BRPI0209792B8 - anti-vla-1 antibody, composition comprising it, nucleic acid and vector, as well as in vitro methods to determine the level of vla-1 in tissue and to identify integrin i domain inhibitor - Google Patents

anti-vla-1 antibody, composition comprising it, nucleic acid and vector, as well as in vitro methods to determine the level of vla-1 in tissue and to identify integrin i domain inhibitor

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Publication number
BRPI0209792B8
BRPI0209792B8 BRPI0209792A BR0209792A BRPI0209792B8 BR PI0209792 B8 BRPI0209792 B8 BR PI0209792B8 BR PI0209792 A BRPI0209792 A BR PI0209792A BR 0209792 A BR0209792 A BR 0209792A BR PI0209792 B8 BRPI0209792 B8 BR PI0209792B8
Authority
BR
Brazil
Prior art keywords
vla
antibody
vector
tissue
nucleic acid
Prior art date
Application number
BRPI0209792A
Other languages
Portuguese (pt)
Other versions
BRPI0209792B1 (en
BR0209792A (en
Inventor
A Garber Ellen
W Saldanha Jose
Karpusas Michael
D Lyne Paul
Original Assignee
Biogen Idec Inc
Biogen Ma Inc
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Biogen Ma Inc, Biogen Inc filed Critical Biogen Idec Inc
Publication of BR0209792A publication Critical patent/BR0209792A/en
Publication of BRPI0209792B1 publication Critical patent/BRPI0209792B1/en
Publication of BRPI0209792B8 publication Critical patent/BRPI0209792B8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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Abstract

"anticorpos para vla-1 ". a presente invenção refere-se a anticorpos que especificamente ligam-se à integrina de vla-1 e métodos de usar estes anticorpos para tratar distúrbios imunológicos em um indivíduo. também incluídas são estruturas cristalinas de complexos formados por anticorpos de vla-1 e seus ligandos, e antagonistas e agonistas vla-1 identificados usando as coordenadas da estrutura destas estruturas."antibodies to vla-1". The present invention relates to antibodies that specifically bind to vla-1 integrin and methods of using these antibodies to treat immunological disorders in an individual. also included are crystal structures of complexes formed by vla-1 antibodies and their ligands, and vla-1 antagonists and agonists identified using the structure coordinates of these structures.

BRPI0209792A 2001-04-13 2002-04-12 anti-vla-1 antibody, composition comprising it, nucleic acid and vector, as well as in vitro methods to determine the level of vla-1 in tissue and to identify integrin i domain inhibitor BRPI0209792B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28379401P 2001-04-13 2001-04-13
US30368901P 2001-07-06 2001-07-06
PCT/US2002/011521 WO2002083854A2 (en) 2001-04-13 2002-04-12 Antibodies to vla-1

Publications (3)

Publication Number Publication Date
BR0209792A BR0209792A (en) 2005-04-26
BRPI0209792B1 BRPI0209792B1 (en) 2017-03-28
BRPI0209792B8 true BRPI0209792B8 (en) 2021-05-25

Family

ID=26962254

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Application Number Title Priority Date Filing Date
BRPI0209792A BRPI0209792B8 (en) 2001-04-13 2002-04-12 anti-vla-1 antibody, composition comprising it, nucleic acid and vector, as well as in vitro methods to determine the level of vla-1 in tissue and to identify integrin i domain inhibitor

Country Status (29)

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US (7) US7358054B2 (en)
EP (1) EP1423431B1 (en)
JP (2) JP4303475B2 (en)
KR (1) KR100927670B1 (en)
CN (1) CN1561345B (en)
AR (1) AR036330A1 (en)
AT (1) ATE471344T1 (en)
AU (1) AU2002258778C1 (en)
BG (1) BG66334B1 (en)
BR (1) BRPI0209792B8 (en)
CA (1) CA2443903C (en)
CZ (1) CZ303450B6 (en)
DE (1) DE60236735D1 (en)
EA (1) EA006705B1 (en)
EE (1) EE200300509A (en)
ES (1) ES2347532T3 (en)
GE (1) GEP20074252B (en)
HU (1) HUP0402250A3 (en)
IL (3) IL158376A0 (en)
IS (1) IS6982A (en)
MX (1) MXPA03009390A (en)
MY (1) MY138286A (en)
NO (1) NO20034554L (en)
NZ (1) NZ529494A (en)
PL (1) PL367324A1 (en)
SK (1) SK288124B6 (en)
UA (1) UA83791C2 (en)
WO (1) WO2002083854A2 (en)
YU (1) YU80903A (en)

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