BR9907218A - Anticorpo monoclonal anti alfav-integrina e seu uso para inibir a fixação de alfav-beta6-integrina à fibronectina - Google Patents

Anticorpo monoclonal anti alfav-integrina e seu uso para inibir a fixação de alfav-beta6-integrina à fibronectina

Info

Publication number
BR9907218A
BR9907218A BR9907218-1A BR9907218A BR9907218A BR 9907218 A BR9907218 A BR 9907218A BR 9907218 A BR9907218 A BR 9907218A BR 9907218 A BR9907218 A BR 9907218A
Authority
BR
Brazil
Prior art keywords
integrin
alpha
fibronectin
antibody
inhibit
Prior art date
Application number
BR9907218-1A
Other languages
English (en)
Inventor
Simon Goodman
Beate Diefenbach
Francesc Mitjans
Ana Carceller
Elisabet Rosell-Vives
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9907218A publication Critical patent/BR9907218A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>"ANTICORPO MONOCLONAL ANTI ALFAv- INTEGRINA E SEU USO PARA INIBIR A FIXAçãO DE ALFAvBETA6-INTEGRINA à FIBRONECTINA"<D>. A invenção refere-se a um novo anticorpo monoclonal e a uma linhagem celular de hibridoma, que produz o dito anticorpo. O anticorpo monoclonal, cuja modalidade preferida é chamada de 14D9.F8, tem as seguintes propriedades: reage apenas com a cadeia <244>v de <244>v-integrinas humanas, e inibe seletivamente a fixação ao substrato de integrina fibronectina da célula portadora de <244>v<225>6-integrina.
BR9907218-1A 1998-01-23 1999-01-11 Anticorpo monoclonal anti alfav-integrina e seu uso para inibir a fixação de alfav-beta6-integrina à fibronectina BR9907218A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98101108 1998-01-23
PCT/EP1999/000101 WO1999037683A1 (en) 1998-01-23 1999-01-11 MONOCLONAL ANTIBODY ANTI αv-INTEGRIN AND ITS USE TO INHIBIT αvβ6-INTEGRIN ATTACHMENT TO FIBRONECTIN

Publications (1)

Publication Number Publication Date
BR9907218A true BR9907218A (pt) 2000-10-24

Family

ID=8231295

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907218-1A BR9907218A (pt) 1998-01-23 1999-01-11 Anticorpo monoclonal anti alfav-integrina e seu uso para inibir a fixação de alfav-beta6-integrina à fibronectina

Country Status (17)

Country Link
EP (1) EP1049718B1 (pt)
JP (1) JP2002501086A (pt)
KR (1) KR20010034327A (pt)
CN (1) CN1168741C (pt)
AR (1) AR014464A1 (pt)
AT (1) ATE322508T1 (pt)
AU (1) AU2716399A (pt)
BR (1) BR9907218A (pt)
CA (1) CA2319160A1 (pt)
DE (1) DE69930723T2 (pt)
HU (1) HUP0101151A3 (pt)
ID (1) ID27810A (pt)
NO (1) NO20003767L (pt)
PL (1) PL341569A1 (pt)
SK (1) SK10772000A3 (pt)
WO (1) WO1999037683A1 (pt)
ZA (1) ZA99453B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Hakko Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
EP2292251A1 (en) 2001-04-24 2011-03-09 Merck Patent GmbH Combination therapy using anti-angiogenic agents and TNF-alpha
US7829087B2 (en) 2001-07-09 2010-11-09 Elan Pharmaceuticals, Inc. Methods of treating cognitive impairment
JP4351043B2 (ja) 2001-07-09 2009-10-28 エラン ファーマシューティカルズ，インコーポレイテッド アミロイド毒性の阻害方法
CA2478833C (en) 2002-03-13 2015-11-10 Biogen, Inc. Anti-.alpha.v.beta.6 antibodies
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
AU2007207465B2 (en) 2006-01-18 2012-12-06 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
DK1989231T3 (en) 2006-03-21 2015-08-24 Genentech Inc COMBINATION THERAPY INVOLVING ALFA5BETA1 antagonists
KR20090027241A (ko) 2006-07-10 2009-03-16 바이오겐 아이덱 엠에이 인코포레이티드 Ｓｍａｄ４-결핍 암의 성장을 억제하기 위한 조성물 및 방법
ES2746925T3 (es) 2006-08-03 2020-03-09 Medimmune Ltd Anticuerpos dirigidos hacia alfaVbeta6 y uso de los mismos
PT2101805E (pt) 2007-01-18 2013-01-31 Merck Patent Gmbh Terapia específica e medicamento usando ligandos integrina para tratar o cancro
US7973138B2 (en) 2007-09-26 2011-07-05 Genentech, Inc. Antibodies
US9345739B2 (en) 2007-11-08 2016-05-24 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
PE20120770A1 (es) 2009-03-25 2012-07-10 Genentech Inc ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS
NZ597339A (en) 2009-05-25 2013-10-25 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
RU2565539C2 (ru) * 2010-02-18 2015-10-20 Те Риджентс Оф Те Юниверсити Оф Калифорния АНТИТЕЛА, НЕЙТРАЛИЗУЮЩИЕ ИНТЕГРИН ανβ8
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0719859T1 (en) * 1994-12-20 2003-12-31 Merck Patent Gmbh Anti-alpha V-integrin monoclonal antibody

Also Published As

Publication number Publication date
CA2319160A1 (en) 1999-07-29
SK10772000A3 (sk) 2001-01-18
EP1049718B1 (en) 2006-04-05
NO20003767D0 (no) 2000-07-21
HUP0101151A3 (en) 2004-06-28
DE69930723D1 (de) 2006-05-18
HUP0101151A2 (hu) 2001-08-28
PL341569A1 (en) 2001-04-23
DE69930723T2 (de) 2006-11-16
ID27810A (id) 2001-04-26
JP2002501086A (ja) 2002-01-15
NO20003767L (no) 2000-07-21
ZA99453B (en) 1999-07-21
EP1049718A1 (en) 2000-11-08
AR014464A1 (es) 2001-02-28
AU2716399A (en) 1999-08-09
ATE322508T1 (de) 2006-04-15
CN1288469A (zh) 2001-03-21
CN1168741C (zh) 2004-09-29
KR20010034327A (ko) 2001-04-25
WO1999037683A1 (en) 1999-07-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.