BR9913157A - Processos para tratar ou previnir infecção causada por pelo menos um vìrus das flaviviridae e doenças associadas com a referida infecção e infecção causada por pelo menos um vìrus do gênero hepacivìrus da flaviviridade e doenças associadas com a referida infecção, composição farmacêutica para tratar ou previnir infecções virais, e, composto - Google Patents
Processos para tratar ou previnir infecção causada por pelo menos um vìrus das flaviviridae e doenças associadas com a referida infecção e infecção causada por pelo menos um vìrus do gênero hepacivìrus da flaviviridade e doenças associadas com a referida infecção, composição farmacêutica para tratar ou previnir infecções virais, e, compostoInfo
- Publication number
- BR9913157A BR9913157A BR9913157-9A BR9913157A BR9913157A BR 9913157 A BR9913157 A BR 9913157A BR 9913157 A BR9913157 A BR 9913157A BR 9913157 A BR9913157 A BR 9913157A
- Authority
- BR
- Brazil
- Prior art keywords
- infection
- virus
- diseases associated
- infection caused
- processes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"PROCESSOS PARA TRATAR OU PREVENIR INFECçãO CAUSADA POR PELO MENOS UM VìRUS DAS FLAVIVIRIDAE E DOENçAS ASSOCIADAS COM A REFERIDA INFECçãO E INFECçãO CAUSADA POR PELO MENOS UM VìRUS DO GêNERO HEPACIVìRUS DAS FLAVIVIRIDAE E DOENçAS ASSOCIADAS COM A REFERIDA INFECçãO, COMPOSIçãO FARMACêUTICA PARA TRATAR OU PREVENIR INFECçõES VIRAIS, E, COMPOSTO". Proporciona-se compostos, composições e processos para o tratamento e a profilaxia de infecções e doenças associadas causadas por vírus da família Flaviviridae através da administração de determinados derivados de rodanina, e seus análogos, sendo que os ácidos alcanóicos de rodanina tri- e tetracíclica e ácidos benzóicos de rodanina são particularmente eficazes.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9747698P | 1998-08-21 | 1998-08-21 | |
US11321298P | 1998-12-22 | 1998-12-22 | |
US11932899P | 1999-02-09 | 1999-02-09 | |
US13558599P | 1999-05-24 | 1999-05-24 | |
US13558699P | 1999-05-24 | 1999-05-24 | |
PCT/US1999/018785 WO2000010573A1 (en) | 1998-08-21 | 1999-08-19 | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9913157A true BR9913157A (pt) | 2001-05-15 |
Family
ID=27536838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9913157-9A BR9913157A (pt) | 1998-08-21 | 1999-08-19 | Processos para tratar ou previnir infecção causada por pelo menos um vìrus das flaviviridae e doenças associadas com a referida infecção e infecção causada por pelo menos um vìrus do gênero hepacivìrus da flaviviridade e doenças associadas com a referida infecção, composição farmacêutica para tratar ou previnir infecções virais, e, composto |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1128832A4 (pt) |
JP (1) | JP2002523371A (pt) |
KR (1) | KR20010099623A (pt) |
CN (1) | CN1325309A (pt) |
AU (1) | AU743411B2 (pt) |
BR (1) | BR9913157A (pt) |
CA (1) | CA2341970A1 (pt) |
ID (1) | ID27787A (pt) |
IL (1) | IL141456A0 (pt) |
WO (1) | WO2000010573A1 (pt) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000076987A1 (en) * | 1999-06-10 | 2000-12-21 | Warner-Lambert Company | Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
CN1384825A (zh) | 1999-08-31 | 2002-12-11 | 马克西亚药品公司 | 亚苄基-噻唑烷二酮及其类似物以及它们在治疗糖尿病中的应用 |
WO2001077091A2 (en) * | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
BR0017338A (pt) * | 2000-09-29 | 2004-04-27 | Neurogen Corp | Composto, processo para preparar um composto, composição farmacêutica, e métodos para tratar um paciente, para inibir quimiotaxia celular promovida com c5a, para localizar receptores de c5a em um tecido, e para reduzir a gravidade ou frequência de uma ou mais sequelas inflamatórias de transplante de órgão |
BR0207846A (pt) | 2001-03-07 | 2005-09-13 | Incyte San Diego Inc | Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas |
AU2002254171A2 (en) | 2001-03-08 | 2002-09-24 | Incyte San Diego, Inc. | RXR activating molecules |
GB2376944A (en) * | 2001-05-18 | 2002-12-31 | Pantherix Ltd | Polycyclic heterocyclic compounds and their therapeutic use |
WO2003007945A1 (en) | 2001-07-20 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US20030134853A1 (en) | 2001-09-26 | 2003-07-17 | Priestley Eldon Scott | Compounds useful for treating hepatitis C virus |
AU2002352706A1 (en) | 2001-11-15 | 2003-06-10 | Maxia Pharmaceuticals, Inc. | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
GB2387172A (en) * | 2002-03-28 | 2003-10-08 | Pantherix Ltd | [(Aryl-/arylthio-)aryl]methylene substituted azole & azine derivatives and their therapeutic use as antibacterials |
US20060281798A1 (en) * | 2002-05-17 | 2006-12-14 | Qlt Inc. | Methods of using thiazolidinedithione derivatives |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
EP1505945B1 (en) | 2002-05-20 | 2008-11-05 | Bristol-Myers Squibb Company | Substituted cycloalkyl p1' hepatitis c virus inhibitors |
ATE503764T1 (de) | 2002-05-20 | 2011-04-15 | Bristol Myers Squibb Co | Inhibitoren des hepatitis-c-virus |
ATE481106T1 (de) | 2002-05-20 | 2010-10-15 | Bristol Myers Squibb Co | Heterocyclische sulfonamid-hepatitis-c-virus- hemmer |
AU2003256335A1 (en) | 2002-07-01 | 2004-01-19 | Pharmacia And Upjohn Company | Inhibitors of hcv ns5b polymerase |
WO2004002977A1 (en) | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company Llc | Inhibitors of hcv ns5b polymerase |
FR2845000B1 (fr) | 2002-09-27 | 2005-05-27 | Oreal | Utilisation d'un compose heterocyclique ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute |
NZ538809A (en) * | 2002-09-30 | 2008-06-30 | Univ California | Thiazolidinone cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof |
US7235573B2 (en) | 2002-09-30 | 2007-06-26 | The Regents Of The University Of California | Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors |
AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
EP2033654B1 (en) | 2003-04-16 | 2012-05-16 | Bristol-Myers Squibb Company | Process for resolving a mixture of alkyl ester enantiomers using an enzyme |
WO2005007141A2 (en) | 2003-07-11 | 2005-01-27 | Proteologics, Inc. | Ubiquitin ligase inhibitors and methods related thereto |
FR2858324A1 (fr) * | 2003-07-30 | 2005-02-04 | Centre Nat Rech Scient | Nouveaux composes antibiotiques, compositions pharmaceutiques les contenant et leurs utilisations |
US7112601B2 (en) | 2003-09-11 | 2006-09-26 | Bristol-Myers Squibb Company | Cycloalkyl heterocycles for treating hepatitis C virus |
US7566732B2 (en) | 2003-10-28 | 2009-07-28 | Rigel Pharmaceuticals, Inc. | Rhodanine compositions for use as antiviral agents |
US7026339B2 (en) | 2003-11-07 | 2006-04-11 | Fan Yang | Inhibitors of HCV NS5B polymerase |
US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EA200901463A1 (ru) | 2004-02-20 | 2010-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
EP2206715A1 (en) | 2004-02-24 | 2010-07-14 | Japan Tobacco, Inc. | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
JP2008540370A (ja) | 2005-05-04 | 2008-11-20 | エフ.ホフマン−ラ ロシュ アーゲー | ヘテロ環式抗ウイルス化合物 |
WO2006138118A2 (en) * | 2005-06-15 | 2006-12-28 | New York Blood Center | Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds |
US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
WO2007131168A2 (en) * | 2006-05-04 | 2007-11-15 | Institute For Hepatitis And Virus Research | Inhibitors of secretion of hepatitis b virus antigens for treatment of a chronic hepatitis virus |
DK2084175T3 (da) | 2006-10-10 | 2011-04-18 | Medivir Ab | HCV nucleosidinhibitor |
WO2008082537A2 (en) * | 2006-12-19 | 2008-07-10 | The General Hospital Corporation | Compounds for modulating integrin cd11b/cd18 |
EA200971074A1 (ru) | 2007-06-29 | 2010-08-30 | Джилид Сайэнс, Инк. | Антивирусные соединения |
KR101596524B1 (ko) | 2007-06-29 | 2016-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 |
US8466177B2 (en) | 2007-11-01 | 2013-06-18 | The Uab Research Foundation | Treating and preventing viral infections |
JP2011517313A (ja) | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ,インク. | 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤 |
US7947717B2 (en) | 2008-07-18 | 2011-05-24 | Burnham Institute For Medical Research | Inhibitors of lethal factor protease |
EP2373168A4 (en) | 2008-12-03 | 2012-08-01 | Presidio Pharmaceuticals Inc | HCV NS5A SHEMMER |
CN104163816A (zh) | 2008-12-03 | 2014-11-26 | 普雷西迪奥制药公司 | Hcv ns5a的抑制剂 |
AU2010229795A1 (en) | 2009-03-27 | 2011-10-13 | Presidio Pharmaceuticals, Inc. | Fused ring inhibitors of hepatitis C |
CA2780044A1 (en) | 2009-11-14 | 2011-05-19 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to hcv treatment |
RU2012127201A (ru) | 2009-12-02 | 2014-01-20 | Ф.Хоффманн-Ля Рош Аг | Биомаркеры для прогнозирования устойчивого ответа на лечение вируса гепатита с |
EP2515903A4 (en) * | 2009-12-23 | 2013-07-10 | Peter Maccallum Cancer Inst | COMPOUNDS, PREPARATION AND USES THEREOF |
US8877707B2 (en) | 2010-05-24 | 2014-11-04 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
KR101159000B1 (ko) | 2010-06-18 | 2012-06-21 | (주) 에빅스젠 | 신규한 로다닌 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 aids 예방 또는 치료용 약학 조성물 |
US9023876B2 (en) | 2010-07-08 | 2015-05-05 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
US9255088B2 (en) | 2010-08-11 | 2016-02-09 | The Regents Of The University Of California | Premature-termination-codons readthrough compounds |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
US20120328565A1 (en) | 2011-06-24 | 2012-12-27 | Brinkman John A | Antiviral compounds |
CA2847083A1 (en) | 2011-10-10 | 2013-04-18 | F. Hoffmann-La Roche Ag | Antiviral compounds |
ES2564906T3 (es) | 2011-12-16 | 2016-03-29 | F. Hoffmann-La Roche Ag | Inhibidores de NS5A del VHC |
JP6118336B2 (ja) | 2011-12-20 | 2017-04-19 | リボサイエンス・エルエルシー | Hcvのrna複製の阻害剤としての4’−アジド、3’−フルオロ置換されたヌクレオシド誘導体 |
PT2794629T (pt) | 2011-12-20 | 2017-07-20 | Riboscience Llc | Derivados de nucleósidos substituídos em 2¿-4¿-difluor-2¿-metilo, como inibidores da replicação do arn de vhc (vírus da hepatite c) |
BR112014015582A8 (pt) | 2012-02-24 | 2017-07-04 | Hoffmann La Roche | compostos antivirais |
WO2013142346A1 (en) | 2012-03-23 | 2013-09-26 | The Regents Of The University Of California | Premature-termination-codons readthrough compounds |
AU2013248972A1 (en) | 2012-04-20 | 2014-11-13 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
BR112015017414A2 (pt) | 2013-01-23 | 2017-07-11 | Hoffmann La Roche | derivados de triazol antivirais |
US9428469B2 (en) | 2013-03-05 | 2016-08-30 | Hoffmann-La Roche | Antiviral compounds |
RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
MX2015015782A (es) | 2013-05-16 | 2016-06-02 | Riboscience Llc | Derivados de nucleosido 4'-fluoro-2'-metil sustituido. |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
KR20160039154A (ko) | 2013-05-16 | 2016-04-08 | 리보사이언스 엘엘씨 | 4''-아자이도-3''-데옥시-3''-플루오로 치환된 뉴클레오시드 유도체 |
KR20200056420A (ko) | 2017-09-21 | 2020-05-22 | 리보사이언스 엘엘씨 | Hcv rna 복제의 억제제로서 4'-플루오로-2'-메틸 치환된 뉴클레오시드 유도체 |
KR101893988B1 (ko) * | 2018-05-16 | 2018-08-31 | (주)에빅스젠 | 로다닌 유도체를 함유하는 aids 예방 또는 치료용 약학 조성물 |
TW202348228A (zh) | 2022-02-24 | 2023-12-16 | 德商艾斯巴赫生物有限公司 | 病毒組合療法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2909467A (en) * | 1958-07-09 | 1959-10-20 | Us Vitamin Pharm Corp | 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione |
US3888984A (en) * | 1972-03-13 | 1975-06-10 | Lilly Industries Ltd | Oxazole and imidazole derivatives as antifungal agents |
AU6610081A (en) * | 1980-01-24 | 1981-07-30 | Senju Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
US4367234A (en) * | 1980-07-28 | 1983-01-04 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
HUT71677A (en) * | 1992-05-01 | 1996-01-29 | Commw Scient Ind Res Org | Process for producing pharmaceutical compositions against flavivirus infections containing heteropolytungstates |
CA2153553A1 (en) * | 1994-07-13 | 1996-01-14 | Hidekazu Suzuki | Stable lipid emulsion |
US5834466A (en) * | 1994-12-22 | 1998-11-10 | The Regents Of The University Of California | Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia |
DE19645974C1 (de) * | 1996-11-07 | 1998-08-13 | Andreas Johannes Kesel | (Z)-5-[[3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylen]-2-thioxo-4- thiazolidinon, Verfahren zu dessen Herstellung und Verwendung |
-
1999
- 1999-08-19 ID IDW20010428A patent/ID27787A/id unknown
- 1999-08-19 WO PCT/US1999/018785 patent/WO2000010573A1/en not_active Application Discontinuation
- 1999-08-19 IL IL14145699A patent/IL141456A0/xx unknown
- 1999-08-19 KR KR1020017002117A patent/KR20010099623A/ko not_active Application Discontinuation
- 1999-08-19 CA CA002341970A patent/CA2341970A1/en not_active Abandoned
- 1999-08-19 BR BR9913157-9A patent/BR9913157A/pt not_active Application Discontinuation
- 1999-08-19 CN CN99812282A patent/CN1325309A/zh active Pending
- 1999-08-19 EP EP99942288A patent/EP1128832A4/en not_active Withdrawn
- 1999-08-19 JP JP2000565894A patent/JP2002523371A/ja active Pending
- 1999-08-19 AU AU55702/99A patent/AU743411B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CN1325309A (zh) | 2001-12-05 |
WO2000010573A1 (en) | 2000-03-02 |
CA2341970A1 (en) | 2000-03-02 |
AU5570299A (en) | 2000-03-14 |
IL141456A0 (en) | 2002-03-10 |
ID27787A (id) | 2001-04-26 |
AU743411B2 (en) | 2002-01-24 |
EP1128832A4 (en) | 2003-03-05 |
EP1128832A1 (en) | 2001-09-05 |
JP2002523371A (ja) | 2002-07-30 |
KR20010099623A (ko) | 2001-11-09 |
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