BRPI0416812A - métodos e reagentes para o tratamento de desordens inflamatórias - Google Patents

métodos e reagentes para o tratamento de desordens inflamatórias

Info

Publication number
BRPI0416812A
BRPI0416812A BRPI0416812-7A BRPI0416812A BRPI0416812A BR PI0416812 A BRPI0416812 A BR PI0416812A BR PI0416812 A BRPI0416812 A BR PI0416812A BR PI0416812 A BRPI0416812 A BR PI0416812A
Authority
BR
Brazil
Prior art keywords
treatment
reagents
methods
inflammatory disorders
compound
Prior art date
Application number
BRPI0416812-7A
Other languages
English (en)
Inventor
Edward Roydon Jost-Price
Palaniyandi Manivasakam
Brendan Smith
Michael S Slavonic
Benjamin A Auspitz
Original Assignee
Combinatorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc filed Critical Combinatorx Inc
Publication of BRPI0416812A publication Critical patent/BRPI0416812A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"MéTODOS E REAGENTES PARA O TRATAMENTO DE DESORDENS INFLAMATóRIAS". A presente invenção refere-se a um método para tratar um imunoinflamatório administrando um composto de fórmula (I), por exemplo, ibudilast ou KC-764, sozinho ou em combinação com um corticosteróide, pirimidopirimidina tetra-substituída, ou outro composto. A invenção também apresenta composições farmacêuticas incluindo a combinação acima para o tratamento ou prevenção de uma desordem imunoinflamatória.
BRPI0416812-7A 2003-11-21 2004-11-17 métodos e reagentes para o tratamento de desordens inflamatórias BRPI0416812A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52411703P 2003-11-21 2003-11-21
PCT/US2004/038512 WO2005051293A2 (en) 2003-11-21 2004-11-17 Methods and reagents for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
BRPI0416812A true BRPI0416812A (pt) 2007-03-06

Family

ID=34632866

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416812-7A BRPI0416812A (pt) 2003-11-21 2004-11-17 métodos e reagentes para o tratamento de desordens inflamatórias

Country Status (17)

Country Link
US (2) US7709495B2 (pt)
EP (1) EP1689390B1 (pt)
JP (1) JP2007512337A (pt)
KR (1) KR20060120208A (pt)
CN (1) CN1905870A (pt)
AT (1) ATE497763T1 (pt)
AU (1) AU2004292445B2 (pt)
BR (1) BRPI0416812A (pt)
CA (1) CA2546347A1 (pt)
DE (1) DE602004031356D1 (pt)
IL (1) IL175781A0 (pt)
NO (1) NO20062300L (pt)
NZ (1) NZ547389A (pt)
RU (1) RU2006121978A (pt)
SG (1) SG148198A1 (pt)
WO (1) WO2005051293A2 (pt)
ZA (1) ZA200604253B (pt)

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EP1689390B1 (en) * 2003-11-21 2011-02-09 Zalicus Inc. Methods and reagents for the treatment of inflammatory disorders
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RU2536274C1 (ru) * 2013-12-20 2014-12-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ лечения бородавок
CN108033959A (zh) * 2018-01-29 2018-05-15 山东省药学科学院 一种异丁司特的化学合成方法
WO2019226515A1 (en) * 2018-05-21 2019-11-28 The University Of North Carolina At Chapel Hill Methods of inhibiting proinflammatory neuroimmune signaling and treating inflammatory disorders
CN113456618A (zh) * 2020-03-31 2021-10-01 天津金耀集团有限公司 一种复方双嘧达莫的吸入制剂及其制备方法
EP4132521A1 (en) * 2020-04-06 2023-02-15 MediciNova, Inc. Methods of reducing plasma level of macrophage migratory inhibitory factor in patients with ibudilast
EP4284366A1 (en) * 2021-01-29 2023-12-06 MediciNova, Inc. Methods of treating chemical gas exposure
CN115414354A (zh) * 2022-08-29 2022-12-02 西南医科大学 花椒毒素在制备治疗血小板减少症药物中的应用

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Also Published As

Publication number Publication date
US20100210606A1 (en) 2010-08-19
EP1689390B1 (en) 2011-02-09
ZA200604253B (en) 2007-10-31
RU2006121978A (ru) 2007-12-27
CN1905870A (zh) 2007-01-31
NO20062300L (no) 2006-08-21
AU2004292445B2 (en) 2010-02-04
IL175781A0 (en) 2008-04-13
EP1689390A2 (en) 2006-08-16
DE602004031356D1 (de) 2011-03-24
EP1689390A4 (en) 2008-03-12
WO2005051293A2 (en) 2005-06-09
ATE497763T1 (de) 2011-02-15
NZ547389A (en) 2009-11-27
US20050187203A1 (en) 2005-08-25
AU2004292445A1 (en) 2005-06-09
JP2007512337A (ja) 2007-05-17
CA2546347A1 (en) 2005-06-09
SG148198A1 (en) 2008-12-31
WO2005051293A3 (en) 2006-03-02
KR20060120208A (ko) 2006-11-24
US7709495B2 (en) 2010-05-04

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