BRPI0404983A - immunogenic compositions - Google Patents

immunogenic compositions

Info

Publication number
BRPI0404983A
BRPI0404983A BRPI0404983A BRPI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A
Authority
BR
Brazil
Prior art keywords
antigen
days
protein
immunogenic compositions
present
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
Jose Maciel Junior Rodrigues
Karla De Melo Lima
Original Assignee
Nanocore Biotecnologia Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanocore Biotecnologia Ltda filed Critical Nanocore Biotecnologia Ltda
Priority to BRPI0404983 priority Critical patent/BRPI0404983A/en
Priority to AU2005279641A priority patent/AU2005279641A1/en
Priority to PCT/BR2005/000179 priority patent/WO2006024122A1/en
Priority to EP05782989A priority patent/EP1858547A1/en
Publication of BRPI0404983A publication Critical patent/BRPI0404983A/en
Priority to ZA200702752A priority patent/ZA200702752B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSIçõES IMUNOGêNICAS". A presente invenção descreve composições capazes de estimular uma resposta imune em um hospedeiro inoculado com um antígeno de interesse e um vetor gênico, onde dita composição compreende microesferas baseadas em co-polímeros derivados do ácido lático e do ácido glicólico, encapsulando antígenos e vetores gênicos e adjuvantes estimuladores de citocinas. Uma concretização da presente invenção é o uso de plasmídeos codificando genes de proteína de Mycobacteriuin e a proteína recombinante encapsulados em microesferas de PLGA onde o DNA é liberado em um período máximo de 30 dias e a liberação do segundo antígeno (peptídeo, proteína, ou outro) tem uma liberação sustentada por período superior a 30 dias."IMMUNOGENIC COMPOSITIONS". The present invention describes compositions capable of stimulating an immune response in a host inoculated with an antigen of interest and a gene vector, wherein said composition comprises microspheres based on copolymers derived from lactic acid and glycolic acid, encapsulating antigens and gene vectors. cytokine stimulating adjuvants. One embodiment of the present invention is the use of plasmids encoding Mycobacteriuin protein genes and recombinant protein encapsulated in PLGA microspheres where DNA is released within 30 days and the release of the second antigen (peptide, protein, or other ) has a sustained release for more than 30 days.

BRPI0404983 2004-09-03 2004-09-03 immunogenic compositions BRPI0404983A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BRPI0404983 BRPI0404983A (en) 2004-09-03 2004-09-03 immunogenic compositions
AU2005279641A AU2005279641A1 (en) 2004-09-03 2005-09-05 Immunogenic compositions
PCT/BR2005/000179 WO2006024122A1 (en) 2004-09-03 2005-09-05 Immunogenic compositions
EP05782989A EP1858547A1 (en) 2004-09-03 2005-09-05 Immunogenic compositions
ZA200702752A ZA200702752B (en) 2004-09-03 2007-04-02 Immunogenic compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0404983 BRPI0404983A (en) 2004-09-03 2004-09-03 immunogenic compositions

Publications (1)

Publication Number Publication Date
BRPI0404983A true BRPI0404983A (en) 2006-05-02

Family

ID=35999654

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0404983 BRPI0404983A (en) 2004-09-03 2004-09-03 immunogenic compositions

Country Status (5)

Country Link
EP (1) EP1858547A1 (en)
AU (1) AU2005279641A1 (en)
BR (1) BRPI0404983A (en)
WO (1) WO2006024122A1 (en)
ZA (1) ZA200702752B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610329B2 (en) * 1993-04-22 2003-08-26 Emisphere Technologies Inc. Compositions for the delivery of antigens
WO1999016466A2 (en) * 1997-09-29 1999-04-08 Beth Israel Deaconess Medical Center Vaccine compositions and methods of enhancing vaccine efficacy
WO2000004876A2 (en) * 1998-07-23 2000-02-03 Johns Hopkins University School Of Medicine Controlled release of bioactive substances
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
WO2003072143A1 (en) * 2002-02-27 2003-09-04 Pharmain, Ltd. Compositions for delivery of therapeutics and other materials, and methods of making and using the same

Also Published As

Publication number Publication date
ZA200702752B (en) 2008-09-25
WO2006024122A1 (en) 2006-03-09
AU2005279641A1 (en) 2006-03-09
EP1858547A1 (en) 2007-11-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

Free format text: COMPLEMENTAR 4A., 5A., 6A., 7A. E 8A. ANUIDADES DE ACORDO COM TABELA VIGENTE REF. AS GUIAS NOS. 220708387486, 220807410702, 220906972687, 221006531100 E 220708387486, RESPECTIVAMENTE E COMPROVAR O RECOLHIMENTO DA 3A. ANUIDADE.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A TAXA DE RESTAURACAO DA 3A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2249 DE 11/02/2014.