BR9810002A - Preparação de <244>1-at nativa purificada cromatograficamente, processo para a preparação da mesma, e, utilização de um material de suporte - Google Patents
Preparação de <244>1-at nativa purificada cromatograficamente, processo para a preparação da mesma, e, utilização de um material de suporteInfo
- Publication number
- BR9810002A BR9810002A BR9810002-5A BR9810002A BR9810002A BR 9810002 A BR9810002 A BR 9810002A BR 9810002 A BR9810002 A BR 9810002A BR 9810002 A BR9810002 A BR 9810002A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- support material
- chromatographically purified
- preparing
- purified native
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PREPARAçãO DE <244>1-AT NATIVA PURIFICADA CROMATOGRAFICAMENTE, PROCESSO PARA A PREPARAçãO DA MESMA, E, UTILIZAçãO DE UM MATERIAL DE SUPORTE". Descreve-se uma preparação de <244>1-AT nativa, purificada cromatograficamente, que apresenta uma pureza de pelo menos 0,7 PE/mg de proteína e uma atividade relativa de <244>1-AT no plasma de pelo menos 120%. A proporção de <244>1-AT ativa para inativa é maior do que no plasma. Além disso, descreve-se um processo para a fabricação desta preparação e também a utilização de um material de suporte, por exemplo um material de suporte inorgânico, como a hidroxilapatila, para a separação de <244>1-AT ativa da <244>1-AT inativa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0100797A AT407114B (de) | 1997-06-10 | 1997-06-10 | Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung |
PCT/AT1998/000130 WO1998056821A1 (de) | 1997-06-10 | 1998-05-20 | Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810002A true BR9810002A (pt) | 2000-08-01 |
Family
ID=3504791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810002-5A BR9810002A (pt) | 1997-06-10 | 1998-05-20 | Preparação de <244>1-at nativa purificada cromatograficamente, processo para a preparação da mesma, e, utilização de um material de suporte |
Country Status (15)
Country | Link |
---|---|
US (1) | US6974792B2 (pt) |
EP (1) | EP0991666B1 (pt) |
JP (1) | JP2002510294A (pt) |
AT (1) | AT407114B (pt) |
AU (1) | AU729389B2 (pt) |
BR (1) | BR9810002A (pt) |
CA (1) | CA2293806C (pt) |
DE (1) | DE59814132D1 (pt) |
DK (1) | DK0991666T3 (pt) |
ES (1) | ES2296334T3 (pt) |
HU (1) | HUP0003712A1 (pt) |
NO (1) | NO995928L (pt) |
PT (1) | PT991666E (pt) |
SK (1) | SK171699A3 (pt) |
WO (1) | WO1998056821A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
AU2012203030B2 (en) * | 2002-12-31 | 2015-02-19 | Csl Behring L.L.C. | Method for purification of alpha-1-antitrypsin |
US7777006B2 (en) * | 2002-12-31 | 2010-08-17 | Csl Behring L.L.C. | Method for purification of alpha-1-antitrypsin |
AU2015200572B2 (en) * | 2002-12-31 | 2016-06-02 | Csl Behring L.L.C. | Method for purification of alpha-1-antitrypsin |
RS20060077A (en) * | 2003-08-12 | 2008-08-07 | Octapharma Ag., | Process for preparing an alpha-1-antitrypsin solution |
EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
ES2305845T5 (es) * | 2003-09-22 | 2012-04-12 | Kamada Ltd. | Preparación a gran escala de un inhibidor de proteinasa alfa-1 y su utilización |
GB0524432D0 (en) * | 2005-11-30 | 2006-01-11 | Nhs Blood & Transplant | Method |
WO2007112953A1 (en) * | 2006-03-30 | 2007-10-11 | Baxter Internaional Inc. | Process for the purification of recombinant alpha 1-antitrypsin involving a step of anion exchange chromatography |
US8623830B2 (en) | 2006-09-12 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Compositions containing α-1-antitrypsin and methods for use |
CN103408658A (zh) | 2007-08-17 | 2013-11-27 | Csl百灵有限公司 | α-1-抗胰蛋白酶和载脂蛋白A-I的纯化方法 |
PT2214699T (pt) * | 2007-11-02 | 2017-01-10 | Grifols Therapeutics Inc | Método, composição e artigo de fabrico para proporcionar alfa-1 antitripsina |
RU2555332C2 (ru) | 2009-11-03 | 2015-07-10 | Грифольс Терапьютикс Инк. | Композиция, способ и набор для альфа-1 ингибитора протеазы |
RU2540480C2 (ru) | 2009-11-24 | 2015-02-10 | Грифольс Терапьютикс Инк. | Способы, композиции и наборы для лиофилизации |
WO2011150284A2 (en) | 2010-05-26 | 2011-12-01 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
US10233556B2 (en) | 2010-07-02 | 2019-03-19 | Lam Research Corporation | Dynamic modulation of cross flow manifold during electroplating |
US10094034B2 (en) | 2015-08-28 | 2018-10-09 | Lam Research Corporation | Edge flow element for electroplating apparatus |
KR20140108516A (ko) | 2011-12-30 | 2014-09-11 | 그리폴스, 에스.에이. | 폐 악화의 발현 또는 진행을 지연시키기 위한 알파1-프로테이나제 억제제 |
CN103788209B (zh) * | 2012-10-29 | 2016-02-24 | 广东双林生物制药有限公司 | 一种α1-蛋白酶抑制剂的制备方法 |
EP3708182A1 (en) | 2013-03-29 | 2020-09-16 | The Regents Of The University Of Colorado | Compositions and methods for preparing a subject for organ or non-organ implantation |
US10364505B2 (en) | 2016-05-24 | 2019-07-30 | Lam Research Corporation | Dynamic modulation of cross flow manifold during elecroplating |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4439358A (en) * | 1982-06-17 | 1984-03-27 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
US4697003A (en) * | 1985-11-01 | 1987-09-29 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
US6284874B1 (en) * | 1994-06-17 | 2001-09-04 | Alpha Therapeutic Corporation | Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste |
US5610285A (en) * | 1994-08-24 | 1997-03-11 | Bayer Corporation | Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions |
US5760179A (en) * | 1996-06-10 | 1998-06-02 | Desmos, Inc. | Purification of soluble laminin 5 |
-
1997
- 1997-06-10 AT AT0100797A patent/AT407114B/de not_active IP Right Cessation
-
1998
- 1998-05-20 BR BR9810002-5A patent/BR9810002A/pt not_active Application Discontinuation
- 1998-05-20 DE DE59814132T patent/DE59814132D1/de not_active Expired - Lifetime
- 1998-05-20 HU HU0003712A patent/HUP0003712A1/hu unknown
- 1998-05-20 DK DK98921263T patent/DK0991666T3/da active
- 1998-05-20 PT PT98921263T patent/PT991666E/pt unknown
- 1998-05-20 EP EP98921263A patent/EP0991666B1/de not_active Expired - Lifetime
- 1998-05-20 AU AU74180/98A patent/AU729389B2/en not_active Expired
- 1998-05-20 CA CA2293806A patent/CA2293806C/en not_active Expired - Fee Related
- 1998-05-20 JP JP50110299A patent/JP2002510294A/ja active Pending
- 1998-05-20 SK SK1716-99A patent/SK171699A3/sk unknown
- 1998-05-20 WO PCT/AT1998/000130 patent/WO1998056821A1/de not_active Application Discontinuation
- 1998-05-20 ES ES98921263T patent/ES2296334T3/es not_active Expired - Lifetime
-
1999
- 1999-12-03 NO NO995928A patent/NO995928L/no not_active Application Discontinuation
-
2001
- 2001-09-24 US US09/963,341 patent/US6974792B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0991666T3 (da) | 2008-04-14 |
CA2293806A1 (en) | 1998-12-17 |
AT407114B (de) | 2000-12-27 |
PT991666E (pt) | 2007-12-27 |
EP0991666B1 (de) | 2007-11-28 |
WO1998056821A1 (de) | 1998-12-17 |
US20020082214A1 (en) | 2002-06-27 |
AU729389B2 (en) | 2001-02-01 |
EP0991666A1 (de) | 2000-04-12 |
DE59814132D1 (de) | 2008-01-10 |
US6974792B2 (en) | 2005-12-13 |
JP2002510294A (ja) | 2002-04-02 |
CA2293806C (en) | 2010-02-09 |
NO995928L (no) | 2000-02-09 |
ES2296334T3 (es) | 2008-04-16 |
NO995928D0 (no) | 1999-12-03 |
HUP0003712A1 (hu) | 2001-02-28 |
AU7418098A (en) | 1998-12-30 |
SK171699A3 (en) | 2000-06-12 |
ATA100797A (de) | 2000-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |