BRPI0515811A - substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition - Google Patents
substituted indols, process for preparation and use thereof, medicament and pharmaceutical compositionInfo
- Publication number
- BRPI0515811A BRPI0515811A BRPI0515811-7A BRPI0515811A BRPI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A BR PI0515811 A BRPI0515811 A BR PI0515811A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- medicament
- pharmaceutical composition
- substituted
- indols
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"INDóIS SUBSTITUìDOS, PROCESSO PARA PREPARAçãO, BEM COMO UTILIZAçãO DOS MESMOS, MEDICAMENTO E COMPOSIçãO FARMACêUTICA". A presente invenção refere-se notadamente ao preparo de indóis substituídos, das composições que os contêm, ao respectivo processo de preparo e à respectiva utilização como medicamento, em particular como agentes anticancerígenos."SUBSTITUTED INDOS, PROCESS FOR PREPARATION, AS WELL AS USE, MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION". The present invention relates notably to the preparation of substituted indoles, the compositions containing them, their preparation process and their use as a medicament, in particular as anticancer agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0412966A FR2878849B1 (en) | 2004-12-06 | 2004-12-06 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
US65046505P | 2005-02-07 | 2005-02-07 | |
PCT/FR2005/003003 WO2006061493A1 (en) | 2004-12-06 | 2005-12-02 | Substituted indoles, compositions containing them, method for the production thereof and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515811A true BRPI0515811A (en) | 2008-08-05 |
Family
ID=38792212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515811-7A BRPI0515811A (en) | 2004-12-06 | 2005-12-02 | substituted indols, process for preparation and use thereof, medicament and pharmaceutical composition |
Country Status (9)
Country | Link |
---|---|
JP (1) | JP2008532926A (en) |
KR (1) | KR20070100277A (en) |
BR (1) | BRPI0515811A (en) |
CR (1) | CR9115A (en) |
EA (1) | EA012613B1 (en) |
IL (1) | IL183438A0 (en) |
MA (1) | MA29026B1 (en) |
MX (1) | MX2007006764A (en) |
NO (1) | NO20073015L (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005037499A1 (en) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | pyrazole |
JP7323218B2 (en) * | 2019-02-18 | 2023-08-08 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | Substituted Fused Aromatic Ring Derivatives, Compositions Thereof, and Uses Thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376529B1 (en) * | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
US5780496A (en) * | 1995-06-07 | 1998-07-14 | Sugen, Inc. | Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions |
JP4623962B2 (en) * | 2001-10-22 | 2011-02-02 | ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク | Protein kinases and phosphatase inhibitors, methods of designing them, and methods of using them |
EP1777223A1 (en) * | 2002-06-24 | 2007-04-25 | Schering Corporation | Indole derivatives useful as histamine H3 antagonists |
FR2842526B1 (en) * | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS COMPRISING A 3-GUANIDINOCARBONYL-1-HETEROARYL-INDOLE DERIVATIVE, PROCESS FOR THE PREPARATION AS MEDICAMENTS |
JP2004149429A (en) * | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | Indole compound and application thereof |
-
2005
- 2005-12-02 KR KR1020077015482A patent/KR20070100277A/en not_active Application Discontinuation
- 2005-12-02 EA EA200701227A patent/EA012613B1/en not_active IP Right Cessation
- 2005-12-02 JP JP2007543884A patent/JP2008532926A/en active Pending
- 2005-12-02 BR BRPI0515811-7A patent/BRPI0515811A/en not_active IP Right Cessation
- 2005-12-02 MX MX2007006764A patent/MX2007006764A/en unknown
-
2007
- 2007-05-09 CR CR9115A patent/CR9115A/en unknown
- 2007-05-17 MA MA29913A patent/MA29026B1/en unknown
- 2007-05-27 IL IL183438A patent/IL183438A0/en unknown
- 2007-06-13 NO NO20073015A patent/NO20073015L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA012613B1 (en) | 2009-10-30 |
MX2007006764A (en) | 2007-08-15 |
EA200701227A1 (en) | 2007-10-26 |
NO20073015L (en) | 2007-08-28 |
IL183438A0 (en) | 2007-09-20 |
CR9115A (en) | 2007-10-23 |
MA29026B1 (en) | 2007-11-01 |
JP2008532926A (en) | 2008-08-21 |
KR20070100277A (en) | 2007-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |