BR9713049A - Ophthalmically safe disinfectant solution for a contact lens, method for disinfecting or cleaning and disinfecting a soft contact lens and kit for disinfecting or disinfecting and cleaning a contact lens. - Google Patents

Ophthalmically safe disinfectant solution for a contact lens, method for disinfecting or cleaning and disinfecting a soft contact lens and kit for disinfecting or disinfecting and cleaning a contact lens.

Info

Publication number
BR9713049A
BR9713049A BR9713049-4A BR9713049A BR9713049A BR 9713049 A BR9713049 A BR 9713049A BR 9713049 A BR9713049 A BR 9713049A BR 9713049 A BR9713049 A BR 9713049A
Authority
BR
Brazil
Prior art keywords
disinfecting
contact lens
cleaning
carbon atoms
alkyl
Prior art date
Application number
BR9713049-4A
Other languages
Portuguese (pt)
Inventor
Susan P Spooner
David J Heiler
Lisa C Simpson
David A Marsch
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of BR9713049A publication Critical patent/BR9713049A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof

Abstract

"SOLUçãO DESINFETANTE OFTALMICAMENTE SEGURA PARA UMA LENTE DE CONTATO, MéTODO PARA DESINFETAR OU LIMPAR E DESINFETAR UMA LENTE DE CONTATO MACIA E KIT PARA DESINFETAR OU DESINFETAR E LIMPAR UMA LENTE DE CONTATO". A presente invenção é dirigida a uma solução desinfetante oftalmicamente segura para lentes de contato compreendendo uma bis (biguanida) tendo fórmula (I) onde R1 e R4 são independentemente selecionados do grupo consistindo de radical ramificado ou não ramificado de alquila tendo 4-12 átomos de carbono, de éter ou tioéter tendo 4-12 átomos de carbono, ou radical cicloalquila ou cicloalquil-alquila tendo 5-12 átomos de carbono; R2 e R3 são independentemente selecionados do grupo consistindo de hidrogênio, alquila tendo 1-12 átomos de carbono, alcóxialquila tendo 1-12 átomos de carbono, ou cicloalquila ou cicloalquil-alquila tendo 5-12 átomos de carbono; R6 e R7 são independentemente selecionados do grupo consistindo de hidrogênio e radical alquila tendo 1-6 átomos de carbono, e A na fórmula acima é selecionado do radical divalente tendo 4-16 átomos de carbono consistindo de uma divalente alquila, alquilóxialquila, alquilsulfeto, ou um polimetileno interrompido com um radical divalente cíclico. Em uma configuração da presente invenção, tais biguanidas podem ser combinadas com uma biguanida polimérica para eficácia biocida complementar e sinergética. A invenção também é dirigida a um método melhorado para desinfetar uma lente de contato."OPHTHALMICALLY SAFE DISINFECTANT SOLUTION FOR A CONTACT LENS, METHOD FOR DISINFECTING OR CLEANING AND DISINFECTING A SOFT CONTACT LENS AND KIT FOR DISINFECTING OR DISINFECTING AND CLEANING A CONTACT LENS". The present invention is directed to an ophthalmically safe disinfectant solution for contact lenses comprising a bis (biguanide) having formula (I) where R1 and R4 are independently selected from the group consisting of branched or unbranched alkyl radicals having 4-12 atoms of carbon, ether or thioether having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl radical having 5-12 carbon atoms; R2 and R3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12 carbon atoms; R6 and R7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the divalent radical having 4-16 carbon atoms consisting of a divalent alkyl, alkyloxyalkyl, alkylsulfide, or a polymethylene interrupted with a cyclic divalent radical. In one embodiment of the present invention, such biguanides can be combined with a polymeric biguanide for complementary and synergistic biocidal efficacy. The invention is also directed to an improved method for disinfecting a contact lens.

BR9713049-4A 1996-11-13 1997-11-04 Ophthalmically safe disinfectant solution for a contact lens, method for disinfecting or cleaning and disinfecting a soft contact lens and kit for disinfecting or disinfecting and cleaning a contact lens. BR9713049A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3164696P 1996-11-13 1996-11-13
PCT/US1997/020087 WO1998020738A1 (en) 1996-11-13 1997-11-04 Compositions and methods in which bis(biguanides) provide enhanced antimicrobial efficacy for disinfecting contact lenses

Publications (1)

Publication Number Publication Date
BR9713049A true BR9713049A (en) 2000-04-04

Family

ID=21860642

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713049-4A BR9713049A (en) 1996-11-13 1997-11-04 Ophthalmically safe disinfectant solution for a contact lens, method for disinfecting or cleaning and disinfecting a soft contact lens and kit for disinfecting or disinfecting and cleaning a contact lens.

Country Status (7)

Country Link
EP (1) EP0942653A1 (en)
JP (1) JP2001504246A (en)
KR (1) KR20000053221A (en)
AU (1) AU5429198A (en)
BR (1) BR9713049A (en)
CA (1) CA2269764A1 (en)
WO (1) WO1998020738A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739900B2 (en) * 1996-11-13 2001-10-25 Bausch & Lomb Incorporated Disinfecting contact lenses with bis(biguanides) and polymeric biguanides
BR9813994A (en) * 1997-11-12 2000-09-26 Bausch & Lomb Ophthalmically safe solution for disinfecting contact lenses and their use
CN1278863A (en) * 1997-11-12 2001-01-03 博士伦公司 Disinfecting contact lenses with polyquaterniums and polymeric biguanides
US6369112B1 (en) * 1998-12-15 2002-04-09 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol
US6309596B1 (en) * 1998-12-15 2001-10-30 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by a poloxamine
BR9916267A (en) 1998-12-18 2001-09-04 Alcon Lab Inc Polybiguanide starch and their use as antimicrobial agents
CA2352076A1 (en) 1998-12-18 2000-06-22 Alcon Laboratories, Inc. Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions
US6634748B1 (en) * 2000-11-15 2003-10-21 Johnson & Johnson Vision Care, Inc. Methods of stabilizing silicone hydrogels against hydrolytic degradation
US20040204496A1 (en) * 2003-04-11 2004-10-14 Ammon Daniel M. Disinfecting solutions effective against bacterial endospores
US20060067981A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Contact lens with improved biocidal activity and related methods and materials
US7897553B2 (en) * 2006-10-23 2011-03-01 Bausch & Lomb Incorporated Biguanide composition with low terminal amine
IL190181A (en) 2008-03-16 2015-08-31 Altos Medical Llc Cleaning, sanitising and sterilising preparations
WO2014060755A1 (en) 2012-10-17 2014-04-24 Arcis Biotechnology Holdings Limited Cleaning, sanitizing and sterilizing preparations
CN105010379B (en) * 2014-04-30 2018-06-01 宁波润增医疗科技有限公司 Fungicide and its application
WO2017142005A1 (en) * 2016-02-17 2017-08-24 株式会社シード Anti-acanthamoeba solvent for contact lenses
US11044912B2 (en) * 2017-01-03 2021-06-29 Hwang-Hsing Chen Branched polymeric biguanide compounds and their uses
CN110078913B (en) * 2019-05-29 2021-08-24 湖南雪天精细化工股份有限公司 Preparation method of polyhexamethylene biguanide hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8312663D0 (en) * 1983-05-09 1983-06-15 Ici Plc Bisbiguanide compounds
CA2009118C (en) * 1989-02-21 1996-02-27 Mary F. Mowrey-Mckee Method and composition for cleaning and disinfecting contact lenses
US4891423A (en) * 1989-03-20 1990-01-02 Stockel Richard F Polymeric biguanides
DE69414836T2 (en) * 1993-01-07 1999-06-17 Polymer Technology Corp PROTECTIVE AGENT FOR SOLUTIONS FOR CONTACT LENSES

Also Published As

Publication number Publication date
WO1998020738A1 (en) 1998-05-22
CA2269764A1 (en) 1998-05-22
JP2001504246A (en) 2001-03-27
EP0942653A1 (en) 1999-09-22
AU5429198A (en) 1998-06-03
KR20000053221A (en) 2000-08-25

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007.