BRPI0409873A - inibidores da integrase do hiv - Google Patents

inibidores da integrase do hiv

Info

Publication number
BRPI0409873A
BRPI0409873A BRPI0409873-0A BRPI0409873A BRPI0409873A BR PI0409873 A BRPI0409873 A BR PI0409873A BR PI0409873 A BRPI0409873 A BR PI0409873A BR PI0409873 A BRPI0409873 A BR PI0409873A
Authority
BR
Brazil
Prior art keywords
relates
optionally polysubstituted
hiv integrase
integrase inhibitors
inhibitors
Prior art date
Application number
BRPI0409873-0A
Other languages
English (en)
Inventor
Wim Gaston Verschueren
Inge Dierynck
Dominique Louis Nest Surleraux
Frederik Frans Desire Daeyaert
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of BRPI0409873A publication Critical patent/BRPI0409873A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

"INIBIDORES DA INTEGRASE DO HIV". A presente invenção diz respeito a compostos tendo a fórmula (I), N-óxidos, sais, formas estereoisoméricas, misturas racêmicas, pró-medicamentos, ésteres e metabólitos destes em que (a) ou (b); A, juntamente com os dois carbonos do anel de fenila a qual ele está ligado forma uma arila monocíclica ou um Het¬ 2¬ monocíclico; R¬ 1¬ é hidrogênio, halo, nitro, ciano, sultam, sultim, C~ 3-7~cicloalquila, C(=O)-R¬ 5¬, S(=O)~ i~-R¬ 6¬, OR¬ 7¬, NR¬ 8¬R¬ 9¬, C(=NR¬ 8¬)-R¬ 5¬, C~ 1-6~alquila opcionalmente polissubstituída, C~ 2-6~alquenila opcionalmente polis-substituída ou C~ 2-6~alquinila opcionalmente polissubstituída. Ainda diz respeito ao seu uso como inibidores da integrase do HIV, processos para a sua preparação assim como composições farmacêuticas e kits de diagnóstico compreendendo-os. Também diz respeito a combinações deste com outros agentes anti-retrovirais, e a seu uso em ensaios como compostos de referência ou como reagentes.
BRPI0409873-0A 2003-04-28 2004-04-27 inibidores da integrase do hiv BRPI0409873A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46598703P 2003-04-28 2003-04-28
EP03101164 2003-04-28
PCT/EP2004/050621 WO2004096807A2 (en) 2003-04-28 2004-04-27 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0409873A true BRPI0409873A (pt) 2006-05-16

Family

ID=33420586

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409873-0A BRPI0409873A (pt) 2003-04-28 2004-04-27 inibidores da integrase do hiv

Country Status (13)

Country Link
US (1) US20060211724A1 (pt)
EP (1) EP1625130A2 (pt)
KR (1) KR20060006047A (pt)
CN (1) CN1812992A (pt)
AP (1) AP2005003451A0 (pt)
AR (1) AR044518A1 (pt)
AU (1) AU2004234087A1 (pt)
BR (1) BRPI0409873A (pt)
CA (1) CA2522990A1 (pt)
MX (1) MXPA05011726A (pt)
NO (1) NO20055230L (pt)
TW (1) TW200507848A (pt)
WO (1) WO2004096807A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125048A2 (en) * 2005-05-16 2006-11-23 Gilead Sciences, Inc. Hiv-integrase inhibitor compounds
CA2608214C (en) 2005-05-19 2013-08-20 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
US20080076740A1 (en) * 2005-07-27 2008-03-27 Gilead Sciences, Inc. Antiviral compounds
US20080039487A1 (en) * 2005-12-21 2008-02-14 Gilead Sciences, Llc Processes and intermediates useful for preparing integrase inhibitor compounds
JP2009537546A (ja) * 2006-05-16 2009-10-29 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼ阻害剤
EP1916249A1 (en) * 2006-10-10 2008-04-30 LEK Pharmaceuticals D.D. 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents
CA2680275C (en) 2007-03-09 2016-08-23 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2009067541A2 (en) * 2007-11-20 2009-05-28 Gilead Sciences, Inc. Integrase inhibitors
AU2009206673B2 (en) 2008-01-25 2015-04-23 Chimerix, Inc. Methods of treating viral infections
EP2262807B1 (en) 2008-03-19 2015-08-12 ChemBridge Corporation Novel tyrosine kinase inhibitors
US9249147B2 (en) 2008-03-19 2016-02-02 Chembridge Corporation Tyrosine kinase inhibitors
US8822500B2 (en) 2008-03-19 2014-09-02 Chembridge Corporation Tyrosine kinase inhibitors
KR20120034592A (ko) * 2009-04-09 2012-04-12 베링거 인겔하임 인터내셔날 게엠베하 Ｈｉｖ 복제의 저해제
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
PL2534150T3 (pl) 2010-02-12 2017-09-29 Chimerix, Inc. Sposoby leczenia infekcji wirusowej
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
EP1326610B1 (en) * 2000-10-12 2006-11-15 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US7442773B2 (en) * 2004-01-23 2008-10-28 The Board Of Trustees Of The University Of Illinois Universal peptide-binding scaffolds and protein chips

Also Published As

Publication number Publication date
AR044518A1 (es) 2005-09-14
NO20055230L (no) 2005-11-07
WO2004096807A8 (en) 2005-09-22
WO2004096807A3 (en) 2005-01-06
WO2004096807A2 (en) 2004-11-11
KR20060006047A (ko) 2006-01-18
AP2005003451A0 (en) 2005-12-31
US20060211724A1 (en) 2006-09-21
CN1812992A (zh) 2006-08-02
TW200507848A (en) 2005-03-01
CA2522990A1 (en) 2004-11-11
EP1625130A2 (en) 2006-02-15
AU2004234087A1 (en) 2004-11-11
MXPA05011726A (es) 2006-01-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.