BR9812671A - Tetrahidrofurano fosfato- e hidróxi ésteres, como pró-medicamentos para o correspondente agente antifúgico - Google Patents

Tetrahidrofurano fosfato- e hidróxi ésteres, como pró-medicamentos para o correspondente agente antifúgico

Info

Publication number
BR9812671A
BR9812671A BR9812671-7A BR9812671A BR9812671A BR 9812671 A BR9812671 A BR 9812671A BR 9812671 A BR9812671 A BR 9812671A BR 9812671 A BR9812671 A BR 9812671A
Authority
BR
Brazil
Prior art keywords
tetrahydrofuran
phosphate
antifungal agent
prodrugs
hydroxy esters
Prior art date
Application number
BR9812671-7A
Other languages
English (en)
Inventor
Frank Bennett
Viyyoor M Girijavallabhan
Naginbhai M Patel
Anil K Saksena
Ashit Ganguly
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9812671A publication Critical patent/BR9812671A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Abstract

Patente de Invenção: <B>"TETRAHIDROFURANO FOSFATO- E HIDRóXI éSTERES, COMO PRó-MEDICAMENTOS PARA O CORRESPONDENTE AGENTE ANTIFúGICO"<D>. São descritos um composto de fórmual (I) em que G é H ou PO~ 3~H~ 2~ ou um sal farmaceuticamente aceitável do mesmo, composições farmacêuticas contendo tais compostos e processo de utilização de tais compostos ou composições farmacêuticas contendo os mesmos para tratar ou prevenir infecção fúngica.
BR9812671-7A 1997-09-25 1998-09-22 Tetrahidrofurano fosfato- e hidróxi ésteres, como pró-medicamentos para o correspondente agente antifúgico BR9812671A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93782797A 1997-09-25 1997-09-25
PCT/US1998/018508 WO1999015522A1 (en) 1997-09-25 1998-09-22 Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent

Publications (1)

Publication Number Publication Date
BR9812671A true BR9812671A (pt) 2000-08-22

Family

ID=25470461

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812671-7A BR9812671A (pt) 1997-09-25 1998-09-22 Tetrahidrofurano fosfato- e hidróxi ésteres, como pró-medicamentos para o correspondente agente antifúgico

Country Status (26)

Country Link
EP (1) EP1027349B1 (pt)
JP (1) JP3473949B2 (pt)
KR (1) KR20010024297A (pt)
CN (1) CN1125066C (pt)
AR (1) AR015458A1 (pt)
AT (1) ATE286502T1 (pt)
AU (1) AU1698199A (pt)
BR (1) BR9812671A (pt)
CA (1) CA2304624C (pt)
CO (1) CO5011088A1 (pt)
DE (1) DE69828524T2 (pt)
ES (1) ES2232974T3 (pt)
HK (1) HK1025960A1 (pt)
HU (1) HUP0004616A3 (pt)
ID (1) ID28294A (pt)
IL (1) IL134469A0 (pt)
MY (1) MY133775A (pt)
NO (1) NO20001557D0 (pt)
NZ (1) NZ502709A (pt)
PE (1) PE120799A1 (pt)
PL (1) PL339488A1 (pt)
PT (1) PT1027349E (pt)
SK (1) SK3912000A3 (pt)
TR (1) TR200000753T2 (pt)
WO (1) WO1999015522A1 (pt)
ZA (1) ZA988688B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1915500A (en) 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
CA2798002C (en) * 2010-05-19 2019-12-03 Sandoz Ag Process for the preparation of chiral triazolones
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283035B6 (sk) * 1993-12-21 2003-02-04 Schering Corporation Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok
US5693626A (en) * 1993-12-21 1997-12-02 Schering Corporation Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
DE69828524T2 (de) 2005-12-29
ID28294A (id) 2001-05-10
SK3912000A3 (en) 2000-08-14
WO1999015522A1 (en) 1999-04-01
PE120799A1 (es) 1999-12-01
AU1698199A (en) 1999-04-12
PT1027349E (pt) 2005-05-31
CO5011088A1 (es) 2001-02-28
IL134469A0 (en) 2001-04-30
ES2232974T3 (es) 2005-06-01
EP1027349A1 (en) 2000-08-16
MY133775A (en) 2007-11-30
CA2304624C (en) 2007-06-19
JP3473949B2 (ja) 2003-12-08
ATE286502T1 (de) 2005-01-15
NO20001557L (no) 2000-03-24
ZA988688B (en) 1999-03-23
TR200000753T2 (tr) 2001-01-22
NZ502709A (en) 2001-11-30
CN1271356A (zh) 2000-10-25
EP1027349B1 (en) 2005-01-05
DE69828524D1 (de) 2005-02-10
CA2304624A1 (en) 1999-04-01
HUP0004616A2 (hu) 2002-03-28
JP2001517665A (ja) 2001-10-09
AR015458A1 (es) 2001-05-02
NO20001557D0 (no) 2000-03-24
KR20010024297A (ko) 2001-03-26
CN1125066C (zh) 2003-10-22
HUP0004616A3 (en) 2002-04-29
HK1025960A1 (en) 2000-12-01
PL339488A1 (en) 2000-12-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O,6O,7O,8O E 9O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.