BRPI0503734A - pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration - Google Patents

pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration

Info

Publication number
BRPI0503734A
BRPI0503734A BRPI0503734A BRPI0503734A BR PI0503734 A BRPI0503734 A BR PI0503734A BR PI0503734 A BRPI0503734 A BR PI0503734A BR PI0503734 A BRPI0503734 A BR PI0503734A
Authority
BR
Brazil
Prior art keywords
morphine
epidural
ready
injection
pharmaceutical composition
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
Ogari De Castro Pacheco
Roberto Debom Moreira
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Priority to BRPI0503734 priority Critical patent/BRPI0503734A/en
Priority to PCT/BR2006/000168 priority patent/WO2007022609A1/en
Publication of BRPI0503734A publication Critical patent/BRPI0503734A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA NA FORMA DE SOLUçãO INJETáVEL DE MORFINA PRONTA PARA USO E FORMA DE DOSAGEM UNITáRIA DE MORFINA PARA ADMINISTRAçãO EPIDURAL OU INTRATECAL". A presente invenção refere-se a uma composição analgésica na forma de uma solução injetável, estéril e apirogênica que é constituída de um sal farmaceuticamente aceitável de morfina dissolvido em um solvente (veículo) farmaceuticamente aceitável, sendo o pH da solução resultante na faixa de 2,5 a 6,5 e a concentração de morfina de cerca de 0,025 a 0,195 mg/mL (expressa como o seu sal hidratado). Tal composição, acondicionada em um container selado, é pronta para uso e é adequada para administração epidural e intratecal em adultos e endovenosa em crianças."PHARMACEUTICAL COMPOSITION IN THE FORM OF INJECTABLE MORPHINE READY FOR USE AND UNITARY MORPHINE DOSAGE FORM FOR EPIDURAL OR INTRATECAL ADMINISTRATION". The present invention relates to an analgesic composition in the form of a sterile, pyrogen-free solution for injection which is comprised of a pharmaceutically acceptable salt of morphine dissolved in a pharmaceutically acceptable solvent (carrier), the pH of the resulting solution being in the range of 2 0.5 to 6.5 and the morphine concentration of about 0.025 to 0.195 mg / mL (expressed as its hydrated salt). Such a composition, packaged in a sealed container, is ready for use and is suitable for epidural and intrathecal administration in adults and intravenous in children.

BRPI0503734 2005-08-23 2005-08-23 pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration BRPI0503734A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0503734 BRPI0503734A (en) 2005-08-23 2005-08-23 pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration
PCT/BR2006/000168 WO2007022609A1 (en) 2005-08-23 2006-08-18 Pharmaceutical composition of morphine in ready-to-use injectable solution form and single dosage form of morphine for epidural or intrathecal administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0503734 BRPI0503734A (en) 2005-08-23 2005-08-23 pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration

Publications (1)

Publication Number Publication Date
BRPI0503734A true BRPI0503734A (en) 2007-04-27

Family

ID=37771186

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0503734 BRPI0503734A (en) 2005-08-23 2005-08-23 pharmaceutical composition in ready-to-use morphine solution for injection and unit dosage form of morphine for epidural or intrathecal administration

Country Status (2)

Country Link
BR (1) BRPI0503734A (en)
WO (1) WO2007022609A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155734B2 (en) * 2012-03-07 2015-10-13 Mallinckrodt Llc Stability of hydromorphone hydrochloride solutions
BR112015021586B1 (en) 2013-03-14 2023-01-31 Fresenius Kabi Deutschland Gmbh INJECTABLE PHARMACEUTICAL MORPHINE FORMULATION AND KIT
EP3424547A1 (en) 2013-03-14 2019-01-09 Fresenius Kabi Austria GmbH Packaging system for oxygen-sensitive drugs
WO2014140899A2 (en) * 2013-03-15 2014-09-18 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367738A (en) * 1981-10-28 1983-01-11 Janssen Pharmaceutica Inc. Pre-filled syringe for abusable drugs
CA2258965A1 (en) * 1996-06-28 1998-01-08 Oxigene, Inc. Useful formulations of acid addition salt drugs

Also Published As

Publication number Publication date
WO2007022609B1 (en) 2007-04-12
WO2007022609A1 (en) 2007-03-01

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B09B Decision: refusal

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL