BRPI0412554A - pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular - Google Patents
pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascularInfo
- Publication number
- BRPI0412554A BRPI0412554A BRPI0412554-1A BRPI0412554A BRPI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- pyrazolines
- par
- antagonists
- cardiovascular disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hematology (AREA)
- Cardiology (AREA)
Abstract
"PIRAZOLINAS COMO ANTAGONISTAS PAR-1 PARA O TRATAMENTO DE DOENçAS CARDIOVASCULARES". A presente invenção refere-se a pirazolinas da fórmula (I) em que E representa metileno, NH, um átomo de oxigênio ou um átomo de enxofre, R¬ 2¬ representa um grupo da fórmula (II), e a processos para sua preparação bem como ao seu uso para a preparação de medicamentos para o tratamento e/ou profilaxia de doenças, particularmente de doenças cardio-vasculares, como por exemplo doenças trombo-embólicas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10331951 | 2003-07-15 | ||
DE102004010545A DE102004010545A1 (de) | 2003-07-15 | 2004-03-04 | Pyrazoline |
PCT/EP2004/007227 WO2005007157A1 (de) | 2003-07-15 | 2004-07-02 | Pyrazoline als par-1-antagonisten zur behandlung von herz-kreislauf-erkrankungen |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412554A true BRPI0412554A (pt) | 2006-09-19 |
Family
ID=34081645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412554-1A BRPI0412554A (pt) | 2003-07-15 | 2004-07-02 | pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1648447A1 (pt) |
AU (1) | AU2004257406A1 (pt) |
BR (1) | BRPI0412554A (pt) |
CA (1) | CA2532316A1 (pt) |
MA (1) | MA27905A1 (pt) |
MX (1) | MXPA06000507A (pt) |
NO (1) | NO20060733L (pt) |
WO (1) | WO2005007157A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004061751A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Cyanoguanidin-substituierte Pyrazoline |
DE102004061747A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Thiophen-substituierte Pyrazoline |
DE102004061748A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Azetidin-substituierte Pyrazoline |
CA2969771A1 (en) | 2014-12-08 | 2016-06-16 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
US20180118722A1 (en) * | 2015-04-17 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
EP3283480A1 (en) | 2015-04-17 | 2018-02-21 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
EP3109237A1 (en) | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
CN111892585A (zh) * | 2020-08-05 | 2020-11-06 | 杭州维坦医药科技有限公司 | 作为p2x3受体拮抗剂的n-甲酰胺基吡唑啉类衍生物及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE188690T1 (de) * | 1990-07-13 | 2000-01-15 | Rohm & Haas | N-aryl-3-aryl-4-substituierte-4,5-dihydro-1h- pyrazol-1-carboxamide und verfahren zu deren herstellung |
DE4217862A1 (de) * | 1991-08-28 | 1993-03-04 | Bayer Ag | Substituierte pyrazoline |
DE4217863A1 (de) * | 1991-08-28 | 1993-03-04 | Bayer Ag | Substituierte pyrazoline |
DE4217864A1 (de) * | 1992-05-29 | 1993-12-02 | Bayer Ag | Substituierte Pyrazoline |
DE4233713A1 (de) * | 1992-10-07 | 1994-04-14 | Bayer Ag | Substituierte 4,5-Dihydro-1-pyrazolcarbonsäureanilide |
-
2004
- 2004-07-02 BR BRPI0412554-1A patent/BRPI0412554A/pt not_active Application Discontinuation
- 2004-07-02 AU AU2004257406A patent/AU2004257406A1/en not_active Abandoned
- 2004-07-02 MX MXPA06000507A patent/MXPA06000507A/es unknown
- 2004-07-02 EP EP04740582A patent/EP1648447A1/de not_active Withdrawn
- 2004-07-02 CA CA002532316A patent/CA2532316A1/en not_active Abandoned
- 2004-07-02 WO PCT/EP2004/007227 patent/WO2005007157A1/de not_active Application Discontinuation
-
2006
- 2006-01-06 MA MA28710A patent/MA27905A1/fr unknown
- 2006-02-15 NO NO20060733A patent/NO20060733L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2004257406A1 (en) | 2005-01-27 |
EP1648447A1 (de) | 2006-04-26 |
CA2532316A1 (en) | 2005-01-27 |
MA27905A1 (fr) | 2006-05-02 |
WO2005007157A1 (de) | 2005-01-27 |
MXPA06000507A (es) | 2006-04-05 |
NO20060733L (no) | 2006-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |