BRPI0415851A - medical uses of compounds exhibiting cb1 antagonistic activity and combination treatment involving said compounds - Google Patents

medical uses of compounds exhibiting cb1 antagonistic activity and combination treatment involving said compounds

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Publication number
BRPI0415851A
BRPI0415851A BRPI0415851-2A BRPI0415851A BRPI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A
Authority
BR
Brazil
Prior art keywords
compounds
treatment
prophylaxis
young patients
combination
Prior art date
Application number
BRPI0415851-2A
Other languages
Portuguese (pt)
Inventor
Jochen Antel
Peter-Colin Gregory
Harald Waldeck
Guenter Krause
Josephus Hubertus Maria Lange
Chris Kruse
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0415851A publication Critical patent/BRPI0415851A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

"UTILIZAçõES MéDICAS DE COMPOSTOS QUE APRESENTAM ATIVIDADE ANTAGONìSTICA DE CB~ 1~ E TRATAMENTO DE COMBINAçãO ENVOLVENDO OS REFERIDOS COMPOSTOS". A presente invenção refere-se a uma nova utilização clínica de compostos com atividade no receptor CB~ 1~ selecionados a partir do grupo de derivados de 4,5-di-hidro-1H-pirazol, derivados de 1H-Imidazol, derivados de tiazol e/ou derivados de 1H-1,2,4-triazol-3-carboxamida, como cada um definido na descrição, ou de um seu pró-fármaco, um seu tautómero ou um seu sal, na preparação de medicamentos para o tratamento e/ou profilaxia de doenças relacionadas com o receptor CB~ 1~ em doentes jovens e/ou para o tratamento e/ou profilaxia da obesidade induzida por fármaco em doentes jovens, assim como em adolescentes. Além disso, a invenção refere-se à utilização dos referidos compostos com atividade no receptor CB~ 1~ em combinação com inibidores de lipase. Os referidos compostos são particularmente adequados em combinação com inibidores de lipase na preparação de medicamentos para o tratamento e/ou profilaxia da obesidade em pacientes adolescentes ou jovens e/ou para o tratamento e/ou profilaxia da obesidade induzida por fármaco em doentes jovens assim como em adolescentes. Os inibidores de lipase preferidos são orlistato, panclicinas, ATL-962 e/ou lipstatina."MEDICAL USES OF COMPOUNDS PRESENTING ANTAGONOSTIC ACTIVITY OF CB ~ 1 ~ AND COMBINATION TREATMENT INVOLVING THESE COMPOUNDS". The present invention relates to a novel clinical use of CB-1-receptor active compounds selected from the group of 4,5-dihydro-1H-pyrazole derivatives, 1H-Imidazole derivatives, thiazole derivatives and / or 1H-1,2,4-triazole-3-carboxamide derivatives as each defined in the description, or a prodrug thereof, a tautomer thereof or a salt thereof, in the preparation of medicaments for the treatment and / or prophylaxis of CB-1 receptor-related diseases in young patients and / or for the treatment and / or prophylaxis of drug-induced obesity in young patients, as well as adolescents. Furthermore, the invention relates to the use of said compounds with CB-1 receptor activity in combination with lipase inhibitors. Said compounds are particularly suitable in combination with lipase inhibitors in the preparation of medicaments for the treatment and / or prophylaxis of obesity in adolescent or young patients and / or for the treatment and / or prophylaxis of drug-induced obesity in young patients as well as in teenagers. Preferred lipase inhibitors are orlistat, panclycines, ATL-962 and / or lipstatin.

BRPI0415851-2A 2003-10-24 2004-10-22 medical uses of compounds exhibiting cb1 antagonistic activity and combination treatment involving said compounds BRPI0415851A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103961 2003-10-24
EP03103967 2003-10-27
PCT/EP2004/052639 WO2005039550A2 (en) 2003-10-24 2004-10-22 Novel medical uses of compounds showing cb1-antagonistic activity and combination treatment involving said compounds

Publications (1)

Publication Number Publication Date
BRPI0415851A true BRPI0415851A (en) 2007-01-02

Family

ID=34524748

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415851-2A BRPI0415851A (en) 2003-10-24 2004-10-22 medical uses of compounds exhibiting cb1 antagonistic activity and combination treatment involving said compounds

Country Status (8)

Country Link
EP (1) EP1753413A2 (en)
JP (1) JP2007513872A (en)
AU (1) AU2004283056A1 (en)
BR (1) BRPI0415851A (en)
CA (1) CA2543338A1 (en)
MX (1) MXPA06004434A (en)
RU (1) RU2006117627A (en)
WO (1) WO2005039550A2 (en)

Families Citing this family (11)

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EP1575901B1 (en) 2002-12-19 2012-10-10 Merck Sharp & Dohme Corp. Substituted amides
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