BRPI0404983A - immunogenic compositions - Google Patents
immunogenic compositionsInfo
- Publication number
- BRPI0404983A BRPI0404983A BRPI0404983A BRPI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A BR PI0404983 A BRPI0404983 A BR PI0404983A
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- days
- protein
- immunogenic compositions
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
"COMPOSIçõES IMUNOGêNICAS". A presente invenção descreve composições capazes de estimular uma resposta imune em um hospedeiro inoculado com um antígeno de interesse e um vetor gênico, onde dita composição compreende microesferas baseadas em co-polímeros derivados do ácido lático e do ácido glicólico, encapsulando antígenos e vetores gênicos e adjuvantes estimuladores de citocinas. Uma concretização da presente invenção é o uso de plasmídeos codificando genes de proteína de Mycobacteriuin e a proteína recombinante encapsulados em microesferas de PLGA onde o DNA é liberado em um período máximo de 30 dias e a liberação do segundo antígeno (peptídeo, proteína, ou outro) tem uma liberação sustentada por período superior a 30 dias."IMMUNOGENIC COMPOSITIONS". The present invention describes compositions capable of stimulating an immune response in a host inoculated with an antigen of interest and a gene vector, wherein said composition comprises microspheres based on copolymers derived from lactic acid and glycolic acid, encapsulating antigens and gene vectors. cytokine stimulating adjuvants. One embodiment of the present invention is the use of plasmids encoding Mycobacteriuin protein genes and recombinant protein encapsulated in PLGA microspheres where DNA is released within 30 days and the release of the second antigen (peptide, protein, or other ) has a sustained release for more than 30 days.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0404983 BRPI0404983A (en) | 2004-09-03 | 2004-09-03 | immunogenic compositions |
AU2005279641A AU2005279641A1 (en) | 2004-09-03 | 2005-09-05 | Immunogenic compositions |
PCT/BR2005/000179 WO2006024122A1 (en) | 2004-09-03 | 2005-09-05 | Immunogenic compositions |
EP05782989A EP1858547A1 (en) | 2004-09-03 | 2005-09-05 | Immunogenic compositions |
ZA200702752A ZA200702752B (en) | 2004-09-03 | 2007-04-02 | Immunogenic compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0404983 BRPI0404983A (en) | 2004-09-03 | 2004-09-03 | immunogenic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0404983A true BRPI0404983A (en) | 2006-05-02 |
Family
ID=35999654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0404983 BRPI0404983A (en) | 2004-09-03 | 2004-09-03 | immunogenic compositions |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1858547A1 (en) |
AU (1) | AU2005279641A1 (en) |
BR (1) | BRPI0404983A (en) |
WO (1) | WO2006024122A1 (en) |
ZA (1) | ZA200702752B (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610329B2 (en) * | 1993-04-22 | 2003-08-26 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
WO1999016466A2 (en) * | 1997-09-29 | 1999-04-08 | Beth Israel Deaconess Medical Center | Vaccine compositions and methods of enhancing vaccine efficacy |
WO2000004876A2 (en) * | 1998-07-23 | 2000-02-03 | Johns Hopkins University School Of Medicine | Controlled release of bioactive substances |
US6998393B2 (en) * | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
WO2003072143A1 (en) * | 2002-02-27 | 2003-09-04 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
-
2004
- 2004-09-03 BR BRPI0404983 patent/BRPI0404983A/en not_active IP Right Cessation
-
2005
- 2005-09-05 EP EP05782989A patent/EP1858547A1/en not_active Withdrawn
- 2005-09-05 WO PCT/BR2005/000179 patent/WO2006024122A1/en active Application Filing
- 2005-09-05 AU AU2005279641A patent/AU2005279641A1/en not_active Abandoned
-
2007
- 2007-04-02 ZA ZA200702752A patent/ZA200702752B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200702752B (en) | 2008-09-25 |
WO2006024122A1 (en) | 2006-03-09 |
AU2005279641A1 (en) | 2006-03-09 |
EP1858547A1 (en) | 2007-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B04C | Request for examination: application reinstated [chapter 4.3 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR 4A., 5A., 6A., 7A. E 8A. ANUIDADES DE ACORDO COM TABELA VIGENTE REF. AS GUIAS NOS. 220708387486, 220807410702, 220906972687, 221006531100 E 220708387486, RESPECTIVAMENTE E COMPROVAR O RECOLHIMENTO DA 3A. ANUIDADE. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A TAXA DE RESTAURACAO DA 3A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2249 DE 11/02/2014. |