BR9810169A - Processo para preparação de trifluormetil acetofenona - Google Patents

Processo para preparação de trifluormetil acetofenona

Info

Publication number
BR9810169A
BR9810169A BR9810169-2A BR9810169A BR9810169A BR 9810169 A BR9810169 A BR 9810169A BR 9810169 A BR9810169 A BR 9810169A BR 9810169 A BR9810169 A BR 9810169A
Authority
BR
Brazil
Prior art keywords
compound
preparation
formula
trifluoromethyl acetophenone
vinylether
Prior art date
Application number
BR9810169-2A
Other languages
English (en)
Inventor
Adriano Indolese
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9810169A publication Critical patent/BR9810169A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE TRIFLUORMETIL ACETOFENONA"<D>. Processo para a preparação de um composto de fórmula (I), onde Y é um grupo que é inerte para as reações, de preferência uma hidrocarbila; e m é de 0 a 4, de preferência 0; em cujo processo a) um composto de fórmula (II), onde X é cloro, bromo ou iodo, de preferência bromo, e Y e m são definidos pela fórmula (I), é reagido com um viniléter de fórmula (IIIa) ou uma enamida de fórmula (IIIb): CH~ 2~=CH-OR~ 1~ (IIIa), CH~ 2~=CH-N(R~ 2~) -CO-R~ 3~ (IIIb), onde R~ 1~ e R~ 2~ são cada um independentemente do outro C~ 1~-C~ 8~ alquila, C~ 2~-C~ 8~ alquenila, C~ 1~-C~ 8~ alcoxialquila, C~ 3~-C~ 6~ cicloalquila, fenil-C~ 1~-C~ 2~ alquila ou C~ 1~-C~ 8~ acila, cujos grupos são opcionalmente substituídos, R~ 3~ é C~ 1~-C~ 8~ alquila, C~ 2~-C~ 8~ alquenila, C~ 1~-C~ 8~ alcoxialquila, C~ 3~-C~ 6~ cicloalquila, ou fenil-C~ 1~-C~ 2~ alquila, cujos grupos são opcionalmente substituídos, em um solvente, na presença de uma base e de uma quantidade catalítica de um composto de paládio compreendendo um ligante de fosfina monodental ou bidental; b) o intermediário resultante de fórmula (IVa) e respectivamente (IVb) é hidrolisado para o composto de fórmula (I).
BR9810169-2A 1997-06-19 1998-06-17 Processo para preparação de trifluormetil acetofenona BR9810169A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9712999.3A GB9712999D0 (en) 1997-06-19 1997-06-19 Process for the preparation of trifluoromethyl acetophenone
PCT/EP1998/003639 WO1998058895A1 (en) 1997-06-19 1998-06-17 Process for the preparation of trifluoromethyl acetophenone

Publications (1)

Publication Number Publication Date
BR9810169A true BR9810169A (pt) 2000-08-08

Family

ID=10814610

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810169-2A BR9810169A (pt) 1997-06-19 1998-06-17 Processo para preparação de trifluormetil acetofenona

Country Status (12)

Country Link
US (1) US6420608B1 (pt)
EP (1) EP0993432B1 (pt)
JP (1) JP2002504133A (pt)
AT (1) ATE225762T1 (pt)
AU (1) AU8337798A (pt)
BR (1) BR9810169A (pt)
DE (1) DE69808624T2 (pt)
DK (1) DK0993432T3 (pt)
ES (1) ES2185183T3 (pt)
GB (1) GB9712999D0 (pt)
WO (1) WO1998058895A1 (pt)
ZA (1) ZA985296B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725038B4 (de) * 1997-06-13 2007-06-06 Henkel Kgaa Emissionsarmer wäßriger Dispersions-Klebstoff und seine Verwendung
JP4649733B2 (ja) * 2000-12-04 2011-03-16 旭硝子株式会社 トリフルオロメチル基含有アセトフェノン化合物の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421730C1 (de) * 1994-06-22 1995-11-23 Hoechst Ag Verfahren zur Herstellung von aromatischen Olefinen unter Katalyse von Palladacyclen

Also Published As

Publication number Publication date
DK0993432T3 (da) 2003-01-27
AU8337798A (en) 1999-01-04
EP0993432A1 (en) 2000-04-19
GB9712999D0 (en) 1997-08-27
JP2002504133A (ja) 2002-02-05
DE69808624D1 (de) 2002-11-14
WO1998058895A1 (en) 1998-12-30
ES2185183T3 (es) 2003-04-16
US6420608B1 (en) 2002-07-16
ATE225762T1 (de) 2002-10-15
EP0993432B1 (en) 2002-10-09
ZA985296B (en) 1998-12-21
DE69808624T2 (de) 2003-02-06

Similar Documents

Publication Publication Date Title
PT788360E (pt) Compostos de acido e ester boronico, sinteses e utilizacoes.
MA22896A1 (fr) Procede de production de n-aryl- et n-heteroarylurees utilisables comme inhibiteurs d&#39;acylcoenzymes a:cholesterol-acyltransferase (acat) .
MY104626A (en) A 1-phenylimidazole derivative and its production and use.
CA2356154A1 (en) Ligands and complexes for enantioselective hydrogenation
PL289487A1 (en) Method of producing new aminophenol derivatives
DE59609733D1 (de) Die verwendung von zinn-katalysatoren sowie vernetzbare mischungen, diese katalysatoren enthaltend
IT7830123A0 (it) Processo per la preparazione di un catalizzatore misto.
MX9705726A (es) Amidas del acido alcoximinoacetico.
DK0508660T3 (da) Fremstilling af difluormethan
ATE246180T1 (de) Benzofuranon-derivate und verfahren zu ihrer herstellung
NL194332B (nl) Werkwijze ter bereiding van L-5-(2-hydroxypropionylamino)-2,4,6- trijoodisoftaalzuur-bis-(1,3-dihydroxypropylamide).
BR9810169A (pt) Processo para preparação de trifluormetil acetofenona
ES2099879T3 (es) 5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.
DE69709883T2 (de) Chirale ferrocene
ES2185196T3 (es) Un procedimiento para la preparacion de tetraazamacrociclos.
DK130397A (da) Fremgangsmåde til fremstilling af 5-amino-2,4,6-triiodisophthalsyre-dichlorid ved chlorering med thionylchlorid i nærværelse af en katalysator
HUP9801720A2 (hu) Új eljárás palatinit előállítására
BR9811579B1 (pt) ácidos 3-ciano-2,4-dialógeno-5-fluorobenzóicos e processo para a preparação dos mesmos.
BR9808047B1 (pt) processo para a preparação de 2-nitroguanidinas 1,3-dissubstituìdas.
BR9913249A (pt) Processo para a produção de um ácido 2-azetidina carboxìlico n-protegido, e, produto
PT924195E (pt) Processo para a preparacao de aminocianacetamida
ES2167447T3 (es) Procedimiento para la produccion de aminoazabicicloalcanos a partir de oximas.
ATE260891T1 (de) Verfahren zur kontinuierlichen herstellung von amino-halogenphenyl-alkylthioethern
ES2004876A6 (es) Un nuevo procedimiento para la preparacion de 4-(6&#39; -metoxi-2&#39; -naftil)butan-2-ona&#34;.
JPS54154725A (en) Production of 3-cycloalkenone

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A,8A E 9AANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.