BRPI0409882A - compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds - Google Patents

compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds

Info

Publication number
BRPI0409882A
BRPI0409882A BRPI0409882-0A BRPI0409882A BRPI0409882A BR PI0409882 A BRPI0409882 A BR PI0409882A BR PI0409882 A BRPI0409882 A BR PI0409882A BR PI0409882 A BRPI0409882 A BR PI0409882A
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical compositions
diseases
treatment
combination
Prior art date
Application number
BRPI0409882-0A
Other languages
Portuguese (pt)
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0409882A publication Critical patent/BRPI0409882A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS, COMPOSIçõES FARMACêUTICAS, MéTODO PARA O TRATAMENTO OU PROFILAXIA DE DOENçAS, E, USOS DE COMPOSTOS E DE UM OU MAIS COMPOSTOS EM COMBINAçãO COM OUTROS COMPOSTOS FARMACOLOGICAMENTE ATIVOS". A invenção refere-se a novos derivados de 3,9-diazabiciclo¢3.3.!noneno e a compostos relacionados e a seu uso como ingredientes ativos na preparação de composições farmacêuticas. A invenção refere-se também a aspectos relacionados, incluindo processos para a preparação dos compostos, composições farmacêuticas contendo um ou mais destes compostos e, em especial a seu uso como inibidores de renina."COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR TREATMENT OR PROPHYLAXY OF DISEASES, AND USES OF COMPOUNDS AND ONE OR MORE COMPOUNDS IN COMBINATION WITH OTHER PHARMACOLOGICALLY ACTIVE COMPOUNDS". The invention relates to novel 3,9-diazabicyclo [3.3] nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also relates to related aspects, including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of these compounds, and in particular their use as renin inhibitors.

BRPI0409882-0A 2003-05-02 2004-04-26 compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds BRPI0409882A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0304622 2003-05-02
PCT/EP2004/004372 WO2004096116A2 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives

Publications (1)

Publication Number Publication Date
BRPI0409882A true BRPI0409882A (en) 2006-05-23

Family

ID=33395698

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409882-0A BRPI0409882A (en) 2003-05-02 2004-04-26 compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds

Country Status (10)

Country Link
EP (1) EP1622564A2 (en)
JP (1) JP2006525259A (en)
KR (1) KR20060015573A (en)
CN (1) CN1780838A (en)
AU (1) AU2004233577A1 (en)
BR (1) BRPI0409882A (en)
CA (1) CA2521898A1 (en)
MX (1) MXPA05011711A (en)
RU (1) RU2005137571A (en)
WO (1) WO2004096116A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1867568A (en) * 2003-10-13 2006-11-22 埃科特莱茵药品有限公司 Diazabicyclononene derivatives and their use as renin inhibitors
WO2005040173A1 (en) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
AU2004295092A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd. Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
AU2005276624B2 (en) 2004-08-25 2011-09-29 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
WO2006021403A1 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
WO2006058546A1 (en) * 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Novel lactame derivatives as renin inhibitors
WO2006063610A1 (en) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
JP4111533B1 (en) 2005-01-28 2008-07-02 アクテリオン ファーマシューティカルズ リミテッド 7- {4- [2- (2,6-dichloro-4-methylphenoxy) ethoxy] phenyl} -3,9-diazabicyclo [3.3.31] as an inhibitor of renin for the treatment of hypertension Non-6-ene-6-carboxylic acid cyclopropyl- (2,3-dimethylbenzyl) amide
WO2006131884A2 (en) * 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP1968940B1 (en) 2005-12-30 2014-04-02 Novartis AG 3 , 5-substitued piperidine compounds as renin inhibitors
EP2007725A2 (en) * 2006-03-16 2008-12-31 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
EP2162436A4 (en) 2007-05-24 2010-08-04 Merck Frosst Canada Ltd Novel case of renin inhibitors
EP2527338B1 (en) 2007-06-25 2015-05-06 Novartis AG N5-(2-ethoxyethyl)-n3-(2-pyridinyl) -3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
JP4790871B2 (en) 2008-05-05 2011-10-12 メルク フロスト カナダ リミテツド 3,4-Substituted piperidine derivatives as renin inhibitors
WO2013038936A1 (en) * 2011-09-13 2013-03-21 タカラバイオ株式会社 Method for terminating peroxidase reaction, and terminating agent for said reaction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
ATE242213T1 (en) * 1995-09-07 2003-06-15 Hoffmann La Roche NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINE FOR THE TREATMENT OF HEART AND KIDNEY FAILURE
BR0309498A (en) * 2002-04-29 2005-02-15 Actelion Pharmaceuticals Ltd Compounds, pharmaceutical compositions, method for the treatment or prophylaxis of ras-related diseases, and use of compounds
US20060009497A1 (en) * 2002-06-27 2006-01-12 Actelion Pharmaceuticals, Ltd. Novel tetrahydropyridine derivatives as renin inhibitors

Also Published As

Publication number Publication date
WO2004096116A3 (en) 2005-03-24
EP1622564A2 (en) 2006-02-08
CN1780838A (en) 2006-05-31
MXPA05011711A (en) 2006-01-23
WO2004096116A2 (en) 2004-11-11
AU2004233577A1 (en) 2004-11-11
RU2005137571A (en) 2006-05-10
CA2521898A1 (en) 2004-11-11
KR20060015573A (en) 2006-02-17
JP2006525259A (en) 2006-11-09

Similar Documents

Publication Publication Date Title
BRPI0409882A (en) compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
BRPI0409884A (en) compounds, pharmaceutical compositions, method for treating or porphyxia of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
BRPI0508540A (en) compound, pharmaceutical composition, and use of a compound
BRPI0410477A (en) compound or a pharmaceutically acceptable salt thereof, method for the prophylaxis or treatment of a chiral condition in a mammal, pharmaceutical formulation, combination, use of a compound, and process for preparing a compound
BR0309498A (en) Compounds, pharmaceutical compositions, method for the treatment or prophylaxis of ras-related diseases, and use of compounds
BR0312000A (en) Compounds, pharmaceutical compositions, method for treating or prophylaxis of diseases, and use of the compounds
BRPI0409818A (en) compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
BRPI0513811A (en) imidazo [4,5-d] pyrimidines, their uses and processes of preparation
BRPI0519280A2 (en) compound, pharmaceutical composition and use of a compound
BRPI0307267B8 (en) use of beta-lactamase inhibitor compounds and pharmaceutical compositions for antibacterial therapy
BR9911482A (en) Compound, pharmaceutical composition, use of the compound, and, processes for the treatment or prophylaxis of inflammatory diseases, and for the preparation of a compound
NO20092529L (en) Substituted 2,3-dihydroimidazo [1,2-c] quinazoline derivatives useful for the treatment of hyperproliferative disorders and diseases associated with angiogenesis
BR0213522A (en) A compound, pharmaceutical composition, methods of inhibiting HIV integrase and for preventing or treating HIV infection or for preventing, treating or delaying the onset of AIDS in a patient, and useful combination for treating or preventing HIV infection or for preventing , treat or delay the onset of AIDS
BRPI0410563B8 (en) pyrazol-quinazoline compounds, their preparation processes and pharmaceutical compositions
BR9907270A (en) Compound, pharmaceutical composition, use of a compound, and, processes for the treatment or prophylaxis of inflammatory diseases, for example, asthma or copd, and for the preparation of a compound
BRPI0517634A (en) thiazole derivative or a pharmaceutically acceptable derivative thereof, process for preparing a compound, pharmaceutical composition, use of a compound or pharmaceutically acceptable salt thereof, and method of treating a disease or condition
MXPA04012965A (en) Viral inhibitors.
AR033367A1 (en) IMIDAZOPIRIMIDINE DERIVATIVES AND TRIAZOLOPIRIMIDINE DERIVATIVES, A PROCEDURE FOR THEIR PREPARATION, MEDICINES, A PHARMACEUTICAL COMPOSITION, AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINES
BR0114610A (en) Compound Usage and Pharmaceutical Composition
DE602005021770D1 (en) INDOLE-1-YL-ACETIC DERIVATIVES
BR0314353A (en) Compounds, pharmaceutical compositions, use of one or more compounds in combination with other pharmacologically active compounds, and method for treating a patient suffering from a disorder.
BRPI0407253A (en) Heterocyclyl-3-sulfonylindazoles as ligands 5-hydroxytryptamine-6 process for their preparation, their uses in the preparation of a pharmaceutical composition and a pharmaceutical composition comprising said compounds
BR0209518A (en) New aryletheroalkylamine derivatives
BRPI0409878A (en) compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
BR0309342A (en) Compound, pharmaceutical composition, use of a compound, and method of treating or prophylaxis of human diseases or conditions.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired