BR9916774A - Derivados de imidazo[4,5-c]piridina-4-ona - Google Patents

Derivados de imidazo[4,5-c]piridina-4-ona

Info

Publication number
BR9916774A
BR9916774A BR9916774-3A BR9916774A BR9916774A BR 9916774 A BR9916774 A BR 9916774A BR 9916774 A BR9916774 A BR 9916774A BR 9916774 A BR9916774 A BR 9916774A
Authority
BR
Brazil
Prior art keywords
pyridine
derivatives
imidazo
deimidazo
decoagulation
Prior art date
Application number
BR9916774-3A
Other languages
English (en)
Inventor
Werner Mederski
Horst Juraszyk
Hanns Wurziger
Christostsaklakidis
Dieter Dorsch
Sabine Bernotat-Danielowski
Guidomelzer
Soheila Anzali
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9916774A publication Critical patent/BR9916774A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "DERIVADOS DEIMIDAZO[4,5-C]PIRIDINA-4-ONA". Os compostos novos dafórmula 1 na qual R, R^ 1,R^ 2^,R^ 3^e n são como definidos nareivindicação 1 da patente, são inibidores do fator Xa decoagulação e podem ser empregados para a profilaxia o/ou terapiade desordens tromboembólicas.
BR9916774-3A 1999-01-08 1999-12-21 Derivados de imidazo[4,5-c]piridina-4-ona BR9916774A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19900471A DE19900471A1 (de) 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate
PCT/EP1999/010236 WO2000040583A2 (de) 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridin-4-on-derivate

Publications (1)

Publication Number Publication Date
BR9916774A true BR9916774A (pt) 2001-10-30

Family

ID=7893790

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916774-3A BR9916774A (pt) 1999-01-08 1999-12-21 Derivados de imidazo[4,5-c]piridina-4-ona

Country Status (16)

Country Link
EP (1) EP1149099A2 (pt)
JP (1) JP2002534429A (pt)
KR (1) KR20010086085A (pt)
CN (1) CN1333772A (pt)
AR (1) AR022220A1 (pt)
AU (1) AU3041700A (pt)
BR (1) BR9916774A (pt)
CA (1) CA2357771A1 (pt)
CZ (1) CZ20012407A3 (pt)
DE (1) DE19900471A1 (pt)
HU (1) HUP0105054A3 (pt)
NO (1) NO20013384D0 (pt)
PL (1) PL349341A1 (pt)
SK (1) SK9442001A3 (pt)
WO (1) WO2000040583A2 (pt)
ZA (1) ZA200106454B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100628407B1 (ko) 1998-12-23 2006-09-26 브리스톨-마이어스 스퀴브 파마 컴파니 Ｘａ 인자 억제제로서의 질소 함유 헤테로비시클릭 화합물
EP1296982B1 (en) * 2000-06-23 2007-09-19 Bristol-Myers Squibb Pharma Company 1-(heteroaryl-phenyl)-condensed pyrazol derivatives as factor xa inhibitors
CA2447488A1 (en) 2001-05-22 2002-11-28 Irina Jacobson Bicyclic inhibitors of factor xa
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
GB0225399D0 (en) * 2002-10-31 2002-12-11 Merck Sharp & Dohme Therapeutic agents
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
EP1706403B9 (en) 2003-12-22 2012-07-25 K.U.Leuven Research & Development Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
SI1841765T1 (sl) 2004-12-21 2009-08-31 Gilead Sciences Inc Imidazo(4,5-c)piridinska spojina in postopek za antivirusno zdravljenje
AU2006271781A1 (en) 2005-07-15 2007-01-25 F. Hoffmann-La Roche Ag Novel heteroaryl fused cyclic amines
PL1942898T5 (pl) 2005-09-14 2014-10-31 Takeda Pharmaceuticals Co Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy
CN102675221A (zh) 2005-09-16 2012-09-19 武田药品工业株式会社 用于制备嘧啶二酮衍生物的方法中的中间体
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
MX2009000235A (es) 2006-07-07 2009-01-23 Gilead Sciences Inc Compuesto de piridazina novedoso y uso del mismo.
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
BR112017002598B1 (pt) * 2014-08-12 2022-03-03 Syngenta Participations Ag Derivados heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW219935B (pt) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
EP1039907A4 (en) * 1997-12-01 2001-09-19 Merck & Co Inc THROMBIN INHIBITORS

Also Published As

Publication number Publication date
JP2002534429A (ja) 2002-10-15
PL349341A1 (en) 2002-07-15
ZA200106454B (en) 2002-11-06
DE19900471A1 (de) 2000-07-13
NO20013384L (no) 2001-07-06
AR022220A1 (es) 2002-09-04
HUP0105054A3 (en) 2002-12-28
CZ20012407A3 (cs) 2001-12-12
HUP0105054A2 (hu) 2002-05-29
WO2000040583A2 (de) 2000-07-13
AU3041700A (en) 2000-07-24
EP1149099A2 (de) 2001-10-31
CA2357771A1 (en) 2000-07-13
KR20010086085A (ko) 2001-09-07
SK9442001A3 (en) 2002-05-09
CN1333772A (zh) 2002-01-30
WO2000040583A3 (de) 2000-09-21
NO20013384D0 (no) 2001-07-06

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]