BRPI0506536A - células tronco do tipo embriÈnico pluripotentes derivadas do limbus da córnea, métodos de isolamento e uso das mesmas - Google Patents
células tronco do tipo embriÈnico pluripotentes derivadas do limbus da córnea, métodos de isolamento e uso das mesmasInfo
- Publication number
- BRPI0506536A BRPI0506536A BRPI0506536-4A BRPI0506536A BRPI0506536A BR PI0506536 A BRPI0506536 A BR PI0506536A BR PI0506536 A BRPI0506536 A BR PI0506536A BR PI0506536 A BRPI0506536 A BR PI0506536A
- Authority
- BR
- Brazil
- Prior art keywords
- stem cells
- elscs
- pluripotent embryonic
- embryonic
- isolation methods
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
- C12N2502/085—Coculture with; Conditioned medium produced by cells of the nervous system eye cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Abstract
CéLULAS TRONCO DO TIPO EMBRIÈNICO PLURIPOTENTES DERIVADAS DO LIMBUS DA CóRNEA, MéTODOS DE ISOLAMENTO E USOS DAS MESMAS, mais precisamente a presente invenção apresenta células tronco do tipo embriónico (ELSCs) pluripotentes de um mamífero isoladas de tecidos límbico de córnea, um tecido não embriónico, onde as ELSCs têm a capacidade de proliferar em uma cultura in vitro, mantêm o potencial para se diferenciar em células da linhagem de endoderme, mesoderme, e ectoderme em cultura, e têm a capacidade de formar corpos do tipo embrióide quando colocadas em cultura em suspensão e, desse modo, essas célula possuem o potencial de diferenciação de múltiplas linhagens e capacidade de se auto-renovarem, sendo que as ditas ELSCs podem ser uma ferramenta terapêutica promissora, e podem fornecer novas alternativas terapêuticas para várias doenças, condições e ferimentos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN240MU2004 | 2004-02-26 | ||
US62147604P | 2004-10-22 | 2004-10-22 | |
PCT/IB2005/000516 WO2005084119A2 (en) | 2004-02-26 | 2005-02-23 | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0506536A true BRPI0506536A (pt) | 2007-05-15 |
BRPI0506536C1 BRPI0506536C1 (pt) | 2007-05-22 |
Family
ID=34921522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRC10506536-4A BRPI0506536C1 (pt) | 2004-02-26 | 2005-02-23 | neurÈnios dopaminérgicos derivados do limbus corneal, métodos de isolamento e usos dos mesmos |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1758984A2 (pt) |
KR (3) | KR100840979B1 (pt) |
AU (1) | AU2005220066B2 (pt) |
BR (1) | BRPI0506536C1 (pt) |
IL (2) | IL177672A (pt) |
WO (1) | WO2005084119A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050186672A1 (en) * | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
WO2008026226A2 (en) * | 2006-09-01 | 2008-03-06 | Stempeutics Research Private Limited | Self-renewing master adult pluripotent stem cells |
EP2539441B1 (en) * | 2010-02-22 | 2016-09-28 | Université Pierre et Marie Curie (Paris 6) | Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage |
KR101323650B1 (ko) * | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 제거방법 |
KR102038503B1 (ko) * | 2015-08-12 | 2019-11-26 | (주) 넥셀 | 고기능성 간세포의 분화방법 |
KR101645901B1 (ko) * | 2015-12-31 | 2016-08-04 | 가톨릭대학교 산학협력단 | 양막 슬라이드 지지체를 이용한 윤부줄기세포 배양방법 |
KR101789917B1 (ko) | 2016-03-29 | 2017-10-26 | 가톨릭대학교 산학협력단 | 윤부줄기세포의 증식 및 줄기세포능을 증대시키는 방법 |
CN107345897A (zh) * | 2016-05-04 | 2017-11-14 | 上海米洋杨生物科技有限公司 | 一种视网膜感光细胞特异性表面蛋白的筛选方法 |
US20190352611A1 (en) * | 2016-11-18 | 2019-11-21 | Regents Of The University Of Minnesota | Surface markers for the isolation of myogenic stem/progenitor cells |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5703047A (en) | 1992-09-21 | 1997-12-30 | Board Of Regents, The University Of Texas System | Methods and treatments for corneal healing with growth factors |
US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US20030161817A1 (en) * | 2001-03-28 | 2003-08-28 | Young Henry E. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
ITRM20010476A1 (it) * | 2001-08-03 | 2003-02-03 | Idi Irccs | Lamine di epitelio corneale umano ricostruite e metodo per il loro ottenimento. |
US7422736B2 (en) * | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
-
2005
- 2005-02-23 AU AU2005220066A patent/AU2005220066B2/en not_active Ceased
- 2005-02-23 EP EP05708629A patent/EP1758984A2/en not_active Withdrawn
- 2005-02-23 KR KR1020067017340A patent/KR100840979B1/ko not_active IP Right Cessation
- 2005-02-23 WO PCT/IB2005/000516 patent/WO2005084119A2/en active Application Filing
- 2005-02-23 KR KR1020087005991A patent/KR20080036636A/ko active Application Filing
- 2005-02-23 BR BRC10506536-4A patent/BRPI0506536C1/pt not_active IP Right Cessation
- 2005-02-23 KR KR1020097002160A patent/KR100931887B1/ko not_active IP Right Cessation
-
2006
- 2006-08-23 IL IL177672A patent/IL177672A/en not_active IP Right Cessation
- 2006-08-23 IL IL177671A patent/IL177671A0/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100840979B1 (ko) | 2008-06-24 |
EP1758984A2 (en) | 2007-03-07 |
KR20090021229A (ko) | 2009-02-27 |
AU2005220066B2 (en) | 2010-01-21 |
KR20060114372A (ko) | 2006-11-06 |
IL177671A0 (en) | 2008-03-20 |
KR100931887B1 (ko) | 2009-12-15 |
AU2005220066A1 (en) | 2005-09-15 |
WO2005084119A2 (en) | 2005-09-15 |
KR20080036636A (ko) | 2008-04-28 |
WO2005084119A3 (en) | 2010-06-17 |
BRPI0506536C1 (pt) | 2007-05-22 |
IL177672A (en) | 2011-03-31 |
IL177672A0 (en) | 2008-03-20 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: ADDITIONAL INVENTOR S CERTIFICATE: REFERENTE A 3A, 4A, 5A E 6A ANUIDADE(S). Free format text: REFERENTE A 6A ANUIDADE(S). |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: ADDITIONAL INVENTOR S CERTIFICATE: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2094 DE 22/02/2011. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2094 DE 22/02/2011. |