BR9803955A - Fabricação de carotenóides. - Google Patents

Fabricação de carotenóides.

Info

Publication number
BR9803955A
BR9803955A BR9803955-5A BR9803955A BR9803955A BR 9803955 A BR9803955 A BR 9803955A BR 9803955 A BR9803955 A BR 9803955A BR 9803955 A BR9803955 A BR 9803955A
Authority
BR
Brazil
Prior art keywords
reaction
carotenoids
manufacture
reaction medium
mixtures
Prior art date
Application number
BR9803955-5A
Other languages
English (en)
Inventor
Werner Rudolph
Peter Rudin
Paul Kreienbuehl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9803955A publication Critical patent/BR9803955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/32—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen
    • C07C1/34—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen reacting phosphines with aldehydes or ketones, e.g. Wittig reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"FABRICAçãO DE CAROTENóIDES<D>". Um processo amplamente aplicável para a fabricação de carotenóides por uma reação de Wittig compreende realização da reação de Wittig em um meio de reação polar em uma maneira de modo que nem todos os reagentes nem o caretenóide assim formado sejam significantemente dissolvidos no meio de reação. Um meio de reação especialmente apropriado é um solvente (mistura) toxicologicamente inofensivo, polar que permanece monofásico na adição de água em uma quantidade de até cerca de 30% em volume e que permite que óxido de triaril fosfina que é formado dissolva bem. álcoois inferiores e acetorna, como solventes sozinhos ou como misturas uns com os outros e/ou com água, são especialmente apropriados. Este processo permite o uso de misturas de reação muito mais concentradas, simplifica a regeneração do solvente e genericamente o procedimento de reação e evita solventes toxicologicamente questionáveis tais como hidrocarbonetos halogenados.
BR9803955-5A 1997-10-03 1998-10-01 Fabricação de carotenóides. BR9803955A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97117192 1997-10-03

Publications (1)

Publication Number Publication Date
BR9803955A true BR9803955A (pt) 2000-04-11

Family

ID=8227436

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9803955-5A BR9803955A (pt) 1997-10-03 1998-10-01 Fabricação de carotenóides.

Country Status (10)

Country Link
US (1) US6150561A (pt)
EP (1) EP0908449B1 (pt)
JP (1) JPH11180901A (pt)
KR (1) KR19990036861A (pt)
CN (1) CN1158255C (pt)
BR (1) BR9803955A (pt)
CA (1) CA2248450A1 (pt)
DE (1) DE59802696D1 (pt)
DK (1) DK0908449T3 (pt)
ES (1) ES2167044T3 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2004904A3 (cs) * 2002-02-25 2004-12-15 Diffusion Pharmaceuticals Llc Bipolární trans karotenoidní soli a jejich použití
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
DE10254809A1 (de) * 2002-11-22 2004-06-03 Basf Ag Verfahren zur Herstellung von Carotinoiden
CA2537210C (en) * 2003-08-25 2013-06-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
KR101315904B1 (ko) * 2005-02-24 2013-10-08 디퓨젼 파마슈티컬즈 엘엘씨 트랜스 카로티노이드, 이들의 합성, 제제화 및 용도
WO2008136900A1 (en) 2007-04-13 2008-11-13 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
KR20100083820A (ko) * 2007-10-31 2010-07-22 디퓨젼 파마슈티컬즈 엘엘씨 저분자 확산을 촉진시키는 신규한 치료요법
CN101157645B (zh) * 2007-11-27 2010-06-02 江南大学 一种藏红花酸的合成方法
WO2010118042A2 (en) * 2009-04-06 2010-10-14 Board Of Regents The University Of Texas At Arlington Catalytic wittig and mitsunobu reactions
CN108464976A (zh) * 2009-06-22 2018-08-31 扩散药品有限公司 扩散促进化合物及其单独或与溶栓药一起的应用
JP2010090151A (ja) * 2009-12-09 2010-04-22 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
EP2575487B1 (en) 2010-06-02 2017-10-18 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
CN102311320B (zh) * 2011-06-30 2013-09-25 绍兴文理学院 一种2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一烷三烯的制备方法
CN105705042B (zh) 2013-11-07 2018-11-09 帝斯曼知识产权资产管理有限公司 纯化虾青素的方法
WO2015067705A1 (en) 2013-11-07 2015-05-14 Dsm Ip Assets B.V. Process for the purification of astaxanthin
CN109965279A (zh) 2013-11-07 2019-07-05 帝斯曼知识产权资产管理有限公司 包含合成的食品级虾青素的粉状制剂、油质悬浮物和膳食补充剂
WO2015067709A1 (en) 2013-11-07 2015-05-14 Dsm Ip Assets B.V. Process for the purification of astaxanthin
WO2015097717A2 (en) * 2013-12-23 2015-07-02 Laurus Labs Private Limited AN IMPROVED PROCESS FOR THE PREPARATION OF β-CAROTENE
JP2014144952A (ja) * 2014-01-10 2014-08-14 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
ES2670671T3 (es) 2014-06-18 2018-05-31 Allied Biotech Corporation Procedimientos de preparación de licopenos a partir de sales C-15 de Wittig y procedimientos para la purificación de sales C-15 de Wittig con contenido en todo-E y en 6Z elevado
CN107074760B (zh) * 2014-10-02 2020-02-21 巴斯夫欧洲公司 纯化虾青素和斑蝥黄的方法
MY174927A (en) * 2014-12-15 2020-05-22 Enpro Subsea Ltd Apparatus, systems and methods for oil and gas operations
EP3432929A4 (en) 2016-03-24 2019-11-27 Diffusion Pharmaceuticals LLC USE OF BIPOLAR TRANSCAROTINOIDS WITH CHEMOTHERAPY AND RADIOTHERAPY FOR THE TREATMENT OF CANCER
CN105906672B (zh) * 2016-04-29 2017-12-29 暨南大学 藏红花色素类化合物及其用途
JP2016183174A (ja) * 2016-05-12 2016-10-20 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
WO2018050793A1 (en) * 2016-09-16 2018-03-22 Basf Se Process for preparing phosphonium salt esters as building blocks for carotenoides
CN106753775B (zh) * 2016-12-29 2020-05-05 山东师范大学 一种高虾青素及其酯含量的南极磷虾油脂的提取方法
JP2018135329A (ja) * 2018-02-19 2018-08-30 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
CN110749688A (zh) * 2019-11-07 2020-02-04 贵州省兽药饲料监察所(贵州省兽药残留监测中心) 一种测定饲料中β-阿朴-8＇-胡萝卜素酸乙酯着色剂含量的方法
CN113511993B (zh) * 2021-07-06 2023-02-24 广州智特奇生物科技股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的合成方法
WO2024068515A1 (en) * 2022-09-29 2024-04-04 Dsm Ip Assets B.V. β-CAROTENE SYNTHESIS (II)
WO2024068514A1 (en) * 2022-09-29 2024-04-04 Dsm Ip Assets B.V. β-CAROTENE SYNTHESIS (I)
CN116102480B (zh) * 2022-12-09 2024-02-27 万华化学集团股份有限公司 一种β-阿朴-12’-胡萝卜醛的连续制备工艺
CN115784957A (zh) * 2022-12-15 2023-03-14 上虞新和成生物化工有限公司 一种虾青素的提纯方法
CN116120218B (zh) * 2023-01-03 2024-05-03 万华化学集团股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517067A (en) * 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
US3496170A (en) * 1966-03-23 1970-02-17 Eastman Kodak Co Carotenoid compounds
DE19509955A1 (de) * 1995-03-18 1996-09-19 Basf Ag Verfahren zur Herstellung von Astaxanthin

Also Published As

Publication number Publication date
CN1158255C (zh) 2004-07-21
KR19990036861A (ko) 1999-05-25
EP0908449A1 (de) 1999-04-14
ES2167044T3 (es) 2002-05-01
EP0908449B1 (de) 2001-11-21
DE59802696D1 (de) 2002-02-21
DK0908449T3 (da) 2002-05-21
CN1215723A (zh) 1999-05-05
CA2248450A1 (en) 1999-04-03
US6150561A (en) 2000-11-21
JPH11180901A (ja) 1999-07-06

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Legal Events

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B25A Requested transfer of rights approved

Free format text: DSM IP ASSETS B.V. (NL)

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, NAO ATENDE AO REQUISITO DE SUFICIENCIA DESCRITIVA ( ART. 24 DA LEI 9279/96 )