BR9809577A - Processo e intermediários para a prepração da (1,2,3,4-tetraidro-isoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxìlico - Google Patents

Processo e intermediários para a prepração da (1,2,3,4-tetraidro-isoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxìlico

Info

Publication number
BR9809577A
BR9809577A BR9809577-3A BR9809577A BR9809577A BR 9809577 A BR9809577 A BR 9809577A BR 9809577 A BR9809577 A BR 9809577A BR 9809577 A BR9809577 A BR 9809577A
Authority
BR
Brazil
Prior art keywords
preparation
carboxylic acid
trifluormethyl
biphenyl
amide
Prior art date
Application number
BR9809577-3A
Other languages
English (en)
Inventor
John Anthony Ragan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9809577A publication Critical patent/BR9809577A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO E INTERMEDIáRIOS PARA A PREPARAçãO DA (1,2,3,4-TETRAIDROISOQUINOLIN-6-IL)-AMIDA DO áCIDO 4'-TRIFLUORMETIL-BIFENIL-2-CARBOXìLICO"<D>. Um processo melhorado, e intermediários, na preparação da (1,2,3,4-tetraidroisoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxílico (I). O composto (I) é útil na preparação da [2-(1H-[1,2,4-triazol-3-il-metil)]-(1,2,3,4-tetraidroisoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxílico (II) o qual é útil como inibidor da proteína de transferência de triglicerídeos microssómicos e/ou da secreção da apolipoproteína B (Apo B), sendo, em consequência, úteis para a prenvenção e tratamento da aterosclerose e das suas sequelas clínicas, para baixar os lípidos séricos, e para as doenças relacionadas. Um composto da fórmula A-CHR^ 1^R^ 2^ onde A é um grupo da fórmula e R^ 1^ é escolhido a partir de H e OR^ 3^, onde R^ 3^ é hidrogênio ou (C~ 1~-C~ 6~)alquila; R^ 2^ é escolhido a partir de OR^ 3^, -CH~ 2~-NH~ 2~<sym>(R^ 5^H)~ m, onde m e R^ 5^H são definidos abaixo, e -CH~ 2~-NO~ 2~; ou R^ 1^ e R^ 2^ juntos formam um grupo =O ou =CH-NO~ 2~; com a condição de que quando R^ 1^e R^ 2^ são ambos um grupo OR^ 3^ então ambos os R^ 3^ são grupos (C~ 1~-C~ 6~)alquila e iguais.
BR9809577-3A 1997-04-18 1998-04-06 Processo e intermediários para a prepração da (1,2,3,4-tetraidro-isoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxìlico BR9809577A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4469097P 1997-04-18 1997-04-18
PCT/IB1998/000493 WO1998047875A1 (en) 1997-04-18 1998-04-06 Process and intermediates for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide

Publications (1)

Publication Number Publication Date
BR9809577A true BR9809577A (pt) 2000-07-04

Family

ID=21933788

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809577-3A BR9809577A (pt) 1997-04-18 1998-04-06 Processo e intermediários para a prepração da (1,2,3,4-tetraidro-isoquinolin-6-il)-amida do ácido 4'-trifluormetil-bifenil-2-carboxìlico

Country Status (17)

Country Link
US (1) US6147214A (pt)
EP (1) EP0975598A1 (pt)
JP (1) JP2000510483A (pt)
KR (1) KR20010006479A (pt)
CN (1) CN1252792A (pt)
AR (1) AR012452A1 (pt)
AU (1) AU6415998A (pt)
BR (1) BR9809577A (pt)
CA (1) CA2286108A1 (pt)
HU (1) HUP0001910A2 (pt)
ID (1) ID23387A (pt)
IL (1) IL131850A0 (pt)
PL (1) PL336481A1 (pt)
TR (1) TR199902579T2 (pt)
TW (1) TW413676B (pt)
WO (1) WO1998047875A1 (pt)
ZA (1) ZA983244B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291465B1 (en) 1999-03-09 2001-09-18 Hoffmann-La Roche Inc. Biphenyl derivatives
WO2001005767A1 (en) * 1999-07-20 2001-01-25 Novartis Ag Organic compounds
PL360081A1 (en) 2000-07-24 2004-09-06 Bayer Cropscience Ag Biphenyl carboxamides
AU2003211617C1 (en) 2002-02-28 2008-03-06 Japan Tobacco Inc. Ester compound and medicinal use thereof
WO2004011427A2 (en) * 2002-07-31 2004-02-05 Smithkline Beecham Corporation Substituted benzanilides as modulators of the ccr5 receptor
UA79300C2 (en) * 2002-08-12 2007-06-11 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion
WO2004039795A2 (en) * 2002-10-29 2004-05-13 Fujisawa Pharmaceutical Co., Ltd. Amide compounds for the treatment of hyperlipidemia
JP4832897B2 (ja) 2003-08-29 2011-12-07 日本たばこ産業株式会社 エステル誘導体及びその医薬用途
US8101774B2 (en) 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
US20080200682A1 (en) * 2005-06-17 2008-08-21 Basf Aktiengesellschaft Process of Producing Bleach Boosters
JP4854253B2 (ja) 2005-09-30 2012-01-18 国立大学法人佐賀大学 脂質代謝改善用組成物
BRPI1014405A2 (pt) 2009-04-29 2016-04-05 Amarin Corp Plc composições farmacêuticas compreendendo epa e um agente cardiovascular e métodos de seu uso
CN104725265B (zh) * 2015-04-13 2016-11-30 江苏海阳化纤有限公司 一种硝基酰胺类化合物的合成方法
CN105418513B (zh) * 2015-11-13 2018-07-31 上海应用技术学院 一种5-(1,3-二硝基丙-2-基)-1h-咪唑化合物及制备方法
CN105418514B (zh) * 2015-11-18 2018-07-31 上海应用技术学院 一种(e)-叔丁基-5-(2-硝基乙烯基)-1h-咪唑-1-甲酸叔丁酯及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040640A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION

Also Published As

Publication number Publication date
JP2000510483A (ja) 2000-08-15
TR199902579T2 (xx) 2000-01-21
ZA983244B (en) 1999-10-18
PL336481A1 (en) 2000-06-19
WO1998047875A1 (en) 1998-10-29
CN1252792A (zh) 2000-05-10
ID23387A (id) 2000-04-20
US6147214A (en) 2000-11-14
TW413676B (en) 2000-12-01
AU6415998A (en) 1998-11-13
KR20010006479A (ko) 2001-01-26
EP0975598A1 (en) 2000-02-02
IL131850A0 (en) 2001-03-19
AR012452A1 (es) 2000-10-18
HUP0001910A2 (hu) 2000-10-28
CA2286108A1 (en) 1998-10-29

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.