BR9809173A - Alternatively targeted adenoviruses - Google Patents
Alternatively targeted adenovirusesInfo
- Publication number
- BR9809173A BR9809173A BR9809173-5A BR9809173A BR9809173A BR 9809173 A BR9809173 A BR 9809173A BR 9809173 A BR9809173 A BR 9809173A BR 9809173 A BR9809173 A BR 9809173A
- Authority
- BR
- Brazil
- Prior art keywords
- adenovirus
- substrate
- present
- provides
- trimer
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title abstract 9
- 239000000758 substrate Substances 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 5
- 239000013638 trimer Substances 0.000 abstract 4
- 230000000903 blocking effect Effects 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 210000002751 lymph Anatomy 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000835 fiber Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 108700026758 Adenovirus hexon capsid Proteins 0.000 abstract 1
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 101710145505 Fiber protein Proteins 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000001902 propagating effect Effects 0.000 abstract 1
- 238000005829 trimerization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<B>ADENOVìRUS ALTERNATIVAMENTE DIRECIONADOS<D> A presente invenção provê um trímero compreendendo três monómeros, cada um tendo um terminal amino de uma proteína de fibra adenoviral e um domínio de trimerização. O trímero apresenta uma afinidade reduzida para um substrato nativo, em comparação com um trímero de fibra adenoviral nativo. A presente invenção provê, ainda, um adenovírus incorporando o trímero da presente invenção. A presente invenção também provê uma linhagem de célula expressando um receptor de superfície de célula não-nativo, ao qual liga-se um adenovírus tendo um ligante para o receptor, e um método de propagar um adenovírus utilizando a linhagem de célula. A presente invenção também provê um método de purificar um adenovírus tendo um ligante para um substrato de uma composição compreendendo o adenovírus. O método envolve a exposição da composição ao substrato, sob condições que promovem o ligante a ligar-se, seletivamente, ao substrato. A presente invenção provê, ainda, um método de inativar um adenovírus tendo um ligante que reconhece um substrato carregado por linfa ou sangue, expondo o vírus ao substrato. No sangue ou linfa, o ligante liga seu substrato, adsorvendo, deste modo, o vírus livre do sangue ou linfa. Adicionalmente, a presente invenção provê uma proteína de bloqueio quimérica, compreendendo um substrato para uma fibra de adenovírus, e um método para interferir com a ligação de receptor adenoviral, incubando um adenovírus com tal proteína de bloqueio quimérica, em uma solução tal que a proteína de bloqueio quimérica liga a fibra.<B> ALTERNATIVELY TARGETED ADENOVIRUS <D> The present invention provides a trimer comprising three monomers, each having an amino terminus of an adenoviral fiber protein and a trimerization domain. The trimer has a reduced affinity for a native substrate, compared to a native adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the trimer of the present invention. The present invention also provides a cell line expressing a non-native cell surface receptor, to which an adenovirus having a ligand for the receptor is attached, and a method of propagating an adenovirus using the cell line. The present invention also provides a method of purifying an adenovirus having a linker for a substrate of a composition comprising the adenovirus. The method involves exposing the composition to the substrate, under conditions that promote the binder to selectively bind to the substrate. The present invention further provides a method of inactivating an adenovirus having a ligand that recognizes a substrate loaded with lymph or blood, exposing the virus to the substrate. In the blood or lymph, the ligand binds its substrate, thus adsorbing the virus free from the blood or lymph. In addition, the present invention provides a chimeric blocking protein, comprising a substrate for an adenovirus fiber, and a method for interfering with adenoviral receptor binding, by incubating an adenovirus with such a chimeric blocking protein, in a solution such that the protein chimeric blocking bond connects the fiber.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4784997P | 1997-05-28 | 1997-05-28 | |
US7166898P | 1998-01-16 | 1998-01-16 | |
PCT/US1998/011024 WO1998054346A1 (en) | 1997-05-28 | 1998-05-28 | Alternatively targeted adenovirus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809173A true BR9809173A (en) | 2000-08-01 |
Family
ID=26725500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809173-5A BR9809173A (en) | 1997-05-28 | 1998-05-28 | Alternatively targeted adenoviruses |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0988390A1 (en) |
JP (1) | JP2001518806A (en) |
BR (1) | BR9809173A (en) |
CA (1) | CA2291323A1 (en) |
HU (1) | HUP0002070A2 (en) |
IL (1) | IL133010A0 (en) |
NZ (1) | NZ501140A (en) |
PL (1) | PL337130A1 (en) |
SK (1) | SK159999A3 (en) |
WO (1) | WO1998054346A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU767975B2 (en) * | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
WO2000046364A1 (en) * | 1999-02-05 | 2000-08-10 | The Uab Research Foundation | Fiber receptor-independent system for the propagation of adenoviral vectors |
JP2000279178A (en) * | 1999-02-24 | 2000-10-10 | Japan Found Cancer Res | Virus vector |
EP1593742A3 (en) * | 1999-06-01 | 2006-02-01 | The University of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection |
US7094398B1 (en) | 1999-06-01 | 2006-08-22 | University Of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
DE60018920T2 (en) * | 1999-06-01 | 2006-04-13 | University Of Washington, Seattle | RECOMBINANT ADENOVIRAL VECTORS EXPRESSING CHIMERIC FIBER PROTEINS FOR CELL SPECIFIC INFECTION AND GENOMIC INTEGRATION |
JP5043271B2 (en) | 2000-04-12 | 2012-10-10 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Peptide-based compounds |
CA2407518A1 (en) * | 2000-04-26 | 2001-11-01 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
EP1167533A1 (en) * | 2000-06-23 | 2002-01-02 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Methods and means for the complementation of viral protein expression in stable cell lines |
GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
NO20004795D0 (en) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptide-based compounds |
HU230901B1 (en) | 2001-07-10 | 2019-01-28 | Ge Healthcare Limited | Peptide-based compounds and pharmaceutical compositions containing them |
FR2842823A1 (en) * | 2002-07-25 | 2004-01-30 | Inst Nat Sante Rech Med | MODIFIED ADENOVIRUSES FOR TARGETING B-LYMPHOCYTES |
US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
EP1613757A2 (en) | 2003-03-28 | 2006-01-11 | The Scripps Research Institute | Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes |
DE602004025726D1 (en) | 2003-11-14 | 2010-04-08 | Genvec Inc | PHARMACEUTICAL COMPOUND FOR THE TREATMENT OF LOCALLY ADVANCED PRIMARY INOPERABLES PANCREATIC CARCINOMA (LAPC). |
EP2567967A3 (en) | 2004-04-12 | 2013-08-21 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method of using adenoviral vectors to induce an immune response |
CA2620495A1 (en) | 2005-08-31 | 2007-03-08 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
BRPI0618441B8 (en) | 2005-11-10 | 2021-07-27 | Genvec Inc | adenoviral vector |
WO2007094653A1 (en) * | 2006-02-13 | 2007-08-23 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles. |
WO2010075058A1 (en) | 2008-12-23 | 2010-07-01 | Ge Healthcare Limited | Application of 99mtc peptide-based compound as a bone marrow imaging agent |
EP2248903A1 (en) | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages |
US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
EA201270607A1 (en) | 2009-11-09 | 2012-09-28 | Генвек, Инк. | MONKEY MONKEY ADENOVIRUS AND METHODS FOR USING IT |
WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
EP2654786B1 (en) | 2010-12-20 | 2019-02-20 | GenVec, Inc. | Adenoviral vector-based dengue fever vaccine |
EP2855669B1 (en) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modified serotype 28 adenoviral vectors |
EP2971008B1 (en) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Oncolytic adenovirus compositions |
TWI710635B (en) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | Adenoviral vector encoding human atonal homolog-1 (hath1) |
EP3072900A1 (en) | 2015-03-27 | 2016-09-28 | Medizinische Hochschule Hannover | Anti-tumour medicament based on adenovirus |
JP7054527B2 (en) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | High-throughput assay to measure adenovirus replication kinetics |
JP7015551B2 (en) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | Exogenous gene expression in therapeutic adenovirus to minimize its impact on viral dynamics |
CA3038968A1 (en) | 2016-09-30 | 2018-04-05 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into t cells |
CA3045892A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851341A (en) * | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1998
- 1998-05-28 BR BR9809173-5A patent/BR9809173A/en not_active IP Right Cessation
- 1998-05-28 HU HU0002070A patent/HUP0002070A2/en unknown
- 1998-05-28 IL IL13301098A patent/IL133010A0/en unknown
- 1998-05-28 WO PCT/US1998/011024 patent/WO1998054346A1/en not_active Application Discontinuation
- 1998-05-28 JP JP50097799A patent/JP2001518806A/en not_active Ceased
- 1998-05-28 NZ NZ501140A patent/NZ501140A/en unknown
- 1998-05-28 PL PL98337130A patent/PL337130A1/en unknown
- 1998-05-28 SK SK1599-99A patent/SK159999A3/en unknown
- 1998-05-28 EP EP98923856A patent/EP0988390A1/en not_active Withdrawn
- 1998-05-28 CA CA002291323A patent/CA2291323A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001518806A (en) | 2001-10-16 |
WO1998054346A1 (en) | 1998-12-03 |
EP0988390A1 (en) | 2000-03-29 |
CA2291323A1 (en) | 1998-12-03 |
NZ501140A (en) | 2001-07-27 |
IL133010A0 (en) | 2001-03-19 |
SK159999A3 (en) | 2000-06-12 |
HUP0002070A2 (en) | 2000-10-28 |
PL337130A1 (en) | 2000-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A7A,8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |