BR9913575A - Composições compreendendo sais de amina simpatomimética inadequadas para uso ilegal - Google Patents

Composições compreendendo sais de amina simpatomimética inadequadas para uso ilegal

Info

Publication number
BR9913575A
BR9913575A BR9913575-2A BR9913575A BR9913575A BR 9913575 A BR9913575 A BR 9913575A BR 9913575 A BR9913575 A BR 9913575A BR 9913575 A BR9913575 A BR 9913575A
Authority
BR
Brazil
Prior art keywords
compositions
sympathomimetic
amine
sympathomimetic amine
combination
Prior art date
Application number
BR9913575-2A
Other languages
English (en)
Inventor
William S Bess
William Michael Nichols
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9913575A publication Critical patent/BR9913575A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES COMPREENDENDO SAIS DE AMINA SIMPATOMIMéTICA INADEQUADAS PARA USO ILEGAL"<D>. A presente invenção torna impossível o uso de composições de amina simpatomimética na produção de droga ilícita. Mais especificamente, a preparação de metanfetamina a partir das formulações de cloridrato de pseudoefedrina descritas é inibida. A presente invenção define composições farmacêuticas compreendendo um sal de amina simpatomimética e pelo menos um inibidor de combinação, o inibidor de combinação, o inibidor de combinação que age ambos para interferir com o isolamento da amina simpatomimética da composição e para interferir com a conversão da amina simpatomimética em outro composto farmacologicamente ativo. As composições consideradas podem também incluir inibidores de reação e separação em qualquer mistura para assegurar a proteção máxima contra o uso das composições contendo amina simpatomimética para fabricação de droga ilegal. A presença dos inibidores de combinação, reação e separação não alteram significantemente a liberação da amina simpatomimética da composição.
BR9913575-2A 1998-09-10 1999-09-09 Composições compreendendo sais de amina simpatomimética inadequadas para uso ilegal BR9913575A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9971298P 1998-09-10 1998-09-10
PCT/US1999/020708 WO2000015261A1 (en) 1998-09-10 1999-09-09 Compositions comprising sympathomimetic amine salts unsuitable for illegal use

Publications (1)

Publication Number Publication Date
BR9913575A true BR9913575A (pt) 2001-05-22

Family

ID=22276270

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913575-2A BR9913575A (pt) 1998-09-10 1999-09-09 Composições compreendendo sais de amina simpatomimética inadequadas para uso ilegal

Country Status (22)

Country Link
US (4) US6359011B1 (pt)
EP (1) EP1112089A1 (pt)
JP (1) JP2002524534A (pt)
KR (1) KR20010075021A (pt)
CN (1) CN1201822C (pt)
AR (1) AR032730A1 (pt)
AU (2) AU771194B2 (pt)
BR (1) BR9913575A (pt)
CA (1) CA2339354A1 (pt)
CO (1) CO5280050A1 (pt)
CR (1) CR6106A (pt)
GT (1) GT199900148A (pt)
HK (1) HK1039898A1 (pt)
HN (1) HN1999000156A (pt)
MY (1) MY117971A (pt)
NZ (1) NZ510012A (pt)
PA (1) PA8481601A1 (pt)
PE (1) PE20001034A1 (pt)
SV (1) SV1999000148A (pt)
TW (1) TW550071B (pt)
UY (1) UY25702A1 (pt)
WO (1) WO2000015261A1 (pt)

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PT1920763E (pt) * 2000-11-30 2014-06-25 Vectura Ltd Composições farmacêuticas para inalação
ITMI20021074A1 (it) * 2002-05-20 2003-11-20 Actimex S R L Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
US20050220877A1 (en) * 2004-03-31 2005-10-06 Patel Ashish A Bilayer tablet comprising an antihistamine and a decongestant
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004045037A1 (de) * 2004-09-15 2006-03-16 Basf Ag Pharmazeutische Darreichungsformen mit erschwerter Extrahierbarkeit eines Sympathomimetikums aus der Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US9198865B2 (en) 2006-01-19 2015-12-01 Dow Global Technologies Llc Biologically active composition comprising ethylcellulose
US9238073B2 (en) * 2006-04-12 2016-01-19 Wyeth Llc Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive
US8273798B2 (en) * 2007-06-04 2012-09-25 Shear Kershman Laboratories Tamper resistant lipid-based oral dosage form for opioid agonists
CA2731801C (en) * 2007-07-23 2013-11-26 Kingsway Pharmaceuticals Inc. Therapeutic formulations for the treatment of cold and flu-like symptoms
JP4879351B2 (ja) 2007-10-19 2012-02-22 大塚製薬株式会社 医薬固形製剤
RU2567723C2 (ru) 2009-07-22 2015-11-10 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
CA2775890C (en) * 2009-09-30 2016-06-21 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
DK2736497T3 (da) 2011-07-29 2017-11-13 Gruenenthal Gmbh Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel.
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
WO2013036567A2 (en) * 2011-09-07 2013-03-14 Johnson Brent A Methods, compositions, and compounds for the reduction of illegal methamphetamine production
US20150238615A1 (en) * 2011-12-12 2015-08-27 Leonard Mackles Denaturants for sympathomimetic amines
CA2880163A1 (en) * 2012-08-01 2014-02-06 Acura Pharmaceuticals, Inc. Stabilization of one-pot methamphetamine synthesis systems
MX366159B (es) 2012-11-30 2019-07-01 Acura Pharmaceuticals Inc Liberacion autorregulada de ingrediente farmaceutico activo.
EP3016645A4 (en) * 2013-07-03 2016-12-21 Acura Pharmaceuticals Inc PROCEDURE AND COMPOSITIONS FOR DETECTING FROM ABUSE
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
AU2015237723B2 (en) 2014-03-26 2018-04-26 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
US11103581B2 (en) 2015-08-31 2021-08-31 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
CA2998259A1 (en) * 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
TW202002957A (zh) 2018-02-09 2020-01-16 德商歌林達有限公司 包含轉化抑制劑之麻黃素及其衍生物之抗損壞調配物

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Also Published As

Publication number Publication date
GT199900148A (es) 2001-02-28
US20060216268A1 (en) 2006-09-28
TW550071B (en) 2003-09-01
EP1112089A1 (en) 2001-07-04
AU5915799A (en) 2000-04-03
UY25702A1 (es) 1999-11-17
AU771194B2 (en) 2004-03-18
PA8481601A1 (es) 2001-04-30
PE20001034A1 (es) 2000-10-18
CN1316911A (zh) 2001-10-10
JP2002524534A (ja) 2002-08-06
AU2004202702B2 (en) 2007-11-22
NZ510012A (en) 2002-11-26
US6359011B1 (en) 2002-03-19
MY117971A (en) 2004-08-30
SV1999000148A (es) 2000-09-11
HK1039898A1 (zh) 2002-05-17
WO2000015261A1 (en) 2000-03-23
CR6106A (es) 2003-12-05
US20050256194A1 (en) 2005-11-17
KR20010075021A (ko) 2001-08-09
CO5280050A1 (es) 2003-05-30
CN1201822C (zh) 2005-05-18
AR032730A1 (es) 2003-11-26
AU2004202702A1 (en) 2004-07-15
CA2339354A1 (en) 2000-03-23
HN1999000156A (es) 2003-08-01
US20020082304A1 (en) 2002-06-27

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 47/32, A61K 47/02, A61K 31/135, A61K 47/38, A61K 47/10, A61P 11/02

Ipc: A61K 47/32 (2009.01), A61K 47/02 (2009.01), A61K 3

B25D Requested change of name of applicant approved

Owner name: WARNER-LAMBERT COMPANY LLC (US)

Free format text: ALTERADO DE: WARNER-LAMBERT COMPANY

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.