A1 (en) 2006-01-13 2007-01-12 Pharmaceutical compounds that contain nanoparticles useful for treating restenotic lesions
EP07701600A EP1978957A4 (en) 2006-01-13 2007-01-12 NANOTEILS CONTAINING PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF RESTENOTIC LESIONS
JP2008549721A JP2009523133A (ja) 2006-01-13 2007-01-12 再狭窄病変治療に有用なナノ粒子含有の薬化合物類
CA002636336A CA2636336A1 (en) 2006-01-13 2007-01-12 Pharmaceutical compounds that contain nanoparticles useful for treating restenotic lesions
PCT/BR2007/000015 WO2007079560A2 (en) 2006-01-13 2007-01-12 Pharmaceutical compounds that contain nanoparticles useful for treating restenotic lesions
US12/217,028 US20090011005A1 (en) 2006-01-13 2008-07-01 Pharmaceuticals compositions containing nanomaterials useful for treating restenotic lesions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRC10600285-4A BRPI0600285C1 (pt) 2006-01-13 2006-01-13 compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas

Publications (2)

Publication Number Publication Date
BRPI0600285A BRPI0600285A (pt) 2007-10-02
BRPI0600285C1 true BRPI0600285C1 (pt) 2011-10-11

Family

ID=38256650

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC10600285-4A BRPI0600285C1 (pt) 2006-01-13 2006-01-13 compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas

Country Status (8)

Country Link
US (1) US20090011005A1 (pt)
EP (1) EP1978957A4 (pt)
JP (1) JP2009523133A (pt)
CN (1) CN101365447A (pt)
AU (1) AU2007204550A1 (pt)
BR (1) BRPI0600285C1 (pt)
CA (1) CA2636336A1 (pt)
WO (1) WO2007079560A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
WO2008063576A2 (en) * 2006-11-20 2008-05-29 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
WO2011139899A2 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
KR101314579B1 (ko) * 2011-04-07 2013-10-10 광주과학기술원 파크리탁셀이 선적된 고분자 나노입자 및 그 제조방법
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
HUP1400075A2 (hu) 2014-02-14 2015-08-28 Druggability Technologies Ip Holdco Jersey Ltd Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
CN114028623B (zh) * 2021-10-26 2024-02-27 江苏朴芃医疗科技有限公司 心脏分流器

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
IL139541A0 (en) * 1998-05-20 2004-02-08 Liposome Co Inc Novel particulate formulations
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20030065382A1 (en) * 2001-10-02 2003-04-03 Fischell Robert E. Means and method for the treatment of coronary artery obstructions
US20050095267A1 (en) * 2002-12-04 2005-05-05 Todd Campbell Nanoparticle-based controlled release polymer coatings for medical implants
EP1608359A4 (en) * 2003-04-03 2011-08-17 Jessie L-S Au DRUG-LOADING PARTICLES TARGETING TUMORS
EP1628641A2 (en) * 2003-05-19 2006-03-01 Baxter International Inc. Solid particles comprising an anticonvulsant or an immunosuppressive coated with one or more surface modifiers
US8043631B2 (en) * 2004-04-02 2011-10-25 Au Jessie L S Tumor targeting drug-loaded particles
JP2008512350A (ja) * 2004-07-01 2008-04-24 イェール ユニバーシティ 標的化され、そして高密度で薬物が負荷されるポリマー性物質
US7727554B2 (en) * 2004-12-21 2010-06-01 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Sustained-release nanoparticle compositions and methods for using the same
US20060257450A1 (en) * 2005-03-21 2006-11-16 Sreenivasu Mudumba Drug delivery systems for treatment of diseases or conditions

Also Published As

Publication number Publication date
US20090011005A1 (en) 2009-01-08
AU2007204550A1 (en) 2007-07-19
WO2007079560A3 (en) 2007-12-27
WO2007079560A2 (en) 2007-07-19
CN101365447A (zh) 2009-02-11
JP2009523133A (ja) 2009-06-18
BRPI0600285A (pt) 2007-10-02
EP1978957A2 (en) 2008-10-15
EP1978957A4 (en) 2013-01-09
CA2636336A1 (en) 2007-07-19

Similar Documents

Publication Publication Date Title
BRPI0600285C1 (pt) compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas
Chen et al. Antibacterial micelles with vancomycin-mediated targeting and pH/lipase-triggered release of antibiotics
Jia et al. Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo
Durán et al. Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity
Habiba et al. Synergistic antibacterial activity of PEGylated silver–graphene quantum dots nanocomposites
Sun et al. Graphene quantum dots-band-aids used for wound disinfection
Phenrat et al. Partial oxidation (“aging”) and surface modification decrease the toxicity of nanosized zerovalent iron
Zhao et al. Synergy of non-antibiotic drugs and pyrimidinethiol on gold nanoparticles against superbugs
Bohanon et al. Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis
Liu et al. Graphene oxide attenuates the cytotoxicity and mutagenicity of PCB 52 via activation of genuine autophagy
BR112012010270A2 (pt) mentisulfonilmetano (msm) para tratamento de micro-organismos resistentes a fármaco
Xue et al. Alkaline “nanoswords” coordinate ferroptosis-like bacterial death for antibiosis and osseointegration
BRPI0519890A2 (pt) macrociclos de 18 elementos e seus análogos
BR112014029010A2 (pt) sistemas para tratamento de infecções pulmonares
BR112014004741A2 (pt) pelo menos uma entidade química; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada
Xiaoli et al. Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells
Zolali et al. Effects of gamma oryzanol on factors of oxidative stress and sepsis-induced lung injury in experimental animal model
Singh et al. MoS2-modified curcumin nanostructures: the novel theranostic hybrid having potent antibacterial and antibiofilm activities against multidrug-resistant hypervirulent klebsiella pneumoniae
Al-Hakkani et al. Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@ hematite nanoparticles
Cui et al. Bis (12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Chavez-Dozal et al. In vitro analysis of flufenamic acid activity against Candida albicans biofilms
Zhong et al. Development of amphiphilic coumarin derivatives as membrane-active antimicrobial agents with potent in vivo efficacy against Gram-positive pathogenic bacteria
Qian et al. Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials
Gu et al. Dihydroartemisinin-loaded chitosan nanoparticles inhibit the rifampicin-resistant mycobacterium tuberculosis by disrupting the cell wall
Zhang et al. Long-term antibacterial activity of guanidinium carbon dots without detectable resistance for the effective treatment of pneumonia caused by Gram-negative bacteria

Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.

B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B11Q Dismissal: the certificate of addition was not accessory to any patent, or a patent which was nominated accessory and no longer exists

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE:

B11T Dismissal of application maintained [chapter 11.20 patent gazette]
B11T Dismissal of application maintained [chapter 11.20 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE: