BR9408343A - Derivados 5-(2-imidazolinil amino) benzimidazol sua preparação e seu uso como agonistas alfa-2 adrenoceptor - Google Patents

Derivados 5-(2-imidazolinil amino) benzimidazol sua preparação e seu uso como agonistas alfa-2 adrenoceptor

Info

Publication number
BR9408343A
BR9408343A BR9408343A BR9408343A BR9408343A BR 9408343 A BR9408343 A BR 9408343A BR 9408343 A BR9408343 A BR 9408343A BR 9408343 A BR9408343 A BR 9408343A BR 9408343 A BR9408343 A BR 9408343A
Authority
BR
Brazil
Prior art keywords
alpha
preparation
benzimidazole derivatives
adrenoceptor agonists
unsubstituted
Prior art date
Application number
BR9408343A
Other languages
English (en)
Inventor
Thomas Lee Cupps
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865464&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9408343(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9408343A publication Critical patent/BR9408343A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR9408343A 1993-12-17 1994-12-15 Derivados 5-(2-imidazolinil amino) benzimidazol sua preparação e seu uso como agonistas alfa-2 adrenoceptor BR9408343A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16986893A 1993-12-17 1993-12-17
US08/349,558 US5478858A (en) 1993-12-17 1994-12-08 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
PCT/US1994/014292 WO1995016685A1 (en) 1993-12-17 1994-12-15 5-(2-imidazolinylamino)benzimidazole derivatives, their preparation and their use as alpha-2 adrenoceptor agonists

Publications (1)

Publication Number Publication Date
BR9408343A true BR9408343A (pt) 1997-08-19

Family

ID=26865464

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9408343A BR9408343A (pt) 1993-12-17 1994-12-15 Derivados 5-(2-imidazolinil amino) benzimidazol sua preparação e seu uso como agonistas alfa-2 adrenoceptor

Country Status (23)

Country Link
US (3) US5478858A (pt)
EP (1) EP0736022B1 (pt)
JP (1) JPH09507216A (pt)
KR (1) KR100385195B1 (pt)
CN (1) CN1076352C (pt)
AT (1) ATE250598T1 (pt)
AU (1) AU699631B2 (pt)
BR (1) BR9408343A (pt)
CA (1) CA2179008C (pt)
CZ (1) CZ286816B6 (pt)
DE (1) DE69433181T2 (pt)
ES (1) ES2202352T3 (pt)
FI (1) FI962494A0 (pt)
HU (1) HU224016B1 (pt)
MY (1) MY131696A (pt)
NO (1) NO309325B1 (pt)
NZ (1) NZ333371A (pt)
PL (1) PL180903B1 (pt)
RU (1) RU2143430C1 (pt)
SG (1) SG49049A1 (pt)
SK (1) SK282566B6 (pt)
TW (1) TW393469B (pt)
WO (1) WO1995016685A1 (pt)

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US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
AU701042B2 (en) * 1995-02-28 1999-01-21 Aventisub Llc Pharmaceutical composition for piperidinoalkanol compounds
US5677321A (en) 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
US5648358A (en) * 1996-03-05 1997-07-15 Mitra; Sekhar Compositions and methods for treating respiratory disorders
US6525018B1 (en) * 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
JP2001506599A (ja) * 1996-11-25 2001-05-22 ザ プロクター アンド ギャンブル カンパニー アルファ−２アドレナリン受容体アゴニストとして有効な２−イミダゾリニルアミノインダゾール化合物
WO1998023596A1 (en) * 1996-11-25 1998-06-04 The Procter & Gamble Company Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
HUP0000479A3 (en) * 1996-11-25 2002-06-28 Procter & Gamble Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists and pharmaceutical compositions containing them
US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
US6306877B1 (en) 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
ES2225998T3 (es) * 1996-11-25 2005-03-16 THE PROCTER & GAMBLE COMPANY Compuestos (2-imidazolinilamino)indol utiles como agonistas del adrenorreceptor alfa 2.
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US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
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US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
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US7919119B2 (en) * 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US8889112B2 (en) * 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US7678387B2 (en) * 2000-06-06 2010-03-16 Capricorn Pharma, Inc. Drug delivery systems
US20070059367A1 (en) * 2000-06-06 2007-03-15 Cherukuri S R Drug Delivery System and Associated Methods
US20100196466A1 (en) * 2000-06-06 2010-08-05 Capricorn Pharma Inc. Drug delivery system
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AU2002220248A1 (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
US20030186880A1 (en) * 2002-03-26 2003-10-02 Podolsky Daniel K. Combination therapy using trefoil peptides
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
CN1599619A (zh) * 2001-10-05 2005-03-23 综合医院公司 治疗真皮损伤的方法和组合物
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US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
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US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20040167194A1 (en) * 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
US7777051B2 (en) * 2003-05-13 2010-08-17 Icagen, Inc. Asymmetric benzimidazoles and related compounds as potassium channel modulators
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
US20070053868A1 (en) * 2005-03-08 2007-03-08 Banner Pharmacaps, Inc. Solvent system for enhancing the solubility of pharmaceutical agents
US7919510B2 (en) 2005-05-18 2011-04-05 Neuraxon, Inc Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity
PL1896022T3 (pl) * 2005-06-17 2013-03-29 Aft Pharmaceuticals Ltd Nowa kompozycja farmaceutyczna i jej zastosowanie w sposobie leczenia pacjentów z przekrwieniem śluzówki górnych dróg oddechowych
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
US20130210876A1 (en) * 2010-01-21 2013-08-15 Allergan, Inc Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect
US9889088B2 (en) * 2010-01-21 2018-02-13 Allergan, Inc. Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect
JP6052685B2 (ja) * 2011-07-25 2016-12-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ α２アドレナリン受容体の調節因子としてのＮ−（イミダゾリジン−２−イリデン）−ヘテロシクロペンタ［ｂ］ピリジン誘導体
US9629847B2 (en) 2011-11-23 2017-04-25 Michael Leighton Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant
US9149474B2 (en) * 2011-11-23 2015-10-06 Michael Leighton Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant
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US20210205273A1 (en) 2018-08-21 2021-07-08 Allergan, Inc. The use of alpha-2-adrenergic receptor agonists for improving vision
US11077053B2 (en) * 2018-08-21 2021-08-03 Allergan, Inc. Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia
CA3168748A1 (en) 2020-02-20 2021-08-26 Mohammed DIBAS Alpha-2-adrenergic receptor agonists for reducing redness and increasing whiteness in eyes and other ophthalmic purposes
WO2021168349A1 (en) 2020-02-20 2021-08-26 Allergan, Inc. Pharmaceutical compositions of alpha-2-adrenergic receptor agonists and their use for improving vision

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EP0775134A4 (en) * 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES

Also Published As

Publication number Publication date
NO962539D0 (no) 1996-06-14
NO309325B1 (no) 2001-01-15
DE69433181T2 (de) 2004-07-01
RU2143430C1 (ru) 1999-12-27
HU224016B1 (hu) 2005-04-28
AU1306295A (en) 1995-07-03
CN1137794A (zh) 1996-12-11
US5541210A (en) 1996-07-30
WO1995016685A1 (en) 1995-06-22
CZ286816B6 (en) 2000-07-12
JPH09507216A (ja) 1997-07-22
SK282566B6 (sk) 2002-10-08
FI962494A (fi) 1996-06-14
CN1076352C (zh) 2001-12-19
DE69433181D1 (de) 2003-10-30
ATE250598T1 (de) 2003-10-15
EP0736022A1 (en) 1996-10-09
US5478858A (en) 1995-12-26
SG49049A1 (en) 1998-05-18
CA2179008A1 (en) 1995-06-22
TW393469B (en) 2000-06-11
ES2202352T3 (es) 2004-04-01
HUT76473A (en) 1997-09-29
NZ333371A (en) 2001-12-21
HU9601663D0 (en) 1996-08-28
FI962494A0 (fi) 1996-06-14
AU699631B2 (en) 1998-12-10
PL180903B1 (pl) 2001-04-30
NO962539L (no) 1996-08-13
PL315059A1 (en) 1996-09-30
MY131696A (en) 2007-08-30
SK77196A3 (en) 1997-03-05
EP0736022B1 (en) 2003-09-24
CA2179008C (en) 1999-08-17
CZ175196A3 (en) 1996-11-13
KR100385195B1 (ko) 2003-08-21
US5691370A (en) 1997-11-25

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
CKFC Appeal: appeal against refusal