BR9809673A - Derivados de triptolida úteis no tratamento de doenças autoimunes - Google Patents

Derivados de triptolida úteis no tratamento de doenças autoimunes

Info

Publication number
BR9809673A
BR9809673A BR9809673-7A BR9809673A BR9809673A BR 9809673 A BR9809673 A BR 9809673A BR 9809673 A BR9809673 A BR 9809673A BR 9809673 A BR9809673 A BR 9809673A
Authority
BR
Brazil
Prior art keywords
treatment
triptolide
derivatives useful
autoimmune diseases
triptolide derivatives
Prior art date
Application number
BR9809673-7A
Other languages
English (en)
Inventor
Michel J Jung
Mahinda Wickramaratne
Michael Hepperle
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of BR9809673A publication Critical patent/BR9809673A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE TRIPTOLIDA úTEIS NO TRATAMENTO DE DOENçAS AUTO-IMUNES"<D>. A presente invenção refere-se a novos derivados de triptolida de fórmulas (1)-(3) e a um método para tratamento de um paciente que sofre de uma doença auto-imune que compreende administrar a um paciente uma quantidade eficaz dos novos derivados de triptolida.
BR9809673-7A 1997-05-23 1998-04-27 Derivados de triptolida úteis no tratamento de doenças autoimunes BR9809673A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86248997A 1997-05-23 1997-05-23
PCT/US1998/008562 WO1998052933A1 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
BR9809673A true BR9809673A (pt) 2000-07-11

Family

ID=25338618

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809673-7A BR9809673A (pt) 1997-05-23 1998-04-27 Derivados de triptolida úteis no tratamento de doenças autoimunes

Country Status (18)

Country Link
EP (1) EP0983256B1 (pt)
JP (1) JP2002500647A (pt)
KR (1) KR20010012820A (pt)
AR (1) AR012737A1 (pt)
AT (1) ATE261434T1 (pt)
AU (1) AU741209B2 (pt)
BR (1) BR9809673A (pt)
CA (1) CA2288327A1 (pt)
DE (1) DE69822297T2 (pt)
ES (1) ES2213279T3 (pt)
HK (1) HK1025954A1 (pt)
HU (1) HUP0003244A3 (pt)
IL (1) IL133089A0 (pt)
NO (1) NO995722L (pt)
NZ (1) NZ500699A (pt)
TW (1) TW462966B (pt)
WO (1) WO1998052933A1 (pt)
ZA (1) ZA984177B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569893B2 (en) * 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
EP1511478A4 (en) 2002-05-31 2009-12-02 Pharmagenesis Inc TRIPTOLIDE DERIVATIVES FOR MODULATING APOPTOSIS AND IMMUNOSUPPRESSION
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
WO2005077008A2 (en) 2004-02-09 2005-08-25 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from tripterygium wilfordii
ES2385716T3 (es) 2004-03-02 2012-07-30 Pharmagenesis, Inc. Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP2414542B1 (en) 2009-03-30 2017-08-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
EP2685976B1 (en) 2011-03-17 2017-12-27 Tel HaShomer Medical Research Infrastructure and Services Ltd. Quinolone analogs for treating autoimmune diseases
EP3074391B1 (en) 2013-11-28 2019-07-31 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
CN113768939A (zh) * 2021-09-30 2021-12-10 深圳艾克斯恩生物科技有限公司 雷公藤二醇在制备预防和/或治疗nlrp3炎症小体介导的炎症性疾病药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6826194A (en) * 1993-05-06 1994-12-12 Pharmagenesis, Inc. 16-hydroxytriptolide composition and method for immunotherapy
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
ATE261434T1 (de) 2004-03-15
WO1998052933A1 (en) 1998-11-26
KR20010012820A (ko) 2001-02-26
AU7363498A (en) 1998-12-11
HUP0003244A3 (en) 2001-09-28
EP0983256A1 (en) 2000-03-08
IL133089A0 (en) 2001-03-19
ZA984177B (en) 1998-11-23
HK1025954A1 (en) 2000-12-01
AR012737A1 (es) 2000-11-08
JP2002500647A (ja) 2002-01-08
HUP0003244A2 (en) 2001-03-28
EP0983256B1 (en) 2004-03-10
CA2288327A1 (en) 1998-11-26
DE69822297D1 (de) 2004-04-15
TW462966B (en) 2001-11-11
DE69822297T2 (de) 2004-07-29
ES2213279T3 (es) 2004-08-16
NO995722L (no) 2000-01-21
AU741209B2 (en) 2001-11-22
NO995722D0 (no) 1999-11-22
NZ500699A (en) 2001-08-31

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Legal Events

Date Code Title Description
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B25D Requested change of name of applicant approved

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

Free format text: ALTERADO DE: HOECHST MARION ROUSSEL, INC.

B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070033918/RJ DE 19/03/2007.