BR9302451A - Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico - Google Patents

Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico

Info

Publication number
BR9302451A
BR9302451A BR9302451A BR9302451A BR9302451A BR 9302451 A BR9302451 A BR 9302451A BR 9302451 A BR9302451 A BR 9302451A BR 9302451 A BR9302451 A BR 9302451A BR 9302451 A BR9302451 A BR 9302451A
Authority
BR
Brazil
Prior art keywords
isomers
acid derivatives
folic acid
chromatographic
industrial preparation
Prior art date
Application number
BR9302451A
Other languages
English (en)
Inventor
Leonardo Ambrosini
Bruno Sala
Original Assignee
Irca Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP93108752A priority Critical patent/EP0627435A1/en
Priority to CA002097884A priority patent/CA2097884A1/en
Priority to JP5166252A priority patent/JPH06345765A/ja
Priority to CN93107281A priority patent/CN1039716C/zh
Application filed by Irca Spa filed Critical Irca Spa
Priority to BR9302451A priority patent/BR9302451A/pt
Priority to AU41542/93A priority patent/AU4154293A/en
Publication of BR9302451A publication Critical patent/BR9302451A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
BR9302451A 1993-06-01 1993-06-23 Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico BR9302451A (pt)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP93108752A EP0627435A1 (en) 1993-06-01 1993-06-01 Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation
CA002097884A CA2097884A1 (en) 1993-06-01 1993-06-07 Method for the industrial preparation of (6s) folic acid derivatives by chromatographic separation
JP5166252A JPH06345765A (ja) 1993-06-01 1993-06-10 クロマトグラフィー分離による（６ｓ）−葉酸誘導体の産業的製造方法
CN93107281A CN1039716C (zh) 1993-06-01 1993-06-19 通过色谱分离制备(6s)叶酸衍生物的工业方法
BR9302451A BR9302451A (pt) 1993-06-01 1993-06-23 Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico
AU41542/93A AU4154293A (en) 1993-06-01 1993-06-25 Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP93108752A EP0627435A1 (en) 1993-06-01 1993-06-01 Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation
CA002097884A CA2097884A1 (en) 1993-06-01 1993-06-07 Method for the industrial preparation of (6s) folic acid derivatives by chromatographic separation
JP5166252A JPH06345765A (ja) 1993-06-01 1993-06-10 クロマトグラフィー分離による（６ｓ）−葉酸誘導体の産業的製造方法
CN93107281A CN1039716C (zh) 1993-06-01 1993-06-19 通过色谱分离制备(6s)叶酸衍生物的工业方法
BR9302451A BR9302451A (pt) 1993-06-01 1993-06-23 Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico
AU41542/93A AU4154293A (en) 1993-06-01 1993-06-25 Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation

Publications (1)

Publication Number Publication Date
BR9302451A true BR9302451A (pt) 1995-01-17

Family

ID=36822330

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9302451A BR9302451A (pt) 1993-06-01 1993-06-23 Processo para a preparação industrial de isômeros (6S) através de separação cromatográfica em uma coluna cromatográfica de misturas diastereoisoméricas (6R,S) de derivados de ácido fólico

Country Status (6)

Country Link
EP (1) EP0627435A1 (pt)
JP (1) JPH06345765A (pt)
CN (1) CN1039716C (pt)
AU (1) AU4154293A (pt)
BR (1) BR9302451A (pt)
CA (1) CA2097884A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2254890T3 (da) 2008-02-20 2015-07-13 Gnosis Spa Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre
CN103393686B (zh) * 2013-07-15 2016-02-17 深圳奥萨医药有限公司 噻唑烷二酮类药物与5-甲基四氢叶酸药物组合物的用途
CN107643353B (zh) * 2016-07-20 2020-05-01 中国计量科学研究院 叶酸的制备纯化方法

Also Published As

Publication number Publication date
AU4154293A (en) 1995-01-19
CN1039716C (zh) 1998-09-09
CA2097884A1 (en) 1994-12-07
JPH06345765A (ja) 1994-12-20
CN1096785A (zh) 1994-12-28
EP0627435A1 (en) 1994-12-07

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal