BRPI0509897A - aparelho e método para distribuição transdérmica de múltiplas vacinas - Google Patents

aparelho e método para distribuição transdérmica de múltiplas vacinas

Info

Publication number
BRPI0509897A
BRPI0509897A BRPI0509897-1A BRPI0509897A BRPI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A
Authority
BR
Brazil
Prior art keywords
array
active agent
immunologically active
regions
biocompatible coating
Prior art date
Application number
BRPI0509897-1A
Other languages
English (en)
Inventor
Joseph C Trautman
Peter E Daddona
Michel J N Cormier
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0509897A publication Critical patent/BRPI0509897A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

APARELHO E MéTODO PARA DISTRIBUIçãO TRANSDéRMICA DE MúLTIPLAS VACINAS. a presente invenção refere-se a um aparelho e método para a distribuição transdérmica de um agente imunologicamente ativo compreendendo um sistema de distribuição possuindo um conjunto de microprojeções que inclui uma pluraridade de microprojeções que são adaptadas para perfurar o stratum corneum e entrar na camada epidérmica subjacente,ou as camadas de ipiderme e derme, o conjunto de microprojeção uma pluraridade de regiões de conjunto, cada uma das regiões de conjunto, cada uma das regiões de conjunto posuindo um revesimento biocompatível diferente na mesma,onde pelo menos um dos revestimentos de região de conjunto iclui um agente imunologicamente ativo. Em uma modalidade, cada revestimento nas regiões de conjunto inclui um agente imunologicamente ativo diferente. Em outra modalidade,o revestimento biocompatível em uma primeira região de conjunto inclui um agente imunologicamente ativo e o revestimento biocompatível em uma segunda região de conjunto inclui um adjuvante de aumento de resposta imune.
BRPI0509897-1A 2004-04-13 2005-03-18 aparelho e método para distribuição transdérmica de múltiplas vacinas BRPI0509897A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56195304P 2004-04-13 2004-04-13
PCT/US2005/009152 WO2005103303A2 (en) 2004-04-13 2005-03-18 Apparatus and method for transdermal delivery of multiple vaccines

Publications (1)

Publication Number Publication Date
BRPI0509897A true BRPI0509897A (pt) 2007-08-07

Family

ID=35197563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509897-1A BRPI0509897A (pt) 2004-04-13 2005-03-18 aparelho e método para distribuição transdérmica de múltiplas vacinas

Country Status (12)

Country Link
US (1) US20050271684A1 (pt)
EP (1) EP1735469A2 (pt)
JP (1) JP2007537783A (pt)
KR (1) KR20070011481A (pt)
CN (1) CN101120101A (pt)
AR (1) AR048545A1 (pt)
AU (1) AU2005235990A1 (pt)
BR (1) BRPI0509897A (pt)
CA (1) CA2562642A1 (pt)
MX (1) MXPA06011971A (pt)
TW (1) TW200600107A (pt)
WO (1) WO2005103303A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
JP2008507590A (ja) * 2004-05-19 2008-03-13 アルザ コーポレイション 免疫活性剤を経皮送達するための方法及び配合物
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
DE102007060599A1 (de) * 2007-12-15 2009-06-18 Merck Patent Gmbh Verfahren zur Extraktion von Membranproteinen
MX2011003277A (es) * 2008-10-14 2012-09-21 Salubrious Pharmaceuticals LLC Proceso para el tratamiento de la artritis reumatoide, temblores/enfermedad de parkinson, esclerosis multiple y cancer de tipo no viral.
US20110196299A1 (en) * 2008-10-25 2011-08-11 Youn-Sung Kim Structure of needle for syringe
CN102281897A (zh) * 2008-10-31 2011-12-14 T·S·顾巴 通过机械破坏表皮进行痘病毒载体的疫苗接种
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
US20110006458A1 (en) * 2009-04-24 2011-01-13 Corium International, Inc. Methods for manufacturing microprojection arrays
WO2010127144A1 (en) 2009-04-29 2010-11-04 Muniyappa Pravin K Device and method for the diagnosis of gastrointestinal allergy
CA2798145C (en) 2010-05-04 2022-10-18 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP5225364B2 (ja) 2010-12-08 2013-07-03 住友ゴム工業株式会社 ストリップ、その製造方法および空気入りタイヤの製造方法
WO2012151272A2 (en) * 2011-05-02 2012-11-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
WO2014100750A1 (en) 2012-12-21 2014-06-26 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
JPWO2014142135A1 (ja) 2013-03-12 2017-02-16 武田薬品工業株式会社 マイクロニードルパッチ
BR122020006959B1 (pt) 2013-03-12 2022-04-26 Corium, Inc Aplicador de microprojeções
JP6700170B2 (ja) 2013-03-15 2020-05-27 コリウム， インコーポレイテッド 治療剤の送達のためのマイクロアレイおよび使用の方法
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN106061546A (zh) * 2014-02-10 2016-10-26 Lts勒曼治疗***股份公司 微针***及其制造方法
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP6724792B2 (ja) * 2015-01-13 2020-07-15 凸版印刷株式会社 経皮投与デバイス
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP7217700B2 (ja) 2016-09-13 2023-02-03 アラーガン、インコーポレイテッド 安定化非タンパク質クロストリジウム毒素組成物
US11241563B2 (en) * 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
CN110831625A (zh) * 2017-07-24 2020-02-21 株式会社培旺精廉宅 疫苗佐剂及微针制剂
WO2019190267A1 (ko) * 2018-03-30 2019-10-03 랩앤피플주식회사 멀티형 마이크로 니들
KR20210025601A (ko) 2018-06-29 2021-03-09 존슨 앤드 존슨 컨수머 인코포레이티드 활성제의 전달을 위한 3차원 미세유체학 장치
US11697009B2 (en) * 2019-09-06 2023-07-11 Industry-Academic Cooperation Foundation, Yonsei University Microneedle patch, micro needle system and method of fabricating the same
US11796548B2 (en) 2020-04-22 2023-10-24 The United States Of America, As Represented By The Secretary Of Agriculture Continuous stable cell line for identification of infectious African swine fever virus in clinical samples
CN115068602B (zh) * 2022-08-22 2022-11-01 北京华诺泰生物医药科技有限公司 一种表面改性氧化铝的复合疫苗佐剂、制备方法及应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) * 1964-09-08 Means for vaccinating
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
DE3113984C2 (de) * 1981-04-07 1983-12-01 Bodenseewerk Perkin-Elmer & Co GmbH, 7770 Überlingen Doppelmonochromator
US4877612A (en) * 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5659578A (en) * 1994-11-23 1997-08-19 At&T Wireless Services, Inc. High rate Reed-Solomon concatenated trellis coded 16 star QAM system for transmission of data over cellular mobile radio
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
US7184826B2 (en) * 1996-06-18 2007-02-27 Alza Corporation Device and method for enhancing transdermal flux of agents being delivered or sampled
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
AU757230B2 (en) * 1997-12-11 2003-02-06 Alza Corporation Device for enhancing transdermal agent flux
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
EP1037686B1 (en) * 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1086214B1 (en) * 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
DK1335711T3 (da) * 2000-09-08 2007-11-26 Alza Corp Transdermal indretning
AU2001296827B2 (en) * 2000-10-13 2005-11-17 Alza Corporation Microblade array impact applicator
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
CN1479589A (zh) * 2000-10-13 2004-03-03 用于冲击敷贴器的微凸起构件保持器
PL365677A1 (en) * 2000-10-26 2005-01-10 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
WO2002085447A2 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
CA2451816A1 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
HUP0402605A2 (hu) * 2001-12-20 2005-06-28 Alza Corporation Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén
EP3061492B1 (en) * 2002-03-11 2018-09-19 Nitto Denko Corporation Transdermal drug delivery patch system
WO2004002566A1 (en) * 2002-06-28 2004-01-08 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20040265365A1 (en) * 2003-06-30 2004-12-30 Daddona Peter E. Method for coating skin piercing microprojections
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
WO2005002453A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
US20050106227A1 (en) * 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
CN100571643C (zh) * 2003-10-31 2009-12-23 阿尔扎公司 用于微凸起阵列的自驱动施加器
WO2005051456A2 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
BRPI0509493A (pt) * 2004-04-01 2007-09-11 Alza Corp aparelho e método para a liberação transdérmica de vacina da influenza
AU2005244734A1 (en) * 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents

Also Published As

Publication number Publication date
WO2005103303A3 (en) 2007-10-18
MXPA06011971A (es) 2007-04-16
AR048545A1 (es) 2006-05-03
AU2005235990A1 (en) 2005-11-03
CA2562642A1 (en) 2005-11-03
KR20070011481A (ko) 2007-01-24
US20050271684A1 (en) 2005-12-08
JP2007537783A (ja) 2007-12-27
EP1735469A2 (en) 2006-12-27
TW200600107A (en) 2006-01-01
WO2005103303A2 (en) 2005-11-03
CN101120101A (zh) 2008-02-06

Similar Documents

Publication Publication Date Title
BRPI0509897A (pt) aparelho e método para distribuição transdérmica de múltiplas vacinas
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
BR0209041A (pt) Emplastro de imunização de disposição de microprojeção e método
BRPI0509788A (pt) aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides
AR046697A1 (es) Metodo y sistema de administracion transdermica de agente asistido por frecuencia
BRPI0416822A (pt) método e sistema de liberação de vacina transdérmica com ultra-som
US20040265365A1 (en) Method for coating skin piercing microprojections
US20040199103A1 (en) Solid solution perforator for drug delivery and other applications
WO2007106597A3 (en) Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
BRPI0509901A (pt) aparelho e método para liberação transdérmica de agentes com base em fentanila
TW200618830A (en) Micorprojection apparatus and system with low infection potential
WO2006020841A3 (en) Apparatus and method for transdermal delivery of natriuretic peptides
UY28398A1 (es) Método y parche de inmunización por disposición de microproyección
BR0209046A (pt) Disposição de microprojeção que possui um agente benéfico contendo revestimento
BRPI0415986A (pt) método e aparelho para reduzir a incidência do uso de tabaco
Chen et al. An update on the use of laser technology in skin vaccination
AR050608A1 (es) Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
Coffey et al. An Ultrahigh‐Density Microneedle Array for Skin Vaccination: Inducing Epidermal Cell Death by Increasing Microneedle Density Enhances Total IgG and IgG1 Immune Responses
Rudd et al. Effective cutaneous vaccination using an inactivated chikungunya virus vaccine delivered by Foroderm
Ameri et al. Formulation approach that enables the coating of a stable influenza vaccine on a transdermal microneedle patch
Donnelly How can microneedles overcome challenges facing transdermal drug delivery?
WO2006089056A3 (en) Apparatus and method for transdermal delivery of erythropoetin-based agents
Chandran et al. Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery
Foroogh Ameri et al. Comparison of the effect of EMLA cream and acupressure on pain Reduction of venipuncture in 6-12 years old children
MX2022013287A (es) Dispositivos de administracion transdermica de agente activo que tienen microprotrusiones recubiertas de vacuna contra el coronavirus.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]