BR9807100A - Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos - Google Patents

Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos

Info

Publication number
BR9807100A
BR9807100A BR9807100-9A BR9807100A BR9807100A BR 9807100 A BR9807100 A BR 9807100A BR 9807100 A BR9807100 A BR 9807100A BR 9807100 A BR9807100 A BR 9807100A
Authority
BR
Brazil
Prior art keywords
disorders
benzo
isoindoles
isoquinolines
stroke
Prior art date
Application number
BR9807100-9A
Other languages
English (en)
Inventor
Michael Boes
Heinz Stadler
Juergen Wichmann
Original Assignee
Hoffamann La Roche Ag F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffamann La Roche Ag F filed Critical Hoffamann La Roche Ag F
Publication of BR9807100A publication Critical patent/BR9807100A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Patente de Invenção: <B>"BENZO[E]ISOINDóIS E BENZO[H]SOQUINOLINAS TRICìCLICOS"<D>. A presente invenção refere-se a novas benzo[e]-isoindóis e benzo[h]isoquinolinas. Uma vez que os compostos de acordo com a invenção podem ligar-se a receptores de serotonina (5HT~ 2~), eles são especialmente adequados para o tratameno ou prevenção de distúbios nervosos centrais tais como depressões, distúrbios bipolares, estados de ansiedade, distúbios do sono e sexual, psicose, esquizofrenia, enxaqueca e outras condições associadas com dor cefálica ou dor de uma espécie dirente, distúrbios de personalidade ou distúbios compulsivos obsessivos, fobias sociais ou ataques de pânico, distúrbios orgânicos mentais, distúrbios menstais na infância, agressividade, distúrbios da memória relacionados com a idade e distúrbios de comportamento, vício, obesidade, bulimia, etc., dano do sistema nervoso causado por trauma, acidente vascular cerebral, doenças neurodegenerativas, etc.; distúrbios cardiovasculares, tais como hipertensão, trombose, acidente vascular cerebral, etc; e distúrbios gastrintestinais tais como disfunção da motilidade do trato gastrintestinal.
BR9807100-9A 1997-01-08 1998-01-07 Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos BR9807100A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100172 1997-01-08
PCT/EP1998/000043 WO1998030546A1 (en) 1997-01-08 1998-01-07 TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES

Publications (1)

Publication Number Publication Date
BR9807100A true BR9807100A (pt) 2000-04-25

Family

ID=26145159

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807100-9A BR9807100A (pt) 1997-01-08 1998-01-07 Benzo[e]isoindóis e benzo[h]isoquinolinas tricìclicos

Country Status (9)

Country Link
EP (1) EP0958285B1 (pt)
JP (1) JP3297058B2 (pt)
AT (1) ATE257470T1 (pt)
AU (1) AU742735B2 (pt)
BR (1) BR9807100A (pt)
CA (1) CA2276098C (pt)
DE (1) DE69820989T2 (pt)
DK (1) DK0958285T3 (pt)
WO (1) WO1998030546A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE310566T1 (de) 1998-09-18 2005-12-15 Alcon Mfg Ltd 5ht2-agoniste zur behandlung des glaukoms
JP2005506280A (ja) 2000-12-20 2005-03-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アリールおよびアミノアリール置換セロトニン受容体アゴニストおよびアンタゴニストリガンド
JP2004115510A (ja) * 2002-09-05 2004-04-15 Toray Fine Chemicals Co Ltd ピペラジン誘導体の製造方法
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
US7423056B2 (en) * 2004-09-03 2008-09-09 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN100402534C (zh) * 2006-11-09 2008-07-16 东南大学 一种三环类化合物及其在制药中的应用
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
EP2510949A4 (en) 2009-12-11 2013-11-13 Astellas Pharma Inc THERAPEUTICS FOR FIBROMYALGIA
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH504438A (de) * 1968-05-27 1971-03-15 Sandoz Ag Verfahren zur Herstellung von 1,2,3,4,4a,5,6,10b-Octahydrobenz(h)isochinolin-6-on
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US5180733A (en) * 1990-03-30 1993-01-19 Abbott Laboratories Biogenic amine uptake inhibitors

Also Published As

Publication number Publication date
CA2276098A1 (en) 1998-07-16
CA2276098C (en) 2007-05-08
DE69820989D1 (de) 2004-02-12
JP3297058B2 (ja) 2002-07-02
EP0958285A1 (en) 1999-11-24
AU742735B2 (en) 2002-01-10
ATE257470T1 (de) 2004-01-15
JP2000507965A (ja) 2000-06-27
DE69820989T2 (de) 2004-12-09
DK0958285T3 (da) 2004-05-17
EP0958285B1 (en) 2004-01-07
AU5986698A (en) 1998-08-03
WO1998030546A1 (en) 1998-07-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM O ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.