BRPI0410283A - métodos de análise de uma região de ácido nucleico marcadora, de detecção ou monitoração de uma população clonal de células em um mamìfero, de diagnóstico e/ou de monitoração de uma condição de doença de mamìfero e de enriquecimento de uma população de moléculas de ácido nucleico em uma amostra biológica - Google Patents
métodos de análise de uma região de ácido nucleico marcadora, de detecção ou monitoração de uma população clonal de células em um mamìfero, de diagnóstico e/ou de monitoração de uma condição de doença de mamìfero e de enriquecimento de uma população de moléculas de ácido nucleico em uma amostra biológicaInfo
- Publication number
- BRPI0410283A BRPI0410283A BRPI0410283-5A BRPI0410283A BRPI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- monitoring
- acid region
- population
- analyzing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"MéTODOS DE ANáLISE DE UMA REGIãO DE áCIDO NUCLEICO MARCADORA, DE DETECçãO OU MONITORAçãO DE UMA POPULAçãO CLONAL DE CéLULAS EM UM MAMìFERO, DE DIAGNóSTICO E/OU DE MONITORAçãO DE UMA CONDIçãO DE DOENçA DE MAMìFERO E DE ENRIQUECIMENTO DE UMA POPULAçãO DE MOLéCULAS DE áCIDO NUCLEICO EM UMA AMOSTRA BIOLóGICA". A presente invenção refere-se a um método de caracterização de uma região de ácido nucleico e, mais particularmente, a um método de análise de uma região de ácido nucleico marcadora. O método da presente invenção baseia-se na identificação de uma ou de ambas as regiões de ácido nucleico flanqueando uma região de ácido nucleico marcadora e proporciona um meio de análise de uma região de ácido nucleico marcadora que é característica de uma população clonal de células. O método da presente invenção é útil no contexto de permitir uma variedade de aplicações incluindo, mas não limitadas a, monitoração da progressão de uma condição caracterizada pela presença de uma população clonal de células (tais como condições neoplásicas), monitoração dos níveis de uma ou mais populações clonais de células, predição da possibilidade de uma reincidência de um indivíduo de um estado remissivo para um estado doentio, para avaliar a efetividade de drogas terapêuticas existentes e/ou agentes terapêuticos novos e identificação da presença de uma região marcadora.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003902299A AU2003902299A0 (en) | 2003-05-13 | 2003-05-13 | A method of analysing a marker nucleic acid molecule |
AU2003902299 | 2003-05-13 | ||
PCT/AU2004/000625 WO2004101815A1 (en) | 2003-05-13 | 2004-05-13 | Identification of clonal cells by repeats in (eg.) t-cell receptor v/d/j genes |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0410283A true BRPI0410283A (pt) | 2006-05-16 |
BRPI0410283B1 BRPI0410283B1 (pt) | 2018-02-06 |
BRPI0410283B8 BRPI0410283B8 (pt) | 2021-07-27 |
Family
ID=31501168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410283A BRPI0410283B8 (pt) | 2003-05-13 | 2004-05-13 | método de caracterização de um gene de região variável de receptor de células t ou imunoglobulina rearranjado |
Country Status (9)
Country | Link |
---|---|
US (1) | US7785783B2 (pt) |
EP (1) | EP1633884B1 (pt) |
JP (3) | JP2007515154A (pt) |
KR (2) | KR101215194B1 (pt) |
CN (1) | CN1806051B (pt) |
AU (3) | AU2003902299A0 (pt) |
BR (1) | BRPI0410283B8 (pt) |
CA (1) | CA2525122C (pt) |
WO (1) | WO2004101815A1 (pt) |
Families Citing this family (47)
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EA200700942A1 (ru) * | 2007-04-06 | 2007-12-28 | Петр Генриевич ЛОХОВ | Способ определения качества клеточной культуры |
ES2331499B1 (es) * | 2007-08-02 | 2010-10-14 | Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud En Sevilla (Fund.Sevilla) | Cebadores, procedimiento y conjunto de utiles para la determinacion d e la funcionalidad del timo humano. |
GB2477439B (en) | 2008-11-07 | 2012-02-15 | Sequenta Inc | Methods for correlating clonotypes with a disease in a patient |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
ES2568509T3 (es) | 2009-01-15 | 2016-04-29 | Adaptive Biotechnologies Corporation | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
RU2014144463A (ru) | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
CN103097888B (zh) | 2010-05-06 | 2016-03-09 | 赛昆塔有限责任公司 | 利用克隆型谱监测健康和疾病状态 |
EP2566984B1 (en) | 2010-05-07 | 2019-04-03 | The Board of Trustees of the Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
US9279159B2 (en) | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
ES2683037T3 (es) | 2011-12-09 | 2018-09-24 | Adaptive Biotechnologies Corporation | Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
US9150905B2 (en) | 2012-05-08 | 2015-10-06 | Adaptive Biotechnologies Corporation | Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions |
CN105189779B (zh) | 2012-10-01 | 2018-05-11 | 适应生物技术公司 | 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估 |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
US9128861B2 (en) | 2013-01-17 | 2015-09-08 | Personalis, Inc. | Methods and systems for genetic analysis |
WO2014121272A2 (en) | 2013-02-04 | 2014-08-07 | Quake Stephen R | Measurement and comparison of immune diversity by high-throughput sequencing |
GB2525568B (en) | 2013-03-15 | 2020-10-14 | Abvitro Llc | Single cell barcoding for antibody discovery |
EP3415626B1 (en) | 2013-03-15 | 2020-01-22 | Lineage Biosciences, Inc. | Methods and compositions for tagging and analyzing samples |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
WO2015031689A1 (en) | 2013-08-30 | 2015-03-05 | Personalis, Inc. | Methods and systems for genomic analysis |
WO2015051275A1 (en) | 2013-10-03 | 2015-04-09 | Personalis, Inc. | Methods for analyzing genotypes |
US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
AU2015227054A1 (en) | 2014-03-05 | 2016-09-22 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
MX2017003382A (es) | 2014-09-15 | 2017-11-20 | Abvitro Llc | Secuenciacion de bibliotecas de nucleotidos de alto rendimiento. |
AU2015339191A1 (en) | 2014-10-29 | 2017-05-18 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
EP3212808B1 (en) | 2014-10-30 | 2022-03-02 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
EP3018214B1 (en) | 2014-11-05 | 2017-12-13 | Fundacion de Investigacion Hospital 12 de Octubre | Method for quantifying the level of minimal residual disease in a subject |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
AU2016222788B2 (en) | 2015-02-24 | 2022-03-31 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
US10920273B2 (en) | 2017-01-17 | 2021-02-16 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
US11008609B2 (en) | 2017-09-01 | 2021-05-18 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
US11814750B2 (en) | 2018-05-31 | 2023-11-14 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
US10801064B2 (en) | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
EP3802870A4 (en) * | 2018-06-11 | 2022-03-23 | Monoquant PTY LTD | AMPLIFICATION METHOD AND PRIMER THEREFOR |
CN110656161B (zh) * | 2018-06-28 | 2022-12-13 | 苏州云泰生物医药科技有限公司 | 用于检测人免疫球蛋白基因重排的毛细管电泳试剂盒及其使用方法 |
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US5296351A (en) * | 1988-10-20 | 1994-03-22 | Alexander A. Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
GB9507238D0 (en) * | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US6238863B1 (en) * | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
CN1264744A (zh) * | 1999-02-26 | 2000-08-30 | 上海生元基因开发有限公司 | 一种通过循环差减进行大规模cDNA克隆和测序的方法 |
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AU2000269239A1 (en) * | 2000-08-22 | 2002-03-04 | Baylor College Of Medicine | T cell receptor Vbeta-Dbeta-Jbeta sequence and methods for its detection |
CN1965089A (zh) * | 2002-10-11 | 2007-05-16 | 鹿特丹伊拉兹马斯大学 | 用于基于pcr的克隆系研究的核酸扩增引物 |
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2003
- 2003-05-13 AU AU2003902299A patent/AU2003902299A0/en not_active Abandoned
-
2004
- 2004-05-13 AU AU2004238887A patent/AU2004238887A1/en not_active Abandoned
- 2004-05-13 WO PCT/AU2004/000625 patent/WO2004101815A1/en active Application Filing
- 2004-05-13 KR KR1020057021561A patent/KR101215194B1/ko active IP Right Grant
- 2004-05-13 JP JP2006529437A patent/JP2007515154A/ja active Pending
- 2004-05-13 US US10/844,603 patent/US7785783B2/en active Active
- 2004-05-13 BR BRPI0410283A patent/BRPI0410283B8/pt active IP Right Grant
- 2004-05-13 CN CN2004800166035A patent/CN1806051B/zh not_active Expired - Lifetime
- 2004-05-13 CA CA2525122A patent/CA2525122C/en not_active Expired - Lifetime
- 2004-05-13 EP EP04732551.9A patent/EP1633884B1/en not_active Expired - Lifetime
- 2004-05-13 KR KR1020127022009A patent/KR20120107521A/ko not_active Application Discontinuation
-
2009
- 2009-11-20 AU AU2009238365A patent/AU2009238365A1/en not_active Abandoned
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2013
- 2013-02-04 JP JP2013019288A patent/JP6189600B2/ja not_active Expired - Lifetime
-
2015
- 2015-10-23 JP JP2015209110A patent/JP2016027825A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1633884A1 (en) | 2006-03-15 |
JP6189600B2 (ja) | 2017-08-30 |
KR20060015604A (ko) | 2006-02-17 |
AU2009238365A1 (en) | 2009-12-10 |
EP1633884B1 (en) | 2014-06-25 |
EP1633884A4 (en) | 2008-03-05 |
JP2016027825A (ja) | 2016-02-25 |
BRPI0410283B8 (pt) | 2021-07-27 |
JP2007515154A (ja) | 2007-06-14 |
AU2003902299A0 (en) | 2003-05-29 |
AU2004238887A1 (en) | 2004-11-25 |
BRPI0410283B1 (pt) | 2018-02-06 |
CA2525122A1 (en) | 2004-11-25 |
US20050255482A1 (en) | 2005-11-17 |
CA2525122C (en) | 2015-11-24 |
CN1806051B (zh) | 2012-05-30 |
JP2013116116A (ja) | 2013-06-13 |
CN1806051A (zh) | 2006-07-19 |
KR20120107521A (ko) | 2012-10-02 |
WO2004101815A1 (en) | 2004-11-25 |
US7785783B2 (en) | 2010-08-31 |
KR101215194B1 (ko) | 2012-12-24 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/05/2004, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |