BRPI0307074A2 - meios sem soro para condrócitos e métodos para seu uso - Google Patents

meios sem soro para condrócitos e métodos para seu uso

Info

Publication number
BRPI0307074A2
BRPI0307074A2 BRPI0307074A BRPI0307074A BRPI0307074A2 BR PI0307074 A2 BRPI0307074 A2 BR PI0307074A2 BR PI0307074 A BRPI0307074 A BR PI0307074A BR PI0307074 A BRPI0307074 A BR PI0307074A BR PI0307074 A2 BRPI0307074 A2 BR PI0307074A2
Authority
BR
Brazil
Prior art keywords
methods
serum free
chondrocyte media
media
free chondrocyte
Prior art date
Application number
BRPI0307074A
Other languages
English (en)
Inventor
Maria E Brown Liesbeth
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of BRPI0307074A2 publication Critical patent/BRPI0307074A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0307074A 2002-01-25 2003-01-24 meios sem soro para condrócitos e métodos para seu uso BRPI0307074A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35194902P 2002-01-25 2002-01-25
US38907802P 2002-06-14 2002-06-14
PCT/US2003/001941 WO2003064598A2 (en) 2002-01-25 2003-01-24 Serum-free media for chondrocytes and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0307074A2 true BRPI0307074A2 (pt) 2017-06-20

Family

ID=27669045

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307074A BRPI0307074A2 (pt) 2002-01-25 2003-01-24 meios sem soro para condrócitos e métodos para seu uso

Country Status (7)

Country Link
US (2) US7169610B2 (pt)
EP (1) EP1478734A4 (pt)
JP (1) JP2005515777A (pt)
AU (1) AU2008264154A1 (pt)
BR (1) BRPI0307074A2 (pt)
CA (1) CA2473360A1 (pt)
WO (1) WO2003064598A2 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923245B2 (en) 2003-12-26 2011-04-12 Miho Furue Medium for ES culturing
WO2006007560A2 (en) 2004-07-01 2006-01-19 University Of Pennsylvania Targeted protein replacement for the treatment of lysosomal storage disorders
JP4469371B2 (ja) * 2004-08-24 2010-05-26 富士ソフト株式会社 脱分化型軟骨細胞の軟骨細胞への再分化用培地
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20090169523A1 (en) 2005-06-13 2009-07-02 Catherine Verfaillie Hsc self-renewal
AU2006272462A1 (en) * 2005-08-16 2007-03-08 Children's Mercy Hospital Quantification of microsphere suspension hybridization and uses thereof
JP5001155B2 (ja) * 2005-08-23 2012-08-15 公立大学法人横浜市立大学 ラミニン５を利用した間葉系幹細胞の培養技術
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1764117A1 (en) 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
JP4385076B2 (ja) 2006-01-13 2009-12-16 独立行政法人科学技術振興機構 動物細胞を無血清培養するための培地用添加剤、キット及びこれらの利用
WO2007149328A1 (en) * 2006-06-20 2007-12-27 Genzyme Corporation Serum-free media and their uses for chondrocyte expansion
EP2442104A3 (en) * 2007-04-06 2012-04-25 Genzyme Corporation Methods of evaluating cells and cell cultures
US20110008893A1 (en) * 2007-12-28 2011-01-13 Fujirebio Inc. Medium for mammalian somatic cells and additive therefor
CA2712496C (en) 2008-01-18 2021-01-12 Wei-Shou Hu Stem cell aggregates and methods for making and using
US20110212523A1 (en) * 2008-11-11 2011-09-01 Yukio Kato Differentiation-inducing culture medium additive and use thereof
KR20220100999A (ko) * 2008-11-25 2022-07-18 코오롱 티슈진 인크. 감작 세포 치료요법
SG10201913618WA (en) 2009-07-21 2020-03-30 Abt Holding Co Use of stem cells to reduce leukocyte extravasation
CA2768576C (en) 2009-07-21 2022-12-06 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
SG10201913904PA (en) 2010-02-25 2020-03-30 Abt Holding Co Modulation of angiogenesis
AU2011220721B2 (en) 2010-02-25 2015-02-05 Abt Holding Company Modulation of macrophage activation
WO2011111787A1 (ja) 2010-03-10 2011-09-15 株式会社ツーセル 間葉系幹細胞を含む細胞製剤及びその製造方法
DK2568991T6 (en) 2010-05-12 2019-03-18 Abt Holding Co MODULATION OF SPLENOCYTES IN CELL THERAPY
US9090878B2 (en) 2010-06-17 2015-07-28 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
CN103237886B (zh) 2010-08-24 2018-10-30 明尼苏达大学董事会 细胞集合体的非静态悬浮培养
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2012104731A2 (en) 2011-01-31 2012-08-09 Katholieke Universiteit Leuven Methods for making cells with an extra-embryonic endodermal precursor phenotype
EP2718416B1 (en) 2011-06-06 2019-11-13 Regenesys bvba Expansion of stem cells in hollow fiber bioreactors
EP2739735A2 (en) 2011-08-01 2014-06-11 Alnylam Pharmaceuticals, Inc. Method for improving the success rate of hematopoietic stem cell transplants
ES2791760T3 (es) 2011-09-07 2020-11-05 Sinai School Medicine Ceramidasa y diferenciación celular
GB201119335D0 (en) 2011-11-09 2011-12-21 Univ Leuven Kath Hepatitis virus infectable stem cells
CN103958665A (zh) 2011-11-11 2014-07-30 基本药品有限责任公司 包含血清替代物和不稳定因子的试剂盒
WO2013181530A1 (en) 2012-06-01 2013-12-05 Icahn School Of Medicine At Mount Sinai Ceramide levels in the treatment and prevention of infections
EP2875125B1 (en) 2012-07-20 2018-10-24 Alfred C. Kuo Methods for producing cartilage and bone
EP2968479B1 (en) 2013-03-14 2019-07-17 Icahn School of Medicine at Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
PL2983680T3 (pl) 2013-04-12 2021-03-08 Houston Methodist Hospital Ulepszanie narządów do przeszczepu
WO2014184666A2 (en) 2013-04-30 2014-11-20 Katholieke Universiteit Leuven Cell therapy for myelodysplastic syndromes
WO2014200339A1 (en) * 2013-06-11 2014-12-18 Pluriomics B.V. Culture medium compositions for maturating cardiomyocytes derived from pluripotent mammalian stem cells
SG11201510040VA (en) 2013-06-12 2016-01-28 Shiseido Co Ltd Serum-free medium containing pdgf for ds cells
CN105992816B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
KR20160125352A (ko) 2013-12-20 2016-10-31 이센셜 파마수티컬스 엘엘씨 세포 배양용 배지
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CA2981277A1 (en) * 2015-03-30 2016-10-06 Ajinomoto Co., Inc. Human serum albumin-containing culture medium for growth of neural stem cells
KR20180102661A (ko) 2016-01-21 2018-09-17 에이비티 홀딩 컴퍼니 상처 치유를 위한 줄기 세포
US11590175B2 (en) * 2017-08-23 2023-02-28 Merakris Therapeutics Llc Compositions containing amniotic components and methods for preparation and use thereof
KR20200064131A (ko) 2017-10-13 2020-06-05 베링거 인겔하임 인터내셔날 게엠베하 관류 배지
US11857576B2 (en) * 2017-12-07 2024-01-02 Vericel Corporation Compositions and methods for repairing cartilage defects
CN109136170B (zh) * 2018-08-20 2022-02-18 东北农业大学 一种适用于鲤鱼三倍体细胞生长的无血清培养基及其应用
CN113061578B (zh) * 2021-04-23 2023-04-21 苏州依科赛生物科技股份有限公司 一种用于细胞培养基的脂质混合物及其配制方法与应用
US20220401496A1 (en) * 2021-06-18 2022-12-22 Hilltop BioSciences, Inc. System and method for therapeutic compositions from a plurality of different birth tissues and exosomes
WO2023168080A1 (en) 2022-03-04 2023-09-07 Vericel Corporation Methods and devices for repairing cartilage defects

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US5871779A (en) * 1994-01-18 1999-02-16 Mount Sinai Hospital Corporation Treatment of arthropathies with vanadate compounds or analogues thereof
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5908782A (en) * 1995-06-05 1999-06-01 Osiris Therapeutics, Inc. Chemically defined medium for human mesenchymal stem cells
US6733746B2 (en) * 1996-03-12 2004-05-11 Invitrogen Corporation Hematopoietic cell culture nutrient supplement
WO1998004681A2 (en) * 1996-07-25 1998-02-05 Genzyme Corporation Chondrocyte media formulations and culture procedures
US6001352A (en) * 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
AU7984498A (en) * 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Serum-free cell growth medium
US6153582A (en) * 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
EP1131407B1 (en) * 1998-11-09 2006-10-11 Consorzio per la Gestione del Centro di Biotecnologie Avanzate Serum free medium for chondrocyte-like cells
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
FR2798671A1 (fr) 1999-09-16 2001-03-23 Univ Paris Curie Compositions de chondrocytes, preparation et utilisations
AU2000251259A1 (en) 2000-02-04 2001-08-14 Zymogenetics Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
US20020041900A1 (en) * 2000-05-01 2002-04-11 Ole Olsen Chondrocyte cultures and fractions therefrom

Also Published As

Publication number Publication date
WO2003064598A3 (en) 2003-10-16
US20070275463A1 (en) 2007-11-29
EP1478734A2 (en) 2004-11-24
US7169610B2 (en) 2007-01-30
EP1478734A4 (en) 2006-04-05
AU2008264154A1 (en) 2009-01-29
US20030211604A1 (en) 2003-11-13
JP2005515777A (ja) 2005-06-02
WO2003064598A2 (en) 2003-08-07
CA2473360A1 (en) 2003-08-07

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Legal Events

Date Code Title Description
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]