BR9916583A - Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv - Google Patents
Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hivInfo
- Publication number
- BR9916583A BR9916583A BR9916583-0A BR9916583A BR9916583A BR 9916583 A BR9916583 A BR 9916583A BR 9916583 A BR9916583 A BR 9916583A BR 9916583 A BR9916583 A BR 9916583A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- inhibitory activity
- activity against
- against hiv
- heteroaromatic derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS HETEROAROMáTICOS TENDO UMA ATIVIDADE INIBITóRIA CONTRA INTEGRASE DE HIV"<D>. Um composto da fórmula (I): em que X é hidróxi, hidróxi protegido ou amino opcionalmente substituído; Y é -COOR^ A^ em que R^ A^ é hidrogênio ou resíduo éster, -CONR^ B^R^ C^ em que R^ B^ e R^ C^ é cada de modo independente hidrogênio ou resíduo amida, aril opcionalmente substituído ou heteroaril opcionalmente substituído; e A¹ é heteroaril opcionalmente substituído; contanto que seja excluído um composto em que Y e/ou A¹ é indol-3-il opcionalmente substituído, um tautómero, uma pró-droga, um sal ou um hidrato do mesmo farmaceuticamente aceitável tem uma atividade inibitória contra uma integrase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP37127098 | 1998-12-25 | ||
JP24747999 | 1999-09-01 | ||
PCT/JP1999/007101 WO2000039086A1 (fr) | 1998-12-25 | 1999-12-17 | Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916583A true BR9916583A (pt) | 2001-09-25 |
Family
ID=26538287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916583-0A BR9916583A (pt) | 1998-12-25 | 1999-12-17 | Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv |
Country Status (22)
Country | Link |
---|---|
US (3) | US6620841B1 (pt) |
EP (1) | EP1142872B1 (pt) |
JP (1) | JP3929244B2 (pt) |
KR (1) | KR20010089708A (pt) |
CN (1) | CN1178913C (pt) |
AP (1) | AP2001002169A0 (pt) |
AT (1) | ATE411286T1 (pt) |
AU (1) | AU763040B2 (pt) |
BR (1) | BR9916583A (pt) |
CA (1) | CA2353961A1 (pt) |
CZ (1) | CZ20012160A3 (pt) |
DE (1) | DE69939749D1 (pt) |
HK (1) | HK1042701A1 (pt) |
HU (1) | HUP0201472A3 (pt) |
ID (1) | ID29027A (pt) |
IL (1) | IL143958A0 (pt) |
NO (1) | NO20013179L (pt) |
NZ (1) | NZ512184A (pt) |
PL (1) | PL348596A1 (pt) |
RU (1) | RU2225860C2 (pt) |
TR (1) | TR200101886T2 (pt) |
WO (1) | WO2000039086A1 (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306891B1 (en) | 1998-06-03 | 2001-10-23 | Merck & Co., Inc. | HIV integrase inhibitors |
US6380249B1 (en) | 1998-06-03 | 2002-04-30 | Merck & Co., Inc. | HIV integrase inhibitors |
US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
US6492423B1 (en) | 1998-07-27 | 2002-12-10 | Istituto Di Ricerche Di Biologia Molecolare Pangeletti Spa | Diketoacid-derivatives as inhibitors of polymerases |
GB9816358D0 (en) | 1998-07-27 | 1998-09-23 | Angeletti P Ist Richerche Bio | Enzyme inhibitors |
KR100423781B1 (ko) | 1999-06-02 | 2004-03-22 | 시오노기세이야쿠가부시키가이샤 | 신규 치환 프로페논 유도체의 제조방법 |
AU5880600A (en) * | 1999-06-25 | 2001-01-31 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
EP1295879A4 (en) * | 2000-06-13 | 2004-04-14 | Shionogi & Co | MEDICINAL COMPOSITIONS CONTAINING PROPENONE DERIVATIVES |
EP1297834A4 (en) * | 2000-06-14 | 2007-05-09 | Shionogi & Co | ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS |
AU2002212701A1 (en) * | 2000-11-09 | 2002-05-21 | Shionogi And Co., Ltd. | Drug-tolerant hiv integrases |
PT2266958T (pt) * | 2001-08-10 | 2017-05-10 | Shionogi & Co | Agente antiviral |
US7169780B2 (en) * | 2001-10-26 | 2007-01-30 | Istitute Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
TW200407132A (en) * | 2001-11-15 | 2004-05-16 | Shionogi & Co | Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester |
WO2003047564A1 (fr) * | 2001-12-05 | 2003-06-12 | Shionogi & Co., Ltd. | Dérivé ayant une activité d'inhibition de l'intégrase du vih |
EP1541558B1 (en) | 2002-08-13 | 2008-08-13 | Shionogi & Co., Ltd. | Heterocyclic compounds having hiv integrase inhibitory activity |
AU2003301439A1 (en) | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
CN1569803B (zh) * | 2003-07-16 | 2011-04-13 | 中国科学院上海药物研究所 | 芳基β-二酮酸的新制备方法 |
US20060019952A1 (en) * | 2004-01-29 | 2006-01-26 | Elixir Pharmaceuticals, Inc. | Anti-viral therapeutics |
US7947721B2 (en) * | 2004-08-25 | 2011-05-24 | Ardes Biosciences Inc. | S-triazolyl α-mercaptoacetanilides as inhibitors of HIV reverse transcriptase |
WO2006030807A1 (ja) * | 2004-09-15 | 2006-03-23 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
US8771733B2 (en) * | 2004-12-03 | 2014-07-08 | Merck Sharp & Dohme Corp. | Pharmaceutical composition containing an anti-nucleating agent |
UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
US7250421B2 (en) * | 2005-01-31 | 2007-07-31 | University Of Georgia Research Foundation, Inc. | Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase |
JP2008542352A (ja) * | 2005-06-01 | 2008-11-27 | ビオアリアンス ファルマ | キノリン化合物及び他のhiv感染治療薬を含む相乗作用のコンビネーション |
WO2007136714A2 (en) * | 2006-05-16 | 2007-11-29 | Gilead Sciences, Inc. | Integrase inhibitors |
WO2008010953A2 (en) | 2006-07-19 | 2008-01-24 | University Of Georgia Research Foundation, Inc. | Pyridinone diketo acids: inhibitors of hiv replication in combination therapy |
WO2008041882A1 (fr) * | 2006-10-03 | 2008-04-10 | Viktor Veniaminovich Tets | Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes) |
CA2713105C (en) | 2008-01-25 | 2016-06-07 | Chimerix, Inc. | Methods of treating viral infections |
US8664255B2 (en) | 2008-10-20 | 2014-03-04 | The Texas A&M University System | Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof |
CN102753526B (zh) | 2009-12-07 | 2014-11-26 | 佐治亚大学研究基金会 | 吡啶酮羟基环戊基羧酰胺:具有治疗用途的hiv 整合酶抑制剂 |
AU2011216243B2 (en) | 2010-02-12 | 2015-07-09 | Chimerix, Inc. | Nucleoside phosphonate salts |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
CN101928258B (zh) * | 2010-08-18 | 2014-10-29 | 杭州民生药业有限公司 | 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途 |
WO2012170765A2 (en) | 2011-06-10 | 2012-12-13 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
WO2014026033A1 (en) | 2012-08-08 | 2014-02-13 | University Of Florida Research Foundation, Inc. | Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
AU2014286993B2 (en) | 2013-07-12 | 2018-10-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
NO2865735T3 (pt) | 2013-07-12 | 2018-07-21 | ||
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
NO2717902T3 (pt) | 2014-06-20 | 2018-06-23 | ||
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
EP3277691B1 (en) | 2015-04-02 | 2019-01-30 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
CN106905244B (zh) * | 2017-02-27 | 2019-08-16 | 武汉工程大学 | 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法 |
AU2020373913B2 (en) * | 2019-10-28 | 2024-04-18 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
CN111943899B (zh) * | 2020-09-08 | 2023-04-21 | 河北凯诺中星科技有限公司 | 一种5-甲酸乙酯四氮唑的合成方法 |
CN113683574B (zh) * | 2021-09-06 | 2023-11-17 | 上海晋鲁医药科技有限公司 | 一种合成1-甲基-1h-1,2,4-***-3-甲酸甲酯的方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3899508A (en) | 1974-04-12 | 1975-08-12 | Lilly Co Eli | 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof |
US3931247A (en) * | 1974-12-11 | 1976-01-06 | Morton-Norwich Products, Inc. | 5-(Substituted)phenylfurfuryl alcohols |
JPS5811878B2 (ja) * | 1974-12-19 | 1983-03-04 | 大正製薬株式会社 | フロ ( 3 2−b ) インド−ルルイノ セイホウ |
JPS56100784A (en) | 1980-01-16 | 1981-08-12 | Yoshitomi Pharmaceut Ind Ltd | Indolizine derivative |
US4273776A (en) * | 1980-01-30 | 1981-06-16 | E. R. Squibb & Sons, Inc. | Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones |
US4423063A (en) | 1980-12-29 | 1983-12-27 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis |
US4336397A (en) | 1980-12-29 | 1982-06-22 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis |
US4332735A (en) * | 1981-07-06 | 1982-06-01 | Morton-Norwich Products, Inc. | Antifungal compound |
US4637829A (en) * | 1984-04-27 | 1987-01-20 | Ciba-Geigy Corporation | Sulfonylureas |
JPS61134346A (ja) | 1984-12-03 | 1986-06-21 | Shionogi & Co Ltd | 4−オキソカルボン酸誘導体および抗潰瘍剤 |
CA1334975C (en) | 1987-11-13 | 1995-03-28 | James H. Holms | Furan and pyrrole containing lipoxygenase inhibiting compounds |
JPH0238403A (ja) | 1988-07-28 | 1990-02-07 | Canon Inc | 光重合性組成物および記録媒体 |
PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
TW224974B (pt) * | 1991-07-02 | 1994-06-11 | Hoffmann La Roche | |
EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
IL132033A0 (en) | 1997-04-04 | 2001-03-19 | Pfizer Prod Inc | Nicotinamide derivatives |
IL122591A0 (en) | 1997-12-14 | 1998-06-15 | Arad Dorit | Pharmaceutical compositions comprising cystein protease inhibitors |
IL137974A0 (en) | 1998-03-26 | 2001-10-31 | Shionogi & Co | Indole derivatives having antiviral activity |
WO1999048371A1 (en) | 1998-03-27 | 1999-09-30 | The Regents Of The University Of California | Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors |
AU4225499A (en) | 1998-06-03 | 1999-12-20 | Merck & Co., Inc. | Hiv integrase inhibitors |
CA2329134A1 (en) | 1998-06-03 | 1999-12-09 | David L. Clark | Hiv integrase inhibitors |
EP1086091A4 (en) | 1998-06-03 | 2001-10-10 | Merck & Co Inc | HIV INTEGRASE INHIBITORS |
AU5880600A (en) | 1999-06-25 | 2001-01-31 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
-
1999
- 1999-12-17 AT AT99961299T patent/ATE411286T1/de not_active IP Right Cessation
- 1999-12-17 KR KR1020017008150A patent/KR20010089708A/ko not_active Application Discontinuation
- 1999-12-17 HU HU0201472A patent/HUP0201472A3/hu unknown
- 1999-12-17 CZ CZ20012160A patent/CZ20012160A3/cs unknown
- 1999-12-17 TR TR2001/01886T patent/TR200101886T2/xx unknown
- 1999-12-17 CA CA002353961A patent/CA2353961A1/en not_active Abandoned
- 1999-12-17 AU AU17979/00A patent/AU763040B2/en not_active Ceased
- 1999-12-17 AP APAP/P/2001/002169A patent/AP2001002169A0/en unknown
- 1999-12-17 NZ NZ512184A patent/NZ512184A/xx unknown
- 1999-12-17 DE DE69939749T patent/DE69939749D1/de not_active Expired - Lifetime
- 1999-12-17 JP JP2000590998A patent/JP3929244B2/ja not_active Expired - Fee Related
- 1999-12-17 BR BR9916583-0A patent/BR9916583A/pt not_active IP Right Cessation
- 1999-12-17 US US09/857,632 patent/US6620841B1/en not_active Expired - Fee Related
- 1999-12-17 PL PL99348596A patent/PL348596A1/xx not_active Application Discontinuation
- 1999-12-17 RU RU2001120016/04A patent/RU2225860C2/ru not_active IP Right Cessation
- 1999-12-17 ID IDW00200101355A patent/ID29027A/id unknown
- 1999-12-17 WO PCT/JP1999/007101 patent/WO2000039086A1/ja not_active Application Discontinuation
- 1999-12-17 CN CNB99816285XA patent/CN1178913C/zh not_active Expired - Fee Related
- 1999-12-17 IL IL14395899A patent/IL143958A0/xx unknown
- 1999-12-17 EP EP99961299A patent/EP1142872B1/en not_active Expired - Lifetime
-
2001
- 2001-06-22 NO NO20013179A patent/NO20013179L/no not_active Application Discontinuation
-
2002
- 2002-06-04 HK HK02104241.7A patent/HK1042701A1/zh unknown
- 2002-11-06 US US10/288,380 patent/US6645956B1/en not_active Expired - Fee Related
-
2003
- 2003-06-18 US US10/463,816 patent/US7098201B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ20012160A3 (cs) | 2001-10-17 |
RU2225860C2 (ru) | 2004-03-20 |
NO20013179D0 (no) | 2001-06-22 |
US6645956B1 (en) | 2003-11-11 |
US7098201B2 (en) | 2006-08-29 |
NZ512184A (en) | 2003-08-29 |
US20040002485A1 (en) | 2004-01-01 |
WO2000039086A1 (fr) | 2000-07-06 |
HK1042701A1 (zh) | 2002-08-23 |
CN1335834A (zh) | 2002-02-13 |
TR200101886T2 (tr) | 2001-12-21 |
CA2353961A1 (en) | 2000-07-06 |
KR20010089708A (ko) | 2001-10-08 |
DE69939749D1 (de) | 2008-11-27 |
AP2001002169A0 (en) | 2001-06-30 |
HUP0201472A2 (hu) | 2003-10-28 |
RU2001120016A (ru) | 2003-12-10 |
IL143958A0 (en) | 2002-04-21 |
CN1178913C (zh) | 2004-12-08 |
ATE411286T1 (de) | 2008-10-15 |
EP1142872B1 (en) | 2008-10-15 |
ID29027A (id) | 2001-07-26 |
AU763040B2 (en) | 2003-07-10 |
AU1797900A (en) | 2000-07-31 |
NO20013179L (no) | 2001-08-27 |
EP1142872A1 (en) | 2001-10-10 |
US6620841B1 (en) | 2003-09-16 |
HUP0201472A3 (en) | 2006-03-28 |
EP1142872A4 (en) | 2002-04-17 |
JP3929244B2 (ja) | 2007-06-13 |
PL348596A1 (en) | 2002-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9916583A (pt) | Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv | |
ES2182852T3 (es) | Derivados de prolinamida. | |
MY133473A (en) | Haterocyclic glycyl beta-alanine derivatives. | |
BR9913097B1 (pt) | Derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo | |
MY141661A (en) | 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | |
HUP0102471A2 (hu) | 4-Benzil-piperidin alkilszulfoxid heterociklusok és használatuk altípus-szelektív NMDA antagonistaként és ezeket tartalmazó gyógyszerkészítmények | |
JO2372B1 (en) | Source drugs of 4-phenylpyridine derivatives | |
AU3851199A (en) | Heterocyclic indole derivatives and mono- or diazaindole derivatives | |
CA2469592A1 (en) | Hiv integrase inhibitors | |
AU2001274806A1 (en) | Sulfonamide derivatives | |
AU699728B2 (en) | Cancerous metastasis inhibitors containing uracil derivatives | |
NO983444L (no) | Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer | |
AU3785897A (en) | Neuraminic acid compound | |
BR0110871A (pt) | Derivados de sulfonamida | |
EP1613328B8 (en) | Use of carbamazepine derivatives for the treatment of agitation in dementia patients | |
HUP0302255A2 (hu) | Szulfonamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
AU3285000A (en) | 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis | |
ES2196174T3 (es) | `derivados de sesquiterpeno de actividad antiviral. | |
RS20050954A (en) | Use of bycyclo/2.2.1/heptane derivatives for the preparation of neuroprotective pharmaceutical compositions | |
TW375525B (en) | Inhibitors for morphine-like drug induced emesis containing active components (R)-1-ethyl-4-methyl hexahydro-1H-1,4-diazepine derivatives | |
BR9908948A (pt) | Composição farmacêutica contendo um inibidor de protease cisteìna para profilaxia e terapia de dano ao tecido cerebral | |
CA2270026A1 (en) | Substituted bicyclic derivatives for treating central nervous system disorders | |
MY139844A (en) | 1,2,4-triaminobenzene derivatives and their uses thereof for the prevention, treatment and/or inhibition of disorders of the central nervous system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O E 7O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |