BR9906772A - Uso de ácido 11-(3-dimetilamino-propilideno)-6,11diidrodibenz[b,e]o xepin-2-acético para a fabricação de um medicamento para tratamento de desordens inflamatórias oftálmicas não-alérgicas e para prevenção de neovascularização ocular - Google Patents

Uso de ácido 11-(3-dimetilamino-propilideno)-6,11diidrodibenz[b,e]o xepin-2-acético para a fabricação de um medicamento para tratamento de desordens inflamatórias oftálmicas não-alérgicas e para prevenção de neovascularização ocular

Info

Publication number
BR9906772A
BR9906772A BR9906772-2A BR9906772A BR9906772A BR 9906772 A BR9906772 A BR 9906772A BR 9906772 A BR9906772 A BR 9906772A BR 9906772 A BR9906772 A BR 9906772A
Authority
BR
Brazil
Prior art keywords
propylidene
inflammatory disorders
ocular neovascularization
dimethylamino
prevention
Prior art date
Application number
BR9906772-2A
Other languages
English (en)
Inventor
John M Yanni
Daniel A Gamache
Lori K Weimer
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of BR9906772A publication Critical patent/BR9906772A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"USO DE áCIDO 11-(3-DIMETILAMINO-PROPILIDENO)-6,11-DIIDRODIBENZ[B,E] OXEPIN-2-ACéTICO PARA A FABRICAçãO DE UM MEDICAMENTO PARA TRATAMENTO DE DESORDENS INFLAMATóRIAS OFTáLMICAS NãO-ALéRGICAS E PARA PREVENçãO DE NEOVASCULARIZAçãO OCULAR"<D>. Formulações oftálmicas contendo como um ingrediente ativo ácido 11-(3-dimetilamino-propilideno)-6,11-diidrodibenz[b,e]oxepin-2-acétic o ou um seu sal farmaceuticamente aceitável são úteis para inibição de liberação de citocina (por exemplo, IL-6 e IL-8) a partir de células oculares humanas. Tais formulações podem ser usadas para tratar ou prevenir neovascularização ocular e distúrbios inflamatórios não-alérgicos tais como olho seco, ceratite, uveíte e inflamação relacionada com infecção.
BR9906772-2A 1998-07-14 1999-06-15 Uso de ácido 11-(3-dimetilamino-propilideno)-6,11diidrodibenz[b,e]o xepin-2-acético para a fabricação de um medicamento para tratamento de desordens inflamatórias oftálmicas não-alérgicas e para prevenção de neovascularização ocular BR9906772A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9276298P 1998-07-14 1998-07-14
PCT/US1999/013275 WO2000003705A1 (en) 1998-07-14 1999-06-15 Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization

Publications (1)

Publication Number Publication Date
BR9906772A true BR9906772A (pt) 2000-09-26

Family

ID=22235027

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9906772-2A BR9906772A (pt) 1998-07-14 1999-06-15 Uso de ácido 11-(3-dimetilamino-propilideno)-6,11diidrodibenz[b,e]o xepin-2-acético para a fabricação de um medicamento para tratamento de desordens inflamatórias oftálmicas não-alérgicas e para prevenção de neovascularização ocular

Country Status (18)

Country Link
EP (1) EP1037627B1 (pt)
JP (1) JP2002520355A (pt)
KR (1) KR100598723B1 (pt)
CN (1) CN1114401C (pt)
AR (1) AR019916A1 (pt)
AT (1) ATE203668T1 (pt)
AU (1) AU742237B2 (pt)
BR (1) BR9906772A (pt)
CA (1) CA2306393C (pt)
DE (1) DE69900207T2 (pt)
DK (1) DK1037627T3 (pt)
ES (1) ES2159209T3 (pt)
GR (1) GR3036422T3 (pt)
HK (1) HK1030362A1 (pt)
PT (1) PT1037627E (pt)
TW (1) TW561046B (pt)
WO (1) WO2000003705A1 (pt)
ZA (1) ZA200001593B (pt)

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AU770975B2 (en) 1999-06-18 2004-03-11 Alcon Laboratories, Inc. Topical ophthalmic mast cell stabilizers for treating allergic eye diseases
WO2002034246A2 (en) * 2000-10-23 2002-05-02 Alcon, Inc. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
BR0209883A (pt) 2001-05-21 2004-06-08 Alcon Inc Uso de inibidores da proteasoma para o tratamento de distúrbios do olho seco
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
BR0209965A (pt) * 2001-05-21 2004-04-06 Alcon Inc Uso de inibidores de nf-kappab para tratar distúrbios do olho seco
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US7977376B2 (en) 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
TWI231759B (en) * 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US6825232B2 (en) 2002-06-14 2004-11-30 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
WO2004010894A2 (en) 2002-07-30 2004-02-05 Omeros Corporation Ophthalmologic irrigation solutions and method
MXPA05003063A (es) 2002-09-20 2005-05-27 Alcon Inc Uso de inhibidores de la sintesis de citosina para el tratamiento de trastornos de ojos secos.
WO2004093878A1 (en) * 2003-04-16 2004-11-04 Alcon, Inc. Use of fused pyridazine derivatives for treating dry eye disorders
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7923471B2 (en) 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
WO2006014434A2 (en) 2004-07-02 2006-02-09 Eliot Lazar Treatment medium delivery device and methods for delivery
US7223737B1 (en) 2004-08-13 2007-05-29 Alcon, Inc. Method of treating dry eye disorders using glycosides
DK1881823T3 (en) * 2005-05-17 2015-03-02 Sarcode Bioscience Inc COMPOSITION AND PROCEDURES FOR TREATMENT OF EYE DISORDERS
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
KR20140083056A (ko) 2006-03-17 2014-07-03 존슨 앤드 존슨 비젼 케어, 인코포레이티드 산화에 불안정한 성분을 포함하는 안정화된 안과용 조성물
CN103393496B (zh) 2006-03-31 2016-08-17 玛提治疗有限公司 用于药物治疗的鼻泪引流***植入物
WO2009035571A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Lacrimal implant detection
US8207226B1 (en) 2008-06-03 2012-06-26 Alcon Research, Ltd. Use of FAAH antagonists for treating dry eye and ocular pain
JP2013510095A (ja) 2009-11-06 2013-03-21 アルコン リサーチ， リミテッド ドライアイの軽減のための栄養サプリメント
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN109311976A (zh) 2016-06-20 2019-02-05 诺华股份有限公司 使用TNFα拮抗剂治疗干眼症的方法

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Also Published As

Publication number Publication date
EP1037627B1 (en) 2001-08-01
PT1037627E (pt) 2001-11-30
CA2306393A1 (en) 2000-01-27
DE69900207D1 (de) 2001-09-06
KR100598723B1 (ko) 2006-07-11
AR019916A1 (es) 2002-03-27
KR20010024508A (ko) 2001-03-26
AU4563499A (en) 2000-02-07
EP1037627A1 (en) 2000-09-27
CA2306393C (en) 2008-12-23
JP2002520355A (ja) 2002-07-09
CN1114401C (zh) 2003-07-16
ATE203668T1 (de) 2001-08-15
CN1275078A (zh) 2000-11-29
ES2159209T3 (es) 2001-09-16
HK1030362A1 (en) 2001-05-04
ZA200001593B (en) 2000-10-25
AU742237B2 (en) 2001-12-20
GR3036422T3 (en) 2001-11-30
DK1037627T3 (da) 2001-10-01
TW561046B (en) 2003-11-11
WO2000003705A1 (en) 2000-01-27
DE69900207T2 (de) 2001-11-22

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: ALCON MANUFACTURING, LTD. (US), KYOWA HAKKO KOGYO CO., LTD. (JP)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 31/335, A61P 27/02, A61P 43/00

Ipc: A61K 31/335 (2007.10), A61P 27/02 (2007.10), A61P

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO METODOS TERAPEUTICOS NAO SAO CONSIDERADOS INVENCAO DE ACORDO COM O ART. 10 ( VIII ) DA LEI 9279/96