BR9610960A - Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso - Google Patents

Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso

Info

Publication number
BR9610960A
BR9610960A BR9610960A BR9610960A BR9610960A BR 9610960 A BR9610960 A BR 9610960A BR 9610960 A BR9610960 A BR 9610960A BR 9610960 A BR9610960 A BR 9610960A BR 9610960 A BR9610960 A BR 9610960A
Authority
BR
Brazil
Prior art keywords
heteroaryl
alkynyl
cycloalkyl
alkenyl
alkyl
Prior art date
Application number
BR9610960A
Other languages
English (en)
Inventor
Jorgen Scheel-Kruger
Peter Moldt
Gunnar M Olsen
Elsebet Ostergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of BR9610960A publication Critical patent/BR9610960A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR9610960A 1995-10-13 1996-10-11 Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso BR9610960A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13
PCT/EP1996/004449 WO1997013770A1 (en) 1995-10-13 1996-10-11 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
BR9610960A true BR9610960A (pt) 1999-03-02

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610960A BR9610960A (pt) 1995-10-13 1996-10-11 Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso

Country Status (24)

Country Link
US (1) US6100275A (pt)
EP (1) EP0859777B1 (pt)
JP (1) JP3462505B2 (pt)
KR (1) KR100274829B1 (pt)
CN (1) CN1083840C (pt)
AT (1) ATE362931T1 (pt)
AU (1) AU709327B2 (pt)
BR (1) BR9610960A (pt)
CA (1) CA2233541C (pt)
CZ (1) CZ285093B6 (pt)
DE (1) DE69637097T2 (pt)
DK (1) DK0859777T3 (pt)
EE (1) EE03446B1 (pt)
HU (1) HUP9802433A3 (pt)
IL (1) IL123583A (pt)
IS (1) IS4681A (pt)
NO (1) NO980919L (pt)
NZ (1) NZ320216A (pt)
PL (1) PL185357B1 (pt)
RU (1) RU2157372C2 (pt)
SK (1) SK283425B6 (pt)
TR (1) TR199800628T2 (pt)
UA (1) UA63894C2 (pt)
WO (1) WO1997013770A1 (pt)

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GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
EP0901490B1 (en) * 1996-05-13 2004-04-07 Syngenta Limited Bicyclic amines as insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
TR199901704T2 (xx) 1996-11-26 1999-12-21 Zeneca Limited 8-Azabisiklo$3.2.1]oktan-, 8-azabisiklo$3.2.1]okt-6-en-,9-azabisiklo$3.3.1] nonan-,9-aza-3-oksabisiklo$3.3.1]nonan-ve 9-aza-3-tiabisiklo$3.3.1]nonan t�revleri, bunlar�n haz�rlanmas� ve insektisidler olarak kullan�mlar�.
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
RU2186780C2 (ru) 1997-05-30 2002-08-10 Ньюросерч А/С Производное 8-азабицикло [3.2.1]окт-2-ена, способы его получения, фармацевтическая композиция
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
WO1999038866A1 (en) * 1998-01-28 1999-08-05 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form
US6403605B1 (en) 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
JP2002518331A (ja) * 1998-06-19 2002-06-25 イーライ・リリー・アンド・カンパニー セロトニン再取り込みの阻害
ATE259804T1 (de) * 1998-11-27 2004-03-15 Neurosearch As 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate
AU2278700A (en) 1999-01-28 2000-08-18 Neurosearch A/S Novel azabicyclo derivatives and their use
ATE301636T1 (de) * 1999-03-01 2005-08-15 Pfizer 1, 2, 3, 4-tetrahydro-1-naphthalenamin verbindungen zur therapeutsichen verwendung
CA2383785C (en) 1999-09-03 2009-02-17 Eli Lilly And Company Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction
US6835733B2 (en) 1999-12-20 2004-12-28 Eli Lilly And Company Tropane linked benzofuran derivatives
EP1289996B1 (en) 2000-05-25 2005-04-06 Targacept, Inc. Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
ATE334979T1 (de) * 2000-10-13 2006-08-15 Neurosearch As Behandlung affektiver störungen durch kombinierte wirkung eines nikotinischen rezeptoragonisten und einer monoaminergischen substanz
US7160899B2 (en) 2001-04-09 2007-01-09 Neurosearch A/S Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
TW589312B (en) 2001-05-25 2004-06-01 Wyeth Corp Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
WO2003094830A2 (en) * 2002-05-07 2003-11-20 Neurosearch A/S Novel azacyclic ethynyl derivatives
EP1869033A1 (en) * 2005-04-08 2007-12-26 Neurosearch A/S Novel enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
AU2009221310A1 (en) * 2008-03-05 2009-09-11 Neurosearch A/S Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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US3657257A (en) * 1970-08-31 1972-04-18 Robins Co Inc A H 3-aryl-8-carbamoyl nortropanes
US4180669A (en) * 1976-12-13 1979-12-25 Abbott Laboratories 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol
US4132710A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna And Harrison, Ltd. [2]Benzopyrano[3,4-c]pyridines and process therefor
JPS55115872A (en) * 1979-02-22 1980-09-06 Wellcome Found Imidazole derivative and medical composition
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
GB9019973D0 (en) * 1990-09-12 1990-10-24 Wyeth John & Brother Ltd Azabicyclic derivatives
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Also Published As

Publication number Publication date
AU709327B2 (en) 1999-08-26
EP0859777A1 (en) 1998-08-26
EE9800062A (et) 1998-08-17
WO1997013770A1 (en) 1997-04-17
TR199800628T2 (xx) 1998-07-21
IL123583A (en) 2003-07-31
CN1199400A (zh) 1998-11-18
US6100275A (en) 2000-08-08
IS4681A (is) 1998-03-04
UA63894C2 (en) 2004-02-16
PL185357B1 (pl) 2003-04-30
KR100274829B1 (ko) 2000-12-15
NZ320216A (en) 1999-05-28
EP0859777B1 (en) 2007-05-23
CZ285093B6 (cs) 1999-05-12
CN1083840C (zh) 2002-05-01
DE69637097D1 (de) 2007-07-05
ATE362931T1 (de) 2007-06-15
CZ75898A3 (cs) 1998-11-11
JPH10512589A (ja) 1998-12-02
RU2157372C2 (ru) 2000-10-10
HUP9802433A3 (en) 2000-03-28
SK28798A3 (en) 1998-09-09
CA2233541C (en) 2002-04-30
CA2233541A1 (en) 1997-04-17
NO980919L (no) 1998-06-08
KR19990063651A (ko) 1999-07-26
SK283425B6 (sk) 2003-07-01
PL326195A1 (en) 1998-08-31
IL123583A0 (en) 1998-10-30
AU7291796A (en) 1997-04-30
JP3462505B2 (ja) 2003-11-05
NO980919D0 (no) 1998-03-03
HUP9802433A2 (hu) 1999-04-28
DK0859777T3 (da) 2007-09-03
DE69637097T2 (de) 2007-09-20
EE03446B1 (et) 2001-06-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE PATENTE COM BASE NOS ARTIGOS 8 E 13 DA LPI NO9.279 DE 14/05/1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]